LeishMANIAdb
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Putative histone deacetylase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative histone deacetylase
Gene product:
histone deacetylase - putative
Species:
Leishmania infantum
UniProt:
A4HTR2_LEIIN
TriTrypDb:
LINF_210028600 *
Length:
630

Annotations

Annotations by Jardim et al.

Histone/chromosome structure, histone deacetylase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000118 histone deacetylase complex 3 1
GO:0005737 cytoplasm 2 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 1
GO:0140513 nuclear protein-containing complex 2 1
GO:1902494 catalytic complex 2 1

Expansion

Sequence features

A4HTR2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTR2

Function

Biological processes
Term Name Level Count
GO:0000122 negative regulation of transcription by RNA polymerase II 8 1
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0006357 regulation of transcription by RNA polymerase II 7 1
GO:0006476 protein deacetylation 6 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009890 negative regulation of biosynthetic process 5 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010558 negative regulation of macromolecule biosynthetic process 6 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0016570 histone modification 5 1
GO:0016575 histone deacetylation 6 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0019538 protein metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031324 negative regulation of cellular metabolic process 5 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0031327 negative regulation of cellular biosynthetic process 6 1
GO:0035601 protein deacylation 5 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0045892 negative regulation of DNA-templated transcription 7 1
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 6 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051172 negative regulation of nitrogen compound metabolic process 5 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0051253 negative regulation of RNA metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:0098732 macromolecule deacylation 5 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1902679 negative regulation of RNA biosynthetic process 7 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:1903507 negative regulation of nucleic acid-templated transcription 8 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0004407 histone deacetylase activity 4 1
GO:0016787 hydrolase activity 2 2
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3 1
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4 1
GO:0019213 deacetylase activity 3 1
GO:0033558 protein lysine deacetylase activity 3 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 392 396 PF00656 0.619
CLV_NRD_NRD_1 155 157 PF00675 0.317
CLV_NRD_NRD_1 312 314 PF00675 0.277
CLV_NRD_NRD_1 375 377 PF00675 0.619
CLV_PCSK_KEX2_1 155 157 PF00082 0.305
CLV_PCSK_KEX2_1 375 377 PF00082 0.610
CLV_PCSK_KEX2_1 5 7 PF00082 0.663
CLV_PCSK_KEX2_1 616 618 PF00082 0.468
CLV_PCSK_PC1ET2_1 5 7 PF00082 0.663
CLV_PCSK_PC1ET2_1 616 618 PF00082 0.499
CLV_PCSK_SKI1_1 147 151 PF00082 0.337
CLV_PCSK_SKI1_1 209 213 PF00082 0.368
CLV_PCSK_SKI1_1 585 589 PF00082 0.287
DEG_APCC_DBOX_1 520 528 PF00400 0.581
DEG_SCF_FBW7_1 50 57 PF00400 0.729
DEG_SCF_FBW7_2 326 332 PF00400 0.592
DEG_SPOP_SBC_1 408 412 PF00917 0.676
DEG_SPOP_SBC_1 419 423 PF00917 0.721
DEG_SPOP_SBC_1 427 431 PF00917 0.663
DOC_ANK_TNKS_1 178 185 PF00023 0.581
DOC_CDC14_PxL_1 52 60 PF14671 0.734
DOC_CKS1_1 326 331 PF01111 0.498
DOC_CKS1_1 51 56 PF01111 0.733
DOC_CYCLIN_RxL_1 269 279 PF00134 0.544
DOC_CYCLIN_RxL_1 582 591 PF00134 0.487
DOC_CYCLIN_yCln2_LP_2 48 51 PF00134 0.743
DOC_MAPK_gen_1 518 527 PF00069 0.581
DOC_MAPK_MEF2A_6 12 21 PF00069 0.595
DOC_MAPK_MEF2A_6 518 526 PF00069 0.487
DOC_PP2B_LxvP_1 48 51 PF13499 0.733
DOC_PP2B_LxvP_1 58 61 PF13499 0.699
DOC_PP2B_PxIxI_1 270 276 PF00149 0.537
DOC_USP7_MATH_1 356 360 PF00917 0.812
DOC_USP7_MATH_1 368 372 PF00917 0.517
DOC_USP7_MATH_1 409 413 PF00917 0.669
DOC_USP7_MATH_1 419 423 PF00917 0.686
DOC_USP7_MATH_1 577 581 PF00917 0.487
DOC_USP7_MATH_1 59 63 PF00917 0.761
DOC_USP7_MATH_1 71 75 PF00917 0.739
DOC_WW_Pin1_4 110 115 PF00397 0.553
DOC_WW_Pin1_4 325 330 PF00397 0.560
DOC_WW_Pin1_4 451 456 PF00397 0.799
DOC_WW_Pin1_4 480 485 PF00397 0.550
DOC_WW_Pin1_4 50 55 PF00397 0.706
DOC_WW_Pin1_4 542 547 PF00397 0.501
DOC_WW_Pin1_4 624 629 PF00397 0.373
DOC_WW_Pin1_4 66 71 PF00397 0.693
DOC_WW_Pin1_4 86 91 PF00397 0.665
LIG_14-3-3_CanoR_1 124 130 PF00244 0.484
LIG_14-3-3_CanoR_1 313 323 PF00244 0.581
LIG_BIR_III_2 481 485 PF00653 0.547
LIG_BRCT_BRCA1_1 527 531 PF00533 0.487
LIG_Clathr_ClatBox_1 401 405 PF01394 0.709
LIG_EH1_1 549 557 PF00400 0.562
LIG_eIF4E_1 550 556 PF01652 0.562
LIG_FHA_1 284 290 PF00498 0.466
LIG_FHA_1 435 441 PF00498 0.684
LIG_FHA_1 444 450 PF00498 0.633
LIG_FHA_1 470 476 PF00498 0.487
LIG_FHA_1 98 104 PF00498 0.446
LIG_FHA_2 333 339 PF00498 0.526
LIG_FHA_2 458 464 PF00498 0.712
LIG_FHA_2 76 82 PF00498 0.701
LIG_IRF3_LxIS_1 294 300 PF10401 0.562
LIG_LIR_Apic_2 118 122 PF02991 0.348
LIG_LIR_Apic_2 288 294 PF02991 0.470
LIG_LIR_Apic_2 87 91 PF02991 0.645
LIG_LIR_Gen_1 217 226 PF02991 0.516
LIG_LIR_Gen_1 382 390 PF02991 0.566
LIG_LIR_Gen_1 502 513 PF02991 0.487
LIG_LIR_Nem_3 170 175 PF02991 0.533
LIG_LIR_Nem_3 217 223 PF02991 0.516
LIG_LIR_Nem_3 25 30 PF02991 0.646
LIG_LIR_Nem_3 382 386 PF02991 0.574
LIG_LIR_Nem_3 502 508 PF02991 0.487
LIG_MYND_1 42 46 PF01753 0.759
LIG_MYND_1 50 54 PF01753 0.635
LIG_NRBOX 338 344 PF00104 0.642
LIG_SH2_CRK 241 245 PF00017 0.562
LIG_SH2_CRK 383 387 PF00017 0.653
LIG_SH2_NCK_1 119 123 PF00017 0.328
LIG_SH2_NCK_1 241 245 PF00017 0.562
LIG_SH2_NCK_1 291 295 PF00017 0.476
LIG_SH2_SRC 291 294 PF00017 0.487
LIG_SH2_STAP1 104 108 PF00017 0.421
LIG_SH2_STAT5 238 241 PF00017 0.428
LIG_SH2_STAT5 30 33 PF00017 0.510
LIG_SH2_STAT5 505 508 PF00017 0.487
LIG_SH2_STAT5 550 553 PF00017 0.476
LIG_SH3_3 220 226 PF00018 0.501
LIG_SH3_3 350 356 PF00018 0.754
LIG_SH3_3 36 42 PF00018 0.605
LIG_SH3_3 48 54 PF00018 0.573
LIG_SH3_3 509 515 PF00018 0.502
LIG_SUMO_SIM_anti_2 130 136 PF11976 0.454
LIG_SUMO_SIM_anti_2 295 300 PF11976 0.487
LIG_SUMO_SIM_anti_2 523 528 PF11976 0.581
LIG_SUMO_SIM_par_1 272 277 PF11976 0.517
LIG_SUMO_SIM_par_1 295 300 PF11976 0.487
LIG_SUMO_SIM_par_1 523 528 PF11976 0.581
LIG_SUMO_SIM_par_1 563 568 PF11976 0.488
LIG_TRAF2_1 462 465 PF00917 0.744
LIG_TYR_ITIM 381 386 PF00017 0.606
LIG_TYR_ITIM 503 508 PF00017 0.487
MOD_CDK_SPK_2 451 456 PF00069 0.568
MOD_CDK_SPxK_1 325 331 PF00069 0.498
MOD_CDK_SPxxK_3 451 458 PF00069 0.706
MOD_CK1_1 190 196 PF00069 0.519
MOD_CK1_1 20 26 PF00069 0.623
MOD_CK1_1 327 333 PF00069 0.525
MOD_CK1_1 410 416 PF00069 0.637
MOD_CK1_1 417 423 PF00069 0.633
MOD_CK1_1 426 432 PF00069 0.509
MOD_CK1_1 624 630 PF00069 0.602
MOD_CK1_1 74 80 PF00069 0.669
MOD_CK2_1 351 357 PF00069 0.672
MOD_CK2_1 447 453 PF00069 0.636
MOD_CK2_1 457 463 PF00069 0.688
MOD_Cter_Amidation 373 376 PF01082 0.765
MOD_GlcNHglycan 212 215 PF01048 0.369
MOD_GlcNHglycan 22 25 PF01048 0.610
MOD_GlcNHglycan 316 319 PF01048 0.367
MOD_GlcNHglycan 343 346 PF01048 0.610
MOD_GlcNHglycan 353 356 PF01048 0.732
MOD_GlcNHglycan 417 420 PF01048 0.674
MOD_GlcNHglycan 425 428 PF01048 0.707
MOD_GlcNHglycan 532 535 PF01048 0.271
MOD_GlcNHglycan 546 549 PF01048 0.234
MOD_GlcNHglycan 589 593 PF01048 0.472
MOD_GlcNHglycan 63 66 PF01048 0.744
MOD_GlcNHglycan 73 76 PF01048 0.644
MOD_GlcNHglycan 91 94 PF01048 0.655
MOD_GSK3_1 187 194 PF00069 0.518
MOD_GSK3_1 210 217 PF00069 0.571
MOD_GSK3_1 407 414 PF00069 0.596
MOD_GSK3_1 415 422 PF00069 0.613
MOD_GSK3_1 423 430 PF00069 0.621
MOD_GSK3_1 443 450 PF00069 0.652
MOD_GSK3_1 50 57 PF00069 0.707
MOD_GSK3_1 538 545 PF00069 0.501
MOD_GSK3_1 71 78 PF00069 0.676
MOD_N-GLC_1 414 419 PF02516 0.768
MOD_N-GLC_1 434 439 PF02516 0.747
MOD_NEK2_1 297 302 PF00069 0.560
MOD_NEK2_1 538 543 PF00069 0.478
MOD_NEK2_1 587 592 PF00069 0.427
MOD_NEK2_2 285 290 PF00069 0.482
MOD_NEK2_2 621 626 PF00069 0.566
MOD_PKA_1 313 319 PF00069 0.581
MOD_PKA_2 178 184 PF00069 0.569
MOD_PKA_2 44 50 PF00069 0.718
MOD_PKA_2 457 463 PF00069 0.774
MOD_Plk_1 104 110 PF00069 0.535
MOD_Plk_1 427 433 PF00069 0.802
MOD_Plk_1 80 86 PF00069 0.715
MOD_Plk_4 104 110 PF00069 0.494
MOD_Plk_4 130 136 PF00069 0.373
MOD_Plk_4 178 184 PF00069 0.553
MOD_Plk_4 285 291 PF00069 0.475
MOD_Plk_4 292 298 PF00069 0.479
MOD_Plk_4 44 50 PF00069 0.724
MOD_Plk_4 607 613 PF00069 0.451
MOD_ProDKin_1 110 116 PF00069 0.564
MOD_ProDKin_1 325 331 PF00069 0.560
MOD_ProDKin_1 451 457 PF00069 0.785
MOD_ProDKin_1 480 486 PF00069 0.550
MOD_ProDKin_1 50 56 PF00069 0.707
MOD_ProDKin_1 542 548 PF00069 0.501
MOD_ProDKin_1 624 630 PF00069 0.388
MOD_ProDKin_1 66 72 PF00069 0.694
MOD_ProDKin_1 86 92 PF00069 0.668
MOD_SUMO_rev_2 609 618 PF00179 0.519
MOD_SUMO_rev_2 9 14 PF00179 0.668
TRG_DiLeu_BaEn_1 504 509 PF01217 0.581
TRG_DiLeu_BaLyEn_6 39 44 PF01217 0.737
TRG_ENDOCYTIC_2 241 244 PF00928 0.562
TRG_ENDOCYTIC_2 383 386 PF00928 0.579
TRG_ENDOCYTIC_2 505 508 PF00928 0.487
TRG_ENDOCYTIC_2 549 552 PF00928 0.470
TRG_ER_diArg_1 154 156 PF00400 0.514
TRG_ER_diArg_1 375 378 PF00400 0.678
TRG_ER_diArg_1 455 458 PF00400 0.573
TRG_NLS_MonoExtC_3 4 10 PF00514 0.708
TRG_NLS_MonoExtN_4 4 9 PF00514 0.717
TRG_Pf-PMV_PEXEL_1 160 164 PF00026 0.362
TRG_Pf-PMV_PEXEL_1 272 277 PF00026 0.265
TRG_Pf-PMV_PEXEL_1 585 589 PF00026 0.287
TRG_Pf-PMV_PEXEL_1 602 607 PF00026 0.434

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0R2 Leptomonas seymouri 61% 94%
A0A0S4JEE2 Bodo saltans 34% 100%
A0A1X0NJV3 Trypanosomatidae 47% 96%
A0A3S7WWW4 Leishmania donovani 99% 100%
A0A422N700 Trypanosoma rangeli 49% 99%
A4HLD0 Leishmania braziliensis 82% 100%
C9ZIZ6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 92%
E9AVI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QBZ5 Leishmania major 93% 100%
V5BFA4 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS