Translation initiation factor-like protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 2 beta subunit - putative

Species:

Leishmania infantum

UniProt:

A4HTK4_LEIIN

TriTrypDb:

LINF_080010700

Length:

345

Annotations

Annotations by Jardim et al.

Translation, Translation initiation factor-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005850	eukaryotic translation initiation factor 2 complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HTK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTK4

Function

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Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	1
GO:0001732	formation of cytoplasmic translation initiation complex	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	1
GO:0008135	translation factor activity, RNA binding	3	12
GO:0031369	translation initiation factor binding	3	1
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.619
CLV_NRD_NRD_1	271	273	PF00675	0.426
CLV_NRD_NRD_1	306	308	PF00675	0.319
CLV_PCSK_FUR_1	7	11	PF00082	0.631
CLV_PCSK_KEX2_1	306	308	PF00082	0.319
CLV_PCSK_KEX2_1	335	337	PF00082	0.438
CLV_PCSK_KEX2_1	9	11	PF00082	0.602
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.438
CLV_PCSK_SKI1_1	319	323	PF00082	0.451
DEG_Nend_Nbox_1	1	3	PF02207	0.509

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Y9	Leptomonas seymouri	72%	99%
A0A0S4KLD6	Bodo saltans	39%	100%
A0A1X0NPQ0	Trypanosomatidae	50%	91%
A0A3R7JYX9	Trypanosoma rangeli	51%	100%
A0A3S5H658	Leishmania donovani	100%	100%
A4H5C4	Leishmania braziliensis	86%	99%
C9ZPG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AMD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QIB4	Leishmania major	97%	100%
V5BGW0	Trypanosoma cruzi	52%	100%

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