LeishMANIAdb
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SH3 domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
SH3 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HTM7_LEIIN
TriTrypDb:
LINF_080013100
Length:
419

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HTM7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTM7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 339 343 PF00656 0.496
CLV_NRD_NRD_1 131 133 PF00675 0.387
CLV_NRD_NRD_1 142 144 PF00675 0.362
CLV_NRD_NRD_1 233 235 PF00675 0.336
CLV_NRD_NRD_1 29 31 PF00675 0.374
CLV_NRD_NRD_1 35 37 PF00675 0.399
CLV_PCSK_FUR_1 179 183 PF00082 0.328
CLV_PCSK_KEX2_1 131 133 PF00082 0.376
CLV_PCSK_KEX2_1 142 144 PF00082 0.345
CLV_PCSK_KEX2_1 181 183 PF00082 0.322
CLV_PCSK_KEX2_1 222 224 PF00082 0.367
CLV_PCSK_KEX2_1 232 234 PF00082 0.453
CLV_PCSK_KEX2_1 29 31 PF00082 0.562
CLV_PCSK_KEX2_1 325 327 PF00082 0.505
CLV_PCSK_KEX2_1 35 37 PF00082 0.397
CLV_PCSK_PC1ET2_1 181 183 PF00082 0.322
CLV_PCSK_PC1ET2_1 222 224 PF00082 0.347
CLV_PCSK_PC1ET2_1 232 234 PF00082 0.336
CLV_PCSK_PC1ET2_1 325 327 PF00082 0.505
CLV_PCSK_SKI1_1 132 136 PF00082 0.374
CLV_PCSK_SKI1_1 409 413 PF00082 0.492
DEG_Nend_UBRbox_3 1 3 PF02207 0.511
DOC_CYCLIN_RxL_1 255 265 PF00134 0.338
DOC_PP4_MxPP_1 388 391 PF00568 0.498
DOC_USP7_MATH_1 149 153 PF00917 0.389
DOC_USP7_MATH_1 311 315 PF00917 0.560
DOC_USP7_MATH_1 347 351 PF00917 0.518
DOC_USP7_MATH_1 364 368 PF00917 0.503
DOC_USP7_MATH_1 379 383 PF00917 0.481
DOC_USP7_MATH_1 384 388 PF00917 0.470
DOC_USP7_MATH_2 123 129 PF00917 0.390
DOC_USP7_UBL2_3 201 205 PF12436 0.389
DOC_USP7_UBL2_3 214 218 PF12436 0.377
DOC_USP7_UBL2_3 228 232 PF12436 0.338
DOC_USP7_UBL2_3 315 319 PF12436 0.520
LIG_14-3-3_CanoR_1 132 138 PF00244 0.377
LIG_14-3-3_CanoR_1 409 414 PF00244 0.521
LIG_Actin_WH2_2 158 175 PF00022 0.350
LIG_FHA_1 295 301 PF00498 0.405
LIG_FHA_2 134 140 PF00498 0.423
LIG_FHA_2 331 337 PF00498 0.489
LIG_FHA_2 381 387 PF00498 0.525
LIG_FHA_2 403 409 PF00498 0.499
LIG_FHA_2 410 416 PF00498 0.492
LIG_FHA_2 92 98 PF00498 0.483
LIG_IBAR_NPY_1 90 92 PF08397 0.495
LIG_LIR_Gen_1 290 299 PF02991 0.413
LIG_LIR_Gen_1 60 69 PF02991 0.379
LIG_LIR_Nem_3 187 192 PF02991 0.435
LIG_LIR_Nem_3 20 25 PF02991 0.425
LIG_LIR_Nem_3 224 230 PF02991 0.345
LIG_LIR_Nem_3 240 244 PF02991 0.356
LIG_LIR_Nem_3 290 294 PF02991 0.422
LIG_LIR_Nem_3 60 65 PF02991 0.349
LIG_MYND_3 166 170 PF01753 0.363
LIG_PCNA_PIPBox_1 338 347 PF02747 0.539
LIG_Pex14_2 237 241 PF04695 0.355
LIG_PTB_Apo_2 260 267 PF02174 0.327
LIG_PTB_Phospho_1 260 266 PF10480 0.324
LIG_SH2_CRK 291 295 PF00017 0.406
LIG_SH2_NCK_1 62 66 PF00017 0.330
LIG_SH2_STAP1 113 117 PF00017 0.509
LIG_SH2_STAP1 375 379 PF00017 0.535
LIG_SH2_STAT3 100 103 PF00017 0.478
LIG_SH2_STAT3 266 269 PF00017 0.321
LIG_SH2_STAT3 345 348 PF00017 0.525
LIG_SH2_STAT5 203 206 PF00017 0.365
LIG_SH2_STAT5 219 222 PF00017 0.370
LIG_SH2_STAT5 230 233 PF00017 0.290
LIG_SH2_STAT5 259 262 PF00017 0.358
LIG_SH2_STAT5 266 269 PF00017 0.365
LIG_SH3_3 388 394 PF00018 0.560
LIG_SH3_3 77 83 PF00018 0.489
LIG_SUMO_SIM_par_1 296 301 PF11976 0.406
LIG_UBA3_1 165 173 PF00899 0.355
LIG_UBA3_1 52 56 PF00899 0.417
MOD_CK1_1 116 122 PF00069 0.450
MOD_CK1_1 14 20 PF00069 0.475
MOD_CK1_1 350 356 PF00069 0.526
MOD_CK2_1 133 139 PF00069 0.470
MOD_CK2_1 171 177 PF00069 0.464
MOD_CK2_1 364 370 PF00069 0.492
MOD_CK2_1 380 386 PF00069 0.563
MOD_CK2_1 409 415 PF00069 0.530
MOD_CK2_1 57 63 PF00069 0.370
MOD_GlcNHglycan 364 367 PF01048 0.535
MOD_GlcNHglycan 59 62 PF01048 0.344
MOD_GSK3_1 113 120 PF00069 0.465
MOD_GSK3_1 290 297 PF00069 0.457
MOD_GSK3_1 311 318 PF00069 0.579
MOD_GSK3_1 347 354 PF00069 0.536
MOD_GSK3_1 358 365 PF00069 0.578
MOD_GSK3_1 380 387 PF00069 0.547
MOD_LATS_1 313 319 PF00433 0.541
MOD_LATS_1 378 384 PF00433 0.503
MOD_N-GLC_1 17 22 PF02516 0.455
MOD_N-GLC_1 237 242 PF02516 0.318
MOD_NEK2_1 133 138 PF00069 0.380
MOD_NEK2_1 237 242 PF00069 0.301
MOD_NEK2_1 294 299 PF00069 0.401
MOD_NEK2_1 369 374 PF00069 0.547
MOD_NEK2_1 72 77 PF00069 0.496
MOD_PIKK_1 125 131 PF00454 0.369
MOD_PIKK_1 99 105 PF00454 0.519
MOD_PKA_1 217 223 PF00069 0.345
MOD_Plk_1 17 23 PF00069 0.444
MOD_Plk_1 237 243 PF00069 0.305
MOD_Plk_1 369 375 PF00069 0.507
MOD_Plk_1 70 76 PF00069 0.411
MOD_Plk_2-3 371 377 PF00069 0.545
MOD_Plk_4 294 300 PF00069 0.425
TRG_DiLeu_BaLyEn_6 161 166 PF01217 0.370
TRG_ENDOCYTIC_2 259 262 PF00928 0.358
TRG_ENDOCYTIC_2 291 294 PF00928 0.412
TRG_ENDOCYTIC_2 62 65 PF00928 0.336
TRG_ER_diArg_1 130 132 PF00400 0.386
TRG_ER_diArg_1 142 144 PF00400 0.344
TRG_ER_diArg_1 29 31 PF00400 0.397
TRG_ER_diArg_1 34 36 PF00400 0.369
TRG_ER_diArg_1 404 407 PF00400 0.505
TRG_NLS_MonoExtC_3 204 209 PF00514 0.394
TRG_Pf-PMV_PEXEL_1 142 146 PF00026 0.346

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P348 Leptomonas seymouri 68% 96%
A0A3Q8IIE7 Leishmania donovani 25% 100%
A0A3S7WQB3 Leishmania donovani 100% 100%
A4H6C6 Leishmania braziliensis 77% 100%
E9AHL0 Leishmania infantum 25% 100%
E9AMG1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9B1M8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 21% 100%
E9B1N5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
Q4Q6I6 Leishmania major 22% 100%
Q4QI82 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS