Cytochrome c oxidase subunit ApiCOX24

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTI8_LEIIN

TriTrypDb:

LINF_080008800

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HTI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.490
CLV_PCSK_KEX2_1	193	195	PF00082	0.657
CLV_PCSK_KEX2_1	4	6	PF00082	0.491
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.657
CLV_PCSK_SKI1_1	214	218	PF00082	0.655
CLV_PCSK_SKI1_1	71	75	PF00082	0.438
DEG_MDM2_SWIB_1	124	131	PF02201	0.389
DOC_MAPK_FxFP_2	67	70	PF00069	0.639
DOC_MAPK_MEF2A_6	103	110	PF00069	0.633
DOC_MAPK_NFAT4_5	103	111	PF00069	0.632
DOC_PP4_FxxP_1	67	70	PF00568	0.639
DOC_USP7_MATH_1	16	20	PF00917	0.680
DOC_USP7_MATH_1	208	212	PF00917	0.514
DOC_USP7_MATH_1	38	42	PF00917	0.577
DOC_USP7_UBL2_3	189	193	PF12436	0.450
LIG_14-3-3_CanoR_1	107	117	PF00244	0.604
LIG_14-3-3_CanoR_1	23	29	PF00244	0.675
LIG_14-3-3_CanoR_1	37	46	PF00244	0.648
LIG_14-3-3_CanoR_1	87	93	PF00244	0.633
LIG_APCC_ABBA_1	60	65	PF00400	0.638
LIG_deltaCOP1_diTrp_1	141	147	PF00928	0.427
LIG_deltaCOP1_diTrp_1	183	188	PF00928	0.458
LIG_deltaCOP1_diTrp_1	209	220	PF00928	0.487
LIG_FHA_1	154	160	PF00498	0.480
LIG_FHA_1	198	204	PF00498	0.519
LIG_FHA_2	79	85	PF00498	0.620
LIG_FHA_2	94	100	PF00498	0.593
LIG_KLC1_Yacidic_2	163	168	PF13176	0.419
LIG_LIR_Apic_2	168	173	PF02991	0.417
LIG_LIR_Apic_2	199	204	PF02991	0.444
LIG_LIR_Apic_2	65	70	PF02991	0.640
LIG_LIR_Gen_1	141	152	PF02991	0.427
LIG_LIR_Gen_1	180	190	PF02991	0.490
LIG_LIR_Nem_3	127	131	PF02991	0.338
LIG_LIR_Nem_3	141	147	PF02991	0.390
LIG_LIR_Nem_3	177	182	PF02991	0.477
LIG_LIR_Nem_3	31	36	PF02991	0.748
LIG_LIR_Nem_3	65	69	PF02991	0.641
LIG_MYND_3	157	161	PF01753	0.451
LIG_PDZ_Class_1	215	220	PF00595	0.517
LIG_Pex14_1	117	121	PF04695	0.416
LIG_Pex14_2	116	120	PF04695	0.378
LIG_Pex14_2	121	125	PF04695	0.378
LIG_Pex14_2	74	78	PF04695	0.718
LIG_SH2_STAP1	182	186	PF00017	0.454
LIG_SH2_STAT3	166	169	PF00017	0.439
LIG_SH2_STAT5	129	132	PF00017	0.354
LIG_SH2_STAT5	166	169	PF00017	0.426
LIG_SH2_STAT5	80	83	PF00017	0.626
LIG_SH3_3	152	158	PF00018	0.417
LIG_SH3_3	51	57	PF00018	0.691
LIG_SH3_3	73	79	PF00018	0.641
LIG_SH3_4	189	196	PF00018	0.451
LIG_TRAF2_1	81	84	PF00917	0.617
LIG_TRAF2_2	204	209	PF00917	0.441
MOD_CK1_1	112	118	PF00069	0.562
MOD_CK1_1	127	133	PF00069	0.241
MOD_CK1_1	92	98	PF00069	0.626
MOD_CK2_1	78	84	PF00069	0.624
MOD_CK2_1	93	99	PF00069	0.590
MOD_CMANNOS	117	120	PF00535	0.335
MOD_GlcNHglycan	24	27	PF01048	0.530
MOD_GlcNHglycan	40	43	PF01048	0.517
MOD_GSK3_1	108	115	PF00069	0.462
MOD_GSK3_1	14	21	PF00069	0.708
MOD_GSK3_1	6	13	PF00069	0.738
MOD_GSK3_1	78	85	PF00069	0.622
MOD_GSK3_1	89	96	PF00069	0.614
MOD_N-GLC_1	108	113	PF02516	0.400
MOD_NEK2_1	108	113	PF00069	0.614
MOD_NEK2_1	124	129	PF00069	0.355
MOD_NEK2_1	22	27	PF00069	0.667
MOD_NEK2_2	18	23	PF00069	0.614
MOD_PK_1	82	88	PF00069	0.627
MOD_PKA_2	22	28	PF00069	0.739
MOD_PKA_2	38	44	PF00069	0.670
MOD_PKA_2	86	92	PF00069	0.626
MOD_Plk_1	82	88	PF00069	0.627
MOD_Plk_1	89	95	PF00069	0.635
MOD_Plk_4	112	118	PF00069	0.482
MOD_Plk_4	124	130	PF00069	0.335
MOD_SUMO_for_1	192	195	PF00179	0.441
MOD_SUMO_rev_2	31	36	PF00179	0.701
MOD_SUMO_rev_2	72	79	PF00179	0.654
TRG_ENDOCYTIC_2	135	138	PF00928	0.382
TRG_ENDOCYTIC_2	182	185	PF00928	0.449
TRG_ER_diArg_1	3	5	PF00400	0.690
TRG_ER_diArg_1	36	39	PF00400	0.726
TRG_PTS1	217	220	PF00515	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P933	Leptomonas seymouri	81%	99%
A0A0S4IVJ7	Bodo saltans	67%	100%
A0A1X0NP20	Trypanosomatidae	72%	100%
A0A3S5H645	Leishmania donovani	100%	100%
A4H5A9	Leishmania braziliensis	90%	100%
C9ZPJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AMB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QID2	Leishmania major	96%	100%
V5DHY0	Trypanosoma cruzi	74%	100%