LeishMANIAdb
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Thiopurine S-methyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Thiopurine S-methyltransferase
Gene product:
Thiopurine S-methyltransferase (TPMT) - putative
Species:
Leishmania infantum
UniProt:
A4HTP9_LEIIN
TriTrypDb:
LINF_080016500
Length:
426

Annotations

Annotations by Jardim et al.

Protein modification, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A4HTP9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTP9

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 8
GO:0032259 methylation 2 8
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0008168 methyltransferase activity 4 10
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 10
GO:0016740 transferase activity 2 10
GO:0016741 transferase activity, transferring one-carbon groups 3 10
GO:0008119 thiopurine S-methyltransferase activity 6 1
GO:0008172 S-methyltransferase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 235 239 PF00656 0.467
CLV_C14_Caspase3-7 363 367 PF00656 0.443
CLV_NRD_NRD_1 101 103 PF00675 0.588
CLV_NRD_NRD_1 198 200 PF00675 0.297
CLV_NRD_NRD_1 29 31 PF00675 0.387
CLV_NRD_NRD_1 8 10 PF00675 0.500
CLV_PCSK_FUR_1 6 10 PF00082 0.427
CLV_PCSK_KEX2_1 198 200 PF00082 0.428
CLV_PCSK_KEX2_1 310 312 PF00082 0.370
CLV_PCSK_KEX2_1 344 346 PF00082 0.310
CLV_PCSK_KEX2_1 379 381 PF00082 0.284
CLV_PCSK_KEX2_1 8 10 PF00082 0.476
CLV_PCSK_PC1ET2_1 310 312 PF00082 0.288
CLV_PCSK_PC1ET2_1 344 346 PF00082 0.359
CLV_PCSK_PC1ET2_1 379 381 PF00082 0.288
CLV_PCSK_SKI1_1 123 127 PF00082 0.539
CLV_PCSK_SKI1_1 159 163 PF00082 0.640
CLV_PCSK_SKI1_1 166 170 PF00082 0.639
CLV_PCSK_SKI1_1 198 202 PF00082 0.297
CLV_PCSK_SKI1_1 268 272 PF00082 0.242
CLV_PCSK_SKI1_1 311 315 PF00082 0.264
CLV_PCSK_SKI1_1 35 39 PF00082 0.457
CLV_PCSK_SKI1_1 376 380 PF00082 0.288
CLV_PCSK_SKI1_1 41 45 PF00082 0.396
DEG_APCC_DBOX_1 158 166 PF00400 0.399
DEG_Nend_Nbox_1 1 3 PF02207 0.682
DEG_SCF_FBW7_2 415 422 PF00400 0.624
DOC_CKS1_1 386 391 PF01111 0.505
DOC_MAPK_gen_1 3 12 PF00069 0.698
DOC_MAPK_gen_1 310 321 PF00069 0.584
DOC_MAPK_gen_1 379 387 PF00069 0.484
DOC_MAPK_MEF2A_6 6 14 PF00069 0.600
DOC_PP2B_LxvP_1 417 420 PF13499 0.621
DOC_PP4_FxxP_1 118 121 PF00568 0.339
DOC_PP4_FxxP_1 270 273 PF00568 0.528
DOC_PP4_FxxP_1 64 67 PF00568 0.300
DOC_PP4_MxPP_1 336 339 PF00568 0.488
DOC_USP7_MATH_1 110 114 PF00917 0.481
DOC_USP7_MATH_1 144 148 PF00917 0.379
DOC_USP7_MATH_1 200 204 PF00917 0.433
DOC_USP7_MATH_1 236 240 PF00917 0.507
DOC_USP7_MATH_2 256 262 PF00917 0.418
DOC_USP7_UBL2_3 31 35 PF12436 0.633
DOC_USP7_UBL2_3 310 314 PF12436 0.484
DOC_USP7_UBL2_3 379 383 PF12436 0.488
DOC_WW_Pin1_4 140 145 PF00397 0.439
DOC_WW_Pin1_4 218 223 PF00397 0.434
DOC_WW_Pin1_4 269 274 PF00397 0.525
DOC_WW_Pin1_4 385 390 PF00397 0.534
DOC_WW_Pin1_4 415 420 PF00397 0.688
DOC_WW_Pin1_4 90 95 PF00397 0.392
LIG_14-3-3_CanoR_1 171 176 PF00244 0.479
LIG_14-3-3_CanoR_1 198 207 PF00244 0.396
LIG_14-3-3_CanoR_1 33 38 PF00244 0.679
LIG_14-3-3_CanoR_1 403 408 PF00244 0.659
LIG_Actin_WH2_2 17 32 PF00022 0.648
LIG_Actin_WH2_2 364 381 PF00022 0.528
LIG_BRCT_BRCA1_1 114 118 PF00533 0.356
LIG_CaM_IQ_9 365 381 PF13499 0.488
LIG_Clathr_ClatBox_1 318 322 PF01394 0.552
LIG_deltaCOP1_diTrp_1 95 101 PF00928 0.329
LIG_DLG_GKlike_1 171 179 PF00625 0.371
LIG_EVH1_1 207 211 PF00568 0.441
LIG_FHA_1 2 8 PF00498 0.631
LIG_FHA_1 224 230 PF00498 0.525
LIG_FHA_1 325 331 PF00498 0.442
LIG_FHA_1 397 403 PF00498 0.584
LIG_FHA_1 404 410 PF00498 0.629
LIG_FHA_1 43 49 PF00498 0.617
LIG_FHA_2 127 133 PF00498 0.314
LIG_FHA_2 402 408 PF00498 0.688
LIG_FHA_2 90 96 PF00498 0.390
LIG_LIR_Apic_2 115 121 PF02991 0.320
LIG_LIR_Apic_2 274 279 PF02991 0.492
LIG_LIR_Apic_2 384 389 PF02991 0.443
LIG_LIR_Apic_2 61 67 PF02991 0.221
LIG_LIR_Gen_1 258 265 PF02991 0.438
LIG_LIR_Gen_1 304 313 PF02991 0.454
LIG_LIR_Gen_1 388 395 PF02991 0.588
LIG_LIR_Nem_3 258 263 PF02991 0.428
LIG_LIR_Nem_3 304 308 PF02991 0.454
LIG_LIR_Nem_3 388 393 PF02991 0.548
LIG_LIR_Nem_3 79 84 PF02991 0.454
LIG_MLH1_MIPbox_1 114 118 PF16413 0.356
LIG_MYND_1 415 419 PF01753 0.684
LIG_Pex14_1 267 271 PF04695 0.459
LIG_Pex14_2 64 68 PF04695 0.300
LIG_SH2_CRK 122 126 PF00017 0.343
LIG_SH2_CRK 260 264 PF00017 0.522
LIG_SH2_CRK 285 289 PF00017 0.484
LIG_SH2_CRK 305 309 PF00017 0.442
LIG_SH2_NCK_1 285 289 PF00017 0.525
LIG_SH2_PTP2 386 389 PF00017 0.521
LIG_SH2_PTP2 81 84 PF00017 0.411
LIG_SH2_SRC 320 323 PF00017 0.442
LIG_SH2_STAP1 285 289 PF00017 0.484
LIG_SH2_STAP1 305 309 PF00017 0.442
LIG_SH2_STAT3 289 292 PF00017 0.442
LIG_SH2_STAT5 307 310 PF00017 0.452
LIG_SH2_STAT5 320 323 PF00017 0.469
LIG_SH2_STAT5 358 361 PF00017 0.465
LIG_SH2_STAT5 386 389 PF00017 0.521
LIG_SH2_STAT5 81 84 PF00017 0.411
LIG_SH3_1 80 86 PF00018 0.382
LIG_SH3_3 202 208 PF00018 0.393
LIG_SH3_3 409 415 PF00018 0.706
LIG_SH3_3 80 86 PF00018 0.403
LIG_SH3_3 9 15 PF00018 0.665
LIG_TRAF2_1 419 422 PF00917 0.654
LIG_UBA3_1 25 31 PF00899 0.642
LIG_WRC_WIRS_1 148 153 PF05994 0.408
MOD_CDK_SPxxK_3 218 225 PF00069 0.442
MOD_CK1_1 143 149 PF00069 0.447
MOD_CK1_1 174 180 PF00069 0.493
MOD_CK1_1 239 245 PF00069 0.539
MOD_CK1_1 36 42 PF00069 0.677
MOD_CK2_1 13 19 PF00069 0.600
MOD_CK2_1 340 346 PF00069 0.459
MOD_CK2_1 401 407 PF00069 0.636
MOD_CK2_1 89 95 PF00069 0.453
MOD_Cter_Amidation 281 284 PF01082 0.284
MOD_GlcNHglycan 134 137 PF01048 0.599
MOD_GlcNHglycan 15 18 PF01048 0.398
MOD_GlcNHglycan 171 174 PF01048 0.710
MOD_GlcNHglycan 185 188 PF01048 0.657
MOD_GlcNHglycan 202 205 PF01048 0.394
MOD_GSK3_1 139 146 PF00069 0.424
MOD_GSK3_1 169 176 PF00069 0.492
MOD_GSK3_1 179 186 PF00069 0.509
MOD_GSK3_1 194 201 PF00069 0.352
MOD_GSK3_1 239 246 PF00069 0.476
MOD_GSK3_1 29 36 PF00069 0.705
MOD_LATS_1 196 202 PF00433 0.221
MOD_NEK2_1 1 6 PF00069 0.618
MOD_NEK2_1 139 144 PF00069 0.365
MOD_NEK2_1 169 174 PF00069 0.448
MOD_NEK2_1 175 180 PF00069 0.420
MOD_NEK2_1 29 34 PF00069 0.667
MOD_NEK2_1 395 400 PF00069 0.514
MOD_NEK2_1 76 81 PF00069 0.506
MOD_PIKK_1 237 243 PF00454 0.542
MOD_PIKK_1 84 90 PF00454 0.469
MOD_PK_1 33 39 PF00069 0.639
MOD_PKA_1 198 204 PF00069 0.297
MOD_PKA_2 198 204 PF00069 0.341
MOD_PKA_2 2 8 PF00069 0.624
MOD_PKA_2 29 35 PF00069 0.656
MOD_PKA_2 395 401 PF00069 0.550
MOD_Plk_1 396 402 PF00069 0.579
MOD_Plk_4 33 39 PF00069 0.639
MOD_ProDKin_1 140 146 PF00069 0.443
MOD_ProDKin_1 218 224 PF00069 0.434
MOD_ProDKin_1 269 275 PF00069 0.525
MOD_ProDKin_1 385 391 PF00069 0.527
MOD_ProDKin_1 415 421 PF00069 0.685
MOD_ProDKin_1 90 96 PF00069 0.386
TRG_DiLeu_BaEn_1 72 77 PF01217 0.381
TRG_ENDOCYTIC_2 122 125 PF00928 0.330
TRG_ENDOCYTIC_2 260 263 PF00928 0.512
TRG_ENDOCYTIC_2 285 288 PF00928 0.520
TRG_ENDOCYTIC_2 305 308 PF00928 0.442
TRG_ENDOCYTIC_2 81 84 PF00928 0.414
TRG_ER_diArg_1 402 405 PF00400 0.687
TRG_ER_diArg_1 6 9 PF00400 0.662
TRG_NLS_MonoExtC_3 29 34 PF00514 0.629
TRG_NLS_MonoExtN_4 28 34 PF00514 0.667
TRG_Pf-PMV_PEXEL_1 345 349 PF00026 0.289
TRG_PTS2 1 14 PF00400 0.619

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4U9 Leptomonas seymouri 69% 100%
A0A0S4INW4 Bodo saltans 39% 100%
A0A1X0NF48 Trypanosomatidae 51% 100%
A0A3S5H690 Leishmania donovani 100% 100%
A4H5F4 Leishmania braziliensis 86% 99%
C9ZPF3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9AMI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QI53 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS