LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein
Species:
Leishmania infantum
UniProt:
A4HTP3_LEIIN
TriTrypDb:
LINF_080015800
Length:
365

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HTP3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTP3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 330 334 PF00656 0.677
CLV_NRD_NRD_1 2 4 PF00675 0.558
CLV_NRD_NRD_1 217 219 PF00675 0.452
CLV_NRD_NRD_1 292 294 PF00675 0.523
CLV_NRD_NRD_1 52 54 PF00675 0.611
CLV_NRD_NRD_1 63 65 PF00675 0.507
CLV_NRD_NRD_1 87 89 PF00675 0.525
CLV_PCSK_FUR_1 157 161 PF00082 0.488
CLV_PCSK_KEX2_1 144 146 PF00082 0.457
CLV_PCSK_KEX2_1 159 161 PF00082 0.417
CLV_PCSK_KEX2_1 191 193 PF00082 0.435
CLV_PCSK_KEX2_1 2 4 PF00082 0.558
CLV_PCSK_KEX2_1 224 226 PF00082 0.407
CLV_PCSK_KEX2_1 292 294 PF00082 0.524
CLV_PCSK_KEX2_1 52 54 PF00082 0.508
CLV_PCSK_PC1ET2_1 144 146 PF00082 0.457
CLV_PCSK_PC1ET2_1 159 161 PF00082 0.417
CLV_PCSK_PC1ET2_1 191 193 PF00082 0.435
CLV_PCSK_PC1ET2_1 224 226 PF00082 0.438
CLV_PCSK_SKI1_1 108 112 PF00082 0.340
CLV_PCSK_SKI1_1 2 6 PF00082 0.714
CLV_PCSK_SKI1_1 237 241 PF00082 0.408
CLV_PCSK_SKI1_1 292 296 PF00082 0.537
CLV_PCSK_SKI1_1 338 342 PF00082 0.447
CLV_PCSK_SKI1_1 88 92 PF00082 0.654
CLV_PCSK_SKI1_1 99 103 PF00082 0.500
DEG_Nend_UBRbox_1 1 4 PF02207 0.567
DEG_SCF_FBW7_2 130 137 PF00400 0.439
DOC_CKS1_1 131 136 PF01111 0.442
DOC_CKS1_1 9 14 PF01111 0.559
DOC_MAPK_gen_1 224 232 PF00069 0.382
DOC_MAPK_gen_1 271 280 PF00069 0.498
DOC_MAPK_gen_1 292 299 PF00069 0.520
DOC_MAPK_gen_1 338 346 PF00069 0.445
DOC_MAPK_gen_1 41 48 PF00069 0.426
DOC_MAPK_MEF2A_6 271 280 PF00069 0.499
DOC_MAPK_MEF2A_6 292 299 PF00069 0.532
DOC_MAPK_MEF2A_6 41 50 PF00069 0.417
DOC_PP2B_LxvP_1 4 7 PF13499 0.646
DOC_USP7_MATH_1 30 34 PF00917 0.597
DOC_USP7_MATH_1 318 322 PF00917 0.569
DOC_USP7_MATH_1 325 329 PF00917 0.569
DOC_USP7_UBL2_3 116 120 PF12436 0.486
DOC_USP7_UBL2_3 41 45 PF12436 0.501
DOC_WW_Pin1_4 130 135 PF00397 0.441
DOC_WW_Pin1_4 284 289 PF00397 0.533
DOC_WW_Pin1_4 321 326 PF00397 0.649
DOC_WW_Pin1_4 8 13 PF00397 0.629
LIG_14-3-3_CanoR_1 2 7 PF00244 0.641
LIG_14-3-3_CanoR_1 298 303 PF00244 0.490
LIG_14-3-3_CanoR_1 64 73 PF00244 0.472
LIG_14-3-3_CanoR_1 88 97 PF00244 0.544
LIG_Actin_WH2_2 93 110 PF00022 0.467
LIG_CSL_BTD_1 285 288 PF09270 0.527
LIG_EVH1_1 26 30 PF00568 0.666
LIG_EVH1_2 27 31 PF00568 0.668
LIG_FHA_1 65 71 PF00498 0.496
LIG_FHA_1 9 15 PF00498 0.697
LIG_FHA_2 131 137 PF00498 0.443
LIG_FHA_2 181 187 PF00498 0.575
LIG_FHA_2 89 95 PF00498 0.559
LIG_LIR_Gen_1 122 131 PF02991 0.436
LIG_LIR_Gen_1 177 187 PF02991 0.468
LIG_LIR_Nem_3 122 126 PF02991 0.438
LIG_LIR_Nem_3 177 182 PF02991 0.464
LIG_LIR_Nem_3 234 239 PF02991 0.413
LIG_NRBOX 228 234 PF00104 0.392
LIG_PCNA_yPIPBox_3 252 264 PF02747 0.425
LIG_Pex14_1 175 179 PF04695 0.439
LIG_SH2_CRK 179 183 PF00017 0.478
LIG_SH2_CRK 195 199 PF00017 0.383
LIG_SH2_CRK 217 221 PF00017 0.435
LIG_SH2_NCK_1 179 183 PF00017 0.606
LIG_SH2_NCK_1 195 199 PF00017 0.523
LIG_SH2_STAP1 195 199 PF00017 0.511
LIG_SH2_STAT5 132 135 PF00017 0.446
LIG_SH2_STAT5 25 28 PF00017 0.528
LIG_SH2_STAT5 62 65 PF00017 0.497
LIG_SH3_3 128 134 PF00018 0.439
LIG_SH3_3 163 169 PF00018 0.522
LIG_SH3_3 24 30 PF00018 0.577
LIG_SUMO_SIM_anti_2 227 234 PF11976 0.423
LIG_SUMO_SIM_anti_2 98 104 PF11976 0.419
LIG_SUMO_SIM_par_1 227 234 PF11976 0.375
LIG_TRAF2_1 288 291 PF00917 0.529
LIG_TRAF2_1 35 38 PF00917 0.539
LIG_TRAF2_1 357 360 PF00917 0.711
LIG_TYR_ITIM 193 198 PF00017 0.504
LIG_UBA3_1 245 252 PF00899 0.423
MOD_CDK_SPxxK_3 8 15 PF00069 0.560
MOD_CK1_1 321 327 PF00069 0.661
MOD_CK2_1 180 186 PF00069 0.620
MOD_CK2_1 284 290 PF00069 0.529
MOD_CK2_1 298 304 PF00069 0.436
MOD_CK2_1 32 38 PF00069 0.484
MOD_GlcNHglycan 279 283 PF01048 0.617
MOD_GlcNHglycan 319 323 PF01048 0.588
MOD_GlcNHglycan 329 332 PF01048 0.588
MOD_GSK3_1 321 328 PF00069 0.689
MOD_GSK3_1 60 67 PF00069 0.516
MOD_N-GLC_1 180 185 PF02516 0.564
MOD_NEK2_1 309 314 PF00069 0.494
MOD_PIKK_1 309 315 PF00454 0.496
MOD_PIKK_1 325 331 PF00454 0.665
MOD_PK_1 298 304 PF00069 0.499
MOD_PKA_1 2 8 PF00069 0.677
MOD_PKA_1 41 47 PF00069 0.429
MOD_PKA_1 64 70 PF00069 0.499
MOD_PKA_1 88 94 PF00069 0.543
MOD_PKA_2 2 8 PF00069 0.637
MOD_PKA_2 247 253 PF00069 0.422
MOD_PKB_1 192 200 PF00069 0.512
MOD_ProDKin_1 130 136 PF00069 0.437
MOD_ProDKin_1 284 290 PF00069 0.534
MOD_ProDKin_1 321 327 PF00069 0.652
MOD_ProDKin_1 8 14 PF00069 0.628
MOD_SUMO_rev_2 135 141 PF00179 0.437
MOD_SUMO_rev_2 354 364 PF00179 0.708
TRG_DiLeu_BaEn_1 290 295 PF01217 0.533
TRG_DiLeu_BaEn_1 76 81 PF01217 0.439
TRG_DiLeu_BaEn_4 290 296 PF01217 0.535
TRG_DiLeu_BaLyEn_6 335 340 PF01217 0.461
TRG_DiLeu_LyEn_5 290 295 PF01217 0.533
TRG_ENDOCYTIC_2 179 182 PF00928 0.456
TRG_ENDOCYTIC_2 195 198 PF00928 0.404
TRG_ER_diArg_1 1 3 PF00400 0.572
TRG_ER_diArg_1 192 195 PF00400 0.451
TRG_ER_diArg_1 292 294 PF00400 0.525
TRG_ER_diArg_1 297 300 PF00400 0.499
TRG_ER_diArg_1 51 53 PF00400 0.585
TRG_Pf-PMV_PEXEL_1 185 190 PF00026 0.557
TRG_Pf-PMV_PEXEL_1 338 342 PF00026 0.447

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5W5 Leptomonas seymouri 84% 100%
A0A0S4IPK0 Bodo saltans 65% 99%
A0A1X0NPG5 Trypanosomatidae 75% 99%
A0A3S5H687 Leishmania donovani 100% 100%
A0A422NFX7 Trypanosoma rangeli 68% 99%
A4H5E9 Leishmania braziliensis 93% 100%
C9ZPE5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 71% 99%
E9AMI0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
Q4QI59 Leishmania major 98% 100%
V5DAE9 Trypanosoma cruzi 70% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS