LeishMANIAdb
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DNA polymerase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DNA polymerase
Gene product:
mitochondrial DNA polymerase beta
Species:
Leishmania infantum
UniProt:
A4HTM9_LEIIN
TriTrypDb:
LINF_080013300
Length:
376

Annotations

Annotations by Jardim et al.

DNA repair, Mitochondrial DNA polymerase beta

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0005737 cytoplasm 2 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HTM9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTM9

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006259 DNA metabolic process 4 12
GO:0006281 DNA repair 5 12
GO:0006396 RNA processing 6 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0006950 response to stress 2 12
GO:0006974 DNA damage response 4 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0031123 RNA 3'-end processing 7 12
GO:0033554 cellular response to stress 3 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0046483 heterocycle metabolic process 3 12
GO:0050896 response to stimulus 1 12
GO:0051716 cellular response to stimulus 2 12
GO:0071076 RNA 3' uridylation 8 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0006302 double-strand break repair 6 1
GO:0006303 double-strand break repair via nonhomologous end joining 7 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003677 DNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0003887 DNA-directed DNA polymerase activity 5 12
GO:0005488 binding 1 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016779 nucleotidyltransferase activity 4 12
GO:0034061 DNA polymerase activity 4 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0050265 RNA uridylyltransferase activity 4 12
GO:0070569 uridylyltransferase activity 5 12
GO:0097159 organic cyclic compound binding 2 12
GO:0140097 catalytic activity, acting on DNA 3 12
GO:0140098 catalytic activity, acting on RNA 3 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0016829 lyase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 187 189 PF00675 0.196
CLV_NRD_NRD_1 268 270 PF00675 0.187
CLV_NRD_NRD_1 3 5 PF00675 0.484
CLV_NRD_NRD_1 8 10 PF00675 0.393
CLV_PCSK_KEX2_1 186 188 PF00082 0.195
CLV_PCSK_KEX2_1 268 270 PF00082 0.187
CLV_PCSK_KEX2_1 3 5 PF00082 0.498
CLV_PCSK_KEX2_1 350 352 PF00082 0.198
CLV_PCSK_KEX2_1 8 10 PF00082 0.408
CLV_PCSK_PC1ET2_1 350 352 PF00082 0.198
CLV_PCSK_PC7_1 4 10 PF00082 0.473
CLV_PCSK_SKI1_1 4 8 PF00082 0.560
CLV_PCSK_SKI1_1 68 72 PF00082 0.201
DEG_COP1_1 276 283 PF00400 0.381
DEG_Nend_Nbox_1 1 3 PF02207 0.516
DOC_CKS1_1 316 321 PF01111 0.487
DOC_CKS1_1 53 58 PF01111 0.487
DOC_CYCLIN_yClb5_NLxxxL_5 46 53 PF00134 0.412
DOC_CYCLIN_yCln2_LP_2 208 214 PF00134 0.430
DOC_MAPK_gen_1 263 272 PF00069 0.388
DOC_MAPK_gen_1 8 18 PF00069 0.337
DOC_MAPK_MEF2A_6 266 274 PF00069 0.388
DOC_PP2B_LxvP_1 203 206 PF13499 0.412
DOC_PP2B_LxvP_1 340 343 PF13499 0.487
DOC_PP2B_LxvP_1 364 367 PF13499 0.398
DOC_USP7_UBL2_3 68 72 PF12436 0.387
DOC_USP7_UBL2_3 88 92 PF12436 0.365
DOC_WW_Pin1_4 315 320 PF00397 0.412
DOC_WW_Pin1_4 52 57 PF00397 0.489
LIG_14-3-3_CanoR_1 3 7 PF00244 0.498
LIG_Actin_WH2_2 78 96 PF00022 0.378
LIG_APCC_ABBA_1 16 21 PF00400 0.398
LIG_BIR_III_2 204 208 PF00653 0.485
LIG_BRCT_BRCA1_1 289 293 PF00533 0.391
LIG_EH1_1 119 127 PF00400 0.398
LIG_FHA_1 213 219 PF00498 0.405
LIG_FHA_1 275 281 PF00498 0.466
LIG_FHA_1 77 83 PF00498 0.337
LIG_FHA_2 119 125 PF00498 0.395
LIG_FHA_2 316 322 PF00498 0.442
LIG_FHA_2 45 51 PF00498 0.398
LIG_FHA_2 53 59 PF00498 0.398
LIG_LIR_Gen_1 176 185 PF02991 0.493
LIG_LIR_Gen_1 290 301 PF02991 0.402
LIG_LIR_Gen_1 359 369 PF02991 0.402
LIG_LIR_Nem_3 176 180 PF02991 0.493
LIG_LIR_Nem_3 290 296 PF02991 0.402
LIG_LIR_Nem_3 310 314 PF02991 0.433
LIG_LIR_Nem_3 359 364 PF02991 0.402
LIG_SH2_NCK_1 326 330 PF00017 0.487
LIG_SH2_NCK_1 368 372 PF00017 0.454
LIG_SH2_SRC 230 233 PF00017 0.404
LIG_SH2_STAT5 145 148 PF00017 0.398
LIG_SH2_STAT5 164 167 PF00017 0.489
LIG_SH2_STAT5 230 233 PF00017 0.418
LIG_SH2_STAT5 306 309 PF00017 0.398
LIG_SH3_4 90 97 PF00018 0.350
LIG_TRAF2_1 154 157 PF00917 0.487
LIG_TRAF2_1 318 321 PF00917 0.412
LIG_TRAF2_1 336 339 PF00917 0.455
LIG_TRAF2_1 95 98 PF00917 0.334
LIG_WRC_WIRS_1 284 289 PF05994 0.398
LIG_WW_3 248 252 PF00397 0.398
MOD_CK1_1 131 137 PF00069 0.487
MOD_CK1_1 279 285 PF00069 0.290
MOD_CK1_1 41 47 PF00069 0.396
MOD_CK2_1 118 124 PF00069 0.403
MOD_CK2_1 315 321 PF00069 0.393
MOD_GlcNHglycan 191 194 PF01048 0.187
MOD_GlcNHglycan 62 65 PF01048 0.290
MOD_GSK3_1 279 286 PF00069 0.300
MOD_GSK3_1 34 41 PF00069 0.471
MOD_NEK2_1 155 160 PF00069 0.398
MOD_NEK2_1 2 7 PF00069 0.501
MOD_NEK2_1 224 229 PF00069 0.422
MOD_NEK2_1 231 236 PF00069 0.377
MOD_NEK2_1 274 279 PF00069 0.459
MOD_NEK2_1 285 290 PF00069 0.354
MOD_PIKK_1 97 103 PF00454 0.398
MOD_PK_1 128 134 PF00069 0.457
MOD_PK_1 175 181 PF00069 0.487
MOD_PKA_2 2 8 PF00069 0.493
MOD_Plk_1 175 181 PF00069 0.496
MOD_Plk_1 231 237 PF00069 0.397
MOD_Plk_1 97 103 PF00069 0.398
MOD_Plk_2-3 353 359 PF00069 0.487
MOD_Plk_4 155 161 PF00069 0.402
MOD_ProDKin_1 315 321 PF00069 0.412
MOD_ProDKin_1 52 58 PF00069 0.489
MOD_SUMO_for_1 343 346 PF00179 0.422
MOD_SUMO_for_1 369 372 PF00179 0.398
MOD_SUMO_rev_2 271 280 PF00179 0.430
MOD_SUMO_rev_2 345 352 PF00179 0.398
MOD_SUMO_rev_2 83 89 PF00179 0.373
TRG_DiLeu_BaEn_4 320 326 PF01217 0.412
TRG_DiLeu_BaLyEn_6 270 275 PF01217 0.398
TRG_ENDOCYTIC_2 242 245 PF00928 0.398
TRG_ENDOCYTIC_2 311 314 PF00928 0.387
TRG_ENDOCYTIC_2 326 329 PF00928 0.387
TRG_ER_diArg_1 185 188 PF00400 0.395
TRG_ER_diArg_1 2 4 PF00400 0.507
TRG_ER_diArg_1 268 270 PF00400 0.387
TRG_ER_diArg_1 7 9 PF00400 0.456
TRG_Pf-PMV_PEXEL_1 323 327 PF00026 0.198

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HU90 Leptomonas seymouri 93% 100%
A0A0S4J2Q4 Bodo saltans 31% 100%
A0A0S4J8Y1 Bodo saltans 38% 100%
A0A1X0NP40 Trypanosomatidae 72% 93%
A0A3R7LYF2 Trypanosoma rangeli 69% 94%
A0A3S7WQD2 Leishmania donovani 100% 100%
A4H5D4 Leishmania braziliensis 98% 100%
C9ZPC6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 67% 92%
E9AMG3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
O57383 Xenopus laevis 31% 100%
P06746 Homo sapiens 30% 100%
P06766 Rattus norvegicus 31% 100%
Q09693 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 74%
Q27958 Bos taurus 30% 100%
Q4QI80 Leishmania major 99% 100%
Q67VC8 Oryza sativa subsp. japonica 29% 68%
Q6DRD3 Danio rerio 30% 100%
Q7T6Y4 Acanthamoeba polyphaga mimivirus 30% 100%
Q8K409 Mus musculus 31% 100%
Q9FNY4 Arabidopsis thaliana 28% 71%
Q9JIW4 Mus musculus 23% 76%
Q9NP87 Homo sapiens 21% 76%
V5BGW3 Trypanosoma cruzi 70% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS