Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTH8_LEIIN

TriTrypDb:

LINF_080007700

Length:

833

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	537	541	PF00656	0.573
CLV_C14_Caspase3-7	631	635	PF00656	0.707
CLV_MEL_PAP_1	158	164	PF00089	0.554
CLV_NRD_NRD_1	203	205	PF00675	0.676
CLV_NRD_NRD_1	350	352	PF00675	0.579
CLV_NRD_NRD_1	381	383	PF00675	0.727
CLV_NRD_NRD_1	389	391	PF00675	0.654
CLV_NRD_NRD_1	426	428	PF00675	0.697
CLV_NRD_NRD_1	526	528	PF00675	0.674
CLV_NRD_NRD_1	529	531	PF00675	0.660
CLV_NRD_NRD_1	554	556	PF00675	0.707
CLV_NRD_NRD_1	569	571	PF00675	0.541
CLV_NRD_NRD_1	691	693	PF00675	0.616
CLV_NRD_NRD_1	70	72	PF00675	0.562
CLV_NRD_NRD_1	773	775	PF00675	0.649
CLV_NRD_NRD_1	810	812	PF00675	0.729
CLV_NRD_NRD_1	92	94	PF00675	0.668
CLV_PCSK_FUR_1	564	568	PF00082	0.662
CLV_PCSK_FUR_1	90	94	PF00082	0.667
CLV_PCSK_KEX2_1	118	120	PF00082	0.702
CLV_PCSK_KEX2_1	203	205	PF00082	0.765
CLV_PCSK_KEX2_1	381	383	PF00082	0.724
CLV_PCSK_KEX2_1	389	391	PF00082	0.651
CLV_PCSK_KEX2_1	526	528	PF00082	0.674
CLV_PCSK_KEX2_1	554	556	PF00082	0.711
CLV_PCSK_KEX2_1	566	568	PF00082	0.566
CLV_PCSK_KEX2_1	569	571	PF00082	0.528
CLV_PCSK_KEX2_1	66	68	PF00082	0.592
CLV_PCSK_KEX2_1	773	775	PF00082	0.649
CLV_PCSK_KEX2_1	801	803	PF00082	0.696
CLV_PCSK_KEX2_1	810	812	PF00082	0.613
CLV_PCSK_KEX2_1	92	94	PF00082	0.668
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.675
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.597
CLV_PCSK_PC1ET2_1	801	803	PF00082	0.696
CLV_PCSK_PC7_1	564	570	PF00082	0.561
CLV_PCSK_SKI1_1	25	29	PF00082	0.583
CLV_PCSK_SKI1_1	390	394	PF00082	0.740
CLV_PCSK_SKI1_1	63	67	PF00082	0.589
CLV_PCSK_SKI1_1	746	750	PF00082	0.667
DEG_ODPH_VHL_1	332	344	PF01847	0.639
DEG_SCF_FBW7_1	435	442	PF00400	0.614
DEG_SPOP_SBC_1	120	124	PF00917	0.677
DEG_SPOP_SBC_1	392	396	PF00917	0.660
DEG_SPOP_SBC_1	738	742	PF00917	0.579
DOC_CKS1_1	728	733	PF01111	0.671
DOC_CYCLIN_yCln2_LP_2	749	755	PF00134	0.629
DOC_MAPK_gen_1	815	824	PF00069	0.637
DOC_MAPK_HePTP_8	743	755	PF00069	0.558
DOC_MAPK_MEF2A_6	746	755	PF00069	0.652
DOC_PP2B_LxvP_1	459	462	PF13499	0.731
DOC_PP2B_LxvP_1	749	752	PF13499	0.628
DOC_PP4_FxxP_1	255	258	PF00568	0.572
DOC_USP7_MATH_1	108	112	PF00917	0.641
DOC_USP7_MATH_1	120	124	PF00917	0.628
DOC_USP7_MATH_1	215	219	PF00917	0.593
DOC_USP7_MATH_1	238	242	PF00917	0.724
DOC_USP7_MATH_1	27	31	PF00917	0.579
DOC_USP7_MATH_1	274	278	PF00917	0.704
DOC_USP7_MATH_1	304	308	PF00917	0.749
DOC_USP7_MATH_1	334	338	PF00917	0.725
DOC_USP7_MATH_1	392	396	PF00917	0.744
DOC_USP7_MATH_1	446	450	PF00917	0.646
DOC_USP7_MATH_1	463	467	PF00917	0.572
DOC_USP7_MATH_1	507	511	PF00917	0.725
DOC_USP7_MATH_1	533	537	PF00917	0.654
DOC_USP7_MATH_1	685	689	PF00917	0.663
DOC_USP7_MATH_1	738	742	PF00917	0.608
DOC_USP7_MATH_1	788	792	PF00917	0.614
DOC_USP7_MATH_1	82	86	PF00917	0.774
DOC_USP7_MATH_1	99	103	PF00917	0.668
DOC_USP7_UBL2_3	79	83	PF12436	0.747
DOC_WW_Pin1_4	254	259	PF00397	0.718
DOC_WW_Pin1_4	326	331	PF00397	0.721
DOC_WW_Pin1_4	435	440	PF00397	0.722
DOC_WW_Pin1_4	468	473	PF00397	0.675
DOC_WW_Pin1_4	605	610	PF00397	0.670
DOC_WW_Pin1_4	636	641	PF00397	0.718
DOC_WW_Pin1_4	647	652	PF00397	0.620
DOC_WW_Pin1_4	659	664	PF00397	0.599
DOC_WW_Pin1_4	71	76	PF00397	0.713
DOC_WW_Pin1_4	727	732	PF00397	0.654
DOC_WW_Pin1_4	784	789	PF00397	0.642
LIG_14-3-3_CanoR_1	100	104	PF00244	0.644
LIG_14-3-3_CanoR_1	161	169	PF00244	0.585
LIG_14-3-3_CanoR_1	31	36	PF00244	0.512
LIG_14-3-3_CanoR_1	319	327	PF00244	0.688
LIG_14-3-3_CanoR_1	526	532	PF00244	0.604
LIG_14-3-3_CanoR_1	567	575	PF00244	0.725
LIG_14-3-3_CanoR_1	666	676	PF00244	0.667
LIG_14-3-3_CanoR_1	67	75	PF00244	0.643
LIG_14-3-3_CanoR_1	720	728	PF00244	0.659
LIG_14-3-3_CanoR_1	90	99	PF00244	0.737
LIG_14-3-3_CterR_2	831	833	PF00244	0.625
LIG_Actin_WH2_2	155	172	PF00022	0.639
LIG_BIR_II_1	1	5	PF00653	0.748
LIG_Clathr_ClatBox_1	454	458	PF01394	0.647
LIG_CtBP_PxDLS_1	827	831	PF00389	0.574
LIG_deltaCOP1_diTrp_1	765	768	PF00928	0.624
LIG_FHA_1	382	388	PF00498	0.700
LIG_FHA_1	408	414	PF00498	0.706
LIG_FHA_1	450	456	PF00498	0.695
LIG_FHA_1	669	675	PF00498	0.687
LIG_FHA_1	692	698	PF00498	0.699
LIG_FHA_1	738	744	PF00498	0.576
LIG_FHA_2	122	128	PF00498	0.721
LIG_FHA_2	175	181	PF00498	0.597
LIG_FHA_2	535	541	PF00498	0.636
LIG_FHA_2	591	597	PF00498	0.686
LIG_IRF3_LxIS_1	827	833	PF10401	0.630
LIG_LIR_Apic_2	252	258	PF02991	0.568
LIG_LIR_Gen_1	337	347	PF02991	0.684
LIG_LIR_Gen_1	758	768	PF02991	0.610
LIG_LIR_Nem_3	335	341	PF02991	0.668
LIG_LIR_Nem_3	581	585	PF02991	0.659
LIG_LIR_Nem_3	758	764	PF02991	0.632
LIG_LYPXL_S_1	749	753	PF13949	0.629
LIG_LYPXL_yS_3	750	753	PF13949	0.629
LIG_MYND_1	330	334	PF01753	0.613
LIG_PCNA_PIPBox_1	285	294	PF02747	0.510
LIG_PCNA_yPIPBox_3	285	298	PF02747	0.514
LIG_Pex14_1	578	582	PF04695	0.646
LIG_PTB_Apo_2	337	344	PF02174	0.611
LIG_PTB_Phospho_1	337	343	PF10480	0.608
LIG_SH2_CRK	339	343	PF00017	0.680
LIG_SH2_CRK	585	589	PF00017	0.660
LIG_SH2_GRB2like	338	341	PF00017	0.607
LIG_SH2_GRB2like	585	588	PF00017	0.662
LIG_SH2_NCK_1	339	343	PF00017	0.613
LIG_SH2_NCK_1	585	589	PF00017	0.660
LIG_SH2_NCK_1	761	765	PF00017	0.671
LIG_SH2_PTP2	292	295	PF00017	0.521
LIG_SH2_SRC	585	588	PF00017	0.662
LIG_SH2_STAT5	131	134	PF00017	0.618
LIG_SH2_STAT5	292	295	PF00017	0.521
LIG_SH2_STAT5	343	346	PF00017	0.697
LIG_SH2_STAT5	412	415	PF00017	0.697
LIG_SH3_1	427	433	PF00018	0.700
LIG_SH3_3	193	199	PF00018	0.670
LIG_SH3_3	423	429	PF00018	0.683
LIG_SH3_3	529	535	PF00018	0.590
LIG_SH3_3	595	601	PF00018	0.623
LIG_SH3_3	657	663	PF00018	0.694
LIG_SH3_3	711	717	PF00018	0.699
LIG_SH3_3	81	87	PF00018	0.694
LIG_SUMO_SIM_par_1	38	43	PF11976	0.571
LIG_SUMO_SIM_par_1	404	411	PF11976	0.683
LIG_SUMO_SIM_par_1	669	678	PF11976	0.687
LIG_TRAF2_1	123	126	PF00917	0.699
LIG_TRAF2_1	283	286	PF00917	0.598
LIG_TRAF2_2	295	300	PF00917	0.622
MOD_CDK_SPK_2	468	473	PF00069	0.602
MOD_CDK_SPK_2	647	652	PF00069	0.689
MOD_CDK_SPK_2	71	76	PF00069	0.633
MOD_CDK_SPxxK_3	659	666	PF00069	0.616
MOD_CK1_1	102	108	PF00069	0.698
MOD_CK1_1	129	135	PF00069	0.735
MOD_CK1_1	15	21	PF00069	0.519
MOD_CK1_1	2	8	PF00069	0.715
MOD_CK1_1	241	247	PF00069	0.836
MOD_CK1_1	254	260	PF00069	0.581
MOD_CK1_1	277	283	PF00069	0.756
MOD_CK1_1	356	362	PF00069	0.714
MOD_CK1_1	364	370	PF00069	0.659
MOD_CK1_1	449	455	PF00069	0.580
MOD_CK1_1	492	498	PF00069	0.664
MOD_CK1_1	510	516	PF00069	0.558
MOD_CK1_1	620	626	PF00069	0.677
MOD_CK1_1	687	693	PF00069	0.649
MOD_CK1_1	704	710	PF00069	0.629
MOD_CK1_1	741	747	PF00069	0.672
MOD_CK2_1	119	125	PF00069	0.703
MOD_CK2_1	685	691	PF00069	0.659
MOD_GlcNHglycan	1	4	PF01048	0.753
MOD_GlcNHglycan	101	104	PF01048	0.751
MOD_GlcNHglycan	110	113	PF01048	0.637
MOD_GlcNHglycan	244	247	PF01048	0.754
MOD_GlcNHglycan	355	358	PF01048	0.752
MOD_GlcNHglycan	44	47	PF01048	0.594
MOD_GlcNHglycan	448	451	PF01048	0.693
MOD_GlcNHglycan	465	468	PF01048	0.573
MOD_GlcNHglycan	512	515	PF01048	0.687
MOD_GlcNHglycan	620	623	PF01048	0.704
MOD_GlcNHglycan	706	709	PF01048	0.601
MOD_GlcNHglycan	732	735	PF01048	0.674
MOD_GlcNHglycan	781	784	PF01048	0.705
MOD_GlcNHglycan	790	793	PF01048	0.590
MOD_GSK3_1	121	128	PF00069	0.621
MOD_GSK3_1	238	245	PF00069	0.777
MOD_GSK3_1	254	261	PF00069	0.662
MOD_GSK3_1	27	34	PF00069	0.559
MOD_GSK3_1	390	397	PF00069	0.730
MOD_GSK3_1	435	442	PF00069	0.614
MOD_GSK3_1	499	506	PF00069	0.662
MOD_GSK3_1	521	528	PF00069	0.607
MOD_GSK3_1	600	607	PF00069	0.649
MOD_GSK3_1	614	621	PF00069	0.584
MOD_GSK3_1	66	73	PF00069	0.640
MOD_GSK3_1	666	673	PF00069	0.618
MOD_GSK3_1	680	687	PF00069	0.595
MOD_GSK3_1	691	698	PF00069	0.613
MOD_GSK3_1	737	744	PF00069	0.601
MOD_GSK3_1	784	791	PF00069	0.600
MOD_GSK3_1	82	89	PF00069	0.606
MOD_N-GLC_1	241	246	PF02516	0.747
MOD_N-GLC_1	419	424	PF02516	0.562
MOD_N-GLC_1	468	473	PF02516	0.750
MOD_N-GLC_1	704	709	PF02516	0.687
MOD_NEK2_1	35	40	PF00069	0.589
MOD_NEK2_1	353	358	PF00069	0.638
MOD_NEK2_1	407	412	PF00069	0.708
MOD_NEK2_1	479	484	PF00069	0.675
MOD_NEK2_1	491	496	PF00069	0.598
MOD_NEK2_1	675	680	PF00069	0.736
MOD_NEK2_1	701	706	PF00069	0.580
MOD_NEK2_1	718	723	PF00069	0.569
MOD_NEK2_2	165	170	PF00069	0.649
MOD_PIKK_1	160	166	PF00454	0.569
MOD_PIKK_1	215	221	PF00454	0.627
MOD_PIKK_1	274	280	PF00454	0.632
MOD_PIKK_1	318	324	PF00454	0.686
MOD_PIKK_1	40	46	PF00454	0.576
MOD_PIKK_1	521	527	PF00454	0.675
MOD_PIKK_1	642	648	PF00454	0.699
MOD_PIKK_1	66	72	PF00454	0.617
MOD_PIKK_1	82	88	PF00454	0.548
MOD_PK_1	546	552	PF00069	0.583
MOD_PK_1	569	575	PF00069	0.632
MOD_PKA_1	381	387	PF00069	0.728
MOD_PKA_1	568	574	PF00069	0.630
MOD_PKA_1	66	72	PF00069	0.617
MOD_PKA_2	129	135	PF00069	0.569
MOD_PKA_2	15	21	PF00069	0.657
MOD_PKA_2	160	166	PF00069	0.586
MOD_PKA_2	318	324	PF00069	0.695
MOD_PKA_2	381	387	PF00069	0.755
MOD_PKA_2	497	503	PF00069	0.734
MOD_PKA_2	525	531	PF00069	0.607
MOD_PKA_2	568	574	PF00069	0.685
MOD_PKA_2	66	72	PF00069	0.617
MOD_PKA_2	691	697	PF00069	0.613
MOD_PKA_2	719	725	PF00069	0.618
MOD_PKA_2	91	97	PF00069	0.786
MOD_PKA_2	99	105	PF00069	0.684
MOD_PKB_1	566	574	PF00069	0.669
MOD_Plk_1	126	132	PF00069	0.550
MOD_Plk_1	304	310	PF00069	0.598
MOD_Plk_1	334	340	PF00069	0.630
MOD_Plk_1	361	367	PF00069	0.609
MOD_Plk_2-3	121	127	PF00069	0.698
MOD_Plk_4	251	257	PF00069	0.569
MOD_Plk_4	35	41	PF00069	0.523
MOD_Plk_4	408	414	PF00069	0.706
MOD_Plk_4	569	575	PF00069	0.686
MOD_Plk_4	670	676	PF00069	0.682
MOD_Plk_4	790	796	PF00069	0.650
MOD_ProDKin_1	254	260	PF00069	0.718
MOD_ProDKin_1	326	332	PF00069	0.716
MOD_ProDKin_1	435	441	PF00069	0.721
MOD_ProDKin_1	468	474	PF00069	0.677
MOD_ProDKin_1	605	611	PF00069	0.671
MOD_ProDKin_1	636	642	PF00069	0.721
MOD_ProDKin_1	647	653	PF00069	0.618
MOD_ProDKin_1	659	665	PF00069	0.596
MOD_ProDKin_1	71	77	PF00069	0.716
MOD_ProDKin_1	727	733	PF00069	0.653
MOD_ProDKin_1	784	790	PF00069	0.636
MOD_SUMO_rev_2	497	504	PF00179	0.597
MOD_SUMO_rev_2	523	533	PF00179	0.604
MOD_SUMO_rev_2	687	694	PF00179	0.655
TRG_ENDOCYTIC_2	338	341	PF00928	0.674
TRG_ENDOCYTIC_2	750	753	PF00928	0.695
TRG_ENDOCYTIC_2	761	764	PF00928	0.558
TRG_ER_diArg_1	202	204	PF00400	0.678
TRG_ER_diArg_1	381	383	PF00400	0.721
TRG_ER_diArg_1	388	390	PF00400	0.659
TRG_ER_diArg_1	553	555	PF00400	0.715
TRG_ER_diArg_1	564	567	PF00400	0.544
TRG_ER_diArg_1	568	570	PF00400	0.534
TRG_ER_diArg_1	676	679	PF00400	0.684
TRG_ER_diArg_1	810	812	PF00400	0.695
TRG_ER_diArg_1	90	93	PF00400	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H639	Leishmania donovani	99%	100%
A4H594	Leishmania braziliensis	46%	96%
E9AMA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	97%
Q4QIE2	Leishmania major	82%	97%