LeishMANIAdb
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Signal peptidase complex catalytic subunit SEC11

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Signal peptidase complex catalytic subunit SEC11
Gene product:
signal peptidase type I - putative
Species:
Leishmania infantum
UniProt:
A4HTJ4_LEIIN
TriTrypDb:
LINF_080009600
Length:
180

Annotations

LeishMANIAdb annotations

The conserved catalytic component of the ER signal peptidase complex.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005783 endoplasmic reticulum 5 1
GO:0005787 signal peptidase complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098796 membrane protein complex 2 1
GO:0140534 endoplasmic reticulum protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1905368 peptidase complex 3 1

Expansion

Sequence features

A4HTJ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTJ4

Function

Biological processes
Term Name Level Count
GO:0006465 signal peptide processing 5 10
GO:0006508 proteolysis 4 10
GO:0006518 peptide metabolic process 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0016485 protein processing 5 10
GO:0019538 protein metabolic process 3 10
GO:0043170 macromolecule metabolic process 3 10
GO:0043603 amide metabolic process 3 10
GO:0044238 primary metabolic process 2 10
GO:0051604 protein maturation 4 10
GO:0071704 organic substance metabolic process 2 10
GO:1901564 organonitrogen compound metabolic process 3 10
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004175 endopeptidase activity 4 10
GO:0004252 serine-type endopeptidase activity 5 10
GO:0008233 peptidase activity 3 10
GO:0008236 serine-type peptidase activity 4 10
GO:0016787 hydrolase activity 2 10
GO:0017171 serine hydrolase activity 3 10
GO:0140096 catalytic activity, acting on a protein 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 112 116 PF00656 0.242
CLV_PCSK_SKI1_1 122 126 PF00082 0.619
CLV_PCSK_SKI1_1 159 163 PF00082 0.570
DEG_Nend_UBRbox_1 1 4 PF02207 0.677
DOC_MAPK_gen_1 159 168 PF00069 0.403
DOC_MAPK_MEF2A_6 147 155 PF00069 0.347
DOC_MAPK_MEF2A_6 159 168 PF00069 0.273
LIG_eIF4E_1 163 169 PF01652 0.382
LIG_FHA_1 20 26 PF00498 0.411
LIG_FHA_2 110 116 PF00498 0.242
LIG_FHA_2 39 45 PF00498 0.329
LIG_GBD_Chelix_1 47 55 PF00786 0.442
LIG_Integrin_RGD_1 61 63 PF01839 0.442
LIG_LIR_Gen_1 141 150 PF02991 0.341
LIG_LIR_Gen_1 24 32 PF02991 0.376
LIG_LIR_Nem_3 141 145 PF02991 0.315
LIG_LIR_Nem_3 24 29 PF02991 0.404
LIG_SH2_CRK 83 87 PF00017 0.342
LIG_SH2_NCK_1 83 87 PF00017 0.342
LIG_SH2_PTP2 163 166 PF00017 0.381
LIG_SH2_STAT5 110 113 PF00017 0.294
LIG_SH2_STAT5 144 147 PF00017 0.349
LIG_SH2_STAT5 150 153 PF00017 0.333
LIG_SH2_STAT5 163 166 PF00017 0.210
LIG_SH2_STAT5 83 86 PF00017 0.343
LIG_SH3_3 68 74 PF00018 0.342
LIG_SUMO_SIM_anti_2 28 33 PF11976 0.372
LIG_SUMO_SIM_anti_2 46 52 PF11976 0.308
LIG_SUMO_SIM_anti_2 63 68 PF11976 0.153
LIG_SUMO_SIM_par_1 19 24 PF11976 0.348
LIG_SUMO_SIM_par_1 46 52 PF11976 0.255
LIG_SUMO_SIM_par_1 72 79 PF11976 0.337
LIG_TRAF2_1 176 179 PF00917 0.425
LIG_TYR_ITIM 148 153 PF00017 0.356
LIG_TYR_ITIM 161 166 PF00017 0.315
MOD_CK2_1 124 130 PF00069 0.291
MOD_CK2_1 173 179 PF00069 0.387
MOD_CK2_1 38 44 PF00069 0.370
MOD_GlcNHglycan 126 129 PF01048 0.576
MOD_GlcNHglycan 51 54 PF01048 0.442
MOD_GSK3_1 21 28 PF00069 0.431
MOD_N-GLC_1 155 160 PF02516 0.619
MOD_NEK2_1 109 114 PF00069 0.240
MOD_NEK2_1 124 129 PF00069 0.312
MOD_NEK2_1 155 160 PF00069 0.403
MOD_NEK2_1 172 177 PF00069 0.404
MOD_NEK2_1 25 30 PF00069 0.327
MOD_PIKK_1 174 180 PF00454 0.454
MOD_Plk_1 43 49 PF00069 0.342
MOD_Plk_4 149 155 PF00069 0.320
MOD_Plk_4 25 31 PF00069 0.381
MOD_Plk_4 4 10 PF00069 0.647
MOD_Plk_4 43 49 PF00069 0.282
MOD_SUMO_rev_2 101 109 PF00179 0.327
TRG_ENDOCYTIC_2 150 153 PF00928 0.330
TRG_ENDOCYTIC_2 163 166 PF00928 0.318
TRG_ER_diArg_1 11 14 PF00400 0.582
TRG_NES_CRM1_1 3 15 PF08389 0.638

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAJ6 Leptomonas seymouri 63% 100%
A0A0S4IUY8 Bodo saltans 49% 100%
A0A1X0NPP1 Trypanosomatidae 45% 87%
A0A3S5H651 Leishmania donovani 100% 100%
A0A422NBA9 Trypanosoma rangeli 46% 86%
A1CL29 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 38% 94%
A1D6D8 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 38% 94%
A3LXS1 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 40% 100%
A4RGA1 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 41% 100%
A5DIZ8 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 41% 100%
A5DS09 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 42% 100%
A6QX24 Ajellomyces capsulatus (strain NAm1 / WU24) 42% 96%
A6ZVU2 Saccharomyces cerevisiae (strain YJM789) 39% 100%
A7E716 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 42% 100%
B0D4L0 Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) 42% 96%
B0XWT3 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 38% 94%
B2B3T2 Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) 38% 100%
B2WEL2 Pyrenophora tritici-repentis (strain Pt-1C-BFP) 41% 100%
B3LTI7 Saccharomyces cerevisiae (strain RM11-1a) 39% 100%
B6HC89 Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) 38% 100%
B6Q5G0 Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) 39% 94%
B8M5K5 Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) 40% 94%
B9WKT4 Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) 42% 100%
C0NKT8 Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) 42% 96%
C0S3S0 Paracoccidioides brasiliensis (strain Pb03) 40% 91%
C1FYD2 Paracoccidioides brasiliensis (strain Pb18) 40% 91%
C1GU90 Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) 39% 91%
C4JYM4 Uncinocarpus reesii (strain UAMH 1704) 34% 86%
C4QXP7 Komagataella phaffii (strain GS115 / ATCC 20864) 41% 100%
C4Y3D4 Clavispora lusitaniae (strain ATCC 42720) 40% 100%
C4YNJ0 Candida albicans (strain WO-1) 43% 100%
C5DDH1 Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) 38% 100%
C5E3W1 Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) 41% 100%
C5FQ45 Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) 38% 90%
C5G8L5 Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) 38% 92%
C5JJG5 Blastomyces gilchristii (strain SLH14081) 38% 92%
C5M4J6 Candida tropicalis (strain ATCC MYA-3404 / T1) 43% 100%
C5PA33 Coccidioides posadasii (strain C735) 35% 86%
C6HB29 Ajellomyces capsulatus (strain H143) 42% 96%
C7GLT4 Saccharomyces cerevisiae (strain JAY291) 39% 100%
C7ZHK5 Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4) 42% 100%
C8ZAS4 Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) 39% 100%
C9S8G0 Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) 42% 100%
C9ZPI2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 87%
D4ALL0 Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) 38% 90%
D4D5I1 Trichophyton verrucosum (strain HKI 0517) 38% 90%
D5GNC3 Tuber melanosporum (strain Mel28) 40% 97%
D8Q7Q5 Schizophyllum commune (strain H4-8 / FGSC 9210) 42% 93%
E3QXY4 Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) 40% 100%
E3RR70 Pyrenophora teres f. teres (strain 0-1) 40% 100%
E4V4X0 Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) 37% 90%
E5A8D2 Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) 39% 100%
E7KDY6 Saccharomyces cerevisiae (strain AWRI796) 39% 100%
E7KQ01 Saccharomyces cerevisiae (strain Lalvin QA23) 39% 100%
E7LVX4 Saccharomyces cerevisiae (strain VIN 13) 39% 100%
E7Q587 Saccharomyces cerevisiae (strain FostersB) 39% 100%
E7QG89 Saccharomyces cerevisiae (strain Zymaflore VL3) 39% 100%
E7R7C4 Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1) 41% 100%
E9AMC4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9CXH2 Coccidioides posadasii (strain RMSCC 757 / Silveira) 35% 86%
E9E796 Metarhizium acridum (strain CQMa 102) 43% 100%
E9F8V9 Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) 41% 100%
F0UDD2 Ajellomyces capsulatus (strain H88) 42% 96%
F0XJH4 Grosmannia clavigera (strain kw1407 / UAMH 11150) 43% 100%
O74323 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 37% 95%
P0C7V7 Homo sapiens 46% 100%
P13679 Canis lupus familiaris 41% 94%
P15367 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
P42667 Rattus norvegicus 44% 100%
P67810 Bos taurus 45% 100%
P67811 Canis lupus familiaris 45% 100%
P67812 Homo sapiens 45% 100%
Q0CQC5 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 40% 94%
Q2H1P3 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 43% 100%
Q2UBW3 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 39% 94%
Q4QIC4 Leishmania major 98% 100%
Q4WYF4 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 38% 94%
Q5A869 Candida albicans (strain SC5314 / ATCC MYA-2876) 43% 100%
Q5B8K4 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 40% 94%
Q5R9C7 Pongo abelii 45% 100%
Q5RC30 Pongo abelii 41% 94%
Q6BP15 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 42% 100%
Q6CAG9 Yarrowia lipolytica (strain CLIB 122 / E 150) 40% 100%
Q6CMR5 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 40% 100%
Q759W4 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 41% 100%
Q7RY44 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 45% 100%
Q86JD4 Dictyostelium discoideum 38% 100%
Q8IE14 Plasmodium falciparum (isolate 3D7) 41% 98%
Q9BY50 Homo sapiens 41% 94%
Q9D8V7 Mus musculus 41% 94%
Q9R0P6 Mus musculus 45% 100%
Q9WTR7 Rattus norvegicus 41% 94%
V5B1H0 Trypanosoma cruzi 46% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS