Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTK6_LEIIN

TriTrypDb:

LINF_080010900

Length:

179

Annotations

LeishMANIAdb annotations

This protein family is endemic to Kinetoplastids, might have emerged de novo and also expanded. . The family also contains Leishmaniid members lacking the signal peptide and only having an MTTPA- start sequence

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HTK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTK6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.464
CLV_PCSK_FUR_1	137	141	PF00082	0.456
CLV_PCSK_KEX2_1	139	141	PF00082	0.463
DEG_APCC_DBOX_1	139	147	PF00400	0.604
DEG_MDM2_SWIB_1	61	69	PF02201	0.423
DEG_SCF_FBW7_1	1	7	PF00400	0.385
DEG_SPOP_SBC_1	146	150	PF00917	0.640
DEG_SPOP_SBC_1	26	30	PF00917	0.357
DOC_CKS1_1	1	6	PF01111	0.428
DOC_CYCLIN_RxL_1	134	145	PF00134	0.642
DOC_USP7_MATH_1	11	15	PF00917	0.425
DOC_USP7_MATH_1	135	139	PF00917	0.693
DOC_USP7_MATH_1	162	166	PF00917	0.674
DOC_WW_Pin1_4	160	165	PF00397	0.690
LIG_14-3-3_CanoR_1	139	144	PF00244	0.731
LIG_BIR_III_4	119	123	PF00653	0.629
LIG_eIF4E_1	66	72	PF01652	0.315
LIG_FHA_1	125	131	PF00498	0.689
LIG_FHA_1	26	32	PF00498	0.359
LIG_FHA_1	5	11	PF00498	0.438
LIG_LIR_Gen_1	2	11	PF02991	0.374
LIG_LIR_Nem_3	109	115	PF02991	0.704
LIG_Pex14_2	61	65	PF04695	0.446
LIG_Pex14_2	87	91	PF04695	0.364
LIG_SH2_CRK	80	84	PF00017	0.278
LIG_SH2_GRB2like	112	115	PF00017	0.630
LIG_SH2_PTP2	66	69	PF00017	0.336
LIG_SH2_STAP1	80	84	PF00017	0.298
LIG_SH2_STAT3	48	51	PF00017	0.456
LIG_SH2_STAT5	112	115	PF00017	0.723
LIG_SH2_STAT5	66	69	PF00017	0.428
LIG_SH2_STAT5	80	83	PF00017	0.419
LIG_SH3_3	37	43	PF00018	0.460
LIG_Sin3_3	68	75	PF02671	0.245
MOD_CK1_1	106	112	PF00069	0.626
MOD_CK1_1	142	148	PF00069	0.687
MOD_CK1_1	149	155	PF00069	0.693
MOD_CK1_1	16	22	PF00069	0.431
MOD_CK1_1	160	166	PF00069	0.713
MOD_CK2_1	160	166	PF00069	0.796
MOD_GlcNHglycan	13	16	PF01048	0.573
MOD_GlcNHglycan	33	36	PF01048	0.652
MOD_GSK3_1	135	142	PF00069	0.713
MOD_GSK3_1	145	152	PF00069	0.630
MOD_GSK3_1	16	23	PF00069	0.448
MOD_GSK3_1	27	34	PF00069	0.414
MOD_GSK3_1	79	86	PF00069	0.245
MOD_N-GLC_1	51	56	PF02516	0.638
MOD_NEK2_1	141	146	PF00069	0.766
MOD_NEK2_1	79	84	PF00069	0.249
MOD_PKA_1	139	145	PF00069	0.666
MOD_PKA_2	124	130	PF00069	0.665
MOD_PKA_2	139	145	PF00069	0.741
MOD_PKB_1	137	145	PF00069	0.697
MOD_Plk_1	152	158	PF00069	0.722
MOD_Plk_1	51	57	PF00069	0.434
MOD_Plk_4	4	10	PF00069	0.369
MOD_Plk_4	83	89	PF00069	0.245
MOD_ProDKin_1	160	166	PF00069	0.692
TRG_ENDOCYTIC_2	112	115	PF00928	0.755
TRG_ENDOCYTIC_2	66	69	PF00928	0.307
TRG_ENDOCYTIC_2	80	83	PF00928	0.313
TRG_ER_diArg_1	137	140	PF00400	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P923	Leptomonas seymouri	38%	85%
A0A3S5H659	Leishmania donovani	31%	100%
A0A3S7WQ87	Leishmania donovani	100%	100%
A4H5C6	Leishmania braziliensis	56%	100%
A4H5C7	Leishmania braziliensis	30%	100%
A4HTK7	Leishmania infantum	30%	100%
E9AMD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9AMD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4QIB1	Leishmania major	29%	100%
Q4QIB2	Leishmania major	84%	100%