LeishMANIAdb
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Dpy-30 motif containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dpy-30 motif containing protein
Gene product:
Dpy-30 motif containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HTN6_LEIIN
TriTrypDb:
LINF_080014100
Length:
565

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 11
GO:0034708 methyltransferase complex 4 11
GO:0035097 histone methyltransferase complex 3 11
GO:0044666 MLL3/4 complex 4 11
GO:0048188 Set1C/COMPASS complex 4 11
GO:0140513 nuclear protein-containing complex 2 11
GO:1902494 catalytic complex 2 11
GO:1990234 transferase complex 3 11
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HTN6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTN6

Function

Biological processes
Term Name Level Count
GO:0006479 protein methylation 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0008213 protein alkylation 5 1
GO:0009987 cellular process 1 1
GO:0016570 histone modification 5 1
GO:0016571 histone methylation 5 1
GO:0018022 peptidyl-lysine methylation 5 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018205 peptidyl-lysine modification 6 1
GO:0019538 protein metabolic process 3 1
GO:0032259 methylation 2 1
GO:0034968 histone lysine methylation 6 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043414 macromolecule methylation 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0051568 histone H3-K4 methylation 7 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 139 143 PF00656 0.657
CLV_C14_Caspase3-7 317 321 PF00656 0.612
CLV_C14_Caspase3-7 329 333 PF00656 0.700
CLV_NRD_NRD_1 161 163 PF00675 0.434
CLV_NRD_NRD_1 362 364 PF00675 0.364
CLV_NRD_NRD_1 45 47 PF00675 0.490
CLV_NRD_NRD_1 537 539 PF00675 0.477
CLV_NRD_NRD_1 54 56 PF00675 0.470
CLV_NRD_NRD_1 90 92 PF00675 0.452
CLV_PCSK_FUR_1 535 539 PF00082 0.523
CLV_PCSK_FUR_1 91 95 PF00082 0.483
CLV_PCSK_KEX2_1 161 163 PF00082 0.457
CLV_PCSK_KEX2_1 362 364 PF00082 0.364
CLV_PCSK_KEX2_1 53 55 PF00082 0.521
CLV_PCSK_KEX2_1 537 539 PF00082 0.535
CLV_PCSK_KEX2_1 93 95 PF00082 0.583
CLV_PCSK_PC1ET2_1 93 95 PF00082 0.551
CLV_PCSK_PC7_1 89 95 PF00082 0.557
CLV_PCSK_SKI1_1 162 166 PF00082 0.399
CLV_PCSK_SKI1_1 169 173 PF00082 0.323
DEG_Kelch_Keap1_1 502 507 PF01344 0.630
DEG_Nend_UBRbox_2 1 3 PF02207 0.514
DEG_SCF_FBW7_1 268 275 PF00400 0.493
DOC_CYCLIN_RxL_1 166 173 PF00134 0.518
DOC_MAPK_gen_1 166 174 PF00069 0.347
DOC_MAPK_MEF2A_6 473 480 PF00069 0.593
DOC_MAPK_NFAT4_5 473 481 PF00069 0.599
DOC_PP1_RVXF_1 254 261 PF00149 0.365
DOC_PP2B_LxvP_1 172 175 PF13499 0.316
DOC_PP4_FxxP_1 353 356 PF00568 0.559
DOC_USP7_MATH_1 24 28 PF00917 0.458
DOC_USP7_MATH_1 274 278 PF00917 0.504
DOC_USP7_MATH_1 299 303 PF00917 0.389
DOC_WW_Pin1_4 228 233 PF00397 0.655
DOC_WW_Pin1_4 268 273 PF00397 0.369
LIG_14-3-3_CanoR_1 169 175 PF00244 0.476
LIG_14-3-3_CanoR_1 454 462 PF00244 0.351
LIG_BIR_III_4 509 513 PF00653 0.491
LIG_BRCT_BRCA1_1 349 353 PF00533 0.652
LIG_eIF4E_1 32 38 PF01652 0.458
LIG_FHA_1 356 362 PF00498 0.507
LIG_FHA_1 368 374 PF00498 0.480
LIG_FHA_1 503 509 PF00498 0.619
LIG_FHA_2 320 326 PF00498 0.611
LIG_FHA_2 340 346 PF00498 0.558
LIG_FHA_2 413 419 PF00498 0.610
LIG_FHA_2 480 486 PF00498 0.640
LIG_GBD_Chelix_1 33 41 PF00786 0.258
LIG_LIR_Apic_2 350 356 PF02991 0.597
LIG_LIR_Gen_1 31 38 PF02991 0.458
LIG_LIR_Gen_1 447 458 PF02991 0.389
LIG_LIR_Gen_1 481 491 PF02991 0.624
LIG_LIR_Nem_3 31 35 PF02991 0.458
LIG_LIR_Nem_3 447 453 PF02991 0.387
LIG_LIR_Nem_3 481 486 PF02991 0.636
LIG_MYND_1 228 232 PF01753 0.655
LIG_NRBOX 262 268 PF00104 0.435
LIG_REV1ctd_RIR_1 162 170 PF16727 0.471
LIG_RPA_C_Fungi 49 61 PF08784 0.494
LIG_SH2_CRK 450 454 PF00017 0.333
LIG_SH2_NCK_1 104 108 PF00017 0.432
LIG_SH2_STAP1 387 391 PF00017 0.569
LIG_SH2_STAP1 543 547 PF00017 0.536
LIG_SH2_STAT5 254 257 PF00017 0.364
LIG_SH2_STAT5 265 268 PF00017 0.284
LIG_SH2_STAT5 32 35 PF00017 0.302
LIG_SH2_STAT5 387 390 PF00017 0.499
LIG_SH2_STAT5 5 8 PF00017 0.302
LIG_SH3_3 23 29 PF00018 0.302
LIG_SH3_3 331 337 PF00018 0.764
LIG_TRAF2_1 149 152 PF00917 0.550
LIG_TRAF2_1 208 211 PF00917 0.490
LIG_TRAF2_1 343 346 PF00917 0.661
LIG_TRAF2_1 557 560 PF00917 0.681
LIG_TRAF2_1 95 98 PF00917 0.444
LIG_TYR_ITIM 263 268 PF00017 0.399
LIG_TYR_ITIM 448 453 PF00017 0.376
LIG_UBA3_1 171 176 PF00899 0.374
LIG_WRC_WIRS_1 480 485 PF05994 0.587
MOD_CDK_SPK_2 268 273 PF00069 0.369
MOD_CK1_1 222 228 PF00069 0.728
MOD_CK2_1 273 279 PF00069 0.464
MOD_CK2_1 339 345 PF00069 0.748
MOD_CK2_1 479 485 PF00069 0.575
MOD_CK2_1 554 560 PF00069 0.624
MOD_GlcNHglycan 142 145 PF01048 0.663
MOD_GlcNHglycan 176 179 PF01048 0.507
MOD_GlcNHglycan 2 5 PF01048 0.302
MOD_GlcNHglycan 224 227 PF01048 0.618
MOD_GlcNHglycan 276 279 PF01048 0.527
MOD_GlcNHglycan 342 345 PF01048 0.721
MOD_GlcNHglycan 456 459 PF01048 0.345
MOD_GlcNHglycan 555 559 PF01048 0.578
MOD_GSK3_1 136 143 PF00069 0.703
MOD_GSK3_1 170 177 PF00069 0.492
MOD_GSK3_1 20 27 PF00069 0.432
MOD_GSK3_1 215 222 PF00069 0.566
MOD_GSK3_1 268 275 PF00069 0.387
MOD_N-GLC_1 268 273 PF02516 0.495
MOD_N-GLC_1 339 344 PF02516 0.563
MOD_NEK2_1 170 175 PF00069 0.435
MOD_NEK2_1 318 323 PF00069 0.571
MOD_PIKK_1 436 442 PF00454 0.447
MOD_PKA_2 140 146 PF00069 0.668
MOD_PKA_2 239 245 PF00069 0.614
MOD_Plk_1 197 203 PF00069 0.524
MOD_Plk_2-3 385 391 PF00069 0.569
MOD_Plk_4 285 291 PF00069 0.499
MOD_Plk_4 444 450 PF00069 0.391
MOD_ProDKin_1 228 234 PF00069 0.650
MOD_ProDKin_1 268 274 PF00069 0.371
MOD_SUMO_for_1 121 124 PF00179 0.530
MOD_SUMO_for_1 182 185 PF00179 0.381
MOD_SUMO_for_1 309 312 PF00179 0.513
MOD_SUMO_rev_2 43 48 PF00179 0.551
TRG_DiLeu_BaEn_1 110 115 PF01217 0.405
TRG_DiLeu_BaEn_4 503 509 PF01217 0.670
TRG_ENDOCYTIC_2 257 260 PF00928 0.318
TRG_ENDOCYTIC_2 265 268 PF00928 0.331
TRG_ENDOCYTIC_2 32 35 PF00928 0.302
TRG_ENDOCYTIC_2 450 453 PF00928 0.328
TRG_ER_diArg_1 192 195 PF00400 0.543
TRG_ER_diArg_1 361 363 PF00400 0.371
TRG_ER_diArg_1 53 55 PF00400 0.588
TRG_ER_diArg_1 537 540 PF00400 0.554
TRG_NLS_MonoCore_2 90 95 PF00514 0.375
TRG_NLS_MonoExtC_3 91 97 PF00514 0.453
TRG_NLS_MonoExtN_4 89 96 PF00514 0.453
TRG_Pf-PMV_PEXEL_1 68 72 PF00026 0.439

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3H1 Leptomonas seymouri 63% 97%
A0A1X0NQN0 Trypanosomatidae 45% 93%
A0A3S7WQC3 Leishmania donovani 100% 100%
A0A422NJV4 Trypanosoma rangeli 39% 100%
A4H5E1 Leishmania braziliensis 82% 100%
C9ZPD6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AMH0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QI73 Leishmania major 94% 100%
V5BR17 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS