Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta-lactamase superfamily domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HTN1_LEIIN

TriTrypDb:

LINF_080013500

Length:

2121

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Phosphorylation

Promastigote: 1963

Expansion

Sequence features

A4HTN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTN1

Function

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Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	1
GO:0000963	mitochondrial RNA processing	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0010467	gene expression	4	1
GO:0016070	RNA metabolic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0042781	3'-tRNA processing endoribonuclease activity	5	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1092	1096	PF00656	0.650
CLV_C14_Caspase3-7	1550	1554	PF00656	0.713
CLV_C14_Caspase3-7	1576	1580	PF00656	0.637
CLV_C14_Caspase3-7	1795	1799	PF00656	0.657
CLV_C14_Caspase3-7	1803	1807	PF00656	0.593
CLV_C14_Caspase3-7	219	223	PF00656	0.601
CLV_C14_Caspase3-7	249	253	PF00656	0.570
CLV_C14_Caspase3-7	673	677	PF00656	0.508
CLV_C14_Caspase3-7	864	868	PF00656	0.643
CLV_MEL_PAP_1	436	442	PF00089	0.510

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD8	Leptomonas seymouri	38%	100%
A0A3S5H673	Leishmania donovani	100%	100%
A4H5D6	Leishmania braziliensis	66%	99%
E9AMG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QI78	Leishmania major	90%	100%

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