SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HTM8_LEIIN

TriTrypDb:

LINF_080013200

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HTM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTM8

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	3
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	3
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.607
CLV_C14_Caspase3-7	389	393	PF00656	0.557
CLV_NRD_NRD_1	171	173	PF00675	0.755
CLV_NRD_NRD_1	28	30	PF00675	0.666
CLV_NRD_NRD_1	311	313	PF00675	0.569
CLV_NRD_NRD_1	32	34	PF00675	0.516
CLV_NRD_NRD_1	421	423	PF00675	0.401
CLV_PCSK_KEX2_1	171	173	PF00082	0.698
CLV_PCSK_KEX2_1	176	178	PF00082	0.651
CLV_PCSK_KEX2_1	28	30	PF00082	0.664
CLV_PCSK_KEX2_1	311	313	PF00082	0.569
CLV_PCSK_KEX2_1	32	34	PF00082	0.518
CLV_PCSK_KEX2_1	421	423	PF00082	0.357
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.722
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.713
CLV_PCSK_PC7_1	172	178	PF00082	0.712
CLV_PCSK_SKI1_1	487	491	PF00082	0.470
DEG_APCC_DBOX_1	184	192	PF00400	0.532
DEG_SCF_TRCP1_1	148	154	PF00400	0.539
DEG_SPOP_SBC_1	109	113	PF00917	0.693
DEG_SPOP_SBC_1	276	280	PF00917	0.613
DEG_SPOP_SBC_1	434	438	PF00917	0.563
DEG_SPOP_SBC_1	441	445	PF00917	0.524
DOC_CYCLIN_RxL_1	484	491	PF00134	0.462
DOC_MAPK_gen_1	28	40	PF00069	0.604
DOC_MAPK_gen_1	347	355	PF00069	0.510
DOC_PP2B_LxvP_1	137	140	PF13499	0.486
DOC_PP2B_PxIxI_1	50	56	PF00149	0.446
DOC_PP4_FxxP_1	47	50	PF00568	0.460
DOC_USP7_MATH_1	110	114	PF00917	0.787
DOC_USP7_MATH_1	123	127	PF00917	0.508
DOC_USP7_MATH_1	304	308	PF00917	0.670
DOC_USP7_MATH_1	435	439	PF00917	0.589
DOC_WW_Pin1_4	105	110	PF00397	0.697
DOC_WW_Pin1_4	437	442	PF00397	0.551
DOC_WW_Pin1_4	444	449	PF00397	0.553
DOC_WW_Pin1_4	55	60	PF00397	0.378
DOC_WW_Pin1_4	98	103	PF00397	0.766
LIG_14-3-3_CanoR_1	238	244	PF00244	0.583
LIG_14-3-3_CanoR_1	265	271	PF00244	0.479
LIG_14-3-3_CanoR_1	33	39	PF00244	0.541
LIG_14-3-3_CanoR_1	333	339	PF00244	0.570
LIG_14-3-3_CanoR_1	403	412	PF00244	0.578
LIG_14-3-3_CanoR_1	421	431	PF00244	0.587
LIG_14-3-3_CanoR_1	432	442	PF00244	0.446
LIG_14-3-3_CanoR_1	494	503	PF00244	0.521
LIG_BIR_II_1	1	5	PF00653	0.742
LIG_BRCT_BRCA1_1	351	355	PF00533	0.534
LIG_FHA_1	162	168	PF00498	0.583
LIG_FHA_1	214	220	PF00498	0.371
LIG_FHA_1	279	285	PF00498	0.535
LIG_FHA_1	35	41	PF00498	0.522
LIG_FHA_1	457	463	PF00498	0.578
LIG_FHA_1	496	502	PF00498	0.496
LIG_FHA_2	21	27	PF00498	0.500
LIG_FHA_2	434	440	PF00498	0.557
LIG_LIR_Apic_2	126	130	PF02991	0.321
LIG_LIR_Apic_2	2	7	PF02991	0.652
LIG_LIR_Gen_1	215	225	PF02991	0.370
LIG_LIR_Gen_1	337	346	PF02991	0.524
LIG_LIR_Gen_1	469	478	PF02991	0.544
LIG_LIR_Nem_3	215	221	PF02991	0.379
LIG_LIR_Nem_3	337	341	PF02991	0.540
LIG_LIR_Nem_3	469	475	PF02991	0.467
LIG_LIR_Nem_3	491	496	PF02991	0.417
LIG_NRP_CendR_1	509	510	PF00754	0.581
LIG_Rb_pABgroove_1	382	390	PF01858	0.540
LIG_SH2_CRK	127	131	PF00017	0.509
LIG_SH2_CRK	202	206	PF00017	0.490
LIG_SH2_CRK	493	497	PF00017	0.421
LIG_SH2_NCK_1	388	392	PF00017	0.534
LIG_SH2_PTP2	4	7	PF00017	0.656
LIG_SH2_PTP2	472	475	PF00017	0.421
LIG_SH2_SRC	4	7	PF00017	0.656
LIG_SH2_STAP1	442	446	PF00017	0.510
LIG_SH2_STAT5	127	130	PF00017	0.503
LIG_SH2_STAT5	202	205	PF00017	0.448
LIG_SH2_STAT5	230	233	PF00017	0.403
LIG_SH2_STAT5	4	7	PF00017	0.656
LIG_SH2_STAT5	472	475	PF00017	0.430
LIG_SH3_3	326	332	PF00018	0.617
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.343
LIG_SUMO_SIM_par_1	383	390	PF11976	0.546
LIG_TRAF2_1	19	22	PF00917	0.607
LIG_TRAF2_1	464	467	PF00917	0.467
LIG_TYR_ITIM	470	475	PF00017	0.552
LIG_WRC_WIRS_1	267	272	PF05994	0.467
LIG_WW_1	331	334	PF00397	0.502
LIG_WW_3	330	334	PF00397	0.530
MOD_CDK_SPxxK_3	55	62	PF00069	0.395
MOD_CK1_1	108	114	PF00069	0.733
MOD_CK1_1	156	162	PF00069	0.701
MOD_CK1_1	248	254	PF00069	0.593
MOD_CK1_1	437	443	PF00069	0.527
MOD_CK2_1	433	439	PF00069	0.569
MOD_Cter_Amidation	30	33	PF01082	0.587
MOD_GlcNHglycan	148	151	PF01048	0.518
MOD_GlcNHglycan	155	158	PF01048	0.607
MOD_GlcNHglycan	288	291	PF01048	0.708
MOD_GlcNHglycan	306	309	PF01048	0.789
MOD_GlcNHglycan	323	326	PF01048	0.485
MOD_GlcNHglycan	389	392	PF01048	0.351
MOD_GSK3_1	104	111	PF00069	0.642
MOD_GSK3_1	152	159	PF00069	0.578
MOD_GSK3_1	201	208	PF00069	0.410
MOD_GSK3_1	274	281	PF00069	0.665
MOD_GSK3_1	292	299	PF00069	0.606
MOD_GSK3_1	341	348	PF00069	0.352
MOD_GSK3_1	356	363	PF00069	0.466
MOD_GSK3_1	433	440	PF00069	0.572
MOD_GSK3_1	442	449	PF00069	0.489
MOD_GSK3_1	94	101	PF00069	0.793
MOD_N-GLC_1	213	218	PF02516	0.504
MOD_N-GLC_1	245	250	PF02516	0.556
MOD_N-GLC_1	374	379	PF02516	0.267
MOD_NEK2_1	146	151	PF00069	0.509
MOD_NEK2_1	231	236	PF00069	0.382
MOD_NEK2_1	341	346	PF00069	0.380
MOD_NEK2_1	367	372	PF00069	0.516
MOD_NEK2_1	374	379	PF00069	0.563
MOD_OFUCOSY	372	378	PF10250	0.267
MOD_PIKK_1	413	419	PF00454	0.510
MOD_PIKK_1	5	11	PF00454	0.714
MOD_PIKK_1	504	510	PF00454	0.487
MOD_PK_1	177	183	PF00069	0.659
MOD_PK_1	349	355	PF00069	0.485
MOD_PKA_1	422	428	PF00069	0.557
MOD_PKA_2	321	327	PF00069	0.696
MOD_PKA_2	341	347	PF00069	0.211
MOD_PKB_1	347	355	PF00069	0.546
MOD_Plk_1	245	251	PF00069	0.567
MOD_Plk_1	374	380	PF00069	0.485
MOD_Plk_1	466	472	PF00069	0.476
MOD_Plk_2-3	474	480	PF00069	0.586
MOD_Plk_4	177	183	PF00069	0.640
MOD_Plk_4	341	347	PF00069	0.428
MOD_ProDKin_1	105	111	PF00069	0.697
MOD_ProDKin_1	437	443	PF00069	0.551
MOD_ProDKin_1	444	450	PF00069	0.553
MOD_ProDKin_1	55	61	PF00069	0.374
MOD_ProDKin_1	98	104	PF00069	0.765
TRG_DiLeu_BaEn_2	490	496	PF01217	0.418
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.411
TRG_ENDOCYTIC_2	202	205	PF00928	0.448
TRG_ENDOCYTIC_2	472	475	PF00928	0.430
TRG_ENDOCYTIC_2	493	496	PF00928	0.408
TRG_ENDOCYTIC_2	57	60	PF00928	0.372
TRG_ER_diArg_1	310	312	PF00400	0.639
TRG_ER_diArg_1	319	322	PF00400	0.623
TRG_ER_diArg_1	32	34	PF00400	0.534
TRG_ER_diArg_1	346	349	PF00400	0.546
TRG_ER_diArg_1	503	506	PF00400	0.524
TRG_NLS_MonoExtC_3	27	32	PF00514	0.678
TRG_NLS_MonoExtN_4	25	32	PF00514	0.701
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I8	Leptomonas seymouri	49%	92%
A0A1X0NPE5	Trypanosomatidae	26%	100%
A0A3S5H671	Leishmania donovani	100%	79%
A0A3S5IRB9	Trypanosoma rangeli	29%	100%
A4H6C5	Leishmania braziliensis	84%	99%
C9ZPC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AMG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4QI81	Leishmania major	94%	100%