Putative histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone deacetylase - putative

Species:

Leishmania infantum

UniProt:

A4HTP2_LEIIN

TriTrypDb:

LINF_080015600

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000118	histone deacetylase complex	3	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HTP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTP2

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006476	protein deacetylation	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0016570	histone modification	5	1
GO:0016575	histone deacetylation	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0035601	protein deacylation	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0098732	macromolecule deacylation	5	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004407	histone deacetylase activity	4	1
GO:0016787	hydrolase activity	2	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	1
GO:0019213	deacetylase activity	3	1
GO:0033558	protein lysine deacetylase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.442
CLV_MEL_PAP_1	87	93	PF00089	0.400
CLV_NRD_NRD_1	581	583	PF00675	0.404
CLV_NRD_NRD_1	62	64	PF00675	0.410
CLV_NRD_NRD_1	75	77	PF00675	0.474
CLV_PCSK_FUR_1	629	633	PF00082	0.402
CLV_PCSK_KEX2_1	20	22	PF00082	0.538
CLV_PCSK_KEX2_1	413	415	PF00082	0.222
CLV_PCSK_KEX2_1	581	583	PF00082	0.410
CLV_PCSK_KEX2_1	62	64	PF00082	0.505
CLV_PCSK_KEX2_1	631	633	PF00082	0.546
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.453
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.222
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.544
CLV_PCSK_SKI1_1	174	178	PF00082	0.367
CLV_PCSK_SKI1_1	248	252	PF00082	0.220
DEG_APCC_DBOX_1	51	59	PF00400	0.394
DOC_CKS1_1	186	191	PF01111	0.422
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.484
DOC_MAPK_DCC_7	204	213	PF00069	0.474
DOC_MAPK_MEF2A_6	204	213	PF00069	0.474
DOC_MAPK_MEF2A_6	324	331	PF00069	0.396
DOC_MAPK_MEF2A_6	376	384	PF00069	0.420
DOC_MAPK_MEF2A_6	523	531	PF00069	0.508
DOC_PP1_RVXF_1	511	517	PF00149	0.379
DOC_PP2B_LxvP_1	213	216	PF13499	0.474
DOC_PP2B_LxvP_1	551	554	PF13499	0.361
DOC_PP2B_PxIxI_1	162	168	PF00149	0.400
DOC_PP2B_PxIxI_1	374	380	PF00149	0.420
DOC_PP4_FxxP_1	258	261	PF00568	0.474
DOC_PP4_FxxP_1	50	53	PF00568	0.628
DOC_PP4_FxxP_1	64	67	PF00568	0.442
DOC_USP7_MATH_1	136	140	PF00917	0.506
DOC_USP7_MATH_1	149	153	PF00917	0.543
DOC_USP7_MATH_1	239	243	PF00917	0.439
DOC_USP7_MATH_1	312	316	PF00917	0.474
DOC_USP7_MATH_1	327	331	PF00917	0.364
DOC_USP7_MATH_1	369	373	PF00917	0.530
DOC_USP7_MATH_1	600	604	PF00917	0.631
DOC_USP7_MATH_1	611	615	PF00917	0.366
DOC_USP7_MATH_1	9	13	PF00917	0.560
DOC_USP7_MATH_1	95	99	PF00917	0.496
DOC_USP7_UBL2_3	119	123	PF12436	0.358
DOC_USP7_UBL2_3	77	81	PF12436	0.420
DOC_WW_Pin1_4	142	147	PF00397	0.704
DOC_WW_Pin1_4	182	187	PF00397	0.449
DOC_WW_Pin1_4	24	29	PF00397	0.553
DOC_WW_Pin1_4	40	45	PF00397	0.585
DOC_WW_Pin1_4	565	570	PF00397	0.390
LIG_14-3-3_CanoR_1	21	29	PF00244	0.407
LIG_14-3-3_CanoR_1	248	253	PF00244	0.437
LIG_14-3-3_CanoR_1	293	300	PF00244	0.503
LIG_14-3-3_CanoR_1	365	374	PF00244	0.474
LIG_14-3-3_CanoR_1	8	14	PF00244	0.434
LIG_14-3-3_CanoR_1	94	102	PF00244	0.532
LIG_APCC_ABBA_1	217	222	PF00400	0.474
LIG_BIR_III_4	135	139	PF00653	0.487
LIG_BRCT_BRCA1_1	26	30	PF00533	0.483
LIG_BRCT_BRCA1_1	46	50	PF00533	0.485
LIG_BRCT_BRCA1_1	486	490	PF00533	0.420
LIG_CaM_IQ_9	638	653	PF13499	0.388
LIG_EVH1_2	28	32	PF00568	0.405
LIG_FHA_1	127	133	PF00498	0.412
LIG_FHA_1	145	151	PF00498	0.661
LIG_FHA_1	285	291	PF00498	0.448
LIG_FHA_1	423	429	PF00498	0.437
LIG_FHA_1	522	528	PF00498	0.439
LIG_FHA_1	554	560	PF00498	0.393
LIG_FHA_2	249	255	PF00498	0.420
LIG_Integrin_RGD_1	422	424	PF01839	0.262
LIG_LIR_Apic_2	257	261	PF02991	0.508
LIG_LIR_Apic_2	47	53	PF02991	0.404
LIG_LIR_Apic_2	491	497	PF02991	0.437
LIG_LIR_Gen_1	251	258	PF02991	0.523
LIG_LIR_Gen_1	330	337	PF02991	0.469
LIG_LIR_Gen_1	347	357	PF02991	0.517
LIG_LIR_Gen_1	402	411	PF02991	0.474
LIG_LIR_Gen_1	504	514	PF02991	0.503
LIG_LIR_Gen_1	585	594	PF02991	0.559
LIG_LIR_LC3C_4	524	529	PF02991	0.474
LIG_LIR_Nem_3	251	255	PF02991	0.483
LIG_LIR_Nem_3	27	33	PF02991	0.408
LIG_LIR_Nem_3	330	334	PF02991	0.469
LIG_LIR_Nem_3	347	352	PF02991	0.517
LIG_LIR_Nem_3	402	408	PF02991	0.537
LIG_LIR_Nem_3	504	510	PF02991	0.503
LIG_LIR_Nem_3	585	589	PF02991	0.468
LIG_NRP_CendR_1	651	653	PF00754	0.465
LIG_SH2_SRC	252	255	PF00017	0.474
LIG_SH2_STAP1	264	268	PF00017	0.439
LIG_SH2_STAT5	127	130	PF00017	0.518
LIG_SH2_STAT5	282	285	PF00017	0.437
LIG_SH2_STAT5	405	408	PF00017	0.420
LIG_SH2_STAT5	427	430	PF00017	0.437
LIG_SH3_2	186	191	PF14604	0.420
LIG_SH3_2	371	376	PF14604	0.431
LIG_SH3_3	157	163	PF00018	0.478
LIG_SH3_3	183	189	PF00018	0.256
LIG_SH3_3	331	337	PF00018	0.437
LIG_SH3_3	368	374	PF00018	0.431
LIG_SH3_CIN85_PxpxPR_1	44	49	PF14604	0.422
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.450
LIG_SUMO_SIM_par_1	378	383	PF11976	0.420
LIG_SUMO_SIM_par_1	482	487	PF11976	0.420
LIG_SUMO_SIM_par_1	526	532	PF11976	0.436
LIG_TYR_ITIM	403	408	PF00017	0.437
LIG_UBA3_1	116	123	PF00899	0.495
LIG_WRC_WIRS_1	255	260	PF05994	0.474
LIG_WRC_WIRS_1	328	333	PF05994	0.474
LIG_WW_3	373	377	PF00397	0.462
MOD_CDK_SPK_2	44	49	PF00069	0.422
MOD_CDK_SPK_2	565	570	PF00069	0.390
MOD_CDK_SPxK_1	185	191	PF00069	0.281
MOD_CK1_1	100	106	PF00069	0.597
MOD_CK1_1	139	145	PF00069	0.703
MOD_CK1_1	185	191	PF00069	0.440
MOD_CK1_1	22	28	PF00069	0.475
MOD_CK1_1	224	230	PF00069	0.424
MOD_CK1_1	344	350	PF00069	0.500
MOD_CK1_1	436	442	PF00069	0.465
MOD_CK1_1	509	515	PF00069	0.533
MOD_CK2_1	248	254	PF00069	0.434
MOD_CK2_1	389	395	PF00069	0.437
MOD_CK2_1	463	469	PF00069	0.494
MOD_GlcNHglycan	11	14	PF01048	0.435
MOD_GlcNHglycan	224	227	PF01048	0.350
MOD_GlcNHglycan	236	239	PF01048	0.259
MOD_GlcNHglycan	269	272	PF01048	0.274
MOD_GlcNHglycan	294	297	PF01048	0.308
MOD_GlcNHglycan	314	317	PF01048	0.127
MOD_GlcNHglycan	319	322	PF01048	0.334
MOD_GlcNHglycan	34	37	PF01048	0.457
MOD_GlcNHglycan	346	349	PF01048	0.304
MOD_GlcNHglycan	367	370	PF01048	0.291
MOD_GlcNHglycan	371	374	PF01048	0.235
MOD_GlcNHglycan	602	605	PF01048	0.665
MOD_GlcNHglycan	99	102	PF01048	0.551
MOD_GSK3_1	136	143	PF00069	0.647
MOD_GSK3_1	20	27	PF00069	0.432
MOD_GSK3_1	220	227	PF00069	0.497
MOD_GSK3_1	310	317	PF00069	0.447
MOD_GSK3_1	365	372	PF00069	0.512
MOD_GSK3_1	40	47	PF00069	0.395
MOD_GSK3_1	549	556	PF00069	0.376
MOD_GSK3_1	600	607	PF00069	0.598
MOD_GSK3_1	96	103	PF00069	0.539
MOD_N-GLC_1	182	187	PF02516	0.539
MOD_N-GLC_1	239	244	PF02516	0.296
MOD_NEK2_1	150	155	PF00069	0.662
MOD_NEK2_1	267	272	PF00069	0.474
MOD_NEK2_1	31	36	PF00069	0.515
MOD_NEK2_1	404	409	PF00069	0.420
MOD_NEK2_1	463	468	PF00069	0.474
MOD_NEK2_1	549	554	PF00069	0.361
MOD_NEK2_1	7	12	PF00069	0.564
MOD_NEK2_2	57	62	PF00069	0.320
MOD_PIKK_1	140	146	PF00454	0.574
MOD_PIKK_1	239	245	PF00454	0.439
MOD_PIKK_1	341	347	PF00454	0.474
MOD_PIKK_1	7	13	PF00454	0.434
MOD_PKA_1	20	26	PF00069	0.435
MOD_PKA_2	20	26	PF00069	0.442
MOD_PKA_2	292	298	PF00069	0.503
MOD_PKA_2	7	13	PF00069	0.564
MOD_PKA_2	95	101	PF00069	0.652
MOD_PKB_1	363	371	PF00069	0.474
MOD_PKB_1	94	102	PF00069	0.533
MOD_Plk_1	163	169	PF00069	0.372
MOD_Plk_1	239	245	PF00069	0.480
MOD_Plk_1	285	291	PF00069	0.463
MOD_Plk_1	300	306	PF00069	0.482
MOD_Plk_2-3	254	260	PF00069	0.474
MOD_Plk_4	389	395	PF00069	0.437
MOD_Plk_4	399	405	PF00069	0.437
MOD_Plk_4	463	469	PF00069	0.474
MOD_Plk_4	506	512	PF00069	0.474
MOD_ProDKin_1	142	148	PF00069	0.702
MOD_ProDKin_1	182	188	PF00069	0.442
MOD_ProDKin_1	24	30	PF00069	0.553
MOD_ProDKin_1	40	46	PF00069	0.587
MOD_ProDKin_1	565	571	PF00069	0.385
MOD_SUMO_rev_2	603	612	PF00179	0.626
TRG_DiLeu_BaEn_1	622	627	PF01217	0.423
TRG_DiLeu_BaLyEn_6	555	560	PF01217	0.395
TRG_ENDOCYTIC_2	252	255	PF00928	0.513
TRG_ENDOCYTIC_2	264	267	PF00928	0.413
TRG_ENDOCYTIC_2	405	408	PF00928	0.437
TRG_ER_diArg_1	362	365	PF00400	0.474
TRG_ER_diArg_1	575	578	PF00400	0.374
TRG_ER_diArg_1	581	584	PF00400	0.393
TRG_ER_diArg_1	61	63	PF00400	0.390
TRG_ER_diArg_1	93	96	PF00400	0.633
TRG_Pf-PMV_PEXEL_1	562	566	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J6F0	Bodo saltans	36%	97%
A0A1X0NP71	Trypanosomatidae	43%	100%
A0A3S5H686	Leishmania donovani	99%	100%
A0A422NJU7	Trypanosoma rangeli	44%	100%
E9AI33	Leishmania braziliensis	81%	100%
E9AMH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P53973	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	92%
Q4QI60	Leishmania major	96%	100%
Q5A960	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	78%
V5BR24	Trypanosoma cruzi	45%	100%