LeishMANIAdb
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EF-hand domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
EF-hand domain-containing protein
Gene product:
Repeat of unknown function (DUF1126) - putative
Species:
Leishmania infantum
UniProt:
A4HTP5_LEIIN
TriTrypDb:
LINF_080016100
Length:
872

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005819 spindle 5 1
GO:0005930 axoneme 2 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0072686 mitotic spindle 6 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HTP5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTP5

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0001539 cilium or flagellum-dependent cell motility 3 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007017 microtubule-based process 2 1
GO:0007051 spindle organization 3 1
GO:0007052 mitotic spindle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022402 cell cycle process 2 1
GO:0048870 cell motility 2 1
GO:0060285 cilium-dependent cell motility 4 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:1902850 microtubule cytoskeleton organization involved in mitosis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 13
GO:0005509 calcium ion binding 5 13
GO:0043167 ion binding 2 13
GO:0043169 cation binding 3 13
GO:0046872 metal ion binding 4 13
GO:0005515 protein binding 2 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0015631 tubulin binding 4 1
GO:0043014 alpha-tubulin binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 163 167 PF00656 0.514
CLV_C14_Caspase3-7 290 294 PF00656 0.450
CLV_C14_Caspase3-7 450 454 PF00656 0.698
CLV_C14_Caspase3-7 456 460 PF00656 0.639
CLV_C14_Caspase3-7 602 606 PF00656 0.513
CLV_C14_Caspase3-7 744 748 PF00656 0.514
CLV_MEL_PAP_1 30 36 PF00089 0.491
CLV_NRD_NRD_1 100 102 PF00675 0.607
CLV_NRD_NRD_1 140 142 PF00675 0.244
CLV_NRD_NRD_1 301 303 PF00675 0.224
CLV_NRD_NRD_1 423 425 PF00675 0.699
CLV_NRD_NRD_1 500 502 PF00675 0.219
CLV_NRD_NRD_1 533 535 PF00675 0.225
CLV_NRD_NRD_1 731 733 PF00675 0.455
CLV_NRD_NRD_1 770 772 PF00675 0.505
CLV_NRD_NRD_1 792 794 PF00675 0.397
CLV_NRD_NRD_1 867 869 PF00675 0.656
CLV_PCSK_FUR_1 768 772 PF00082 0.577
CLV_PCSK_KEX2_1 140 142 PF00082 0.216
CLV_PCSK_KEX2_1 172 174 PF00082 0.223
CLV_PCSK_KEX2_1 301 303 PF00082 0.272
CLV_PCSK_KEX2_1 423 425 PF00082 0.695
CLV_PCSK_KEX2_1 500 502 PF00082 0.219
CLV_PCSK_KEX2_1 532 534 PF00082 0.240
CLV_PCSK_KEX2_1 731 733 PF00082 0.562
CLV_PCSK_KEX2_1 770 772 PF00082 0.505
CLV_PCSK_KEX2_1 792 794 PF00082 0.397
CLV_PCSK_KEX2_1 843 845 PF00082 0.487
CLV_PCSK_KEX2_1 867 869 PF00082 0.712
CLV_PCSK_PC1ET2_1 172 174 PF00082 0.223
CLV_PCSK_PC1ET2_1 532 534 PF00082 0.282
CLV_PCSK_PC1ET2_1 843 845 PF00082 0.547
CLV_PCSK_SKI1_1 110 114 PF00082 0.351
CLV_PCSK_SKI1_1 220 224 PF00082 0.318
CLV_PCSK_SKI1_1 385 389 PF00082 0.226
CLV_PCSK_SKI1_1 397 401 PF00082 0.346
CLV_PCSK_SKI1_1 424 428 PF00082 0.721
CLV_PCSK_SKI1_1 434 438 PF00082 0.672
CLV_PCSK_SKI1_1 447 451 PF00082 0.696
CLV_PCSK_SKI1_1 486 490 PF00082 0.272
CLV_PCSK_SKI1_1 500 504 PF00082 0.228
CLV_PCSK_SKI1_1 535 539 PF00082 0.281
CLV_PCSK_SKI1_1 731 735 PF00082 0.402
CLV_PCSK_SKI1_1 740 744 PF00082 0.313
DEG_APCC_DBOX_1 219 227 PF00400 0.343
DEG_SPOP_SBC_1 861 865 PF00917 0.561
DOC_CKS1_1 785 790 PF01111 0.386
DOC_CYCLIN_RxL_1 431 439 PF00134 0.538
DOC_CYCLIN_yCln2_LP_2 29 32 PF00134 0.481
DOC_CYCLIN_yCln2_LP_2 408 414 PF00134 0.505
DOC_CYCLIN_yCln2_LP_2 489 495 PF00134 0.450
DOC_MAPK_DCC_7 782 791 PF00069 0.362
DOC_MAPK_FxFP_2 814 817 PF00069 0.342
DOC_MAPK_gen_1 140 146 PF00069 0.470
DOC_MAPK_gen_1 301 309 PF00069 0.417
DOC_MAPK_gen_1 532 539 PF00069 0.450
DOC_MAPK_gen_1 647 655 PF00069 0.373
DOC_MAPK_MEF2A_6 301 309 PF00069 0.518
DOC_MAPK_MEF2A_6 370 378 PF00069 0.459
DOC_PP1_RVXF_1 115 122 PF00149 0.403
DOC_PP1_RVXF_1 279 286 PF00149 0.416
DOC_PP2B_LxvP_1 29 32 PF13499 0.481
DOC_PP2B_LxvP_1 408 411 PF13499 0.502
DOC_PP4_FxxP_1 125 128 PF00568 0.514
DOC_PP4_FxxP_1 71 74 PF00568 0.684
DOC_PP4_FxxP_1 777 780 PF00568 0.600
DOC_PP4_FxxP_1 814 817 PF00568 0.325
DOC_SPAK_OSR1_1 501 505 PF12202 0.479
DOC_USP7_MATH_1 12 16 PF00917 0.626
DOC_USP7_MATH_1 432 436 PF00917 0.676
DOC_USP7_MATH_1 465 469 PF00917 0.545
DOC_USP7_MATH_1 733 737 PF00917 0.529
DOC_USP7_MATH_1 860 864 PF00917 0.576
DOC_USP7_MATH_1 88 92 PF00917 0.526
DOC_USP7_UBL2_3 538 542 PF12436 0.467
DOC_WW_Pin1_4 319 324 PF00397 0.438
DOC_WW_Pin1_4 475 480 PF00397 0.678
DOC_WW_Pin1_4 784 789 PF00397 0.353
LIG_14-3-3_CanoR_1 110 115 PF00244 0.292
LIG_14-3-3_CanoR_1 141 147 PF00244 0.459
LIG_14-3-3_CanoR_1 204 213 PF00244 0.485
LIG_14-3-3_CanoR_1 319 323 PF00244 0.514
LIG_14-3-3_CanoR_1 403 409 PF00244 0.506
LIG_14-3-3_CanoR_1 423 427 PF00244 0.400
LIG_14-3-3_CanoR_1 500 505 PF00244 0.446
LIG_14-3-3_CanoR_1 67 72 PF00244 0.597
LIG_14-3-3_CanoR_1 713 718 PF00244 0.654
LIG_14-3-3_CanoR_1 758 764 PF00244 0.375
LIG_14-3-3_CanoR_1 8 12 PF00244 0.625
LIG_APCC_ABBA_1 305 310 PF00400 0.479
LIG_BIR_II_1 1 5 PF00653 0.608
LIG_BIR_III_4 459 463 PF00653 0.587
LIG_BIR_III_4 612 616 PF00653 0.539
LIG_BIR_III_4 700 704 PF00653 0.439
LIG_BRCT_BRCA1_1 192 196 PF00533 0.525
LIG_BRCT_BRCA1_1 253 257 PF00533 0.518
LIG_BRCT_BRCA1_1 271 275 PF00533 0.382
LIG_BRCT_BRCA1_1 414 418 PF00533 0.510
LIG_BRCT_BRCA1_1 509 513 PF00533 0.450
LIG_FHA_1 150 156 PF00498 0.412
LIG_FHA_1 377 383 PF00498 0.449
LIG_FHA_1 431 437 PF00498 0.636
LIG_FHA_1 478 484 PF00498 0.494
LIG_FHA_1 831 837 PF00498 0.507
LIG_FHA_2 111 117 PF00498 0.412
LIG_FHA_2 448 454 PF00498 0.614
LIG_FHA_2 476 482 PF00498 0.598
LIG_FHA_2 506 512 PF00498 0.430
LIG_FHA_2 560 566 PF00498 0.437
LIG_FHA_2 596 602 PF00498 0.661
LIG_FHA_2 689 695 PF00498 0.329
LIG_FHA_2 776 782 PF00498 0.566
LIG_FHA_2 802 808 PF00498 0.412
LIG_GBD_Chelix_1 623 631 PF00786 0.489
LIG_LIR_Apic_2 69 74 PF02991 0.538
LIG_LIR_Apic_2 776 780 PF02991 0.519
LIG_LIR_Apic_2 813 817 PF02991 0.408
LIG_LIR_Gen_1 189 199 PF02991 0.439
LIG_LIR_Gen_1 641 648 PF02991 0.407
LIG_LIR_Gen_1 687 696 PF02991 0.381
LIG_LIR_Nem_3 108 112 PF02991 0.452
LIG_LIR_Nem_3 145 149 PF02991 0.538
LIG_LIR_Nem_3 189 194 PF02991 0.426
LIG_LIR_Nem_3 208 213 PF02991 0.336
LIG_LIR_Nem_3 243 248 PF02991 0.465
LIG_LIR_Nem_3 254 260 PF02991 0.530
LIG_LIR_Nem_3 366 372 PF02991 0.506
LIG_LIR_Nem_3 482 488 PF02991 0.450
LIG_LIR_Nem_3 510 516 PF02991 0.470
LIG_LIR_Nem_3 641 645 PF02991 0.347
LIG_LIR_Nem_3 687 693 PF02991 0.454
LIG_LIR_Nem_3 813 819 PF02991 0.427
LIG_MLH1_MIPbox_1 414 418 PF16413 0.510
LIG_MYND_1 27 31 PF01753 0.580
LIG_PCNA_PIPBox_1 808 817 PF02747 0.339
LIG_PCNA_yPIPBox_3 80 90 PF02747 0.413
LIG_Pex14_2 121 125 PF04695 0.437
LIG_Pex14_2 218 222 PF04695 0.466
LIG_REV1ctd_RIR_1 397 407 PF16727 0.405
LIG_SH2_GRB2like 507 510 PF00017 0.418
LIG_SH2_NCK_1 516 520 PF00017 0.418
LIG_SH2_PTP2 191 194 PF00017 0.514
LIG_SH2_STAP1 395 399 PF00017 0.520
LIG_SH2_STAP1 516 520 PF00017 0.502
LIG_SH2_STAP1 592 596 PF00017 0.491
LIG_SH2_STAP1 834 838 PF00017 0.427
LIG_SH2_STAT5 191 194 PF00017 0.490
LIG_SH2_STAT5 21 24 PF00017 0.514
LIG_SH2_STAT5 330 333 PF00017 0.534
LIG_SH2_STAT5 395 398 PF00017 0.494
LIG_SH2_STAT5 417 420 PF00017 0.597
LIG_SH2_STAT5 507 510 PF00017 0.447
LIG_SH2_STAT5 561 564 PF00017 0.461
LIG_SH2_STAT5 689 692 PF00017 0.391
LIG_SH2_STAT5 824 827 PF00017 0.522
LIG_SH2_STAT5 846 849 PF00017 0.412
LIG_SH3_1 546 552 PF00018 0.493
LIG_SH3_3 174 180 PF00018 0.473
LIG_SH3_3 227 233 PF00018 0.390
LIG_SH3_3 442 448 PF00018 0.717
LIG_SH3_3 537 543 PF00018 0.535
LIG_SH3_3 546 552 PF00018 0.485
LIG_SH3_3 650 656 PF00018 0.487
LIG_SH3_3 782 788 PF00018 0.500
LIG_SH3_3 814 820 PF00018 0.359
LIG_SH3_CIN85_PxpxPR_1 541 546 PF14604 0.514
LIG_SUMO_SIM_anti_2 313 318 PF11976 0.421
LIG_SUMO_SIM_anti_2 691 697 PF11976 0.388
LIG_SUMO_SIM_par_1 150 157 PF11976 0.440
LIG_SUMO_SIM_par_1 410 416 PF11976 0.521
LIG_SUMO_SIM_par_1 616 621 PF11976 0.474
LIG_SUMO_SIM_par_1 650 657 PF11976 0.359
LIG_TRAF2_1 187 190 PF00917 0.455
LIG_WRC_WIRS_1 143 148 PF05994 0.393
LIG_WRC_WIRS_1 639 644 PF05994 0.392
LIG_WRC_WIRS_1 774 779 PF05994 0.491
LIG_WW_3 30 34 PF00397 0.497
MOD_CK1_1 261 267 PF00069 0.518
MOD_CK1_1 322 328 PF00069 0.393
MOD_CK1_1 716 722 PF00069 0.573
MOD_CK1_1 863 869 PF00069 0.487
MOD_CK2_1 262 268 PF00069 0.530
MOD_CK2_1 318 324 PF00069 0.292
MOD_CK2_1 505 511 PF00069 0.276
MOD_CK2_1 595 601 PF00069 0.610
MOD_CK2_1 651 657 PF00069 0.341
MOD_CK2_1 801 807 PF00069 0.395
MOD_Cter_Amidation 421 424 PF01082 0.621
MOD_Cter_Amidation 768 771 PF01082 0.528
MOD_GlcNHglycan 162 165 PF01048 0.238
MOD_GlcNHglycan 253 256 PF01048 0.497
MOD_GlcNHglycan 263 267 PF01048 0.486
MOD_GlcNHglycan 338 341 PF01048 0.376
MOD_GlcNHglycan 467 470 PF01048 0.622
MOD_GlcNHglycan 517 520 PF01048 0.258
MOD_GlcNHglycan 718 721 PF01048 0.591
MOD_GSK3_1 258 265 PF00069 0.542
MOD_GSK3_1 318 325 PF00069 0.324
MOD_GSK3_1 422 429 PF00069 0.588
MOD_GSK3_1 475 482 PF00069 0.573
MOD_GSK3_1 622 629 PF00069 0.454
MOD_GSK3_1 63 70 PF00069 0.708
MOD_GSK3_1 630 637 PF00069 0.367
MOD_GSK3_1 684 691 PF00069 0.398
MOD_GSK3_1 797 804 PF00069 0.427
MOD_GSK3_1 863 870 PF00069 0.533
MOD_LATS_1 632 638 PF00433 0.511
MOD_N-GLC_1 12 17 PF02516 0.558
MOD_N-GLC_1 205 210 PF02516 0.303
MOD_N-GLC_1 67 72 PF02516 0.638
MOD_N-GLC_1 829 834 PF02516 0.503
MOD_NEK2_1 329 334 PF00069 0.334
MOD_NEK2_1 383 388 PF00069 0.429
MOD_NEK2_1 502 507 PF00069 0.257
MOD_NEK2_1 57 62 PF00069 0.671
MOD_NEK2_1 7 12 PF00069 0.591
MOD_NEK2_1 759 764 PF00069 0.339
MOD_NEK2_1 78 83 PF00069 0.455
MOD_NEK2_1 89 94 PF00069 0.453
MOD_NEK2_2 404 409 PF00069 0.415
MOD_NEK2_2 479 484 PF00069 0.438
MOD_PIKK_1 258 264 PF00454 0.511
MOD_PIKK_1 822 828 PF00454 0.453
MOD_PK_1 338 344 PF00069 0.344
MOD_PKA_1 500 506 PF00069 0.338
MOD_PKA_2 291 297 PF00069 0.393
MOD_PKA_2 318 324 PF00069 0.310
MOD_PKA_2 422 428 PF00069 0.602
MOD_PKA_2 500 506 PF00069 0.329
MOD_PKA_2 57 63 PF00069 0.678
MOD_PKA_2 66 72 PF00069 0.638
MOD_PKA_2 684 690 PF00069 0.504
MOD_PKA_2 7 13 PF00069 0.630
MOD_PKA_2 781 787 PF00069 0.488
MOD_Plk_1 149 155 PF00069 0.266
MOD_Plk_1 269 275 PF00069 0.559
MOD_Plk_1 310 316 PF00069 0.238
MOD_Plk_1 346 352 PF00069 0.273
MOD_Plk_1 412 418 PF00069 0.491
MOD_Plk_1 656 662 PF00069 0.483
MOD_Plk_1 67 73 PF00069 0.675
MOD_Plk_4 133 139 PF00069 0.405
MOD_Plk_4 149 155 PF00069 0.278
MOD_Plk_4 413 419 PF00069 0.582
MOD_Plk_4 432 438 PF00069 0.628
MOD_Plk_4 440 446 PF00069 0.586
MOD_Plk_4 502 508 PF00069 0.235
MOD_Plk_4 587 593 PF00069 0.520
MOD_Plk_4 638 644 PF00069 0.484
MOD_Plk_4 781 787 PF00069 0.461
MOD_Plk_4 849 855 PF00069 0.563
MOD_ProDKin_1 319 325 PF00069 0.287
MOD_ProDKin_1 475 481 PF00069 0.660
MOD_ProDKin_1 784 790 PF00069 0.350
MOD_SUMO_rev_2 564 572 PF00179 0.393
MOD_SUMO_rev_2 719 729 PF00179 0.594
MOD_SUMO_rev_2 736 744 PF00179 0.342
TRG_DiLeu_BaEn_1 807 812 PF01217 0.297
TRG_DiLeu_BaEn_2 303 309 PF01217 0.285
TRG_DiLeu_BaEn_4 189 195 PF01217 0.393
TRG_ENDOCYTIC_2 122 125 PF00928 0.301
TRG_ENDOCYTIC_2 191 194 PF00928 0.387
TRG_ENDOCYTIC_2 286 289 PF00928 0.310
TRG_ENDOCYTIC_2 369 372 PF00928 0.393
TRG_ENDOCYTIC_2 845 848 PF00928 0.383
TRG_ER_diArg_1 140 142 PF00400 0.250
TRG_ER_diArg_1 180 183 PF00400 0.302
TRG_ER_diArg_1 300 302 PF00400 0.385
TRG_ER_diArg_1 500 502 PF00400 0.272
TRG_ER_diArg_1 767 770 PF00400 0.565
TRG_ER_diArg_1 791 793 PF00400 0.347
TRG_NLS_MonoCore_2 531 536 PF00514 0.393
TRG_Pf-PMV_PEXEL_1 23 28 PF00026 0.415
TRG_Pf-PMV_PEXEL_1 274 278 PF00026 0.426
TRG_Pf-PMV_PEXEL_1 737 741 PF00026 0.442
TRG_Pf-PMV_PEXEL_1 793 797 PF00026 0.358

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5H4 Leptomonas seymouri 70% 100%
A0A0N1HZ98 Leptomonas seymouri 22% 100%
A0A0N1PBW1 Leptomonas seymouri 25% 100%
A0A0S4IJW8 Bodo saltans 36% 100%
A0A1X0NEV8 Trypanosomatidae 46% 100%
A0A1X0NLI2 Trypanosomatidae 24% 100%
A0A3Q8IDH4 Leishmania donovani 23% 100%
A0A3R7KM50 Trypanosoma rangeli 47% 100%
A0A3R7L048 Trypanosoma rangeli 24% 100%
A0A3S5H688 Leishmania donovani 99% 100%
A0A422NK00 Trypanosoma rangeli 26% 100%
A4HE78 Leishmania braziliensis 22% 97%
A4I1J2 Leishmania infantum 23% 100%
C9ZJX4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 100%
C9ZPE7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
D0A5T5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
E9AI34 Leishmania braziliensis 87% 100%
E9AMI2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9AXM7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
Q4Q9U5 Leishmania major 23% 100%
Q4QI57 Leishmania major 95% 100%
Q9D9T8 Mus musculus 24% 100%
V5ASV2 Trypanosoma cruzi 24% 100%
V5D3X9 Trypanosoma cruzi 22% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS