Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTR3_LEIIN

TriTrypDb:

LINF_210028700

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HTR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTR3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.678
CLV_C14_Caspase3-7	231	235	PF00656	0.602
CLV_PCSK_SKI1_1	175	179	PF00082	0.459
CLV_PCSK_SKI1_1	58	62	PF00082	0.546
CLV_PCSK_SKI1_1	63	67	PF00082	0.519
DEG_Nend_UBRbox_2	1	3	PF02207	0.486
DEG_ODPH_VHL_1	12	24	PF01847	0.484
DOC_USP7_MATH_1	104	108	PF00917	0.755
DOC_USP7_MATH_1	77	81	PF00917	0.729
DOC_USP7_UBL2_3	96	100	PF12436	0.751
DOC_WW_Pin1_4	150	155	PF00397	0.760
DOC_WW_Pin1_4	63	68	PF00397	0.731
DOC_WW_Pin1_4	79	84	PF00397	0.736
LIG_14-3-3_CanoR_1	47	57	PF00244	0.701
LIG_FHA_1	187	193	PF00498	0.788
LIG_FHA_2	112	118	PF00498	0.650
LIG_LIR_Gen_1	16	27	PF02991	0.361
LIG_LIR_Gen_1	2	12	PF02991	0.489
LIG_LIR_Nem_3	16	22	PF02991	0.361
LIG_LIR_Nem_3	2	7	PF02991	0.493
LIG_SH2_CRK	17	21	PF00017	0.331
LIG_SH2_PTP2	19	22	PF00017	0.325
LIG_SH2_SRC	17	20	PF00017	0.452
LIG_SH2_STAP1	17	21	PF00017	0.369
LIG_SH2_STAT5	19	22	PF00017	0.514
LIG_SH3_3	151	157	PF00018	0.826
LIG_SH3_3	3	9	PF00018	0.535
LIG_SH3_3	51	57	PF00018	0.738
LIG_TRAF2_1	143	146	PF00917	0.778
MOD_CDK_SPxK_1	150	156	PF00069	0.788
MOD_CDK_SPxxK_3	63	70	PF00069	0.734
MOD_CK1_1	188	194	PF00069	0.768
MOD_CK1_1	69	75	PF00069	0.742
MOD_CK1_1	79	85	PF00069	0.793
MOD_GlcNHglycan	106	109	PF01048	0.501
MOD_GlcNHglycan	139	142	PF01048	0.545
MOD_GlcNHglycan	230	233	PF01048	0.482
MOD_GlcNHglycan	79	82	PF01048	0.550
MOD_GlcNHglycan	85	88	PF01048	0.478
MOD_GSK3_1	162	169	PF00069	0.804
MOD_GSK3_1	75	82	PF00069	0.746
MOD_N-GLC_1	150	155	PF02516	0.612
MOD_N-GLC_1	202	207	PF02516	0.506
MOD_NEK2_1	134	139	PF00069	0.725
MOD_NEK2_1	228	233	PF00069	0.661
MOD_PIKK_1	155	161	PF00454	0.763
MOD_Plk_1	111	117	PF00069	0.649
MOD_ProDKin_1	150	156	PF00069	0.762
MOD_ProDKin_1	63	69	PF00069	0.732
MOD_ProDKin_1	79	85	PF00069	0.738
TRG_DiLeu_BaEn_1	219	224	PF01217	0.722
TRG_DiLeu_BaEn_4	219	225	PF01217	0.721
TRG_ENDOCYTIC_2	17	20	PF00928	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR49	Leptomonas seymouri	43%	100%
A0A3Q8IE41	Leishmania donovani	95%	98%
A4H9A5	Leishmania braziliensis	62%	100%
A4HXM5	Leishmania infantum	95%	98%
C9ZUK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ARC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QBZ4	Leishmania major	85%	100%
Q4QE42	Leishmania major	85%	100%