Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTH2_LEIIN

TriTrypDb:

LINF_080007100

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.646
CLV_C14_Caspase3-7	319	323	PF00656	0.624
CLV_NRD_NRD_1	178	180	PF00675	0.770
CLV_NRD_NRD_1	191	193	PF00675	0.578
CLV_NRD_NRD_1	298	300	PF00675	0.729
CLV_NRD_NRD_1	412	414	PF00675	0.545
CLV_NRD_NRD_1	5	7	PF00675	0.646
CLV_PCSK_FUR_1	295	299	PF00082	0.579
CLV_PCSK_FUR_1	410	414	PF00082	0.592
CLV_PCSK_KEX2_1	117	119	PF00082	0.710
CLV_PCSK_KEX2_1	178	180	PF00082	0.779
CLV_PCSK_KEX2_1	191	193	PF00082	0.548
CLV_PCSK_KEX2_1	297	299	PF00082	0.750
CLV_PCSK_KEX2_1	4	6	PF00082	0.651
CLV_PCSK_KEX2_1	412	414	PF00082	0.545
CLV_PCSK_KEX2_1	460	462	PF00082	0.636
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.686
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.636
CLV_PCSK_SKI1_1	151	155	PF00082	0.574
CLV_PCSK_SKI1_1	184	188	PF00082	0.691
DEG_SPOP_SBC_1	286	290	PF00917	0.666
DOC_ANK_TNKS_1	104	111	PF00023	0.647
DOC_MAPK_gen_1	410	420	PF00069	0.590
DOC_MAPK_MEF2A_6	243	250	PF00069	0.680
DOC_PP2B_LxvP_1	269	272	PF13499	0.673
DOC_PP2B_LxvP_1	355	358	PF13499	0.725
DOC_PP4_FxxP_1	251	254	PF00568	0.618
DOC_USP7_MATH_1	15	19	PF00917	0.658
DOC_USP7_MATH_1	263	267	PF00917	0.680
DOC_USP7_MATH_1	286	290	PF00917	0.700
DOC_USP7_MATH_1	363	367	PF00917	0.613
DOC_USP7_MATH_1	39	43	PF00917	0.681
DOC_USP7_MATH_1	429	433	PF00917	0.703
DOC_USP7_MATH_1	44	48	PF00917	0.673
DOC_USP7_MATH_1	54	58	PF00917	0.604
DOC_WW_Pin1_4	216	221	PF00397	0.659
DOC_WW_Pin1_4	264	269	PF00397	0.745
DOC_WW_Pin1_4	271	276	PF00397	0.631
DOC_WW_Pin1_4	446	451	PF00397	0.562
LIG_14-3-3_CanoR_1	170	176	PF00244	0.606
LIG_14-3-3_CanoR_1	287	292	PF00244	0.669
LIG_14-3-3_CanoR_1	394	402	PF00244	0.569
LIG_14-3-3_CanoR_1	434	443	PF00244	0.521
LIG_ActinCP_TwfCPI_2	251	258	PF01115	0.625
LIG_APCC_ABBA_1	120	125	PF00400	0.704
LIG_BIR_III_2	217	221	PF00653	0.610
LIG_BIR_III_2	262	266	PF00653	0.647
LIG_BRCT_BRCA1_1	438	442	PF00533	0.706
LIG_deltaCOP1_diTrp_1	158	162	PF00928	0.587
LIG_FHA_1	27	33	PF00498	0.719
LIG_FHA_2	171	177	PF00498	0.689
LIG_FHA_2	465	471	PF00498	0.660
LIG_Integrin_RGD_1	107	109	PF01839	0.669
LIG_Integrin_RGD_1	192	194	PF01839	0.621
LIG_LIR_Apic_2	31	36	PF02991	0.675
LIG_LIR_Apic_2	403	409	PF02991	0.601
LIG_LIR_Gen_1	439	450	PF02991	0.577
LIG_LIR_Nem_3	439	445	PF02991	0.635
LIG_MYND_1	268	272	PF01753	0.670
LIG_Pex14_2	442	446	PF04695	0.628
LIG_PTAP_UEV_1	93	98	PF05743	0.686
LIG_SH2_CRK	33	37	PF00017	0.623
LIG_SH2_SRC	406	409	PF00017	0.617
LIG_SH2_STAT5	119	122	PF00017	0.763
LIG_SH2_STAT5	406	409	PF00017	0.617
LIG_SH3_1	33	39	PF00018	0.617
LIG_SH3_3	138	144	PF00018	0.694
LIG_SH3_3	262	268	PF00018	0.658
LIG_SH3_3	269	275	PF00018	0.616
LIG_SH3_3	33	39	PF00018	0.617
LIG_SH3_3	448	454	PF00018	0.611
LIG_SH3_3	471	477	PF00018	0.527
LIG_SH3_3	493	499	PF00018	0.568
LIG_SH3_3	91	97	PF00018	0.805
LIG_SUMO_SIM_par_1	266	274	PF11976	0.711
LIG_TRAF2_1	122	125	PF00917	0.701
LIG_TRAF2_1	56	59	PF00917	0.725
LIG_TRAF2_1	83	86	PF00917	0.665
LIG_TRFH_1	405	409	PF08558	0.620
LIG_WW_3	1	5	PF00397	0.657
LIG_WW_3	143	147	PF00397	0.675
MOD_CK1_1	101	107	PF00069	0.659
MOD_CK1_1	274	280	PF00069	0.701
MOD_CK1_1	281	287	PF00069	0.629
MOD_CK1_1	346	352	PF00069	0.694
MOD_CK1_1	432	438	PF00069	0.670
MOD_CK1_1	449	455	PF00069	0.489
MOD_CK2_1	298	304	PF00069	0.779
MOD_CK2_1	314	320	PF00069	0.496
MOD_CK2_1	52	58	PF00069	0.704
MOD_Cter_Amidation	176	179	PF01082	0.703
MOD_DYRK1A_RPxSP_1	264	268	PF00069	0.642
MOD_GlcNHglycan	100	103	PF01048	0.680
MOD_GlcNHglycan	124	130	PF01048	0.635
MOD_GlcNHglycan	162	165	PF01048	0.713
MOD_GlcNHglycan	282	286	PF01048	0.728
MOD_GlcNHglycan	300	303	PF01048	0.742
MOD_GlcNHglycan	316	319	PF01048	0.626
MOD_GlcNHglycan	345	348	PF01048	0.691
MOD_GlcNHglycan	350	353	PF01048	0.671
MOD_GlcNHglycan	366	369	PF01048	0.534
MOD_GlcNHglycan	427	430	PF01048	0.736
MOD_GlcNHglycan	54	57	PF01048	0.707
MOD_GlcNHglycan	78	81	PF01048	0.666
MOD_GSK3_1	270	277	PF00069	0.797
MOD_GSK3_1	281	288	PF00069	0.656
MOD_GSK3_1	309	316	PF00069	0.743
MOD_GSK3_1	381	388	PF00069	0.806
MOD_GSK3_1	389	396	PF00069	0.626
MOD_GSK3_1	425	432	PF00069	0.782
MOD_GSK3_1	433	440	PF00069	0.671
MOD_LATS_1	182	188	PF00433	0.593
MOD_N-GLC_1	278	283	PF02516	0.681
MOD_NEK2_1	309	314	PF00069	0.702
MOD_NEK2_1	425	430	PF00069	0.764
MOD_NEK2_2	112	117	PF00069	0.659
MOD_NEK2_2	28	33	PF00069	0.718
MOD_PKA_1	298	304	PF00069	0.721
MOD_PKA_2	194	200	PF00069	0.644
MOD_PKA_2	263	269	PF00069	0.651
MOD_PKA_2	286	292	PF00069	0.736
MOD_PKA_2	298	304	PF00069	0.641
MOD_PKA_2	309	315	PF00069	0.561
MOD_PKA_2	393	399	PF00069	0.738
MOD_PKA_2	400	406	PF00069	0.637
MOD_PKA_2	433	439	PF00069	0.554
MOD_Plk_1	304	310	PF00069	0.607
MOD_Plk_4	304	310	PF00069	0.607
MOD_Plk_4	330	336	PF00069	0.643
MOD_Plk_4	437	443	PF00069	0.514
MOD_ProDKin_1	216	222	PF00069	0.660
MOD_ProDKin_1	264	270	PF00069	0.745
MOD_ProDKin_1	271	277	PF00069	0.630
MOD_ProDKin_1	446	452	PF00069	0.567
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.664
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.635
TRG_ER_diArg_1	295	298	PF00400	0.756
TRG_ER_diArg_1	3	6	PF00400	0.651
TRG_ER_diArg_1	411	413	PF00400	0.579
TRG_NLS_MonoExtC_3	211	217	PF00514	0.674
TRG_NLS_MonoExtN_4	210	216	PF00514	0.681
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	359	364	PF00026	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H635	Leishmania donovani	99%	100%
A4H588	Leishmania braziliensis	51%	100%
E9AMA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QIE8	Leishmania major	87%	100%