Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTI7_LEIIN

TriTrypDb:

LINF_080008700

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTI7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.612
CLV_C14_Caspase3-7	468	472	PF00656	0.765
CLV_NRD_NRD_1	241	243	PF00675	0.452
CLV_NRD_NRD_1	561	563	PF00675	0.481
CLV_PCSK_KEX2_1	241	243	PF00082	0.452
CLV_PCSK_KEX2_1	329	331	PF00082	0.634
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.634
CLV_PCSK_SKI1_1	354	358	PF00082	0.713
CLV_PCSK_SKI1_1	448	452	PF00082	0.612
DEG_COP1_1	460	473	PF00400	0.614
DEG_SCF_FBW7_1	105	111	PF00400	0.616
DEG_SPOP_SBC_1	355	359	PF00917	0.701
DEG_SPOP_SBC_1	453	457	PF00917	0.639
DEG_SPOP_SBC_1	67	71	PF00917	0.583
DOC_CKS1_1	105	110	PF01111	0.607
DOC_CYCLIN_RxL_1	442	456	PF00134	0.584
DOC_MAPK_gen_1	562	568	PF00069	0.418
DOC_PP2B_LxvP_1	450	453	PF13499	0.747
DOC_PP2B_LxvP_1	482	485	PF13499	0.683
DOC_USP7_MATH_1	119	123	PF00917	0.646
DOC_USP7_MATH_1	125	129	PF00917	0.733
DOC_USP7_MATH_1	132	136	PF00917	0.662
DOC_USP7_MATH_1	181	185	PF00917	0.579
DOC_USP7_MATH_1	308	312	PF00917	0.659
DOC_USP7_MATH_1	355	359	PF00917	0.756
DOC_WW_Pin1_4	104	109	PF00397	0.647
DOC_WW_Pin1_4	136	141	PF00397	0.657
DOC_WW_Pin1_4	203	208	PF00397	0.608
DOC_WW_Pin1_4	276	281	PF00397	0.691
DOC_WW_Pin1_4	337	342	PF00397	0.651
DOC_WW_Pin1_4	358	363	PF00397	0.755
DOC_WW_Pin1_4	365	370	PF00397	0.496
DOC_WW_Pin1_4	372	377	PF00397	0.611
DOC_WW_Pin1_4	411	416	PF00397	0.546
DOC_WW_Pin1_4	517	522	PF00397	0.656
LIG_14-3-3_CanoR_1	169	178	PF00244	0.419
LIG_14-3-3_CanoR_1	232	240	PF00244	0.408
LIG_14-3-3_CanoR_1	354	364	PF00244	0.748
LIG_14-3-3_CanoR_1	448	453	PF00244	0.613
LIG_14-3-3_CanoR_1	500	506	PF00244	0.573
LIG_14-3-3_CanoR_1	513	519	PF00244	0.544
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BIR_III_4	301	305	PF00653	0.644
LIG_BIR_III_4	318	322	PF00653	0.565
LIG_EH1_1	34	42	PF00400	0.367
LIG_eIF4E_1	35	41	PF01652	0.424
LIG_EVH1_1	104	108	PF00568	0.484
LIG_EVH1_1	141	145	PF00568	0.676
LIG_FHA_1	312	318	PF00498	0.548
LIG_FHA_1	337	343	PF00498	0.782
LIG_FHA_1	355	361	PF00498	0.516
LIG_FHA_1	412	418	PF00498	0.553
LIG_FHA_1	525	531	PF00498	0.622
LIG_FHA_2	507	513	PF00498	0.553
LIG_HP1_1	285	289	PF01393	0.675
LIG_LIR_Gen_1	23	33	PF02991	0.599
LIG_LIR_Nem_3	23	29	PF02991	0.602
LIG_MYND_1	481	485	PF01753	0.637
LIG_RPA_C_Fungi	229	241	PF08784	0.403
LIG_SH2_STAT3	416	419	PF00017	0.658
LIG_SH2_STAT5	247	250	PF00017	0.449
LIG_SH2_STAT5	416	419	PF00017	0.551
LIG_SH2_STAT5	9	12	PF00017	0.455
LIG_SH2_STAT5	98	101	PF00017	0.450
LIG_SH3_3	102	108	PF00018	0.530
LIG_SH3_3	110	116	PF00018	0.669
LIG_SH3_3	134	140	PF00018	0.712
LIG_SH3_3	279	285	PF00018	0.617
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.494
LIG_SUMO_SIM_anti_2	564	570	PF11976	0.423
LIG_SUMO_SIM_par_1	448	457	PF11976	0.699
LIG_TRAF2_1	172	175	PF00917	0.424
LIG_UBA3_1	373	378	PF00899	0.721
LIG_WRC_WIRS_1	26	31	PF05994	0.531
LIG_WW_2	142	145	PF00397	0.705
MOD_CDC14_SPxK_1	375	378	PF00782	0.618
MOD_CDK_SPxK_1	372	378	PF00069	0.611
MOD_CK1_1	2	8	PF00069	0.633
MOD_CK1_1	25	31	PF00069	0.431
MOD_CK1_1	265	271	PF00069	0.669
MOD_CK1_1	311	317	PF00069	0.717
MOD_CK1_1	320	326	PF00069	0.595
MOD_CK1_1	358	364	PF00069	0.739
MOD_CK1_1	397	403	PF00069	0.601
MOD_CK1_1	409	415	PF00069	0.682
MOD_CK1_1	457	463	PF00069	0.654
MOD_CK1_1	517	523	PF00069	0.685
MOD_CK1_1	72	78	PF00069	0.692
MOD_CK2_1	169	175	PF00069	0.447
MOD_CK2_1	176	182	PF00069	0.492
MOD_CK2_1	456	462	PF00069	0.705
MOD_CK2_1	47	53	PF00069	0.571
MOD_CK2_1	77	83	PF00069	0.633
MOD_GlcNHglycan	11	14	PF01048	0.445
MOD_GlcNHglycan	121	124	PF01048	0.721
MOD_GlcNHglycan	126	130	PF01048	0.650
MOD_GlcNHglycan	134	137	PF01048	0.564
MOD_GlcNHglycan	152	155	PF01048	0.581
MOD_GlcNHglycan	171	174	PF01048	0.349
MOD_GlcNHglycan	188	191	PF01048	0.781
MOD_GlcNHglycan	213	216	PF01048	0.481
MOD_GlcNHglycan	235	238	PF01048	0.598
MOD_GlcNHglycan	268	271	PF01048	0.667
MOD_GlcNHglycan	318	322	PF01048	0.774
MOD_GlcNHglycan	389	394	PF01048	0.630
MOD_GlcNHglycan	456	459	PF01048	0.774
MOD_GlcNHglycan	464	467	PF01048	0.688
MOD_GlcNHglycan	72	75	PF01048	0.671
MOD_GlcNHglycan	79	82	PF01048	0.628
MOD_GSK3_1	104	111	PF00069	0.754
MOD_GSK3_1	132	139	PF00069	0.625
MOD_GSK3_1	181	188	PF00069	0.564
MOD_GSK3_1	21	28	PF00069	0.527
MOD_GSK3_1	262	269	PF00069	0.709
MOD_GSK3_1	272	279	PF00069	0.683
MOD_GSK3_1	3	10	PF00069	0.511
MOD_GSK3_1	332	339	PF00069	0.606
MOD_GSK3_1	350	357	PF00069	0.613
MOD_GSK3_1	385	392	PF00069	0.695
MOD_GSK3_1	394	401	PF00069	0.542
MOD_GSK3_1	448	455	PF00069	0.683
MOD_GSK3_1	457	464	PF00069	0.614
MOD_GSK3_1	47	54	PF00069	0.510
MOD_GSK3_1	513	520	PF00069	0.702
MOD_GSK3_1	66	73	PF00069	0.563
MOD_N-GLC_2	488	490	PF02516	0.549
MOD_N-GLC_2	529	531	PF02516	0.434
MOD_NEK2_1	1	6	PF00069	0.702
MOD_NEK2_1	167	172	PF00069	0.437
MOD_NEK2_1	211	216	PF00069	0.446
MOD_NEK2_1	22	27	PF00069	0.430
MOD_NEK2_1	363	368	PF00069	0.617
MOD_NEK2_1	396	401	PF00069	0.709
MOD_NEK2_1	493	498	PF00069	0.565
MOD_NEK2_1	501	506	PF00069	0.543
MOD_NEK2_1	59	64	PF00069	0.586
MOD_OFUCOSY	490	497	PF10250	0.549
MOD_PIKK_1	262	268	PF00454	0.682
MOD_PIKK_1	322	328	PF00454	0.592
MOD_PIKK_1	4	10	PF00454	0.618
MOD_PK_1	562	568	PF00069	0.457
MOD_PKA_1	562	568	PF00069	0.457
MOD_PKA_2	233	239	PF00069	0.427
MOD_PKA_2	462	468	PF00069	0.751
MOD_PKB_1	330	338	PF00069	0.592
MOD_Plk_1	22	28	PF00069	0.534
MOD_Plk_4	193	199	PF00069	0.542
MOD_Plk_4	514	520	PF00069	0.575
MOD_Plk_4	530	536	PF00069	0.571
MOD_ProDKin_1	104	110	PF00069	0.658
MOD_ProDKin_1	136	142	PF00069	0.656
MOD_ProDKin_1	203	209	PF00069	0.604
MOD_ProDKin_1	276	282	PF00069	0.689
MOD_ProDKin_1	337	343	PF00069	0.648
MOD_ProDKin_1	358	364	PF00069	0.754
MOD_ProDKin_1	365	371	PF00069	0.496
MOD_ProDKin_1	372	378	PF00069	0.611
MOD_ProDKin_1	411	417	PF00069	0.543
MOD_ProDKin_1	517	523	PF00069	0.650
MOD_SUMO_rev_2	214	222	PF00179	0.401
MOD_SUMO_rev_2	322	331	PF00179	0.615
TRG_DiLeu_BaEn_1	36	41	PF01217	0.469
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.647
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.518
TRG_ENDOCYTIC_2	26	29	PF00928	0.538
TRG_ENDOCYTIC_2	42	45	PF00928	0.275
TRG_ENDOCYTIC_2	98	101	PF00928	0.450
TRG_ER_diArg_1	240	242	PF00400	0.462
TRG_ER_diArg_1	330	333	PF00400	0.641
TRG_ER_diArg_1	498	501	PF00400	0.467
TRG_ER_diArg_1	552	555	PF00400	0.537
TRG_NES_CRM1_1	290	301	PF08389	0.685
TRG_NLS_MonoExtC_3	328	333	PF00514	0.633
TRG_Pf-PMV_PEXEL_1	169	174	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML5	Leptomonas seymouri	42%	100%
A0A3S7WQ81	Leishmania donovani	99%	100%
A4H5A8	Leishmania braziliensis	66%	100%
E9AMB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QID3	Leishmania major	88%	100%