Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTQ4_LEIIN

TriTrypDb:

LINF_080017000

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.649
CLV_PCSK_KEX2_1	11	13	PF00082	0.649
CLV_PCSK_SKI1_1	167	171	PF00082	0.460
CLV_PCSK_SKI1_1	192	196	PF00082	0.516
CLV_PCSK_SKI1_1	294	298	PF00082	0.503
CLV_PCSK_SKI1_1	52	56	PF00082	0.529
CLV_Separin_Metazoa	134	138	PF03568	0.453
DEG_APCC_DBOX_1	356	364	PF00400	0.390
DEG_Nend_UBRbox_2	1	3	PF02207	0.523
DEG_SPOP_SBC_1	36	40	PF00917	0.466
DOC_CYCLIN_yCln2_LP_2	358	364	PF00134	0.416
DOC_MAPK_gen_1	11	18	PF00069	0.530
DOC_MAPK_MEF2A_6	11	18	PF00069	0.581
DOC_MAPK_MEF2A_6	141	150	PF00069	0.404
DOC_MAPK_NFAT4_5	11	19	PF00069	0.571
DOC_PP2B_LxvP_1	16	19	PF13499	0.537
DOC_PP2B_LxvP_1	358	361	PF13499	0.468
DOC_PP4_FxxP_1	332	335	PF00568	0.417
DOC_USP7_MATH_1	119	123	PF00917	0.619
DOC_USP7_MATH_1	157	161	PF00917	0.444
DOC_USP7_MATH_1	177	181	PF00917	0.474
DOC_USP7_MATH_1	206	210	PF00917	0.537
DOC_USP7_MATH_1	250	254	PF00917	0.589
DOC_USP7_MATH_1	275	279	PF00917	0.623
DOC_USP7_MATH_1	369	373	PF00917	0.500
DOC_WW_Pin1_4	185	190	PF00397	0.693
DOC_WW_Pin1_4	251	256	PF00397	0.605
DOC_WW_Pin1_4	75	80	PF00397	0.379
LIG_14-3-3_CanoR_1	273	283	PF00244	0.484
LIG_14-3-3_CanoR_1	318	325	PF00244	0.431
LIG_14-3-3_CanoR_1	382	391	PF00244	0.421
LIG_14-3-3_CanoR_1	52	62	PF00244	0.461
LIG_BRCT_BRCA1_1	301	305	PF00533	0.421
LIG_Clathr_ClatBox_1	230	234	PF01394	0.456
LIG_FHA_1	37	43	PF00498	0.479
LIG_FHA_1	4	10	PF00498	0.587
LIG_FHA_2	69	75	PF00498	0.460
LIG_LIR_Apic_2	329	335	PF02991	0.547
LIG_LIR_Apic_2	348	352	PF02991	0.271
LIG_LIR_Gen_1	96	104	PF02991	0.445
LIG_LIR_Nem_3	193	198	PF02991	0.622
LIG_LIR_Nem_3	96	101	PF02991	0.410
LIG_MYND_1	45	49	PF01753	0.459
LIG_PCNA_APIM_2	292	298	PF02747	0.304
LIG_Pex14_2	390	394	PF04695	0.439
LIG_REV1ctd_RIR_1	293	302	PF16727	0.456
LIG_REV1ctd_RIR_1	388	394	PF16727	0.437
LIG_SH2_CRK	115	119	PF00017	0.645
LIG_SH2_CRK	289	293	PF00017	0.433
LIG_SH2_CRK	29	33	PF00017	0.390
LIG_SH2_CRK	349	353	PF00017	0.390
LIG_SH2_CRK	84	88	PF00017	0.701
LIG_SH2_NCK_1	289	293	PF00017	0.433
LIG_SH2_PTP2	197	200	PF00017	0.431
LIG_SH2_STAP1	109	113	PF00017	0.368
LIG_SH2_STAT5	197	200	PF00017	0.431
LIG_SH2_STAT5	389	392	PF00017	0.300
LIG_SH2_STAT5	64	67	PF00017	0.344
LIG_SH3_3	195	201	PF00018	0.504
LIG_SH3_3	279	285	PF00018	0.472
LIG_SH3_3	358	364	PF00018	0.499
LIG_TRAF2_1	269	272	PF00917	0.518
LIG_TRFH_1	349	353	PF08558	0.523
LIG_TYR_ITIM	287	292	PF00017	0.435
LIG_TYR_ITIM	82	87	PF00017	0.495
MOD_CDK_SPK_2	75	80	PF00069	0.379
MOD_CDK_SPxxK_3	185	192	PF00069	0.710
MOD_CDK_SPxxK_3	253	260	PF00069	0.524
MOD_CK1_1	100	106	PF00069	0.472
MOD_CK1_1	181	187	PF00069	0.638
MOD_CK1_1	253	259	PF00069	0.784
MOD_CK1_1	261	267	PF00069	0.672
MOD_CK1_1	278	284	PF00069	0.343
MOD_CK2_1	261	267	PF00069	0.697
MOD_CK2_1	68	74	PF00069	0.339
MOD_GlcNHglycan	109	112	PF01048	0.469
MOD_GlcNHglycan	206	209	PF01048	0.663
MOD_GlcNHglycan	212	215	PF01048	0.570
MOD_GlcNHglycan	263	266	PF01048	0.638
MOD_GlcNHglycan	277	280	PF01048	0.425
MOD_GlcNHglycan	301	304	PF01048	0.546
MOD_GlcNHglycan	319	322	PF01048	0.439
MOD_GlcNHglycan	84	87	PF01048	0.477
MOD_GSK3_1	157	164	PF00069	0.357
MOD_GSK3_1	177	184	PF00069	0.474
MOD_GSK3_1	202	209	PF00069	0.531
MOD_GSK3_1	271	278	PF00069	0.699
MOD_GSK3_1	64	71	PF00069	0.326
MOD_N-GLC_1	151	156	PF02516	0.519
MOD_NEK2_1	107	112	PF00069	0.397
MOD_NEK2_1	151	156	PF00069	0.454
MOD_NEK2_1	161	166	PF00069	0.410
MOD_NEK2_1	299	304	PF00069	0.440
MOD_NEK2_1	37	42	PF00069	0.446
MOD_NEK2_1	383	388	PF00069	0.389
MOD_NEK2_1	50	55	PF00069	0.348
MOD_NEK2_1	68	73	PF00069	0.219
MOD_NEK2_1	97	102	PF00069	0.440
MOD_NEK2_2	369	374	PF00069	0.372
MOD_PIKK_1	178	184	PF00454	0.678
MOD_PKA_2	261	267	PF00069	0.768
MOD_PKA_2	317	323	PF00069	0.474
MOD_Plk_1	119	125	PF00069	0.585
MOD_Plk_1	12	18	PF00069	0.570
MOD_Plk_1	258	264	PF00069	0.511
MOD_Plk_4	119	125	PF00069	0.616
MOD_Plk_4	146	152	PF00069	0.367
MOD_Plk_4	157	163	PF00069	0.328
MOD_Plk_4	278	284	PF00069	0.595
MOD_Plk_4	37	43	PF00069	0.471
MOD_Plk_4	4	10	PF00069	0.579
MOD_Plk_4	64	70	PF00069	0.312
MOD_ProDKin_1	185	191	PF00069	0.690
MOD_ProDKin_1	251	257	PF00069	0.608
MOD_ProDKin_1	75	81	PF00069	0.390
MOD_SUMO_rev_2	143	149	PF00179	0.499
TRG_DiLeu_BaEn_1	17	22	PF01217	0.521
TRG_DiLeu_BaLyEn_6	379	384	PF01217	0.305
TRG_ENDOCYTIC_2	227	230	PF00928	0.519
TRG_ENDOCYTIC_2	289	292	PF00928	0.431
TRG_ENDOCYTIC_2	29	32	PF00928	0.399
TRG_ENDOCYTIC_2	84	87	PF00928	0.705
TRG_ER_diArg_1	10	12	PF00400	0.656
TRG_ER_diArg_1	260	263	PF00400	0.594
TRG_ER_diArg_1	354	357	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE21	Leptomonas seymouri	61%	87%
A0A0S4INY1	Bodo saltans	32%	86%
A0A1X0NGS9	Trypanosomatidae	37%	100%
A0A3S5H694	Leishmania donovani	99%	100%
A4HC41	Leishmania braziliensis	82%	100%
C9ZPG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AMJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QI48	Leishmania major	94%	100%
V5BEE3	Trypanosoma cruzi	35%	100%