Pre-mRNA-splicing factor SLU7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTQ1_LEIIN

TriTrypDb:

LINF_080016700

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

A4HTQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTQ1

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	12
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	12
GO:0000398	mRNA splicing, via spliceosome	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008380	RNA splicing	7	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000386	second spliceosomal transesterification activity	4	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0030628	pre-mRNA 3'-splice site binding	6	12
GO:0036002	pre-mRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.558
CLV_NRD_NRD_1	26	28	PF00675	0.407
CLV_NRD_NRD_1	281	283	PF00675	0.503
CLV_NRD_NRD_1	69	71	PF00675	0.547
CLV_PCSK_KEX2_1	150	152	PF00082	0.450
CLV_PCSK_KEX2_1	281	283	PF00082	0.480
CLV_PCSK_KEX2_1	403	405	PF00082	0.384
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.442
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.410
CLV_PCSK_SKI1_1	14	18	PF00082	0.567
CLV_PCSK_SKI1_1	262	266	PF00082	0.419
CLV_PCSK_SKI1_1	304	308	PF00082	0.675
DEG_Nend_UBRbox_2	1	3	PF02207	0.716
DEG_SPOP_SBC_1	331	335	PF00917	0.755
DEG_SPOP_SBC_1	342	346	PF00917	0.695
DOC_AGCK_PIF_2	271	276	PF00069	0.536
DOC_CYCLIN_yClb3_PxF_3	46	54	PF00134	0.526
DOC_MAPK_DCC_7	27	36	PF00069	0.397
DOC_MAPK_gen_1	150	160	PF00069	0.527
DOC_MAPK_MEF2A_6	153	162	PF00069	0.536
DOC_PP4_FxxP_1	220	223	PF00568	0.466
DOC_USP7_MATH_1	234	238	PF00917	0.433
DOC_USP7_MATH_1	363	367	PF00917	0.607
DOC_USP7_MATH_1	410	414	PF00917	0.443
DOC_USP7_MATH_1	8	12	PF00917	0.677
DOC_USP7_UBL2_3	204	208	PF12436	0.449
DOC_USP7_UBL2_3	403	407	PF12436	0.462
DOC_WW_Pin1_4	306	311	PF00397	0.552
DOC_WW_Pin1_4	343	348	PF00397	0.703
DOC_WW_Pin1_4	42	47	PF00397	0.398
LIG_14-3-3_CanoR_1	111	119	PF00244	0.417
LIG_BIR_III_4	408	412	PF00653	0.395
LIG_BRCT_BRCA1_1	115	119	PF00533	0.477
LIG_BRCT_BRCA1_1	267	271	PF00533	0.445
LIG_FHA_1	128	134	PF00498	0.509
LIG_FHA_1	301	307	PF00498	0.701
LIG_FHA_1	357	363	PF00498	0.642
LIG_FHA_2	132	138	PF00498	0.439
LIG_FHA_2	307	313	PF00498	0.458
LIG_FHA_2	38	44	PF00498	0.461
LIG_Integrin_RGD_1	242	244	PF01839	0.416
LIG_LIR_Apic_2	217	223	PF02991	0.513
LIG_LIR_Apic_2	388	392	PF02991	0.475
LIG_LIR_Gen_1	252	261	PF02991	0.405
LIG_LIR_Gen_1	268	279	PF02991	0.411
LIG_LIR_Nem_3	250	256	PF02991	0.418
LIG_LIR_Nem_3	258	264	PF02991	0.391
LIG_LIR_Nem_3	268	274	PF02991	0.402
LIG_LIR_Nem_3	388	393	PF02991	0.454
LIG_PDZ_Class_1	412	417	PF00595	0.589
LIG_SH2_CRK	261	265	PF00017	0.499
LIG_SH2_GRB2like	129	132	PF00017	0.554
LIG_SH2_GRB2like	253	256	PF00017	0.495
LIG_SH2_SRC	256	259	PF00017	0.524
LIG_SH2_STAP1	129	133	PF00017	0.543
LIG_SH2_STAT5	129	132	PF00017	0.554
LIG_SH2_STAT5	209	212	PF00017	0.476
LIG_SH2_STAT5	256	259	PF00017	0.429
LIG_SH2_STAT5	389	392	PF00017	0.349
LIG_SH3_3	174	180	PF00018	0.603
LIG_SH3_3	344	350	PF00018	0.601
LIG_SH3_3	43	49	PF00018	0.414
LIG_SUMO_SIM_par_1	32	40	PF11976	0.399
LIG_TRAF2_1	140	143	PF00917	0.551
LIG_TRAF2_1	40	43	PF00917	0.447
LIG_TRFH_1	29	33	PF08558	0.403
MOD_CK1_1	127	133	PF00069	0.526
MOD_CK1_1	333	339	PF00069	0.636
MOD_CK1_1	341	347	PF00069	0.608
MOD_CK1_1	374	380	PF00069	0.535
MOD_CK1_1	98	104	PF00069	0.460
MOD_CK2_1	133	139	PF00069	0.537
MOD_CK2_1	331	337	PF00069	0.633
MOD_CK2_1	37	43	PF00069	0.415
MOD_GlcNHglycan	340	343	PF01048	0.660
MOD_GlcNHglycan	412	415	PF01048	0.555
MOD_GlcNHglycan	74	77	PF01048	0.655
MOD_GSK3_1	109	116	PF00069	0.451
MOD_GSK3_1	127	134	PF00069	0.327
MOD_GSK3_1	300	307	PF00069	0.642
MOD_GSK3_1	314	321	PF00069	0.425
MOD_GSK3_1	331	338	PF00069	0.591
MOD_GSK3_1	354	361	PF00069	0.662
MOD_GSK3_1	371	378	PF00069	0.574
MOD_NEK2_1	314	319	PF00069	0.445
MOD_NEK2_1	354	359	PF00069	0.675
MOD_NEK2_2	95	100	PF00069	0.317
MOD_PIKK_1	145	151	PF00454	0.510
MOD_PIKK_1	256	262	PF00454	0.516
MOD_PIKK_1	319	325	PF00454	0.642
MOD_PK_1	124	130	PF00069	0.518
MOD_PK_1	9	15	PF00069	0.606
MOD_PKA_1	9	15	PF00069	0.562
MOD_PKA_2	131	137	PF00069	0.517
MOD_Plk_1	171	177	PF00069	0.458
MOD_Plk_2-3	171	177	PF00069	0.458
MOD_Plk_4	124	130	PF00069	0.518
MOD_Plk_4	371	377	PF00069	0.601
MOD_Plk_4	385	391	PF00069	0.314
MOD_Plk_4	62	68	PF00069	0.507
MOD_ProDKin_1	306	312	PF00069	0.549
MOD_ProDKin_1	343	349	PF00069	0.698
MOD_ProDKin_1	42	48	PF00069	0.395
MOD_SUMO_rev_2	137	146	PF00179	0.558
MOD_SUMO_rev_2	2	11	PF00179	0.575
MOD_SUMO_rev_2	217	225	PF00179	0.442
MOD_SUMO_rev_2	333	341	PF00179	0.680
MOD_SUMO_rev_2	80	88	PF00179	0.608
TRG_ENDOCYTIC_2	254	257	PF00928	0.413
TRG_ENDOCYTIC_2	261	264	PF00928	0.393
TRG_ER_diArg_1	184	187	PF00400	0.613
TRG_ER_diArg_1	280	282	PF00400	0.566
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	262	267	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD09	Leptomonas seymouri	68%	98%
A0A0S4IP46	Bodo saltans	36%	97%
A0A1X0NEY6	Trypanosomatidae	48%	92%
A0A3R7NLB9	Trypanosoma rangeli	45%	98%
A0A3S5H692	Leishmania donovani	100%	100%
A4H5F6	Leishmania braziliensis	82%	100%
C9ZPF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	87%
E9AMI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O95391	Homo sapiens	26%	71%
P0CR52	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	73%
P0CR53	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	73%
Q3KQD1	Xenopus laevis	28%	72%
Q3ZBE5	Bos taurus	26%	71%
Q4QI51	Leishmania major	96%	100%
Q4R4P2	Macaca fascicularis	26%	71%
Q4WWR2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	88%
Q51LA6	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	23%	88%
Q54TA0	Dictyostelium discoideum	27%	75%
Q5B3U2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	89%
Q5U3F2	Danio rerio	28%	73%
Q5ZIG2	Gallus gallus	27%	74%
Q7SDY6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	100%
Q80ZG5	Rattus norvegicus	27%	71%
Q8BHJ9	Mus musculus	26%	71%
Q9SHY8	Arabidopsis thaliana	26%	78%
Q9VAQ7	Drosophila melanogaster	35%	73%
V5DAD7	Trypanosoma cruzi	46%	90%