LeishMANIAdb
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Translation initiation factor-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Translation initiation factor-like protein
Gene product:
eukaryotic translation initiation factor 2 beta subunit - putative
Species:
Leishmania infantum
UniProt:
A4HTK4_LEIIN
TriTrypDb:
LINF_080010700
Length:
345

Annotations

Annotations by Jardim et al.

Translation, Translation initiation factor-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005850 eukaryotic translation initiation factor 2 complex 2 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HTK4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTK4

Function

Biological processes
Term Name Level Count
GO:0001731 formation of translation preinitiation complex 7 1
GO:0001732 formation of cytoplasmic translation initiation complex 7 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0022618 ribonucleoprotein complex assembly 6 1
GO:0043933 protein-containing complex organization 4 1
GO:0065003 protein-containing complex assembly 5 1
GO:0071826 ribonucleoprotein complex subunit organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003743 translation initiation factor activity 4 12
GO:0005488 binding 1 12
GO:0008135 translation factor activity, RNA binding 3 12
GO:0045182 translation regulator activity 1 12
GO:0090079 translation regulator activity, nucleic acid binding 2 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003723 RNA binding 4 1
GO:0003729 mRNA binding 5 1
GO:0005515 protein binding 2 1
GO:0031369 translation initiation factor binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 10 12 PF00675 0.619
CLV_NRD_NRD_1 271 273 PF00675 0.426
CLV_NRD_NRD_1 306 308 PF00675 0.319
CLV_PCSK_FUR_1 7 11 PF00082 0.631
CLV_PCSK_KEX2_1 306 308 PF00082 0.319
CLV_PCSK_KEX2_1 335 337 PF00082 0.438
CLV_PCSK_KEX2_1 9 11 PF00082 0.602
CLV_PCSK_PC1ET2_1 335 337 PF00082 0.438
CLV_PCSK_SKI1_1 319 323 PF00082 0.451
DEG_Nend_Nbox_1 1 3 PF02207 0.509
DEG_SPOP_SBC_1 161 165 PF00917 0.529
DOC_MAPK_gen_1 335 345 PF00069 0.472
DOC_MAPK_MEF2A_6 210 217 PF00069 0.389
DOC_PP2B_LxvP_1 213 216 PF13499 0.360
DOC_PP4_FxxP_1 238 241 PF00568 0.281
DOC_USP7_MATH_1 162 166 PF00917 0.606
DOC_USP7_MATH_1 172 176 PF00917 0.629
DOC_USP7_MATH_1 51 55 PF00917 0.696
DOC_USP7_MATH_1 97 101 PF00917 0.597
LIG_14-3-3_CanoR_1 186 191 PF00244 0.416
LIG_14-3-3_CanoR_1 272 281 PF00244 0.421
LIG_APCC_ABBA_1 58 63 PF00400 0.659
LIG_BRCT_BRCA1_1 99 103 PF00533 0.454
LIG_FHA_1 26 32 PF00498 0.734
LIG_FHA_1 316 322 PF00498 0.368
LIG_FHA_2 273 279 PF00498 0.281
LIG_FHA_2 28 34 PF00498 0.781
LIG_FHA_2 78 84 PF00498 0.587
LIG_LIR_Apic_2 236 241 PF02991 0.360
LIG_LIR_Gen_1 111 120 PF02991 0.472
LIG_LIR_Gen_1 156 162 PF02991 0.594
LIG_LIR_Gen_1 275 285 PF02991 0.324
LIG_LIR_Nem_3 111 115 PF02991 0.526
LIG_LIR_Nem_3 116 120 PF02991 0.473
LIG_LIR_Nem_3 156 161 PF02991 0.560
LIG_LIR_Nem_3 192 198 PF02991 0.498
LIG_LIR_Nem_3 275 280 PF02991 0.306
LIG_MYND_3 215 219 PF01753 0.409
LIG_PCNA_yPIPBox_3 186 195 PF02747 0.535
LIG_SH2_CRK 112 116 PF00017 0.526
LIG_SH2_CRK 117 121 PF00017 0.457
LIG_SH2_STAP1 117 121 PF00017 0.504
LIG_SH2_STAT5 284 287 PF00017 0.266
LIG_SH2_STAT5 288 291 PF00017 0.266
LIG_SH3_3 50 56 PF00018 0.665
LIG_SH3_3 66 72 PF00018 0.600
LIG_TRAF2_1 131 134 PF00917 0.484
LIG_TRAF2_1 177 180 PF00917 0.561
LIG_TRAF2_1 30 33 PF00917 0.661
LIG_TYR_ITIM 110 115 PF00017 0.512
LIG_UBA3_1 217 225 PF00899 0.409
LIG_UBA3_1 281 290 PF00899 0.325
MOD_CK1_1 15 21 PF00069 0.792
MOD_CK1_1 205 211 PF00069 0.268
MOD_CK1_1 54 60 PF00069 0.744
MOD_CK1_1 73 79 PF00069 0.655
MOD_CK2_1 15 21 PF00069 0.679
MOD_CK2_1 172 178 PF00069 0.644
MOD_CK2_1 27 33 PF00069 0.652
MOD_CK2_1 77 83 PF00069 0.623
MOD_Cter_Amidation 221 224 PF01082 0.301
MOD_Cter_Amidation 304 307 PF01082 0.281
MOD_GlcNHglycan 165 168 PF01048 0.577
MOD_GlcNHglycan 174 177 PF01048 0.553
MOD_GlcNHglycan 203 207 PF01048 0.499
MOD_GlcNHglycan 329 332 PF01048 0.456
MOD_GlcNHglycan 53 56 PF01048 0.696
MOD_GlcNHglycan 72 75 PF01048 0.635
MOD_GlcNHglycan 92 95 PF01048 0.713
MOD_GSK3_1 12 19 PF00069 0.770
MOD_GSK3_1 27 34 PF00069 0.482
MOD_GSK3_1 313 320 PF00069 0.284
MOD_GSK3_1 323 330 PF00069 0.487
MOD_GSK3_1 73 80 PF00069 0.628
MOD_GSK3_1 97 104 PF00069 0.601
MOD_N-GLC_1 172 177 PF02516 0.630
MOD_N-GLC_2 292 294 PF02516 0.281
MOD_N-GLC_2 313 315 PF02516 0.266
MOD_NEK2_2 56 61 PF00069 0.590
MOD_PIKK_1 64 70 PF00454 0.593
MOD_PK_1 251 257 PF00069 0.281
MOD_PKA_1 223 229 PF00069 0.409
MOD_PKA_1 272 278 PF00069 0.409
MOD_PKA_2 125 131 PF00069 0.487
MOD_Plk_1 143 149 PF00069 0.570
MOD_Plk_1 251 257 PF00069 0.280
MOD_Plk_1 297 303 PF00069 0.266
MOD_Plk_2-3 17 23 PF00069 0.687
MOD_Plk_4 186 192 PF00069 0.426
MOD_Plk_4 223 229 PF00069 0.409
MOD_SUMO_for_1 267 270 PF00179 0.281
MOD_SUMO_rev_2 243 248 PF00179 0.409
TRG_ENDOCYTIC_2 112 115 PF00928 0.488
TRG_ENDOCYTIC_2 117 120 PF00928 0.443
TRG_ENDOCYTIC_2 187 190 PF00928 0.388
TRG_ER_diArg_1 306 308 PF00400 0.317
TRG_ER_diArg_1 7 10 PF00400 0.625
TRG_NLS_MonoExtN_4 220 227 PF00514 0.281
TRG_Pf-PMV_PEXEL_1 283 287 PF00026 0.281

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3Y9 Leptomonas seymouri 72% 99%
A0A0S4KLD6 Bodo saltans 39% 100%
A0A1X0NPQ0 Trypanosomatidae 50% 91%
A0A3R7JYX9 Trypanosoma rangeli 51% 100%
A0A3S5H658 Leishmania donovani 100% 100%
A4H5C4 Leishmania braziliensis 86% 99%
C9ZPG8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 100%
E9AMD5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QIB4 Leishmania major 97% 100%
V5BGW0 Trypanosoma cruzi 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS