Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTJ8_LEIIN

TriTrypDb:

LINF_080010100

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.790
CLV_NRD_NRD_1	160	162	PF00675	0.716
CLV_NRD_NRD_1	285	287	PF00675	0.713
CLV_NRD_NRD_1	315	317	PF00675	0.699
CLV_NRD_NRD_1	335	337	PF00675	0.389
CLV_NRD_NRD_1	350	352	PF00675	0.460
CLV_NRD_NRD_1	4	6	PF00675	0.747
CLV_NRD_NRD_1	59	61	PF00675	0.746
CLV_NRD_NRD_1	80	82	PF00675	0.605
CLV_PCSK_KEX2_1	160	162	PF00082	0.716
CLV_PCSK_KEX2_1	232	234	PF00082	0.830
CLV_PCSK_KEX2_1	285	287	PF00082	0.713
CLV_PCSK_KEX2_1	314	316	PF00082	0.716
CLV_PCSK_KEX2_1	335	337	PF00082	0.605
CLV_PCSK_KEX2_1	350	352	PF00082	0.460
CLV_PCSK_KEX2_1	80	82	PF00082	0.608
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.716
CLV_PCSK_PC7_1	311	317	PF00082	0.715
CLV_PCSK_SKI1_1	279	283	PF00082	0.730
DEG_APCC_DBOX_1	313	321	PF00400	0.733
DEG_APCC_DBOX_1	349	357	PF00400	0.553
DEG_APCC_DBOX_1	89	97	PF00400	0.714
DEG_SPOP_SBC_1	43	47	PF00917	0.696
DOC_MAPK_gen_1	350	358	PF00069	0.513
DOC_USP7_MATH_1	159	163	PF00917	0.711
DOC_USP7_MATH_1	341	345	PF00917	0.572
DOC_USP7_MATH_1	43	47	PF00917	0.696
DOC_USP7_MATH_1	85	89	PF00917	0.591
DOC_WW_Pin1_4	177	182	PF00397	0.702
DOC_WW_Pin1_4	212	217	PF00397	0.810
DOC_WW_Pin1_4	262	267	PF00397	0.801
DOC_WW_Pin1_4	27	32	PF00397	0.797
DOC_WW_Pin1_4	320	325	PF00397	0.673
DOC_WW_Pin1_4	69	74	PF00397	0.710
LIG_14-3-3_CanoR_1	149	158	PF00244	0.670
LIG_14-3-3_CanoR_1	296	303	PF00244	0.653
LIG_14-3-3_CanoR_1	335	342	PF00244	0.655
LIG_14-3-3_CanoR_1	350	359	PF00244	0.452
LIG_14-3-3_CanoR_1	66	74	PF00244	0.689
LIG_14-3-3_CanoR_1	80	89	PF00244	0.549
LIG_deltaCOP1_diTrp_1	277	282	PF00928	0.722
LIG_eIF4E_1	102	108	PF01652	0.694
LIG_FHA_1	181	187	PF00498	0.823
LIG_FHA_1	353	359	PF00498	0.596
LIG_FHA_2	325	331	PF00498	0.682
LIG_Integrin_RGD_1	242	244	PF01839	0.600
LIG_LIR_Nem_3	185	191	PF02991	0.750
LIG_LIR_Nem_3	193	198	PF02991	0.619
LIG_LIR_Nem_3	275	281	PF02991	0.724
LIG_PDZ_Class_3	357	362	PF00595	0.662
LIG_Pex14_1	278	282	PF04695	0.663
LIG_PTAP_UEV_1	168	173	PF05743	0.620
LIG_REV1ctd_RIR_1	279	290	PF16727	0.673
LIG_SH2_NCK_1	102	106	PF00017	0.689
LIG_SH2_NCK_1	337	341	PF00017	0.583
LIG_SH2_STAP1	164	168	PF00017	0.608
LIG_SH2_STAP1	337	341	PF00017	0.583
LIG_SH2_STAT5	102	105	PF00017	0.686
LIG_SH2_STAT5	337	340	PF00017	0.651
LIG_SH3_2	16	21	PF14604	0.759
LIG_SH3_3	10	16	PF00018	0.757
LIG_SH3_3	133	139	PF00018	0.686
LIG_SH3_3	166	172	PF00018	0.612
LIG_TRAF2_1	12	15	PF00917	0.680
LIG_TRAF2_1	97	100	PF00917	0.691
MOD_CK1_1	167	173	PF00069	0.706
MOD_CK1_1	180	186	PF00069	0.744
MOD_CK1_1	265	271	PF00069	0.708
MOD_CK1_1	272	278	PF00069	0.587
MOD_CK1_1	344	350	PF00069	0.493
MOD_CK1_1	41	47	PF00069	0.772
MOD_CK1_1	65	71	PF00069	0.779
MOD_CK1_1	84	90	PF00069	0.510
MOD_CK2_1	187	193	PF00069	0.720
MOD_CK2_1	324	330	PF00069	0.696
MOD_Cter_Amidation	230	233	PF01082	0.783
MOD_DYRK1A_RPxSP_1	29	33	PF00069	0.726
MOD_GlcNHglycan	161	164	PF01048	0.742
MOD_GlcNHglycan	165	169	PF01048	0.695
MOD_GlcNHglycan	237	240	PF01048	0.623
MOD_GlcNHglycan	287	290	PF01048	0.681
MOD_GlcNHglycan	346	349	PF01048	0.624
MOD_GlcNHglycan	41	44	PF01048	0.729
MOD_GlcNHglycan	83	86	PF01048	0.678
MOD_GSK3_1	173	180	PF00069	0.841
MOD_GSK3_1	182	189	PF00069	0.666
MOD_GSK3_1	215	222	PF00069	0.791
MOD_GSK3_1	265	272	PF00069	0.658
MOD_GSK3_1	285	292	PF00069	0.668
MOD_GSK3_1	320	327	PF00069	0.726
MOD_GSK3_1	38	45	PF00069	0.707
MOD_GSK3_1	60	67	PF00069	0.724
MOD_GSK3_1	81	88	PF00069	0.656
MOD_N-GLC_1	318	323	PF02516	0.611
MOD_NEK2_1	129	134	PF00069	0.737
MOD_NEK2_1	287	292	PF00069	0.588
MOD_NEK2_1	64	69	PF00069	0.615
MOD_NEK2_2	182	187	PF00069	0.592
MOD_PIKK_1	95	101	PF00454	0.685
MOD_PKA_1	285	291	PF00069	0.716
MOD_PKA_1	335	341	PF00069	0.593
MOD_PKA_1	60	66	PF00069	0.610
MOD_PKA_2	159	165	PF00069	0.716
MOD_PKA_2	285	291	PF00069	0.716
MOD_PKA_2	335	341	PF00069	0.593
MOD_PKA_2	65	71	PF00069	0.665
MOD_PKB_1	58	66	PF00069	0.608
MOD_Plk_1	268	274	PF00069	0.608
MOD_Plk_4	103	109	PF00069	0.614
MOD_Plk_4	269	275	PF00069	0.638
MOD_ProDKin_1	177	183	PF00069	0.700
MOD_ProDKin_1	212	218	PF00069	0.810
MOD_ProDKin_1	262	268	PF00069	0.797
MOD_ProDKin_1	27	33	PF00069	0.794
MOD_ProDKin_1	320	326	PF00069	0.665
MOD_ProDKin_1	69	75	PF00069	0.708
MOD_SUMO_rev_2	238	248	PF00179	0.665
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.726
TRG_ENDOCYTIC_2	191	194	PF00928	0.690
TRG_ER_diArg_1	285	287	PF00400	0.646
TRG_ER_diArg_1	314	316	PF00400	0.783
TRG_ER_diArg_1	334	336	PF00400	0.392
TRG_ER_diArg_1	349	351	PF00400	0.455
TRG_ER_diArg_1	57	60	PF00400	0.688
TRG_ER_diArg_1	79	81	PF00400	0.604
TRG_NLS_MonoExtN_4	2	9	PF00514	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H654	Leishmania donovani	98%	99%
A4H5B7	Leishmania braziliensis	49%	95%
E9AMC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	90%
Q4QIB9	Leishmania major	82%	99%