Movement protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Movement protein

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTK7_LEIIN

TriTrypDb:

LINF_080011000

Length:

166

Annotations

LeishMANIAdb annotations

This protein family is endemic to Kinetoplastids, might have emerged de novo and also expanded. . The family also contains Leishmaniid members lacking the signal peptide and only having an MTTPA- start sequence

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HTK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.692
CLV_NRD_NRD_1	101	103	PF00675	0.528
CLV_NRD_NRD_1	109	111	PF00675	0.477
CLV_NRD_NRD_1	161	163	PF00675	0.432
CLV_NRD_NRD_1	69	71	PF00675	0.401
CLV_PCSK_FUR_1	99	103	PF00082	0.501
CLV_PCSK_KEX2_1	101	103	PF00082	0.527
CLV_PCSK_KEX2_1	109	111	PF00082	0.476
CLV_PCSK_KEX2_1	163	165	PF00082	0.426
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.416
CLV_PCSK_SKI1_1	31	35	PF00082	0.612
CLV_PCSK_SKI1_1	70	74	PF00082	0.405
DEG_MDM2_SWIB_1	34	42	PF02201	0.378
DOC_CKS1_1	1	6	PF01111	0.432
DOC_MAPK_RevD_3	149	164	PF00069	0.606
DOC_USP7_MATH_1	118	122	PF00917	0.723
DOC_USP7_MATH_1	15	19	PF00917	0.389
DOC_USP7_UBL2_3	73	77	PF12436	0.576
LIG_14-3-3_CanoR_1	109	114	PF00244	0.681
LIG_14-3-3_CterR_2	162	166	PF00244	0.653
LIG_EVH1_2	29	33	PF00568	0.392
LIG_FHA_1	38	44	PF00498	0.295
LIG_FHA_2	137	143	PF00498	0.629
LIG_FHA_2	8	14	PF00498	0.415
LIG_FHA_2	95	101	PF00498	0.638
LIG_GBD_Chelix_1	50	58	PF00786	0.256
LIG_LIR_Gen_1	143	154	PF02991	0.616
LIG_LIR_Gen_1	18	29	PF02991	0.416
LIG_LIR_Nem_3	143	149	PF02991	0.653
LIG_LIR_Nem_3	18	24	PF02991	0.425
LIG_LIR_Nem_3	82	88	PF02991	0.651
LIG_Pex14_2	34	38	PF04695	0.403
LIG_PTB_Apo_2	80	87	PF02174	0.594
LIG_SH2_CRK	21	25	PF00017	0.418
LIG_SH2_CRK	39	43	PF00017	0.235
LIG_SH2_PTP2	146	149	PF00017	0.634
LIG_SH2_PTP2	53	56	PF00017	0.398
LIG_SH2_STAT3	66	69	PF00017	0.648
LIG_SH2_STAT5	146	149	PF00017	0.634
LIG_SH2_STAT5	39	42	PF00017	0.416
LIG_SH2_STAT5	53	56	PF00017	0.359
LIG_SH2_STAT5	80	83	PF00017	0.676
LIG_SH3_3	150	156	PF00018	0.640
LIG_SH3_3	9	15	PF00018	0.450
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.300
LIG_TYR_ITIM	19	24	PF00017	0.392
MOD_CK1_1	103	109	PF00069	0.688
MOD_CK1_1	135	141	PF00069	0.733
MOD_CK2_1	102	108	PF00069	0.794
MOD_CK2_1	118	124	PF00069	0.602
MOD_CK2_1	136	142	PF00069	0.758
MOD_CK2_1	7	13	PF00069	0.419
MOD_GlcNHglycan	118	121	PF01048	0.453
MOD_GlcNHglycan	132	135	PF01048	0.433
MOD_GSK3_1	100	107	PF00069	0.709
MOD_GSK3_1	108	115	PF00069	0.680
MOD_GSK3_1	130	137	PF00069	0.730
MOD_GSK3_1	90	97	PF00069	0.721
MOD_PIKK_1	94	100	PF00454	0.708
MOD_PKA_1	101	107	PF00069	0.686
MOD_PKA_1	109	115	PF00069	0.677
MOD_PKA_2	100	106	PF00069	0.683
MOD_PKA_2	108	114	PF00069	0.692
MOD_PKB_1	99	107	PF00069	0.716
MOD_Plk_4	109	115	PF00069	0.638
MOD_Plk_4	15	21	PF00069	0.432
MOD_Plk_4	29	35	PF00069	0.369
TRG_ENDOCYTIC_2	146	149	PF00928	0.645
TRG_ENDOCYTIC_2	21	24	PF00928	0.523
TRG_ENDOCYTIC_2	39	42	PF00928	0.293
TRG_ENDOCYTIC_2	53	56	PF00928	0.356
TRG_ER_diArg_1	161	164	PF00400	0.652
TRG_NLS_MonoExtC_3	69	74	PF00514	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P923	Leptomonas seymouri	43%	79%
A0A3S5H659	Leishmania donovani	96%	99%
A0A3S7WQ87	Leishmania donovani	30%	100%
A4H5C6	Leishmania braziliensis	39%	100%
A4H5C7	Leishmania braziliensis	58%	100%
A4HTK6	Leishmania infantum	30%	100%
E9AMD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AMD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4QIB1	Leishmania major	85%	100%
Q4QIB2	Leishmania major	36%	100%