LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HTJ1_LEIIN
TriTrypDb:
LINF_080009300 *
Length:
1984

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
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Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HTJ1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTJ1

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 1455 1459 PF00656 0.336
CLV_C14_Caspase3-7 1619 1623 PF00656 0.607
CLV_C14_Caspase3-7 1950 1954 PF00656 0.532
CLV_C14_Caspase3-7 556 560 PF00656 0.571
CLV_C14_Caspase3-7 64 68 PF00656 0.553
CLV_C14_Caspase3-7 728 732 PF00656 0.549
CLV_C14_Caspase3-7 930 934 PF00656 0.596
CLV_NRD_NRD_1 1106 1108 PF00675 0.497
CLV_NRD_NRD_1 1171 1173 PF00675 0.381
CLV_NRD_NRD_1 1196 1198 PF00675 0.406
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Homologs

ProteinTaxonomySequence identityCoverage
A0A3S5H649 Leishmania donovani 100% 100%
A4H5B2 Leishmania braziliensis 77% 100%
E9AMC1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QIC7 Leishmania major 93% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS