Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2453) - putative

Species:

Leishmania infantum

UniProt:

A4HTN7_LEIIN

TriTrypDb:

LINF_080014200

Length:

833

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HTN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTN7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005509	calcium ion binding	5	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.494
CLV_C14_Caspase3-7	263	267	PF00656	0.467
CLV_C14_Caspase3-7	440	444	PF00656	0.462
CLV_C14_Caspase3-7	580	584	PF00656	0.451
CLV_NRD_NRD_1	2	4	PF00675	0.485
CLV_NRD_NRD_1	33	35	PF00675	0.677
CLV_NRD_NRD_1	346	348	PF00675	0.675
CLV_NRD_NRD_1	411	413	PF00675	0.698
CLV_NRD_NRD_1	456	458	PF00675	0.693
CLV_NRD_NRD_1	466	468	PF00675	0.718
CLV_PCSK_FUR_1	379	383	PF00082	0.673
CLV_PCSK_KEX2_1	2	4	PF00082	0.485
CLV_PCSK_KEX2_1	33	35	PF00082	0.677
CLV_PCSK_KEX2_1	346	348	PF00082	0.661
CLV_PCSK_KEX2_1	381	383	PF00082	0.660
CLV_PCSK_KEX2_1	411	413	PF00082	0.668
CLV_PCSK_KEX2_1	456	458	PF00082	0.706
CLV_PCSK_KEX2_1	465	467	PF00082	0.750
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.660
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.797
CLV_PCSK_PC7_1	377	383	PF00082	0.675
CLV_PCSK_SKI1_1	118	122	PF00082	0.654
CLV_PCSK_SKI1_1	254	258	PF00082	0.737
CLV_PCSK_SKI1_1	360	364	PF00082	0.719
CLV_PCSK_SKI1_1	411	415	PF00082	0.609
CLV_PCSK_SKI1_1	467	471	PF00082	0.745
CLV_PCSK_SKI1_1	823	827	PF00082	0.464
DEG_APCC_DBOX_1	117	125	PF00400	0.449
DEG_APCC_DBOX_1	410	418	PF00400	0.406
DEG_Nend_UBRbox_1	1	4	PF02207	0.697
DEG_SCF_FBW7_1	24	30	PF00400	0.530
DEG_SCF_SKP2-CKS1_1	458	465	PF00560	0.480
DEG_SPOP_SBC_1	218	222	PF00917	0.498
DEG_SPOP_SBC_1	279	283	PF00917	0.519
DEG_SPOP_SBC_1	349	353	PF00917	0.530
DEG_SPOP_SBC_1	48	52	PF00917	0.484
DEG_SPOP_SBC_1	64	68	PF00917	0.433
DEG_SPOP_SBC_1	82	86	PF00917	0.427
DOC_ANK_TNKS_1	581	588	PF00023	0.453
DOC_CDC14_PxL_1	764	772	PF14671	0.265
DOC_CKS1_1	24	29	PF01111	0.528
DOC_MAPK_DCC_7	730	738	PF00069	0.301
DOC_MAPK_gen_1	545	552	PF00069	0.613
DOC_MAPK_MEF2A_6	730	738	PF00069	0.301
DOC_USP7_MATH_1	104	108	PF00917	0.437
DOC_USP7_MATH_1	135	139	PF00917	0.442
DOC_USP7_MATH_1	187	191	PF00917	0.519
DOC_USP7_MATH_1	248	252	PF00917	0.540
DOC_USP7_MATH_1	259	263	PF00917	0.495
DOC_USP7_MATH_1	264	268	PF00917	0.462
DOC_USP7_MATH_1	271	275	PF00917	0.481
DOC_USP7_MATH_1	279	283	PF00917	0.431
DOC_USP7_MATH_1	300	304	PF00917	0.522
DOC_USP7_MATH_1	324	328	PF00917	0.541
DOC_USP7_MATH_1	333	337	PF00917	0.488
DOC_USP7_MATH_1	349	353	PF00917	0.465
DOC_USP7_MATH_1	43	47	PF00917	0.459
DOC_USP7_MATH_1	484	488	PF00917	0.501
DOC_USP7_MATH_1	508	512	PF00917	0.544
DOC_USP7_MATH_1	527	531	PF00917	0.515
DOC_USP7_MATH_1	537	541	PF00917	0.505
DOC_USP7_MATH_1	59	63	PF00917	0.460
DOC_USP7_MATH_1	594	598	PF00917	0.501
DOC_USP7_MATH_1	613	617	PF00917	0.436
DOC_USP7_MATH_1	635	639	PF00917	0.481
DOC_USP7_MATH_1	64	68	PF00917	0.485
DOC_USP7_MATH_1	646	650	PF00917	0.477
DOC_USP7_MATH_1	705	709	PF00917	0.407
DOC_USP7_MATH_1	793	797	PF00917	0.671
DOC_USP7_MATH_1	82	86	PF00917	0.428
DOC_USP7_MATH_1	95	99	PF00917	0.443
DOC_USP7_UBL2_3	802	806	PF12436	0.610
DOC_WW_Pin1_4	185	190	PF00397	0.476
DOC_WW_Pin1_4	23	28	PF00397	0.287
DOC_WW_Pin1_4	269	274	PF00397	0.520
DOC_WW_Pin1_4	275	280	PF00397	0.496
DOC_WW_Pin1_4	298	303	PF00397	0.522
DOC_WW_Pin1_4	325	330	PF00397	0.521
DOC_WW_Pin1_4	351	356	PF00397	0.477
DOC_WW_Pin1_4	371	376	PF00397	0.471
DOC_WW_Pin1_4	459	464	PF00397	0.484
DOC_WW_Pin1_4	55	60	PF00397	0.501
DOC_WW_Pin1_4	566	571	PF00397	0.448
DOC_WW_Pin1_4	599	604	PF00397	0.543
DOC_WW_Pin1_4	628	633	PF00397	0.597
DOC_WW_Pin1_4	93	98	PF00397	0.451
LIG_14-3-3_CanoR_1	10	19	PF00244	0.493
LIG_14-3-3_CanoR_1	34	44	PF00244	0.496
LIG_14-3-3_CanoR_1	360	369	PF00244	0.535
LIG_14-3-3_CanoR_1	545	552	PF00244	0.569
LIG_14-3-3_CanoR_1	605	609	PF00244	0.485
LIG_14-3-3_CanoR_1	735	739	PF00244	0.314
LIG_14-3-3_CanoR_1	748	756	PF00244	0.231
LIG_14-3-3_CanoR_1	799	805	PF00244	0.606
LIG_BIR_III_4	622	626	PF00653	0.505
LIG_BRCT_BRCA1_1	285	289	PF00533	0.457
LIG_BRCT_BRCA1_1	420	424	PF00533	0.410
LIG_EVH1_2	174	178	PF00568	0.479
LIG_FHA_1	112	118	PF00498	0.431
LIG_FHA_1	179	185	PF00498	0.503
LIG_FHA_1	241	247	PF00498	0.487
LIG_FHA_1	338	344	PF00498	0.518
LIG_FHA_1	558	564	PF00498	0.450
LIG_FHA_1	681	687	PF00498	0.530
LIG_FHA_2	186	192	PF00498	0.521
LIG_FHA_2	261	267	PF00498	0.462
LIG_FHA_2	438	444	PF00498	0.447
LIG_GBD_Chelix_1	384	392	PF00786	0.646
LIG_LIR_Gen_1	20	29	PF02991	0.287
LIG_LIR_Gen_1	286	297	PF02991	0.455
LIG_LIR_Gen_1	427	435	PF02991	0.428
LIG_LIR_Gen_1	661	670	PF02991	0.350
LIG_LIR_Nem_3	20	25	PF02991	0.287
LIG_LIR_Nem_3	421	426	PF02991	0.427
LIG_LIR_Nem_3	427	431	PF02991	0.399
LIG_LIR_Nem_3	631	636	PF02991	0.477
LIG_LIR_Nem_3	661	665	PF02991	0.412
LIG_LIR_Nem_3	79	83	PF02991	0.443
LIG_MAD2	664	672	PF02301	0.385
LIG_MLH1_MIPbox_1	420	424	PF16413	0.410
LIG_MYND_1	396	400	PF01753	0.437
LIG_NRBOX	387	393	PF00104	0.445
LIG_PTAP_UEV_1	96	101	PF05743	0.446
LIG_RPA_C_Fungi	612	624	PF08784	0.623
LIG_SH2_NCK_1	102	106	PF00017	0.555
LIG_SH2_NCK_1	428	432	PF00017	0.523
LIG_SH2_NCK_1	728	732	PF00017	0.385
LIG_SH2_NCK_1	746	750	PF00017	0.385
LIG_SH2_SRC	428	431	PF00017	0.533
LIG_SH2_STAP1	428	432	PF00017	0.523
LIG_SH2_STAP1	451	455	PF00017	0.508
LIG_SH2_STAP1	728	732	PF00017	0.342
LIG_SH2_STAT5	102	105	PF00017	0.560
LIG_SH2_STAT5	322	325	PF00017	0.561
LIG_SH2_STAT5	423	426	PF00017	0.519
LIG_SH2_STAT5	656	659	PF00017	0.617
LIG_SH2_STAT5	662	665	PF00017	0.538
LIG_SH2_STAT5	728	731	PF00017	0.385
LIG_SH3_3	282	288	PF00018	0.613
LIG_SH3_3	478	484	PF00018	0.558
LIG_SH3_3	499	505	PF00018	0.625
LIG_SH3_3	53	59	PF00018	0.600
LIG_SH3_3	629	635	PF00018	0.669
LIG_SH3_3	91	97	PF00018	0.572
LIG_Sin3_3	234	241	PF02671	0.628
LIG_TRAF2_1	779	782	PF00917	0.583
LIG_TYR_ITIM	426	431	PF00017	0.541
LIG_UBA3_1	562	568	PF00899	0.618
LIG_WW_3	732	736	PF00397	0.385
MOD_CDC14_SPxK_1	374	377	PF00782	0.638
MOD_CDC14_SPxK_1	602	605	PF00782	0.630
MOD_CDK_SPK_2	351	356	PF00069	0.570
MOD_CDK_SPxK_1	371	377	PF00069	0.641
MOD_CDK_SPxK_1	459	465	PF00069	0.606
MOD_CDK_SPxK_1	599	605	PF00069	0.629
MOD_CDK_SPxxK_3	298	305	PF00069	0.628
MOD_CDK_SPxxK_3	459	466	PF00069	0.609
MOD_CK1_1	106	112	PF00069	0.523
MOD_CK1_1	179	185	PF00069	0.648
MOD_CK1_1	194	200	PF00069	0.570
MOD_CK1_1	214	220	PF00069	0.548
MOD_CK1_1	272	278	PF00069	0.677
MOD_CK1_1	280	286	PF00069	0.644
MOD_CK1_1	328	334	PF00069	0.668
MOD_CK1_1	336	342	PF00069	0.607
MOD_CK1_1	351	357	PF00069	0.582
MOD_CK1_1	394	400	PF00069	0.497
MOD_CK1_1	407	413	PF00069	0.361
MOD_CK1_1	445	451	PF00069	0.513
MOD_CK1_1	475	481	PF00069	0.630
MOD_CK1_1	503	509	PF00069	0.675
MOD_CK1_1	569	575	PF00069	0.678
MOD_CK1_1	601	607	PF00069	0.729
MOD_CK1_1	638	644	PF00069	0.583
MOD_CK1_1	747	753	PF00069	0.392
MOD_CK1_1	773	779	PF00069	0.566
MOD_CK1_1	84	90	PF00069	0.590
MOD_CK1_1	98	104	PF00069	0.531
MOD_CK2_1	106	112	PF00069	0.562
MOD_CK2_1	122	128	PF00069	0.443
MOD_CK2_1	149	155	PF00069	0.621
MOD_CK2_1	179	185	PF00069	0.643
MOD_CK2_1	300	306	PF00069	0.627
MOD_CK2_1	444	450	PF00069	0.522
MOD_GlcNHglycan	106	109	PF01048	0.541
MOD_GlcNHglycan	137	140	PF01048	0.518
MOD_GlcNHglycan	144	147	PF01048	0.528
MOD_GlcNHglycan	169	172	PF01048	0.646
MOD_GlcNHglycan	178	181	PF01048	0.592
MOD_GlcNHglycan	194	197	PF01048	0.548
MOD_GlcNHglycan	199	202	PF01048	0.646
MOD_GlcNHglycan	203	207	PF01048	0.624
MOD_GlcNHglycan	216	219	PF01048	0.568
MOD_GlcNHglycan	249	253	PF01048	0.669
MOD_GlcNHglycan	266	269	PF01048	0.575
MOD_GlcNHglycan	285	288	PF01048	0.503
MOD_GlcNHglycan	302	305	PF01048	0.531
MOD_GlcNHglycan	331	334	PF01048	0.649
MOD_GlcNHglycan	335	338	PF01048	0.661
MOD_GlcNHglycan	40	43	PF01048	0.614
MOD_GlcNHglycan	406	409	PF01048	0.511
MOD_GlcNHglycan	45	48	PF01048	0.580
MOD_GlcNHglycan	474	477	PF01048	0.647
MOD_GlcNHglycan	486	489	PF01048	0.579
MOD_GlcNHglycan	521	524	PF01048	0.768
MOD_GlcNHglycan	531	534	PF01048	0.615
MOD_GlcNHglycan	539	542	PF01048	0.612
MOD_GlcNHglycan	571	574	PF01048	0.638
MOD_GlcNHglycan	609	613	PF01048	0.734
MOD_GlcNHglycan	61	64	PF01048	0.562
MOD_GlcNHglycan	637	640	PF01048	0.609
MOD_GlcNHglycan	643	646	PF01048	0.617
MOD_GlcNHglycan	695	698	PF01048	0.446
MOD_GlcNHglycan	713	716	PF01048	0.218
MOD_GlcNHglycan	772	775	PF01048	0.540
MOD_GlcNHglycan	97	100	PF01048	0.574
MOD_GSK3_1	100	107	PF00069	0.520
MOD_GSK3_1	135	142	PF00069	0.556
MOD_GSK3_1	187	194	PF00069	0.640
MOD_GSK3_1	202	209	PF00069	0.561
MOD_GSK3_1	210	217	PF00069	0.610
MOD_GSK3_1	218	225	PF00069	0.543
MOD_GSK3_1	23	30	PF00069	0.537
MOD_GSK3_1	260	267	PF00069	0.665
MOD_GSK3_1	271	278	PF00069	0.569
MOD_GSK3_1	279	286	PF00069	0.596
MOD_GSK3_1	318	325	PF00069	0.664
MOD_GSK3_1	329	336	PF00069	0.585
MOD_GSK3_1	351	358	PF00069	0.649
MOD_GSK3_1	363	370	PF00069	0.555
MOD_GSK3_1	43	50	PF00069	0.507
MOD_GSK3_1	500	507	PF00069	0.672
MOD_GSK3_1	537	544	PF00069	0.727
MOD_GSK3_1	55	62	PF00069	0.552
MOD_GSK3_1	594	601	PF00069	0.722
MOD_GSK3_1	604	611	PF00069	0.637
MOD_GSK3_1	634	641	PF00069	0.637
MOD_GSK3_1	695	702	PF00069	0.407
MOD_GSK3_1	72	79	PF00069	0.490
MOD_GSK3_1	740	747	PF00069	0.347
MOD_GSK3_1	89	96	PF00069	0.504
MOD_N-GLC_1	147	152	PF02516	0.609
MOD_N-GLC_1	210	215	PF02516	0.624
MOD_N-GLC_1	613	618	PF02516	0.654
MOD_N-GLC_1	680	685	PF02516	0.520
MOD_NEK2_1	149	154	PF00069	0.636
MOD_NEK2_1	17	22	PF00069	0.287
MOD_NEK2_1	178	183	PF00069	0.649
MOD_NEK2_1	458	463	PF00069	0.575
MOD_NEK2_1	608	613	PF00069	0.588
MOD_NEK2_1	679	684	PF00069	0.417
MOD_NEK2_1	695	700	PF00069	0.231
MOD_NEK2_1	770	775	PF00069	0.548
MOD_NEK2_2	646	651	PF00069	0.592
MOD_PIKK_1	212	218	PF00454	0.602
MOD_PIKK_1	305	311	PF00454	0.677
MOD_PIKK_1	506	512	PF00454	0.576
MOD_PIKK_1	699	705	PF00454	0.385
MOD_PIKK_1	747	753	PF00454	0.405
MOD_PIKK_1	773	779	PF00454	0.566
MOD_PK_1	442	448	PF00069	0.536
MOD_PKA_2	292	298	PF00069	0.575
MOD_PKA_2	367	373	PF00069	0.663
MOD_PKA_2	604	610	PF00069	0.591
MOD_PKA_2	726	732	PF00069	0.385
MOD_PKA_2	734	740	PF00069	0.311
MOD_PKA_2	747	753	PF00069	0.257
MOD_Plk_1	442	448	PF00069	0.564
MOD_Plk_1	679	685	PF00069	0.385
MOD_Plk_1	807	813	PF00069	0.487
MOD_Plk_2-3	240	246	PF00069	0.590
MOD_Plk_4	222	228	PF00069	0.689
MOD_Plk_4	318	324	PF00069	0.571
MOD_Plk_4	658	664	PF00069	0.473
MOD_Plk_4	680	686	PF00069	0.414
MOD_Plk_4	89	95	PF00069	0.614
MOD_ProDKin_1	185	191	PF00069	0.589
MOD_ProDKin_1	23	29	PF00069	0.287
MOD_ProDKin_1	269	275	PF00069	0.646
MOD_ProDKin_1	298	304	PF00069	0.649
MOD_ProDKin_1	325	331	PF00069	0.650
MOD_ProDKin_1	351	357	PF00069	0.587
MOD_ProDKin_1	371	377	PF00069	0.575
MOD_ProDKin_1	459	465	PF00069	0.606
MOD_ProDKin_1	55	61	PF00069	0.620
MOD_ProDKin_1	566	572	PF00069	0.549
MOD_ProDKin_1	599	605	PF00069	0.684
MOD_ProDKin_1	628	634	PF00069	0.755
MOD_ProDKin_1	93	99	PF00069	0.548
MOD_SUMO_for_1	130	133	PF00179	0.540
TRG_DiLeu_BaEn_1	409	414	PF01217	0.496
TRG_DiLeu_BaLyEn_6	765	770	PF01217	0.385
TRG_DiLeu_LyEn_5	409	414	PF01217	0.496
TRG_ENDOCYTIC_2	423	426	PF00928	0.519
TRG_ENDOCYTIC_2	428	431	PF00928	0.477
TRG_ENDOCYTIC_2	662	665	PF00928	0.615
TRG_ER_diArg_1	1	3	PF00400	0.609
TRG_ER_diArg_1	376	379	PF00400	0.613
TRG_ER_diArg_1	411	413	PF00400	0.555
TRG_ER_diArg_1	455	457	PF00400	0.596
TRG_ER_diArg_1	811	814	PF00400	0.494
TRG_NLS_MonoCore_2	229	234	PF00514	0.651
TRG_NLS_MonoExtN_4	228	234	PF00514	0.656
TRG_NLS_MonoExtN_4	463	469	PF00514	0.706
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H678	Leishmania donovani	100%	100%
A4H5E2	Leishmania braziliensis	68%	99%
E9AMH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	97%
Q4QI72	Leishmania major	88%	100%