Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTJ6_LEIIN

TriTrypDb:

LINF_080009900

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 106

Expansion

Sequence features

A4HTJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	90	94	PF00656	0.767
CLV_PCSK_KEX2_1	47	49	PF00082	0.577
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.577
CLV_PCSK_SKI1_1	139	143	PF00082	0.483
DEG_APCC_DBOX_1	217	225	PF00400	0.615
DOC_CKS1_1	20	25	PF01111	0.544
DOC_MAPK_gen_1	130	140	PF00069	0.520
DOC_MAPK_MEF2A_6	139	148	PF00069	0.560
DOC_USP7_MATH_1	31	35	PF00917	0.602
DOC_USP7_MATH_1	88	92	PF00917	0.656
DOC_WW_Pin1_4	19	24	PF00397	0.543
DOC_WW_Pin1_4	196	201	PF00397	0.659
DOC_WW_Pin1_4	211	216	PF00397	0.420
DOC_WW_Pin1_4	229	234	PF00397	0.666
DOC_WW_Pin1_4	35	40	PF00397	0.502
LIG_14-3-3_CanoR_1	139	148	PF00244	0.528
LIG_14-3-3_CanoR_1	226	230	PF00244	0.634
LIG_14-3-3_CanoR_1	87	97	PF00244	0.544
LIG_Actin_WH2_2	112	128	PF00022	0.621
LIG_APCC_ABBA_1	129	134	PF00400	0.585
LIG_BIR_II_1	1	5	PF00653	0.593
LIG_BIR_III_4	83	87	PF00653	0.560
LIG_BIR_III_4	93	97	PF00653	0.482
LIG_FHA_1	135	141	PF00498	0.447
LIG_FHA_2	3	9	PF00498	0.570
LIG_FHA_2	36	42	PF00498	0.651
LIG_PCNA_yPIPBox_3	246	258	PF02747	0.633
LIG_PTB_Apo_2	165	172	PF02174	0.596
LIG_PTB_Phospho_1	165	171	PF10480	0.589
LIG_SH2_GRB2like	166	169	PF00017	0.595
LIG_SH2_NCK_1	49	53	PF00017	0.526
LIG_SH2_SRC	12	15	PF00017	0.493
LIG_SH2_SRC	49	52	PF00017	0.530
LIG_SH2_STAP1	12	16	PF00017	0.565
LIG_SH2_STAP1	166	170	PF00017	0.597
LIG_SH2_STAT5	56	59	PF00017	0.538
LIG_SH3_3	192	198	PF00018	0.687
LIG_SH3_3	230	236	PF00018	0.663
LIG_SUMO_SIM_anti_2	117	123	PF11976	0.512
LIG_TRAF2_1	24	27	PF00917	0.604
LIG_UBA3_1	16	21	PF00899	0.565
LIG_WW_2	233	236	PF00397	0.612
MOD_CDK_SPK_2	211	216	PF00069	0.527
MOD_CDK_SPxxK_3	211	218	PF00069	0.440
MOD_CK1_1	150	156	PF00069	0.450
MOD_CK1_1	70	76	PF00069	0.745
MOD_CK2_1	171	177	PF00069	0.721
MOD_CK2_1	2	8	PF00069	0.541
MOD_CK2_1	37	43	PF00069	0.474
MOD_GlcNHglycan	182	185	PF01048	0.610
MOD_GlcNHglycan	263	266	PF01048	0.711
MOD_GlcNHglycan	269	272	PF01048	0.721
MOD_GlcNHglycan	72	75	PF01048	0.733
MOD_GlcNHglycan	93	97	PF01048	0.699
MOD_GSK3_1	166	173	PF00069	0.657
MOD_GSK3_1	225	232	PF00069	0.535
MOD_GSK3_1	31	38	PF00069	0.583
MOD_GSK3_1	88	95	PF00069	0.764
MOD_N-GLC_1	103	108	PF02516	0.697
MOD_N-GLC_1	229	234	PF02516	0.701
MOD_NEK2_1	147	152	PF00069	0.432
MOD_NEK2_1	252	257	PF00069	0.512
MOD_NEK2_2	166	171	PF00069	0.635
MOD_PIKK_1	147	153	PF00454	0.440
MOD_PIKK_1	88	94	PF00454	0.738
MOD_PKA_2	217	223	PF00069	0.619
MOD_PKA_2	225	231	PF00069	0.666
MOD_PKA_2	267	273	PF00069	0.627
MOD_PKA_2	78	84	PF00069	0.661
MOD_Plk_1	103	109	PF00069	0.755
MOD_Plk_2-3	103	109	PF00069	0.736
MOD_Plk_2-3	8	14	PF00069	0.497
MOD_Plk_4	166	172	PF00069	0.621
MOD_ProDKin_1	19	25	PF00069	0.537
MOD_ProDKin_1	196	202	PF00069	0.651
MOD_ProDKin_1	211	217	PF00069	0.415
MOD_ProDKin_1	229	235	PF00069	0.663
MOD_ProDKin_1	35	41	PF00069	0.502
TRG_DiLeu_BaEn_1	136	141	PF01217	0.489
TRG_DiLeu_BaEn_1	143	148	PF01217	0.487
TRG_DiLeu_LyEn_5	136	141	PF01217	0.561
TRG_ENDOCYTIC_2	49	52	PF00928	0.513
TRG_NES_CRM1_1	120	134	PF08389	0.516
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMT4	Leptomonas seymouri	53%	99%
A0A1X0NP32	Trypanosomatidae	30%	100%
A0A3S7WQ75	Leishmania donovani	100%	100%
A0A422NB91	Trypanosoma rangeli	30%	100%
A4H5B5	Leishmania braziliensis	75%	100%
C9ZPH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AMC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QIC1	Leishmania major	90%	100%
V5BLF3	Trypanosoma cruzi	28%	100%