Cathepsin L-like protease

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase B (CPB)

Species:

Leishmania infantum

UniProt:

A4HTP0_LEIIN

TriTrypDb:

LINF_080014700

Length:

381

Annotations

Annotations by Jardim et al.

Proteases, Cathepsin L-like protease

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 38, no: 6
NetGPI	no	yes: 0, no: 44

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	9
GO:0000323	lytic vacuole	6	8
GO:0005615	extracellular space	2	8
GO:0005764	lysosome	7	8
GO:0005773	vacuole	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Expansion

Sequence features

A4HTP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTP0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	45
GO:0006807	nitrogen compound metabolic process	2	45
GO:0008152	metabolic process	1	45
GO:0019538	protein metabolic process	3	45
GO:0043170	macromolecule metabolic process	3	45
GO:0044238	primary metabolic process	2	45
GO:0071704	organic substance metabolic process	2	45
GO:1901564	organonitrogen compound metabolic process	3	45
GO:0051603	proteolysis involved in protein catabolic process	5	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	45
GO:0008233	peptidase activity	3	45
GO:0008234	cysteine-type peptidase activity	4	45
GO:0016787	hydrolase activity	2	45
GO:0140096	catalytic activity, acting on a protein	2	45
GO:0004175	endopeptidase activity	4	28
GO:0004197	cysteine-type endopeptidase activity	5	28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.427
CLV_NRD_NRD_1	116	118	PF00675	0.575
CLV_NRD_NRD_1	366	368	PF00675	0.534
CLV_NRD_NRD_1	46	48	PF00675	0.462
CLV_PCSK_KEX2_1	366	368	PF00082	0.487
CLV_PCSK_KEX2_1	42	44	PF00082	0.491
CLV_PCSK_KEX2_1	46	48	PF00082	0.464
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.491
CLV_PCSK_SKI1_1	5	9	PF00082	0.616
CLV_Separin_Metazoa	67	71	PF03568	0.400
DEG_APCC_DBOX_1	119	127	PF00400	0.502
DEG_APCC_DBOX_1	4	12	PF00400	0.615
DEG_SCF_FBW7_1	331	336	PF00400	0.457
DOC_CKS1_1	30	35	PF01111	0.620
DOC_CYCLIN_RxL_1	58	71	PF00134	0.400
DOC_MAPK_MEF2A_6	304	311	PF00069	0.369
DOC_PP2B_LxvP_1	354	357	PF13499	0.397
DOC_SPAK_OSR1_1	80	84	PF12202	0.353
DOC_USP7_MATH_1	146	150	PF00917	0.517
DOC_USP7_MATH_1	215	219	PF00917	0.334
DOC_WW_Pin1_4	136	141	PF00397	0.397
DOC_WW_Pin1_4	29	34	PF00397	0.564
DOC_WW_Pin1_4	329	334	PF00397	0.493
LIG_14-3-3_CanoR_1	352	357	PF00244	0.471
LIG_BIR_II_1	1	5	PF00653	0.615
LIG_eIF4E_1	273	279	PF01652	0.176
LIG_FHA_1	283	289	PF00498	0.450
LIG_FHA_1	345	351	PF00498	0.538
LIG_FHA_2	49	55	PF00498	0.443
LIG_GBD_Chelix_1	309	317	PF00786	0.206
LIG_LIR_Gen_1	239	245	PF02991	0.477
LIG_LIR_Gen_1	303	313	PF02991	0.380
LIG_LIR_Gen_1	343	354	PF02991	0.524
LIG_LIR_Nem_3	239	244	PF02991	0.403
LIG_LIR_Nem_3	268	273	PF02991	0.329
LIG_LIR_Nem_3	303	309	PF02991	0.323
LIG_LIR_Nem_3	84	89	PF02991	0.442
LIG_SH2_CRK	205	209	PF00017	0.472
LIG_SH2_CRK	49	53	PF00017	0.389
LIG_SH2_GRB2like	98	101	PF00017	0.492
LIG_SH2_PTP2	241	244	PF00017	0.246
LIG_SH2_PTP2	306	309	PF00017	0.334
LIG_SH2_SRC	98	101	PF00017	0.523
LIG_SH2_STAT5	104	107	PF00017	0.413
LIG_SH2_STAT5	216	219	PF00017	0.337
LIG_SH2_STAT5	241	244	PF00017	0.462
LIG_SH2_STAT5	29	32	PF00017	0.476
LIG_SH2_STAT5	306	309	PF00017	0.334
LIG_SH2_STAT5	98	101	PF00017	0.516
LIG_SH3_3	239	245	PF00018	0.298
LIG_SH3_3	27	33	PF00018	0.527
LIG_SH3_3	353	359	PF00018	0.593
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.334
LIG_SUMO_SIM_par_1	169	175	PF11976	0.360
LIG_TYR_ITIM	288	293	PF00017	0.474
LIG_UBA3_1	349	358	PF00899	0.393
MOD_CDK_SPxK_1	136	142	PF00069	0.397
MOD_CK1_1	246	252	PF00069	0.491
MOD_CK1_1	269	275	PF00069	0.333
MOD_CK1_1	335	341	PF00069	0.731
MOD_CK2_1	169	175	PF00069	0.312
MOD_CK2_1	293	299	PF00069	0.344
MOD_CK2_1	48	54	PF00069	0.426
MOD_CK2_1	87	93	PF00069	0.338
MOD_Cter_Amidation	364	367	PF01082	0.473
MOD_GlcNHglycan	122	126	PF01048	0.551
MOD_GlcNHglycan	153	156	PF01048	0.461
MOD_GlcNHglycan	217	220	PF01048	0.338
MOD_GlcNHglycan	274	277	PF01048	0.430
MOD_GlcNHglycan	323	326	PF01048	0.377
MOD_GlcNHglycan	337	340	PF01048	0.477
MOD_GlcNHglycan	368	371	PF01048	0.518
MOD_GSK3_1	210	217	PF00069	0.350
MOD_GSK3_1	265	272	PF00069	0.357
MOD_GSK3_1	329	336	PF00069	0.562
MOD_N-GLC_1	227	232	PF02516	0.499
MOD_N-GLC_1	246	251	PF02516	0.461
MOD_N-GLC_1	282	287	PF02516	0.428
MOD_N-GLC_2	186	188	PF02516	0.471
MOD_N-GLC_2	314	316	PF02516	0.360
MOD_N-GLC_2	340	342	PF02516	0.639
MOD_NEK2_1	1	6	PF00069	0.614
MOD_NEK2_1	227	232	PF00069	0.386
MOD_NEK2_1	41	46	PF00069	0.472
MOD_NEK2_1	81	86	PF00069	0.438
MOD_PIKK_1	158	164	PF00454	0.478
MOD_PK_1	352	358	PF00069	0.401
MOD_PKA_1	366	372	PF00069	0.471
MOD_PKA_2	366	372	PF00069	0.492
MOD_Plk_1	121	127	PF00069	0.619
MOD_Plk_1	210	216	PF00069	0.320
MOD_Plk_1	246	252	PF00069	0.472
MOD_Plk_1	265	271	PF00069	0.300
MOD_Plk_4	246	252	PF00069	0.366
MOD_Plk_4	266	272	PF00069	0.316
MOD_ProDKin_1	136	142	PF00069	0.397
MOD_ProDKin_1	29	35	PF00069	0.561
MOD_ProDKin_1	329	335	PF00069	0.501
MOD_SUMO_rev_2	39	44	PF00179	0.490
TRG_DiLeu_BaEn_4	54	60	PF01217	0.413
TRG_ENDOCYTIC_2	205	208	PF00928	0.347
TRG_ENDOCYTIC_2	241	244	PF00928	0.513
TRG_ENDOCYTIC_2	290	293	PF00928	0.332
TRG_ENDOCYTIC_2	306	309	PF00928	0.306
TRG_ENDOCYTIC_2	49	52	PF00928	0.413
TRG_ER_diArg_1	366	368	PF00400	0.483
TRG_ER_diArg_1	45	47	PF00400	0.452
TRG_NES_CRM1_1	57	71	PF08389	0.400
TRG_NLS_MonoExtC_3	116	122	PF00514	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A072UTP9	Medicago truncatula	37%	100%
A0A0N0P293	Leptomonas seymouri	33%	100%
A0A0N0P8D1	Leptomonas seymouri	26%	100%
A0A0N1PA65	Leptomonas seymouri	51%	82%
A0A0S4III3	Bodo saltans	43%	100%
A0A0S4IMD3	Bodo saltans	43%	100%
A0A0S4ISD8	Bodo saltans	46%	71%
A0A0S4IWQ5	Bodo saltans	35%	100%
A0A0S4IY45	Bodo saltans	33%	100%
A0A0S4J328	Bodo saltans	47%	100%
A0A0S4J3Q7	Bodo saltans	29%	100%
A0A0S4J628	Bodo saltans	44%	69%
A0A0S4J918	Bodo saltans	39%	100%
A0A0S4J9K9	Bodo saltans	44%	100%
A0A0S4JPQ2	Bodo saltans	32%	100%
A0A0S4JSZ3	Bodo saltans	32%	100%
A0A0S4JV57	Bodo saltans	32%	100%
A0A0S4JXJ3	Bodo saltans	29%	99%
A0A0S4KGP4	Bodo saltans	42%	100%
A0A0S4KI32	Bodo saltans	30%	100%
A0A0S4KJA5	Bodo saltans	44%	82%
A0A1X0NIG8	Trypanosomatidae	30%	88%
A0A1X0NM52	Trypanosomatidae	51%	100%
A0A1X0NXC8	Trypanosomatidae	30%	100%
A0A3R7L7E7	Trypanosoma rangeli	54%	72%
A0A3S5H682	Leishmania donovani	96%	97%
A0A3S5H683	Leishmania donovani	95%	86%
A0A3S5H684	Leishmania donovani	95%	86%
A0A3S5H685	Leishmania donovani	95%	86%
A0A3S7WQD0	Leishmania donovani	95%	86%
A0A6L0WJ22	Leishmania infantum	95%	100%
A0E358	Paramecium tetraurelia	33%	100%
A1E295	Sus scrofa	29%	100%
A1KXI0	Blomia tropicalis	30%	100%
A2XQE8	Oryza sativa subsp. indica	35%	100%
A4H5E4	Leishmania braziliensis	71%	100%
A4H5E5	Leishmania braziliensis	71%	100%
A4H5E6	Leishmania braziliensis	71%	100%
A4HA92	Leishmania braziliensis	45%	100%
A4HYH2	Leishmania infantum	45%	100%
A4I4D6	Leishmania infantum	27%	100%
A5HII1	Actinidia deliciosa	33%	100%
A8DS38	Tabernaemontana divaricata	37%	100%
B2LSD2	Mucuna pruriens	36%	89%
C9ZQB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	84%
C9ZQB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	85%
C9ZQB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	94%
D3ZZ07	Rattus norvegicus	31%	100%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E8NHJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E8NHL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E8NHS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9ADT5	Leishmania major	30%	100%
E9ALZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AMH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9AS96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
F4JNL3	Arabidopsis thaliana	30%	100%
O10364	Orgyia pseudotsugata multicapsid polyhedrosis virus	35%	100%
O17473	Brugia pahangi	34%	96%
O23791	Ananas comosus	31%	100%
O35186	Rattus norvegicus	34%	100%
O45734	Caenorhabditis elegans	40%	100%
O46427	Sus scrofa	34%	100%
O60911	Homo sapiens	38%	100%
O65039	Ricinus communis	36%	100%
O65493	Arabidopsis thaliana	35%	100%
O70370	Mus musculus	34%	100%
O91466	Cydia pomonella granulosis virus (isolate Mexico/1963)	34%	100%
O97397	Phaedon cochleariae	31%	100%
P00784	Carica papaya	35%	100%
P00785	Actinidia chinensis var. chinensis	34%	100%
P00786	Rattus norvegicus	36%	100%
P00787	Rattus norvegicus	28%	100%
P04988	Dictyostelium discoideum	36%	100%
P04989	Dictyostelium discoideum	33%	100%
P05167	Hordeum vulgare	38%	100%
P05994	Carica papaya	32%	100%
P06797	Mus musculus	38%	100%
P07154	Rattus norvegicus	38%	100%
P07711	Homo sapiens	35%	100%
P07858	Homo sapiens	29%	100%
P08176	Dermatophagoides pteronyssinus	28%	100%
P09668	Homo sapiens	36%	100%
P10056	Carica papaya	35%	100%
P10605	Mus musculus	29%	100%
P12412	Vigna mungo	35%	100%
P13277	Homarus americanus	38%	100%
P14080	Carica papaya	36%	100%
P14658	Trypanosoma brucei brucei	50%	85%
P15242	Rattus norvegicus	34%	100%
P16311	Dermatophagoides farinae	30%	100%
P22497	Theileria parva	32%	87%
P22895	Glycine max	37%	100%
P25249	Hordeum vulgare	39%	100%
P25250	Hordeum vulgare	37%	100%
P25251	Brassica napus	37%	100%
P25326	Bos taurus	33%	100%
P25773	Felis catus	35%	100%
P25774	Homo sapiens	33%	100%
P25775	Leishmania mexicana	47%	100%
P25776	Oryza sativa subsp. japonica	37%	83%
P25777	Oryza sativa subsp. japonica	36%	82%
P25778	Oryza sativa subsp. japonica	39%	100%
P25779	Trypanosoma cruzi	54%	82%
P25780	Euroglyphus maynei	28%	100%
P25781	Theileria annulata	33%	86%
P25782	Homarus americanus	35%	100%
P25783	Autographa californica nuclear polyhedrosis virus	37%	100%
P25784	Homarus americanus	35%	100%
P25792	Schistosoma mansoni	23%	100%
P25803	Phaseolus vulgaris	35%	100%
P25804	Pisum sativum	41%	100%
P25805	Plasmodium falciparum	28%	67%
P25807	Caenorhabditis elegans	27%	100%
P25975	Bos taurus	37%	100%
P35591	Leishmania pifanoi	47%	100%
P36184	Entamoeba histolytica	30%	100%
P36185	Entamoeba histolytica	30%	100%
P36400	Leishmania mexicana	78%	86%
P41715	Choristoneura fumiferana nuclear polyhedrosis virus	37%	100%
P41721	Bombyx mori nuclear polyhedrosis virus	36%	100%
P43156	Hemerocallis sp.	38%	100%
P43157	Schistosoma japonicum	27%	100%
P43233	Gallus gallus	28%	100%
P43234	Homo sapiens	36%	100%
P43235	Homo sapiens	34%	100%
P43236	Oryctolagus cuniculus	34%	100%
P43295	Arabidopsis thaliana	40%	100%
P43296	Arabidopsis thaliana	39%	100%
P43297	Arabidopsis thaliana	37%	82%
P43508	Caenorhabditis elegans	26%	100%
P43509	Caenorhabditis elegans	30%	100%
P43510	Caenorhabditis elegans	28%	100%
P46102	Plasmodium vinckei	29%	75%
P49935	Mus musculus	35%	100%
P54639	Dictyostelium discoideum	32%	86%
P54640	Dictyostelium discoideum	31%	100%
P55097	Mus musculus	34%	100%
P56202	Homo sapiens	32%	100%
P56203	Mus musculus	33%	100%
P61276	Macaca fascicularis	34%	100%
P61277	Macaca mulatta	34%	100%
P80884	Ananas comosus	31%	100%
P90850	Caenorhabditis elegans	30%	84%
P92131	Giardia intestinalis	30%	100%
P92132	Giardia intestinalis	33%	100%
P92133	Giardia intestinalis	31%	100%
Q01957	Entamoeba histolytica	31%	100%
Q01958	Entamoeba histolytica	31%	100%
Q02765	Rattus norvegicus	33%	100%
Q05094	Leishmania pifanoi	78%	86%
Q06964	Entamoeba histolytica	32%	100%
Q10716	Zea mays	38%	100%
Q10717	Zea mays	38%	100%
Q1EIQ3	Psoroptes ovis	30%	100%
Q23894	Dictyostelium discoideum	32%	100%
Q24940	Fasciola hepatica	38%	100%
Q26534	Schistosoma mansoni	37%	100%
Q26636	Sarcophaga peregrina	37%	100%
Q28944	Sus scrofa	38%	100%
Q3T0I2	Bos taurus	35%	100%
Q3ZKN1	Canis lupus familiaris	35%	100%
Q40143	Solanum lycopersicum	37%	100%
Q4QD68	Leishmania major	49%	100%
Q4QI61	Leishmania major	86%	100%
Q4QI62	Leishmania major	86%	100%
Q4QI64	Leishmania major	86%	100%
Q4QI65	Leishmania major	86%	100%
Q4QI66	Leishmania major	86%	100%
Q4QI67	Leishmania major	85%	100%
Q4QI68	Leishmania major	85%	100%
Q4R5M2	Macaca fascicularis	29%	100%
Q54TR1	Dictyostelium discoideum	35%	72%
Q5E968	Bos taurus	34%	100%
Q5E998	Bos taurus	37%	100%
Q5R6D1	Pongo abelii	29%	100%
Q63088	Rattus norvegicus	35%	100%
Q6VTL7	Choristoneura fumiferana defective polyhedrosis virus	37%	100%
Q6YD92	Petrosia ficiformis	34%	100%
Q7F3A8	Oryza sativa subsp. japonica	37%	100%
Q7GDU7	Oryza sativa subsp. japonica	38%	100%
Q7XR52	Oryza sativa subsp. japonica	37%	78%
Q7XWK5	Oryza sativa subsp. japonica	35%	100%
Q80LP4	Adoxophyes honmai nucleopolyhedrovirus	37%	100%
Q80UB0	Mus musculus	33%	100%
Q86GF7	Pandalus borealis	35%	100%
Q8B9D5	Rachiplusia ou multiple nucleopolyhedrovirus (strain R1)	37%	100%
Q8BM88	Mus musculus	35%	100%
Q8H166	Arabidopsis thaliana	39%	100%
Q8HY81	Canis lupus familiaris	36%	100%
Q8HY82	Saimiri boliviensis boliviensis	34%	100%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	36%	100%
Q8RWQ9	Arabidopsis thaliana	37%	100%
Q8V5U0	Heliothis zea nuclear polyhedrosis virus	38%	100%
Q8VYS0	Arabidopsis thaliana	38%	100%
Q91BH1	Spodoptera litura multicapsid nucleopolyhedrovirus	36%	100%
Q91CL9	Antheraea pernyi nuclear polyhedrosis virus	36%	100%
Q91GE3	Epiphyas postvittana nucleopolyhedrovirus	37%	100%
Q91ZF2	Mus musculus	31%	100%
Q94503	Dictyostelium discoideum	35%	88%
Q94504	Dictyostelium discoideum	35%	83%
Q94714	Paramecium tetraurelia	34%	100%
Q94715	Paramecium tetraurelia	30%	100%
Q94B08	Arabidopsis thaliana	37%	100%
Q95029	Drosophila melanogaster	38%	100%
Q9BIE1	Leishmania donovani	45%	100%
Q9FGR9	Arabidopsis thaliana	36%	100%
Q9FJ47	Arabidopsis thaliana	38%	100%
Q9FMH8	Arabidopsis thaliana	38%	82%
Q9GKL8	Chlorocebus aethiops	35%	100%
Q9GL24	Canis lupus familiaris	37%	100%
Q9GLE3	Sus scrofa	33%	100%
Q9GQM5	Leishmania donovani	27%	100%
Q9J8B9	Spodoptera exigua nuclear polyhedrosis virus (strain US)	37%	100%
Q9JI81	Mus musculus	32%	100%
Q9JIA9	Mus musculus	34%	100%
Q9JL96	Mus musculus	32%	100%
Q9LM66	Arabidopsis thaliana	37%	100%
Q9LT77	Arabidopsis thaliana	34%	100%
Q9LT78	Arabidopsis thaliana	36%	84%
Q9LXW3	Arabidopsis thaliana	35%	100%
Q9PYY5	Xestia c-nigrum granulosis virus	37%	100%
Q9QZE3	Rattus norvegicus	31%	100%
Q9R013	Mus musculus	41%	82%
Q9R014	Mus musculus	36%	100%
Q9STL4	Arabidopsis thaliana	34%	100%
Q9STL5	Arabidopsis thaliana	36%	100%
Q9SUL1	Arabidopsis thaliana	39%	100%
Q9SUS9	Arabidopsis thaliana	35%	100%
Q9SUT0	Arabidopsis thaliana	33%	100%
Q9TST1	Felis catus	32%	100%
Q9UBX1	Homo sapiens	40%	79%
Q9WGE0	Hyphantria cunea nuclear polyhedrosis virus	35%	100%
Q9YMP9	Lymantria dispar multicapsid nuclear polyhedrosis virus	38%	100%
Q9YWK4	Buzura suppressaria nuclear polyhedrosis virus	33%	100%
V5B261	Trypanosoma cruzi	34%	97%
V5LU01	Ambrosia artemisiifolia	34%	99%