DCD domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTK5_LEIIN

TriTrypDb:

LINF_080010800

Length:

237

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTK5

PDB structure(s): 7aih_Ad , 7am2_Ad , 7ane_Ad

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.747
CLV_NRD_NRD_1	57	59	PF00675	0.429
CLV_PCSK_KEX2_1	4	6	PF00082	0.747
CLV_PCSK_SKI1_1	206	210	PF00082	0.396
CLV_PCSK_SKI1_1	225	229	PF00082	0.363
CLV_PCSK_SKI1_1	74	78	PF00082	0.468
DEG_Nend_UBRbox_3	1	3	PF02207	0.632
DOC_ANK_TNKS_1	30	37	PF00023	0.664
DOC_CDC14_PxL_1	24	32	PF14671	0.600
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.415
DOC_PP2B_LxvP_1	69	72	PF13499	0.431
DOC_USP7_MATH_1	37	41	PF00917	0.711
DOC_USP7_MATH_1	95	99	PF00917	0.708
DOC_USP7_UBL2_3	55	59	PF12436	0.551
DOC_WW_Pin1_4	10	15	PF00397	0.710
DOC_WW_Pin1_4	119	124	PF00397	0.710
LIG_14-3-3_CanoR_1	211	216	PF00244	0.500
LIG_14-3-3_CanoR_1	58	68	PF00244	0.436
LIG_APCC_ABBAyCdc20_2	61	67	PF00400	0.417
LIG_FHA_1	203	209	PF00498	0.406
LIG_LIR_Gen_1	62	73	PF02991	0.421
LIG_LIR_Nem_3	62	68	PF02991	0.408
LIG_LIR_Nem_3	79	83	PF02991	0.418
LIG_MYND_1	142	146	PF01753	0.455
LIG_MYND_1	47	51	PF01753	0.692
LIG_PDZ_Class_2	232	237	PF00595	0.354
LIG_REV1ctd_RIR_1	153	163	PF16727	0.410
LIG_SH2_CRK	140	144	PF00017	0.502
LIG_SH2_CRK	182	186	PF00017	0.484
LIG_SH2_NCK_1	129	133	PF00017	0.620
LIG_SH2_NCK_1	24	28	PF00017	0.603
LIG_SH2_SRC	140	143	PF00017	0.516
LIG_SH2_SRC	24	27	PF00017	0.606
LIG_SH2_STAP1	170	174	PF00017	0.462
LIG_SH2_STAP1	65	69	PF00017	0.405
LIG_SH2_STAT5	216	219	PF00017	0.368
LIG_SH3_1	140	146	PF00018	0.456
LIG_SH3_3	120	126	PF00018	0.654
LIG_SH3_3	140	146	PF00018	0.368
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.581
LIG_UBA3_1	199	207	PF00899	0.400
MOD_CK1_1	116	122	PF00069	0.680
MOD_CK1_1	54	60	PF00069	0.602
MOD_GlcNHglycan	115	118	PF01048	0.598
MOD_GlcNHglycan	119	122	PF01048	0.601
MOD_GlcNHglycan	135	138	PF01048	0.549
MOD_GlcNHglycan	41	44	PF01048	0.678
MOD_GlcNHglycan	97	100	PF01048	0.678
MOD_GSK3_1	112	119	PF00069	0.618
MOD_GSK3_1	15	22	PF00069	0.689
MOD_N-GLC_1	95	100	PF02516	0.752
MOD_NEK2_1	19	24	PF00069	0.683
MOD_NEK2_1	209	214	PF00069	0.393
MOD_NEK2_1	39	44	PF00069	0.384
MOD_PK_1	211	217	PF00069	0.382
MOD_PKA_2	133	139	PF00069	0.496
MOD_PKA_2	158	164	PF00069	0.414
MOD_Plk_4	173	179	PF00069	0.579
MOD_Plk_4	211	217	PF00069	0.382
MOD_ProDKin_1	10	16	PF00069	0.705
MOD_ProDKin_1	119	125	PF00069	0.706
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.632
TRG_ENDOCYTIC_2	128	131	PF00928	0.590
TRG_ENDOCYTIC_2	182	185	PF00928	0.411
TRG_ENDOCYTIC_2	65	68	PF00928	0.399
TRG_ER_diArg_1	3	5	PF00400	0.746
TRG_NLS_MonoExtC_3	57	63	PF00514	0.424
TRG_NLS_MonoExtN_4	55	62	PF00514	0.439
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9E3	Leptomonas seymouri	74%	83%
A0A1X0NP31	Trypanosomatidae	61%	100%
A0A3R7M469	Trypanosoma rangeli	59%	100%
A0A3S7WQ78	Leishmania donovani	100%	100%
A4H5C5	Leishmania braziliensis	91%	100%
C9ZPG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AMD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QIB3	Leishmania major	97%	100%
V5B1E9	Trypanosoma cruzi	58%	100%