Isochorismatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Isochorismatase family - putative

Species:

Leishmania infantum

UniProt:

A4HTI2_LEIIN

TriTrypDb:

LINF_080008100

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 15
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTI2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.367
CLV_C14_Caspase3-7	292	296	PF00656	0.472
CLV_NRD_NRD_1	267	269	PF00675	0.493
CLV_PCSK_KEX2_1	267	269	PF00082	0.629
CLV_PCSK_SKI1_1	108	112	PF00082	0.306
CLV_PCSK_SKI1_1	238	242	PF00082	0.392
CLV_PCSK_SKI1_1	68	72	PF00082	0.335
DEG_Nend_UBRbox_1	1	4	PF02207	0.457
DEG_SCF_FBW7_1	37	44	PF00400	0.489
DOC_ANK_TNKS_1	266	273	PF00023	0.499
DOC_MAPK_gen_1	138	146	PF00069	0.302
DOC_MAPK_gen_1	238	246	PF00069	0.424
DOC_MAPK_MEF2A_6	238	246	PF00069	0.386
DOC_PP2B_PxIxI_1	241	247	PF00149	0.332
DOC_PP4_FxxP_1	239	242	PF00568	0.400
DOC_USP7_MATH_1	106	110	PF00917	0.425
DOC_USP7_MATH_1	17	21	PF00917	0.409
DOC_USP7_MATH_1	283	287	PF00917	0.518
DOC_WW_Pin1_4	10	15	PF00397	0.418
DOC_WW_Pin1_4	28	33	PF00397	0.394
DOC_WW_Pin1_4	37	42	PF00397	0.471
DOC_WW_Pin1_4	46	51	PF00397	0.453
LIG_14-3-3_CanoR_1	141	145	PF00244	0.313
LIG_14-3-3_CanoR_1	8	16	PF00244	0.425
LIG_FHA_1	185	191	PF00498	0.465
LIG_FHA_1	207	213	PF00498	0.472
LIG_FHA_1	4	10	PF00498	0.431
LIG_FHA_2	179	185	PF00498	0.525
LIG_FHA_2	231	237	PF00498	0.379
LIG_FHA_2	290	296	PF00498	0.483
LIG_LIR_Apic_2	236	242	PF02991	0.521
LIG_LIR_Nem_3	215	220	PF02991	0.577
LIG_Pex14_2	250	254	PF04695	0.358
LIG_SH2_STAT5	39	42	PF00017	0.492
LIG_SH3_3	44	50	PF00018	0.686
LIG_SH3_4	241	248	PF00018	0.437
LIG_UBA3_1	243	249	PF00899	0.404
MOD_CDK_SPxK_1	37	43	PF00069	0.488
MOD_CK1_1	49	55	PF00069	0.595
MOD_DYRK1A_RPxSP_1	46	50	PF00069	0.480
MOD_GlcNHglycan	19	22	PF01048	0.421
MOD_GlcNHglycan	226	229	PF01048	0.417
MOD_GlcNHglycan	285	288	PF01048	0.535
MOD_GlcNHglycan	301	304	PF01048	0.533
MOD_GlcNHglycan	54	57	PF01048	0.457
MOD_GSK3_1	220	227	PF00069	0.361
MOD_GSK3_1	28	35	PF00069	0.652
MOD_GSK3_1	283	290	PF00069	0.521
MOD_GSK3_1	37	44	PF00069	0.607
MOD_GSK3_1	46	53	PF00069	0.562
MOD_GSK3_1	79	86	PF00069	0.575
MOD_NEK2_1	206	211	PF00069	0.489
MOD_NEK2_1	212	217	PF00069	0.503
MOD_NEK2_1	220	225	PF00069	0.387
MOD_NEK2_1	230	235	PF00069	0.432
MOD_NEK2_1	288	293	PF00069	0.451
MOD_NEK2_2	106	111	PF00069	0.371
MOD_PIKK_1	198	204	PF00454	0.472
MOD_PIKK_1	254	260	PF00454	0.442
MOD_PIKK_1	30	36	PF00454	0.434
MOD_PIKK_1	41	47	PF00454	0.487
MOD_PKA_2	140	146	PF00069	0.311
MOD_Plk_1	106	112	PF00069	0.345
MOD_Plk_4	140	146	PF00069	0.393
MOD_ProDKin_1	10	16	PF00069	0.421
MOD_ProDKin_1	28	34	PF00069	0.398
MOD_ProDKin_1	37	43	PF00069	0.472
MOD_ProDKin_1	46	52	PF00069	0.450
TRG_DiLeu_BaEn_2	106	112	PF01217	0.328
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.409
TRG_ER_diArg_1	266	268	PF00400	0.484
TRG_NES_CRM1_1	184	197	PF08389	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P932	Leptomonas seymouri	38%	100%
A0A0N1I400	Leptomonas seymouri	56%	100%
A0A3S5H641	Leishmania donovani	37%	100%
A0A3S5H642	Leishmania donovani	46%	100%
A0A3S7WQ71	Leishmania donovani	99%	100%
A4H5A0	Leishmania braziliensis	40%	100%
A4H5A1	Leishmania braziliensis	67%	100%
A4H5A2	Leishmania braziliensis	47%	100%
A4HTI1	Leishmania infantum	37%	100%
A4HTI3	Leishmania infantum	46%	100%
E9AMA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AMB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9AMB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
G4YEI5	Phytophthora sojae (strain P6497)	26%	100%
Q4QID7	Leishmania major	46%	100%
Q4QID8	Leishmania major	79%	100%
Q4QID9	Leishmania major	38%	100%