This protein family is endemic to Kinetoplastids, might have emerged de novo and also expanded. . The family also contains Leishmaniid members lacking the signal peptide and only having an MTTPA- start sequence
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 0 |
Forrest at al. (procyclic) | no | yes: 0 |
Silverman et al. | no | yes: 0 |
Pissara et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 2, no: 9 |
NetGPI | no | yes: 0, no: 11 |
Term | Name | Level | Count |
---|---|---|---|
GO:0016020 | membrane | 2 | 9 |
GO:0110165 | cellular anatomical entity | 1 | 9 |
Related structures:
AlphaFold database: A4HTK6
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_NRD_NRD_1 | 139 | 141 | PF00675 | 0.464 |
CLV_PCSK_FUR_1 | 137 | 141 | PF00082 | 0.456 |
CLV_PCSK_KEX2_1 | 139 | 141 | PF00082 | 0.463 |
DEG_APCC_DBOX_1 | 139 | 147 | PF00400 | 0.604 |
DEG_MDM2_SWIB_1 | 61 | 69 | PF02201 | 0.423 |
DEG_SCF_FBW7_1 | 1 | 7 | PF00400 | 0.385 |
DEG_SPOP_SBC_1 | 146 | 150 | PF00917 | 0.640 |
DEG_SPOP_SBC_1 | 26 | 30 | PF00917 | 0.357 |
DOC_CKS1_1 | 1 | 6 | PF01111 | 0.428 |
DOC_CYCLIN_RxL_1 | 134 | 145 | PF00134 | 0.642 |
DOC_USP7_MATH_1 | 11 | 15 | PF00917 | 0.425 |
DOC_USP7_MATH_1 | 135 | 139 | PF00917 | 0.693 |
DOC_USP7_MATH_1 | 162 | 166 | PF00917 | 0.674 |
DOC_WW_Pin1_4 | 160 | 165 | PF00397 | 0.690 |
LIG_14-3-3_CanoR_1 | 139 | 144 | PF00244 | 0.731 |
LIG_BIR_III_4 | 119 | 123 | PF00653 | 0.629 |
LIG_eIF4E_1 | 66 | 72 | PF01652 | 0.315 |
LIG_FHA_1 | 125 | 131 | PF00498 | 0.689 |
LIG_FHA_1 | 26 | 32 | PF00498 | 0.359 |
LIG_FHA_1 | 5 | 11 | PF00498 | 0.438 |
LIG_LIR_Gen_1 | 2 | 11 | PF02991 | 0.374 |
LIG_LIR_Nem_3 | 109 | 115 | PF02991 | 0.704 |
LIG_Pex14_2 | 61 | 65 | PF04695 | 0.446 |
LIG_Pex14_2 | 87 | 91 | PF04695 | 0.364 |
LIG_SH2_CRK | 80 | 84 | PF00017 | 0.278 |
LIG_SH2_GRB2like | 112 | 115 | PF00017 | 0.630 |
LIG_SH2_PTP2 | 66 | 69 | PF00017 | 0.336 |
LIG_SH2_STAP1 | 80 | 84 | PF00017 | 0.298 |
LIG_SH2_STAT3 | 48 | 51 | PF00017 | 0.456 |
LIG_SH2_STAT5 | 112 | 115 | PF00017 | 0.723 |
LIG_SH2_STAT5 | 66 | 69 | PF00017 | 0.428 |
LIG_SH2_STAT5 | 80 | 83 | PF00017 | 0.419 |
LIG_SH3_3 | 37 | 43 | PF00018 | 0.460 |
LIG_Sin3_3 | 68 | 75 | PF02671 | 0.245 |
MOD_CK1_1 | 106 | 112 | PF00069 | 0.626 |
MOD_CK1_1 | 142 | 148 | PF00069 | 0.687 |
MOD_CK1_1 | 149 | 155 | PF00069 | 0.693 |
MOD_CK1_1 | 16 | 22 | PF00069 | 0.431 |
MOD_CK1_1 | 160 | 166 | PF00069 | 0.713 |
MOD_CK2_1 | 160 | 166 | PF00069 | 0.796 |
MOD_GlcNHglycan | 13 | 16 | PF01048 | 0.573 |
MOD_GlcNHglycan | 33 | 36 | PF01048 | 0.652 |
MOD_GSK3_1 | 135 | 142 | PF00069 | 0.713 |
MOD_GSK3_1 | 145 | 152 | PF00069 | 0.630 |
MOD_GSK3_1 | 16 | 23 | PF00069 | 0.448 |
MOD_GSK3_1 | 27 | 34 | PF00069 | 0.414 |
MOD_GSK3_1 | 79 | 86 | PF00069 | 0.245 |
MOD_N-GLC_1 | 51 | 56 | PF02516 | 0.638 |
MOD_NEK2_1 | 141 | 146 | PF00069 | 0.766 |
MOD_NEK2_1 | 79 | 84 | PF00069 | 0.249 |
MOD_PKA_1 | 139 | 145 | PF00069 | 0.666 |
MOD_PKA_2 | 124 | 130 | PF00069 | 0.665 |
MOD_PKA_2 | 139 | 145 | PF00069 | 0.741 |
MOD_PKB_1 | 137 | 145 | PF00069 | 0.697 |
MOD_Plk_1 | 152 | 158 | PF00069 | 0.722 |
MOD_Plk_1 | 51 | 57 | PF00069 | 0.434 |
MOD_Plk_4 | 4 | 10 | PF00069 | 0.369 |
MOD_Plk_4 | 83 | 89 | PF00069 | 0.245 |
MOD_ProDKin_1 | 160 | 166 | PF00069 | 0.692 |
TRG_ENDOCYTIC_2 | 112 | 115 | PF00928 | 0.755 |
TRG_ENDOCYTIC_2 | 66 | 69 | PF00928 | 0.307 |
TRG_ENDOCYTIC_2 | 80 | 83 | PF00928 | 0.313 |
TRG_ER_diArg_1 | 137 | 140 | PF00400 | 0.651 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A0N0P923 | Leptomonas seymouri | 38% | 85% |
A0A3S5H659 | Leishmania donovani | 31% | 100% |
A0A3S7WQ87 | Leishmania donovani | 100% | 100% |
A4H5C6 | Leishmania braziliensis | 56% | 100% |
A4H5C7 | Leishmania braziliensis | 30% | 100% |
A4HTK7 | Leishmania infantum | 30% | 100% |
E9AMD7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 83% | 100% |
E9AMD8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 100% |
Q4QIB1 | Leishmania major | 29% | 100% |
Q4QIB2 | Leishmania major | 84% | 100% |