Putative tuzin

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative tuzin

Gene product:

tuzin - putative

Species:

Leishmania infantum

UniProt:

A4HTM1_LEIIN

TriTrypDb:

LINF_080012600

Length:

635

Annotations

Annotations by Jardim et al.

Vesicle mediated transport, tuzin

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

A4HTM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.454
CLV_NRD_NRD_1	39	41	PF00675	0.401
CLV_NRD_NRD_1	474	476	PF00675	0.514
CLV_NRD_NRD_1	565	567	PF00675	0.616
CLV_NRD_NRD_1	68	70	PF00675	0.376
CLV_NRD_NRD_1	7	9	PF00675	0.502
CLV_PCSK_FUR_1	263	267	PF00082	0.382
CLV_PCSK_KEX2_1	265	267	PF00082	0.434
CLV_PCSK_KEX2_1	39	41	PF00082	0.400
CLV_PCSK_KEX2_1	474	476	PF00082	0.514
CLV_PCSK_KEX2_1	565	567	PF00082	0.637
CLV_PCSK_KEX2_1	582	584	PF00082	0.577
CLV_PCSK_KEX2_1	68	70	PF00082	0.375
CLV_PCSK_KEX2_1	7	9	PF00082	0.509
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.600
CLV_PCSK_SKI1_1	131	135	PF00082	0.312
CLV_PCSK_SKI1_1	225	229	PF00082	0.387
CLV_PCSK_SKI1_1	359	363	PF00082	0.591
CLV_PCSK_SKI1_1	40	44	PF00082	0.348
CLV_PCSK_SKI1_1	440	444	PF00082	0.637
CLV_PCSK_SKI1_1	559	563	PF00082	0.496
CLV_PCSK_SKI1_1	8	12	PF00082	0.445
DEG_Kelch_actinfilin_1	447	451	PF01344	0.230
DEG_Nend_Nbox_1	1	3	PF02207	0.619
DEG_SPOP_SBC_1	17	21	PF00917	0.617
DEG_SPOP_SBC_1	22	26	PF00917	0.633
DOC_CYCLIN_RxL_1	5	15	PF00134	0.602
DOC_MAPK_DCC_7	93	101	PF00069	0.631
DOC_MAPK_gen_1	209	218	PF00069	0.550
DOC_MAPK_gen_1	474	481	PF00069	0.282
DOC_MAPK_gen_1	68	74	PF00069	0.542
DOC_MAPK_MEF2A_6	446	454	PF00069	0.335
DOC_MAPK_MEF2A_6	474	483	PF00069	0.293
DOC_MAPK_MEF2A_6	93	101	PF00069	0.634
DOC_PP1_RVXF_1	181	188	PF00149	0.450
DOC_PP1_RVXF_1	495	501	PF00149	0.341
DOC_PP1_RVXF_1	606	613	PF00149	0.319
DOC_PP2B_LxvP_1	159	162	PF13499	0.515
DOC_PP2B_LxvP_1	417	420	PF13499	0.373
DOC_PP2B_LxvP_1	94	97	PF13499	0.539
DOC_PP2B_PxIxI_1	369	375	PF00149	0.300
DOC_PP4_FxxP_1	43	46	PF00568	0.656
DOC_SPAK_OSR1_1	306	310	PF12202	0.381
DOC_USP7_MATH_1	13	17	PF00917	0.633
DOC_USP7_MATH_1	22	26	PF00917	0.708
DOC_USP7_MATH_1	234	238	PF00917	0.566
DOC_USP7_MATH_1	484	488	PF00917	0.300
DOC_USP7_MATH_1	97	101	PF00917	0.677
DOC_USP7_UBL2_3	310	314	PF12436	0.372
DOC_USP7_UBL2_3	578	582	PF12436	0.370
LIG_14-3-3_CanoR_1	235	239	PF00244	0.516
LIG_14-3-3_CanoR_1	265	275	PF00244	0.615
LIG_14-3-3_CanoR_1	294	303	PF00244	0.441
LIG_14-3-3_CanoR_1	39	46	PF00244	0.673
LIG_14-3-3_CanoR_1	549	555	PF00244	0.371
LIG_14-3-3_CanoR_1	8	17	PF00244	0.651
LIG_Actin_WH2_2	169	185	PF00022	0.475
LIG_Actin_WH2_2	396	413	PF00022	0.362
LIG_APCC_ABBA_1	524	529	PF00400	0.342
LIG_BIR_III_4	520	524	PF00653	0.274
LIG_BRCT_BRCA1_1	129	133	PF00533	0.530
LIG_BRCT_BRCA1_1	278	282	PF00533	0.275
LIG_BRCT_BRCA1_1	82	86	PF00533	0.602
LIG_deltaCOP1_diTrp_1	355	362	PF00928	0.364
LIG_deltaCOP1_diTrp_1	618	622	PF00928	0.318
LIG_EH1_1	132	140	PF00400	0.473
LIG_eIF4E_1	555	561	PF01652	0.317
LIG_FHA_1	145	151	PF00498	0.562
LIG_FHA_1	167	173	PF00498	0.571
LIG_FHA_1	194	200	PF00498	0.509
LIG_FHA_1	489	495	PF00498	0.430
LIG_FHA_2	329	335	PF00498	0.611
LIG_LIR_Apic_2	41	46	PF02991	0.661
LIG_LIR_Apic_2	499	504	PF02991	0.356
LIG_LIR_Gen_1	509	519	PF02991	0.364
LIG_LIR_Nem_3	103	109	PF02991	0.553
LIG_LIR_Nem_3	269	275	PF02991	0.460
LIG_LIR_Nem_3	499	503	PF02991	0.334
LIG_LIR_Nem_3	509	515	PF02991	0.343
LIG_NRBOX	147	153	PF00104	0.461
LIG_NRBOX	537	543	PF00104	0.331
LIG_Pex14_2	282	286	PF04695	0.315
LIG_Pex14_2	86	90	PF04695	0.603
LIG_SH2_CRK	272	276	PF00017	0.283
LIG_SH2_CRK	501	505	PF00017	0.365
LIG_SH2_CRK	613	617	PF00017	0.358
LIG_SH2_GRB2like	555	558	PF00017	0.290
LIG_SH2_NCK_1	501	505	PF00017	0.317
LIG_SH2_NCK_1	613	617	PF00017	0.353
LIG_SH2_SRC	512	515	PF00017	0.411
LIG_SH2_SRC	589	592	PF00017	0.323
LIG_SH2_STAT3	555	558	PF00017	0.302
LIG_SH2_STAT5	106	109	PF00017	0.535
LIG_SH2_STAT5	181	184	PF00017	0.533
LIG_SH2_STAT5	217	220	PF00017	0.552
LIG_SH2_STAT5	296	299	PF00017	0.387
LIG_SH2_STAT5	378	381	PF00017	0.349
LIG_SH2_STAT5	501	504	PF00017	0.366
LIG_SH2_STAT5	514	517	PF00017	0.337
LIG_SH2_STAT5	555	558	PF00017	0.365
LIG_SH3_3	478	484	PF00018	0.316
LIG_SH3_3	55	61	PF00018	0.666
LIG_SUMO_SIM_par_1	371	376	PF11976	0.296
LIG_TYR_ITIM	611	616	PF00017	0.329
MOD_CK1_1	100	106	PF00069	0.655
MOD_CK1_1	15	21	PF00069	0.689
MOD_CK1_1	3	9	PF00069	0.600
MOD_CK1_1	320	326	PF00069	0.487
MOD_CK1_1	336	342	PF00069	0.532
MOD_CK1_1	487	493	PF00069	0.423
MOD_CK1_1	600	606	PF00069	0.381
MOD_CK2_1	234	240	PF00069	0.546
MOD_CK2_1	328	334	PF00069	0.629
MOD_CK2_1	548	554	PF00069	0.385
MOD_GlcNHglycan	189	192	PF01048	0.358
MOD_GlcNHglycan	232	235	PF01048	0.327
MOD_GlcNHglycan	25	28	PF01048	0.546
MOD_GlcNHglycan	268	271	PF01048	0.350
MOD_GlcNHglycan	276	279	PF01048	0.286
MOD_GlcNHglycan	319	322	PF01048	0.713
MOD_GlcNHglycan	339	342	PF01048	0.664
MOD_GlcNHglycan	34	38	PF01048	0.522
MOD_GlcNHglycan	40	43	PF01048	0.466
MOD_GlcNHglycan	550	553	PF01048	0.514
MOD_GSK3_1	17	24	PF00069	0.680
MOD_GSK3_1	187	194	PF00069	0.501
MOD_GSK3_1	219	226	PF00069	0.520
MOD_GSK3_1	230	237	PF00069	0.473
MOD_GSK3_1	295	302	PF00069	0.418
MOD_GSK3_1	328	335	PF00069	0.553
MOD_GSK3_1	343	350	PF00069	0.404
MOD_GSK3_1	382	389	PF00069	0.325
MOD_GSK3_1	484	491	PF00069	0.299
MOD_GSK3_1	9	16	PF00069	0.662
MOD_N-GLC_1	144	149	PF02516	0.368
MOD_N-GLC_1	504	509	PF02516	0.545
MOD_NEK2_1	230	235	PF00069	0.510
MOD_NEK2_1	276	281	PF00069	0.343
MOD_NEK2_1	33	38	PF00069	0.718
MOD_NEK2_1	337	342	PF00069	0.399
MOD_NEK2_1	386	391	PF00069	0.287
MOD_NEK2_1	488	493	PF00069	0.372
MOD_NEK2_1	506	511	PF00069	0.346
MOD_NEK2_1	527	532	PF00069	0.325
MOD_NEK2_1	597	602	PF00069	0.344
MOD_NEK2_1	612	617	PF00069	0.356
MOD_NEK2_2	284	289	PF00069	0.292
MOD_PIKK_1	115	121	PF00454	0.707
MOD_PIKK_1	228	234	PF00454	0.497
MOD_PIKK_1	506	512	PF00454	0.356
MOD_PIKK_1	63	69	PF00454	0.572
MOD_PK_1	438	444	PF00069	0.266
MOD_PKA_2	234	240	PF00069	0.520
MOD_PKA_2	343	349	PF00069	0.409
MOD_PKA_2	38	44	PF00069	0.579
MOD_PKA_2	548	554	PF00069	0.385
MOD_Plk_1	33	39	PF00069	0.599
MOD_Plk_1	333	339	PF00069	0.512
MOD_Plk_1	406	412	PF00069	0.413
MOD_Plk_1	597	603	PF00069	0.331
MOD_Plk_4	234	240	PF00069	0.508
MOD_Plk_4	490	496	PF00069	0.286
MOD_Plk_4	80	86	PF00069	0.538
TRG_DiLeu_BaEn_1	214	219	PF01217	0.535
TRG_ENDOCYTIC_2	181	184	PF00928	0.524
TRG_ENDOCYTIC_2	272	275	PF00928	0.304
TRG_ENDOCYTIC_2	512	515	PF00928	0.357
TRG_ENDOCYTIC_2	613	616	PF00928	0.352
TRG_ER_diArg_1	265	267	PF00400	0.658
TRG_ER_diArg_1	38	40	PF00400	0.655
TRG_ER_diArg_1	564	566	PF00400	0.456
TRG_ER_diArg_1	68	70	PF00400	0.681
TRG_NES_CRM1_1	408	423	PF08389	0.365
TRG_NES_CRM1_1	513	525	PF08389	0.364
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	41%	97%
A0A0N1PB02	Leptomonas seymouri	49%	97%
A0A0S4J6C6	Bodo saltans	45%	98%
A0A1X0P9A6	Trypanosomatidae	44%	93%
A0A3Q8IHH1	Leishmania donovani	36%	87%
A0A3R7K2Y9	Trypanosoma rangeli	51%	93%
A0A3S5H668	Leishmania donovani	46%	100%
A0A3S5H669	Leishmania donovani	100%	100%
A0A3S7X835	Leishmania donovani	46%	100%
A4H5C9	Leishmania braziliensis	46%	100%
A4H5D0	Leishmania braziliensis	75%	99%
A4HAZ7	Leishmania braziliensis	44%	97%
A4HAZ9	Leishmania braziliensis	45%	100%
A4HB01	Leishmania braziliensis	46%	100%
A4HTM0	Leishmania infantum	47%	100%
A4IA57	Leishmania infantum	47%	100%
C6K3V8	Leptomonas seymouri	44%	100%
C6K3V9	Leptomonas seymouri	72%	97%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	94%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	94%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	98%
Q4Q1U8	Leishmania major	38%	100%
Q4Q2R4	Leishmania major	47%	99%
Q4Q310	Leishmania major	38%	100%
Q4Q312	Leishmania major	38%	100%
Q4Q340	Leishmania major	38%	100%
Q4Q342	Leishmania major	38%	100%
Q4QI90	Leishmania major	94%	100%
Q4QI91	Leishmania major	45%	94%