Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTK9_LEIIN

TriTrypDb:

LINF_080011300

Length:

143

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HTK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	51	53	PF00675	0.615
CLV_NRD_NRD_1	99	101	PF00675	0.415
CLV_PCSK_KEX2_1	14	16	PF00082	0.434
CLV_PCSK_KEX2_1	51	53	PF00082	0.615
CLV_PCSK_KEX2_1	98	100	PF00082	0.417
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.424
CLV_PCSK_SKI1_1	14	18	PF00082	0.308
DEG_Nend_UBRbox_2	1	3	PF02207	0.747
DEG_SCF_FBW7_1	41	47	PF00400	0.506
DOC_CKS1_1	41	46	PF01111	0.511
DOC_CYCLIN_RxL_1	11	18	PF00134	0.578
DOC_MAPK_gen_1	14	22	PF00069	0.510
DOC_MAPK_gen_1	51	58	PF00069	0.377
DOC_MAPK_MEF2A_6	51	60	PF00069	0.371
DOC_WW_Pin1_4	138	143	PF00397	0.744
DOC_WW_Pin1_4	40	45	PF00397	0.448
LIG_14-3-3_CanoR_1	129	139	PF00244	0.736
LIG_14-3-3_CanoR_1	15	22	PF00244	0.442
LIG_14-3-3_CanoR_1	51	55	PF00244	0.513
LIG_EH1_1	68	76	PF00400	0.372
LIG_FHA_1	45	51	PF00498	0.431
LIG_LIR_Apic_2	133	138	PF02991	0.667
LIG_LIR_Nem_3	62	67	PF02991	0.366
LIG_NRBOX	73	79	PF00104	0.293
LIG_PDZ_Class_1	138	143	PF00595	0.673
LIG_Pex14_1	65	69	PF04695	0.286
LIG_Pex14_2	61	65	PF04695	0.383
LIG_SH2_CRK	135	139	PF00017	0.667
LIG_SH2_CRK	84	88	PF00017	0.372
LIG_SH2_GRB2like	135	138	PF00017	0.668
LIG_SH2_NCK_1	84	88	PF00017	0.372
LIG_SH2_STAP1	54	58	PF00017	0.445
LIG_SH2_STAT5	49	52	PF00017	0.426
LIG_SH3_3	38	44	PF00018	0.530
LIG_SH3_3	53	59	PF00018	0.322
LIG_TYR_ITIM	82	87	PF00017	0.343
LIG_TYR_ITSM	60	67	PF00017	0.360
MOD_CDK_SPxxK_3	44	51	PF00069	0.482
MOD_CK1_1	130	136	PF00069	0.736
MOD_GlcNHglycan	111	114	PF01048	0.457
MOD_GlcNHglycan	129	132	PF01048	0.443
MOD_GSK3_1	127	134	PF00069	0.702
MOD_GSK3_1	40	47	PF00069	0.463
MOD_PIKK_1	118	124	PF00454	0.717
MOD_PIKK_1	59	65	PF00454	0.398
MOD_PKA_2	131	137	PF00069	0.620
MOD_PKA_2	50	56	PF00069	0.408
MOD_Plk_1	103	109	PF00069	0.653
MOD_ProDKin_1	40	46	PF00069	0.447
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.622
TRG_ENDOCYTIC_2	64	67	PF00928	0.361
TRG_ENDOCYTIC_2	84	87	PF00928	0.183
TRG_ER_diArg_1	50	52	PF00400	0.416
TRG_ER_diArg_1	97	100	PF00400	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC93	Leptomonas seymouri	50%	100%
A0A3S5H661	Leishmania donovani	99%	100%
A4H5E7	Leishmania braziliensis	60%	100%
E9AME0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QIA9	Leishmania major	84%	100%