Putative tuzin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative tuzin

Gene product:

tuzin - putative

Species:

Leishmania infantum

UniProt:

A4HTM2_LEIIN

TriTrypDb:

LINF_080012700

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HTM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.521
CLV_NRD_NRD_1	170	172	PF00675	0.507
CLV_NRD_NRD_1	230	232	PF00675	0.606
CLV_NRD_NRD_1	239	241	PF00675	0.523
CLV_NRD_NRD_1	275	277	PF00675	0.639
CLV_NRD_NRD_1	288	290	PF00675	0.591
CLV_NRD_NRD_1	323	325	PF00675	0.791
CLV_NRD_NRD_1	338	340	PF00675	0.486
CLV_PCSK_FUR_1	286	290	PF00082	0.653
CLV_PCSK_KEX2_1	116	118	PF00082	0.521
CLV_PCSK_KEX2_1	131	133	PF00082	0.447
CLV_PCSK_KEX2_1	170	172	PF00082	0.507
CLV_PCSK_KEX2_1	212	214	PF00082	0.577
CLV_PCSK_KEX2_1	230	232	PF00082	0.606
CLV_PCSK_KEX2_1	239	241	PF00082	0.523
CLV_PCSK_KEX2_1	275	277	PF00082	0.639
CLV_PCSK_KEX2_1	288	290	PF00082	0.591
CLV_PCSK_KEX2_1	323	325	PF00082	0.791
CLV_PCSK_KEX2_1	338	340	PF00082	0.486
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.505
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.577
CLV_PCSK_PC7_1	208	214	PF00082	0.587
CLV_PCSK_PC7_1	319	325	PF00082	0.650
CLV_PCSK_SKI1_1	123	127	PF00082	0.554
CLV_PCSK_SKI1_1	157	161	PF00082	0.439
CLV_PCSK_SKI1_1	193	197	PF00082	0.622
CLV_PCSK_SKI1_1	55	59	PF00082	0.521
DEG_APCC_DBOX_1	122	130	PF00400	0.498
DOC_CYCLIN_RxL_1	52	62	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.569
DOC_MAPK_gen_1	170	178	PF00069	0.517
DOC_MAPK_gen_1	208	216	PF00069	0.633
DOC_MAPK_gen_1	239	248	PF00069	0.560
DOC_PP1_RVXF_1	155	161	PF00149	0.436
DOC_PP1_RVXF_1	210	217	PF00149	0.578
DOC_PP2B_LxvP_1	14	17	PF13499	0.583
DOC_USP7_MATH_1	181	185	PF00917	0.565
DOC_USP7_MATH_1	292	296	PF00917	0.668
DOC_WW_Pin1_4	278	283	PF00397	0.652
DOC_WW_Pin1_4	288	293	PF00397	0.573
LIG_14-3-3_CanoR_1	191	196	PF00244	0.602
LIG_14-3-3_CanoR_1	201	207	PF00244	0.620
LIG_14-3-3_CanoR_1	213	223	PF00244	0.578
LIG_14-3-3_CanoR_1	233	242	PF00244	0.583
LIG_14-3-3_CanoR_1	294	298	PF00244	0.676
LIG_14-3-3_CanoR_1	338	342	PF00244	0.574
LIG_14-3-3_CanoR_1	94	103	PF00244	0.580
LIG_APCC_ABBA_1	24	29	PF00400	0.501
LIG_BRCT_BRCA1_1	60	64	PF00533	0.574
LIG_FHA_1	173	179	PF00498	0.548
LIG_FHA_1	180	186	PF00498	0.512
LIG_FHA_1	278	284	PF00498	0.706
LIG_FHA_1	54	60	PF00498	0.651
LIG_FHA_1	95	101	PF00498	0.636
LIG_GBD_Chelix_1	158	166	PF00786	0.479
LIG_LIR_Nem_3	53	57	PF02991	0.597
LIG_SH2_CRK	54	58	PF00017	0.571
LIG_SH2_STAP1	7	11	PF00017	0.646
LIG_SH2_STAT5	36	39	PF00017	0.583
LIG_SH3_1	221	227	PF00018	0.594
LIG_SH3_3	221	227	PF00018	0.594
LIG_SH3_3	297	303	PF00018	0.674
LIG_SH3_3	63	69	PF00018	0.561
LIG_SUMO_SIM_par_1	16	21	PF11976	0.618
LIG_SUMO_SIM_par_1	55	62	PF11976	0.546
MOD_CDC14_SPxK_1	291	294	PF00782	0.663
MOD_CDK_SPxK_1	288	294	PF00069	0.657
MOD_CK2_1	81	87	PF00069	0.610
MOD_GlcNHglycan	145	148	PF01048	0.631
MOD_GlcNHglycan	149	152	PF01048	0.579
MOD_GlcNHglycan	179	182	PF01048	0.533
MOD_GlcNHglycan	37	40	PF01048	0.574
MOD_GlcNHglycan	60	64	PF01048	0.574
MOD_GSK3_1	139	146	PF00069	0.574
MOD_GSK3_1	177	184	PF00069	0.592
MOD_GSK3_1	215	222	PF00069	0.576
MOD_GSK3_1	288	295	PF00069	0.699
MOD_N-GLC_1	143	148	PF02516	0.502
MOD_N-GLC_1	50	55	PF02516	0.610
MOD_NEK2_1	112	117	PF00069	0.520
MOD_NEK2_1	153	158	PF00069	0.553
MOD_NEK2_1	185	190	PF00069	0.569
MOD_NEK2_1	337	342	PF00069	0.576
MOD_NEK2_1	58	63	PF00069	0.611
MOD_PK_1	139	145	PF00069	0.527
MOD_PK_1	191	197	PF00069	0.567
MOD_PKA_2	202	208	PF00069	0.619
MOD_PKA_2	293	299	PF00069	0.674
MOD_PKB_1	231	239	PF00069	0.652
MOD_Plk_4	202	208	PF00069	0.680
MOD_Plk_4	69	75	PF00069	0.545
MOD_ProDKin_1	278	284	PF00069	0.653
MOD_ProDKin_1	288	294	PF00069	0.578
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.575
TRG_ENDOCYTIC_2	54	57	PF00928	0.566
TRG_ER_diArg_1	116	119	PF00400	0.566
TRG_ER_diArg_1	230	233	PF00400	0.769
TRG_ER_diArg_1	239	241	PF00400	0.554
TRG_ER_diArg_1	274	276	PF00400	0.634
TRG_ER_diArg_1	326	329	PF00400	0.756
TRG_ER_diArg_1	337	339	PF00400	0.523
TRG_NLS_Bipartite_1	116	134	PF00514	0.503
TRG_NLS_MonoExtC_3	129	135	PF00514	0.502
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQC8	Leishmania donovani	99%	80%
A4HAZ7	Leishmania braziliensis	40%	73%