RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4HTN3_LEIIN

TriTrypDb:

LINF_080013800

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTN3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.492
CLV_C14_Caspase3-7	257	261	PF00656	0.451
CLV_C14_Caspase3-7	321	325	PF00656	0.427
CLV_C14_Caspase3-7	416	420	PF00656	0.331
CLV_NRD_NRD_1	18	20	PF00675	0.511
CLV_NRD_NRD_1	240	242	PF00675	0.527
CLV_NRD_NRD_1	75	77	PF00675	0.538
CLV_PCSK_KEX2_1	18	20	PF00082	0.511
CLV_PCSK_KEX2_1	240	242	PF00082	0.527
CLV_PCSK_KEX2_1	75	77	PF00082	0.538
CLV_PCSK_SKI1_1	115	119	PF00082	0.389
CLV_PCSK_SKI1_1	230	234	PF00082	0.513
CLV_PCSK_SKI1_1	377	381	PF00082	0.280
DEG_APCC_DBOX_1	381	389	PF00400	0.322
DOC_CKS1_1	166	171	PF01111	0.529
DOC_CYCLIN_yCln2_LP_2	539	545	PF00134	0.454
DOC_PP1_RVXF_1	228	234	PF00149	0.513
DOC_PP2B_LxvP_1	286	289	PF13499	0.494
DOC_PP2B_LxvP_1	412	415	PF13499	0.287
DOC_PP2B_LxvP_1	586	589	PF13499	0.263
DOC_PP2B_LxvP_1	59	62	PF13499	0.516
DOC_PP4_FxxP_1	233	236	PF00568	0.517
DOC_PP4_MxPP_1	1	4	PF00568	0.513
DOC_USP7_MATH_1	378	382	PF00917	0.288
DOC_USP7_MATH_1	428	432	PF00917	0.450
DOC_USP7_MATH_2	292	298	PF00917	0.490
DOC_WW_Pin1_4	153	158	PF00397	0.526
DOC_WW_Pin1_4	159	164	PF00397	0.533
DOC_WW_Pin1_4	165	170	PF00397	0.529
DOC_WW_Pin1_4	232	237	PF00397	0.517
DOC_WW_Pin1_4	25	30	PF00397	0.519
DOC_WW_Pin1_4	284	289	PF00397	0.484
DOC_WW_Pin1_4	424	429	PF00397	0.373
DOC_WW_Pin1_4	487	492	PF00397	0.488
DOC_WW_Pin1_4	494	499	PF00397	0.521
LIG_14-3-3_CanoR_1	377	385	PF00244	0.296
LIG_14-3-3_CanoR_1	547	552	PF00244	0.464
LIG_14-3-3_CanoR_1	559	567	PF00244	0.279
LIG_BIR_III_4	260	264	PF00653	0.449
LIG_CSL_BTD_1	493	496	PF09270	0.518
LIG_FHA_1	135	141	PF00498	0.487
LIG_FHA_1	313	319	PF00498	0.454
LIG_FHA_1	340	346	PF00498	0.464
LIG_FHA_1	369	375	PF00498	0.280
LIG_FHA_1	509	515	PF00498	0.334
LIG_FHA_2	246	252	PF00498	0.493
LIG_FHA_2	262	268	PF00498	0.412
LIG_GSK3_LRP6_1	159	164	PF00069	0.533
LIG_GSK3_LRP6_1	288	293	PF00069	0.493
LIG_Integrin_RGD_1	55	57	PF01839	0.523
LIG_LIR_Gen_1	410	418	PF02991	0.304
LIG_LIR_Nem_3	334	339	PF02991	0.455
LIG_LIR_Nem_3	386	392	PF02991	0.310
LIG_LIR_Nem_3	410	414	PF02991	0.286
LIG_MYND_1	422	426	PF01753	0.337
LIG_NBox_RRM_1	258	268	PF00076	0.427
LIG_PTAP_UEV_1	162	167	PF05743	0.533
LIG_SH2_CRK	567	571	PF00017	0.246
LIG_SH2_CRK	69	73	PF00017	0.527
LIG_SH2_STAP1	176	180	PF00017	0.526
LIG_SH2_STAT3	176	179	PF00017	0.528
LIG_SH2_STAT5	567	570	PF00017	0.239
LIG_SH3_3	137	143	PF00018	0.488
LIG_SH3_3	151	157	PF00018	0.525
LIG_SH3_3	160	166	PF00018	0.533
LIG_SH3_3	18	24	PF00018	0.512
LIG_SH3_3	286	292	PF00018	0.495
LIG_SH3_3	481	487	PF00018	0.461
LIG_SH3_3	490	496	PF00018	0.511
LIG_SUMO_SIM_anti_2	597	602	PF11976	0.287
LIG_SUMO_SIM_par_1	19	25	PF11976	0.513
LIG_TYR_ITIM	565	570	PF00017	0.236
LIG_WRC_WIRS_1	389	394	PF05994	0.295
LIG_WW_2	3	6	PF00397	0.488
MOD_CDK_SPK_2	165	170	PF00069	0.529
MOD_CDK_SPK_2	494	499	PF00069	0.521
MOD_CDK_SPxxK_3	25	32	PF00069	0.519
MOD_CK1_1	107	113	PF00069	0.383
MOD_CK1_1	134	140	PF00069	0.486
MOD_CK1_1	28	34	PF00069	0.522
MOD_CK1_1	299	305	PF00069	0.464
MOD_CK1_1	549	555	PF00069	0.453
MOD_CK2_1	108	114	PF00069	0.384
MOD_CK2_1	288	294	PF00069	0.495
MOD_CK2_1	435	441	PF00069	0.509
MOD_GlcNHglycan	100	105	PF01048	0.394
MOD_GlcNHglycan	163	166	PF01048	0.531
MOD_GlcNHglycan	274	277	PF01048	0.375
MOD_GlcNHglycan	296	299	PF01048	0.483
MOD_GlcNHglycan	301	304	PF01048	0.463
MOD_GlcNHglycan	35	38	PF01048	0.522
MOD_GlcNHglycan	44	47	PF01048	0.525
MOD_GlcNHglycan	443	446	PF01048	0.472
MOD_GlcNHglycan	501	504	PF01048	0.509
MOD_GlcNHglycan	560	563	PF01048	0.309
MOD_GlcNHglycan	59	62	PF01048	0.516
MOD_GlcNHglycan	83	88	PF01048	0.526
MOD_GlcNHglycan	90	93	PF01048	0.523
MOD_GSK3_1	100	107	PF00069	0.389
MOD_GSK3_1	130	137	PF00069	0.477
MOD_GSK3_1	161	168	PF00069	0.534
MOD_GSK3_1	250	257	PF00069	0.469
MOD_GSK3_1	284	291	PF00069	0.488
MOD_GSK3_1	308	315	PF00069	0.456
MOD_GSK3_1	345	352	PF00069	0.464
MOD_GSK3_1	388	395	PF00069	0.296
MOD_GSK3_1	424	431	PF00069	0.394
MOD_GSK3_1	543	550	PF00069	0.458
MOD_GSK3_1	83	90	PF00069	0.525
MOD_LATS_1	545	551	PF00433	0.463
MOD_N-GLC_1	25	30	PF02516	0.519
MOD_N-GLC_2	479	481	PF02516	0.470
MOD_NEK2_1	308	313	PF00069	0.455
MOD_NEK2_1	331	336	PF00069	0.439
MOD_NEK2_1	345	350	PF00069	0.468
MOD_NEK2_1	369	374	PF00069	0.281
MOD_NEK2_1	402	407	PF00069	0.300
MOD_NEK2_2	131	136	PF00069	0.475
MOD_PIKK_1	199	205	PF00454	0.532
MOD_PIKK_1	252	258	PF00454	0.461
MOD_PK_1	113	119	PF00069	0.390
MOD_PKA_1	240	246	PF00069	0.516
MOD_PKA_2	211	217	PF00069	0.525
MOD_PKA_2	240	246	PF00069	0.516
MOD_PKA_2	33	39	PF00069	0.523
MOD_PKA_2	349	355	PF00069	0.462
MOD_PKA_2	400	406	PF00069	0.281
MOD_PKA_2	441	447	PF00069	0.480
MOD_PKA_2	546	552	PF00069	0.464
MOD_PKA_2	558	564	PF00069	0.315
MOD_Plk_1	100	106	PF00069	0.389
MOD_Plk_1	107	113	PF00069	0.383
MOD_Plk_1	250	256	PF00069	0.473
MOD_Plk_2-3	108	114	PF00069	0.384
MOD_Plk_2-3	594	600	PF00069	0.290
MOD_Plk_4	254	260	PF00069	0.452
MOD_Plk_4	326	332	PF00069	0.423
MOD_Plk_4	383	389	PF00069	0.317
MOD_Plk_4	571	577	PF00069	0.258
MOD_ProDKin_1	153	159	PF00069	0.526
MOD_ProDKin_1	165	171	PF00069	0.530
MOD_ProDKin_1	232	238	PF00069	0.517
MOD_ProDKin_1	25	31	PF00069	0.518
MOD_ProDKin_1	284	290	PF00069	0.485
MOD_ProDKin_1	424	430	PF00069	0.385
MOD_ProDKin_1	487	493	PF00069	0.492
MOD_ProDKin_1	494	500	PF00069	0.521
MOD_SUMO_for_1	457	460	PF00179	0.425
TRG_DiLeu_BaEn_1	611	616	PF01217	0.347
TRG_ENDOCYTIC_2	389	392	PF00928	0.303
TRG_ENDOCYTIC_2	567	570	PF00928	0.239
TRG_ER_diArg_1	18	20	PF00400	0.511
TRG_ER_diArg_1	228	231	PF00400	0.513