Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTJ7_LEIIN

TriTrypDb:

LINF_080010000

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTJ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.608
CLV_NRD_NRD_1	235	237	PF00675	0.701
CLV_PCSK_KEX2_1	237	239	PF00082	0.688
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.688
DOC_CYCLIN_RxL_1	295	305	PF00134	0.609
DOC_PP1_RVXF_1	296	303	PF00149	0.582
DOC_PP2B_LxvP_1	246	249	PF13499	0.629
DOC_PP2B_LxvP_1	363	366	PF13499	0.643
DOC_PP4_MxPP_1	43	46	PF00568	0.664
DOC_USP7_MATH_1	106	110	PF00917	0.625
DOC_USP7_MATH_1	229	233	PF00917	0.675
DOC_USP7_MATH_1	279	283	PF00917	0.610
DOC_USP7_MATH_1	290	294	PF00917	0.540
DOC_USP7_MATH_1	315	319	PF00917	0.648
DOC_USP7_MATH_1	376	380	PF00917	0.592
DOC_USP7_MATH_1	47	51	PF00917	0.689
DOC_USP7_MATH_1	74	78	PF00917	0.717
DOC_USP7_MATH_1	95	99	PF00917	0.646
DOC_WW_Pin1_4	157	162	PF00397	0.748
DOC_WW_Pin1_4	195	200	PF00397	0.782
DOC_WW_Pin1_4	202	207	PF00397	0.750
DOC_WW_Pin1_4	225	230	PF00397	0.635
DOC_WW_Pin1_4	249	254	PF00397	0.677
DOC_WW_Pin1_4	318	323	PF00397	0.663
DOC_WW_Pin1_4	41	46	PF00397	0.704
DOC_WW_Pin1_4	96	101	PF00397	0.659
LIG_14-3-3_CanoR_1	111	121	PF00244	0.534
LIG_14-3-3_CanoR_1	317	322	PF00244	0.668
LIG_14-3-3_CanoR_1	37	45	PF00244	0.569
LIG_14-3-3_CanoR_1	73	79	PF00244	0.686
LIG_14-3-3_CanoR_1	80	86	PF00244	0.580
LIG_APCC_ABBA_1	284	289	PF00400	0.572
LIG_BRCT_BRCA1_1	354	358	PF00533	0.635
LIG_BRCT_BRCA1_1	49	53	PF00533	0.656
LIG_FHA_1	174	180	PF00498	0.694
LIG_FHA_1	2	8	PF00498	0.556
LIG_FHA_1	255	261	PF00498	0.672
LIG_FHA_1	289	295	PF00498	0.619
LIG_FHA_1	346	352	PF00498	0.613
LIG_FHA_1	375	381	PF00498	0.644
LIG_FHA_2	170	176	PF00498	0.635
LIG_FHA_2	18	24	PF00498	0.639
LIG_FHA_2	270	276	PF00498	0.601
LIG_GSK3_LRP6_1	45	50	PF00069	0.634
LIG_LIR_Gen_1	212	221	PF02991	0.623
LIG_LIR_Gen_1	280	290	PF02991	0.597
LIG_LIR_Gen_1	355	366	PF02991	0.639
LIG_LIR_Nem_3	212	216	PF02991	0.622
LIG_LIR_Nem_3	280	286	PF02991	0.597
LIG_LIR_Nem_3	355	361	PF02991	0.636
LIG_NRBOX	117	123	PF00104	0.575
LIG_PDZ_Class_2	411	416	PF00595	0.601
LIG_Pex14_1	354	358	PF04695	0.635
LIG_SH2_NCK_1	150	154	PF00017	0.606
LIG_SH2_STAP1	150	154	PF00017	0.606
LIG_SH2_STAT5	213	216	PF00017	0.626
LIG_SH2_STAT5	303	306	PF00017	0.653
LIG_SH3_2	46	51	PF14604	0.680
LIG_SH3_3	193	199	PF00018	0.750
LIG_SH3_3	218	224	PF00018	0.652
LIG_SH3_3	43	49	PF00018	0.672
LIG_SUMO_SIM_anti_2	410	415	PF11976	0.592
LIG_SUMO_SIM_par_1	337	343	PF11976	0.638
LIG_ULM_U2AF65_1	236	242	PF00076	0.641
LIG_WRC_WIRS_1	110	115	PF05994	0.598
LIG_WW_3	167	171	PF00397	0.627
MOD_CDC14_SPxK_1	205	208	PF00782	0.604
MOD_CDC14_SPxK_1	48	51	PF00782	0.682
MOD_CDK_SPxK_1	202	208	PF00069	0.611
MOD_CDK_SPxK_1	45	51	PF00069	0.654
MOD_CDK_SPxxK_3	318	325	PF00069	0.664
MOD_CK1_1	104	110	PF00069	0.715
MOD_CK1_1	112	118	PF00069	0.530
MOD_CK1_1	149	155	PF00069	0.673
MOD_CK1_1	159	165	PF00069	0.589
MOD_CK1_1	198	204	PF00069	0.666
MOD_CK1_1	269	275	PF00069	0.614
MOD_CK1_1	282	288	PF00069	0.589
MOD_CK1_1	318	324	PF00069	0.704
MOD_CK1_1	32	38	PF00069	0.664
MOD_CK1_1	345	351	PF00069	0.653
MOD_CK2_1	169	175	PF00069	0.641
MOD_CK2_1	187	193	PF00069	0.594
MOD_CK2_1	395	401	PF00069	0.644
MOD_CMANNOS	241	244	PF00535	0.670
MOD_GlcNHglycan	151	154	PF01048	0.713
MOD_GlcNHglycan	185	188	PF01048	0.637
MOD_GlcNHglycan	231	234	PF01048	0.697
MOD_GlcNHglycan	304	307	PF01048	0.651
MOD_GlcNHglycan	354	357	PF01048	0.637
MOD_GlcNHglycan	38	41	PF01048	0.580
MOD_GlcNHglycan	405	408	PF01048	0.584
MOD_GSK3_1	109	116	PF00069	0.598
MOD_GSK3_1	169	176	PF00069	0.670
MOD_GSK3_1	183	190	PF00069	0.584
MOD_GSK3_1	198	205	PF00069	0.620
MOD_GSK3_1	225	232	PF00069	0.637
MOD_GSK3_1	316	323	PF00069	0.694
MOD_GSK3_1	32	39	PF00069	0.550
MOD_GSK3_1	338	345	PF00069	0.651
MOD_GSK3_1	403	410	PF00069	0.579
MOD_GSK3_1	41	48	PF00069	0.638
MOD_GSK3_1	91	98	PF00069	0.589
MOD_N-GLC_1	32	37	PF02516	0.661
MOD_NEK2_1	113	118	PF00069	0.491
MOD_NEK2_1	156	161	PF00069	0.620
MOD_NEK2_1	174	179	PF00069	0.571
MOD_NEK2_1	214	219	PF00069	0.576
MOD_NEK2_1	302	307	PF00069	0.652
MOD_NEK2_1	352	357	PF00069	0.738
MOD_NEK2_1	403	408	PF00069	0.592
MOD_NEK2_1	91	96	PF00069	0.679
MOD_NEK2_2	106	111	PF00069	0.683
MOD_NEK2_2	187	192	PF00069	0.650
MOD_NEK2_2	290	295	PF00069	0.635
MOD_PIKK_1	104	110	PF00454	0.741
MOD_PIKK_1	116	122	PF00454	0.467
MOD_PIKK_1	159	165	PF00454	0.669
MOD_PIKK_1	395	401	PF00454	0.616
MOD_PKA_1	236	242	PF00069	0.641
MOD_PKA_2	169	175	PF00069	0.697
MOD_PKA_2	17	23	PF00069	0.572
MOD_PKA_2	183	189	PF00069	0.744
MOD_PKA_2	269	275	PF00069	0.635
MOD_PKA_2	29	35	PF00069	0.597
MOD_PKA_2	316	322	PF00069	0.668
MOD_PKA_2	36	42	PF00069	0.578
MOD_PKA_2	7	13	PF00069	0.607
MOD_Plk_1	174	180	PF00069	0.649
MOD_Plk_1	279	285	PF00069	0.636
MOD_Plk_1	91	97	PF00069	0.520
MOD_Plk_2-3	17	23	PF00069	0.533
MOD_Plk_4	113	119	PF00069	0.659
MOD_Plk_4	279	285	PF00069	0.594
MOD_Plk_4	376	382	PF00069	0.592
MOD_Plk_4	81	87	PF00069	0.560
MOD_ProDKin_1	157	163	PF00069	0.749
MOD_ProDKin_1	195	201	PF00069	0.780
MOD_ProDKin_1	202	208	PF00069	0.750
MOD_ProDKin_1	225	231	PF00069	0.635
MOD_ProDKin_1	249	255	PF00069	0.679
MOD_ProDKin_1	318	324	PF00069	0.664
MOD_ProDKin_1	41	47	PF00069	0.705
MOD_ProDKin_1	96	102	PF00069	0.661
TRG_ENDOCYTIC_2	213	216	PF00928	0.626
TRG_ER_diArg_1	235	238	PF00400	0.700
TRG_NES_CRM1_1	212	227	PF08389	0.604
TRG_NLS_MonoExtC_3	235	240	PF00514	0.650
TRG_NLS_MonoExtN_4	235	241	PF00514	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H653	Leishmania donovani	99%	100%
A4H5B6	Leishmania braziliensis	52%	100%
E9AMC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QIC0	Leishmania major	83%	100%