LeishMANIAdb
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Inositol phosphosphingolipid phospholipase C-Like

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Inositol phosphosphingolipid phospholipase C-Like
Gene product:
inositol phosphosphingolipid phospholipase C-Like
Species:
Leishmania infantum
UniProt:
A4HTH1_LEIIN
TriTrypDb:
LINF_080007000
Length:
653

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, Inositol phosphosphingolipid phospholipase C-Like ISCL

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0005783 endoplasmic reticulum 5 1
GO:0016020 membrane 2 5
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0071944 cell periphery 2 1
GO:0110165 cellular anatomical entity 1 5

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HTH1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTH1

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 1
GO:0006643 membrane lipid metabolic process 4 1
GO:0006644 phospholipid metabolic process 4 1
GO:0006665 sphingolipid metabolic process 4 1
GO:0006672 ceramide metabolic process 4 1
GO:0006684 sphingomyelin metabolic process 4 1
GO:0006685 sphingomyelin catabolic process 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0008610 lipid biosynthetic process 4 1
GO:0009056 catabolic process 2 1
GO:0009058 biosynthetic process 2 1
GO:0009268 response to pH 3 1
GO:0009395 phospholipid catabolic process 5 1
GO:0009628 response to abiotic stimulus 2 1
GO:0009987 cellular process 1 1
GO:0010447 response to acidic pH 4 1
GO:0016042 lipid catabolic process 4 1
GO:0019637 organophosphate metabolic process 3 1
GO:0030148 sphingolipid biosynthetic process 5 1
GO:0030149 sphingolipid catabolic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043603 amide metabolic process 3 1
GO:0043604 amide biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044242 cellular lipid catabolic process 4 1
GO:0044248 cellular catabolic process 3 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0046434 organophosphate catabolic process 4 1
GO:0046466 membrane lipid catabolic process 5 1
GO:0046467 membrane lipid biosynthetic process 4 1
GO:0046513 ceramide biosynthetic process 5 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
GO:0071214 cellular response to abiotic stimulus 3 1
GO:0071467 cellular response to pH 4 1
GO:0071468 cellular response to acidic pH 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0104004 cellular response to environmental stimulus 3 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901575 organic substance catabolic process 3 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004620 phospholipase activity 5 11
GO:0004767 sphingomyelin phosphodiesterase activity 6 11
GO:0008081 phosphoric diester hydrolase activity 5 11
GO:0016298 lipase activity 4 11
GO:0016787 hydrolase activity 2 11
GO:0016788 hydrolase activity, acting on ester bonds 3 11
GO:0042578 phosphoric ester hydrolase activity 4 11
GO:0003676 nucleic acid binding 3 3
GO:0003743 translation initiation factor activity 4 3
GO:0005488 binding 1 3
GO:0008135 translation factor activity, RNA binding 3 3
GO:0045182 translation regulator activity 1 3
GO:0090079 translation regulator activity, nucleic acid binding 2 3
GO:0097159 organic cyclic compound binding 2 3
GO:1901363 heterocyclic compound binding 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 252 256 PF00656 0.206
CLV_C14_Caspase3-7 300 304 PF00656 0.356
CLV_NRD_NRD_1 360 362 PF00675 0.671
CLV_NRD_NRD_1 467 469 PF00675 0.449
CLV_NRD_NRD_1 76 78 PF00675 0.505
CLV_PCSK_KEX2_1 166 168 PF00082 0.467
CLV_PCSK_KEX2_1 218 220 PF00082 0.540
CLV_PCSK_KEX2_1 344 346 PF00082 0.685
CLV_PCSK_KEX2_1 467 469 PF00082 0.449
CLV_PCSK_KEX2_1 579 581 PF00082 0.531
CLV_PCSK_KEX2_1 76 78 PF00082 0.474
CLV_PCSK_PC1ET2_1 166 168 PF00082 0.421
CLV_PCSK_PC1ET2_1 218 220 PF00082 0.526
CLV_PCSK_PC1ET2_1 344 346 PF00082 0.685
CLV_PCSK_PC1ET2_1 579 581 PF00082 0.531
CLV_PCSK_SKI1_1 15 19 PF00082 0.521
CLV_PCSK_SKI1_1 249 253 PF00082 0.577
CLV_PCSK_SKI1_1 268 272 PF00082 0.393
CLV_PCSK_SKI1_1 287 291 PF00082 0.524
CLV_PCSK_SKI1_1 579 583 PF00082 0.526
DEG_SPOP_SBC_1 398 402 PF00917 0.421
DOC_CYCLIN_RxL_1 166 176 PF00134 0.267
DOC_CYCLIN_RxL_1 263 275 PF00134 0.336
DOC_MAPK_gen_1 166 173 PF00069 0.309
DOC_MAPK_gen_1 28 36 PF00069 0.286
DOC_MAPK_MEF2A_6 121 130 PF00069 0.244
DOC_PP1_RVXF_1 13 20 PF00149 0.349
DOC_PP2B_LxvP_1 228 231 PF13499 0.327
DOC_PP4_FxxP_1 285 288 PF00568 0.337
DOC_USP7_MATH_1 548 552 PF00917 0.766
DOC_USP7_MATH_1 559 563 PF00917 0.800
DOC_USP7_MATH_1 611 615 PF00917 0.565
DOC_USP7_UBL2_3 358 362 PF12436 0.576
DOC_WW_Pin1_4 405 410 PF00397 0.502
DOC_WW_Pin1_4 417 422 PF00397 0.423
DOC_WW_Pin1_4 534 539 PF00397 0.662
DOC_WW_Pin1_4 544 549 PF00397 0.674
DOC_WW_Pin1_4 581 586 PF00397 0.703
DOC_WW_Pin1_4 63 68 PF00397 0.267
LIG_14-3-3_CanoR_1 15 20 PF00244 0.340
LIG_14-3-3_CanoR_1 174 181 PF00244 0.244
LIG_14-3-3_CanoR_1 249 254 PF00244 0.259
LIG_14-3-3_CanoR_1 425 431 PF00244 0.410
LIG_14-3-3_CanoR_1 580 585 PF00244 0.799
LIG_14-3-3_CanoR_1 71 76 PF00244 0.355
LIG_14-3-3_CanoR_1 77 83 PF00244 0.343
LIG_14-3-3_CanoR_1 92 100 PF00244 0.324
LIG_Actin_WH2_2 220 237 PF00022 0.267
LIG_ActinCP_TwfCPI_2 285 293 PF01115 0.221
LIG_APCC_ABBA_1 111 116 PF00400 0.324
LIG_APCC_Cbox_1 168 174 PF00515 0.324
LIG_BIR_II_1 1 5 PF00653 0.455
LIG_BRCT_BRCA1_1 255 259 PF00533 0.203
LIG_BRCT_BRCA1_1 381 385 PF00533 0.332
LIG_BRCT_BRCA1_1 613 617 PF00533 0.433
LIG_BRCT_BRCA1_1 95 99 PF00533 0.256
LIG_Clathr_ClatBox_1 269 273 PF01394 0.337
LIG_EH1_1 384 392 PF00400 0.358
LIG_FHA_1 100 106 PF00498 0.228
LIG_FHA_1 147 153 PF00498 0.248
LIG_FHA_1 16 22 PF00498 0.252
LIG_FHA_1 190 196 PF00498 0.259
LIG_FHA_1 351 357 PF00498 0.558
LIG_FHA_1 400 406 PF00498 0.512
LIG_FHA_1 412 418 PF00498 0.339
LIG_FHA_1 493 499 PF00498 0.718
LIG_FHA_1 524 530 PF00498 0.626
LIG_FHA_1 618 624 PF00498 0.411
LIG_FHA_2 131 137 PF00498 0.267
LIG_FHA_2 250 256 PF00498 0.233
LIG_FHA_2 318 324 PF00498 0.370
LIG_FHA_2 37 43 PF00498 0.304
LIG_FHA_2 418 424 PF00498 0.336
LIG_FHA_2 427 433 PF00498 0.275
LIG_FHA_2 489 495 PF00498 0.544
LIG_LIR_Gen_1 180 186 PF02991 0.287
LIG_LIR_Gen_1 256 267 PF02991 0.334
LIG_LIR_Gen_1 335 341 PF02991 0.446
LIG_LIR_Gen_1 42 49 PF02991 0.324
LIG_LIR_Gen_1 447 458 PF02991 0.341
LIG_LIR_Gen_1 56 65 PF02991 0.256
LIG_LIR_Nem_3 168 173 PF02991 0.242
LIG_LIR_Nem_3 180 184 PF02991 0.298
LIG_LIR_Nem_3 264 270 PF02991 0.330
LIG_LIR_Nem_3 335 340 PF02991 0.466
LIG_LIR_Nem_3 42 47 PF02991 0.324
LIG_LIR_Nem_3 447 453 PF02991 0.341
LIG_LIR_Nem_3 56 61 PF02991 0.256
LIG_LIR_Nem_3 594 598 PF02991 0.567
LIG_LIR_Nem_3 72 78 PF02991 0.199
LIG_LYPXL_yS_3 108 111 PF13949 0.319
LIG_Pex14_2 58 62 PF04695 0.378
LIG_Pex14_2 78 82 PF04695 0.188
LIG_Pex14_2 99 103 PF04695 0.304
LIG_REV1ctd_RIR_1 115 125 PF16727 0.337
LIG_REV1ctd_RIR_1 282 287 PF16727 0.267
LIG_SH2_CRK 44 48 PF00017 0.244
LIG_SH2_CRK 450 454 PF00017 0.367
LIG_SH2_NCK_1 156 160 PF00017 0.267
LIG_SH2_NCK_1 485 489 PF00017 0.554
LIG_SH2_STAP1 148 152 PF00017 0.253
LIG_SH2_STAP1 44 48 PF00017 0.244
LIG_SH2_STAP1 485 489 PF00017 0.591
LIG_SH2_STAP1 608 612 PF00017 0.658
LIG_SH2_STAT5 148 151 PF00017 0.300
LIG_SH2_STAT5 170 173 PF00017 0.228
LIG_SH2_STAT5 266 269 PF00017 0.373
LIG_SH2_STAT5 437 440 PF00017 0.342
LIG_SH2_STAT5 73 76 PF00017 0.254
LIG_SH3_3 125 131 PF00018 0.308
LIG_SH3_3 224 230 PF00018 0.263
LIG_SH3_3 321 327 PF00018 0.343
LIG_SH3_3 495 501 PF00018 0.702
LIG_SH3_3 555 561 PF00018 0.786
LIG_SH3_4 358 365 PF00018 0.405
LIG_Sin3_3 454 461 PF02671 0.225
LIG_SUMO_SIM_anti_2 45 51 PF11976 0.244
LIG_SUMO_SIM_anti_2 455 460 PF11976 0.434
LIG_SUMO_SIM_par_1 149 157 PF11976 0.323
LIG_SUMO_SIM_par_1 45 51 PF11976 0.244
LIG_TRAF2_1 240 243 PF00917 0.249
LIG_TRAF2_1 471 474 PF00917 0.598
LIG_TYR_ITSM 446 453 PF00017 0.319
LIG_UBA3_1 212 218 PF00899 0.301
LIG_UBA3_1 390 397 PF00899 0.306
LIG_WRC_WIRS_1 16 21 PF05994 0.259
LIG_WW_3 229 233 PF00397 0.324
MOD_CK1_1 160 166 PF00069 0.324
MOD_CK1_1 189 195 PF00069 0.263
MOD_CK1_1 2 8 PF00069 0.429
MOD_CK1_1 204 210 PF00069 0.314
MOD_CK1_1 261 267 PF00069 0.369
MOD_CK1_1 408 414 PF00069 0.506
MOD_CK1_1 531 537 PF00069 0.662
MOD_CK2_1 317 323 PF00069 0.406
MOD_CK2_1 36 42 PF00069 0.332
MOD_CK2_1 362 368 PF00069 0.488
MOD_CK2_1 404 410 PF00069 0.495
MOD_CK2_1 417 423 PF00069 0.338
MOD_CK2_1 467 473 PF00069 0.631
MOD_CK2_1 580 586 PF00069 0.692
MOD_Cter_Amidation 342 345 PF01082 0.680
MOD_Cter_Amidation 359 362 PF01082 0.569
MOD_GlcNHglycan 135 140 PF01048 0.511
MOD_GlcNHglycan 329 332 PF01048 0.734
MOD_GlcNHglycan 370 373 PF01048 0.747
MOD_GlcNHglycan 469 472 PF01048 0.480
MOD_GlcNHglycan 476 479 PF01048 0.464
MOD_GlcNHglycan 609 612 PF01048 0.414
MOD_GlcNHglycan 614 617 PF01048 0.331
MOD_GlcNHglycan 84 87 PF01048 0.444
MOD_GSK3_1 143 150 PF00069 0.291
MOD_GSK3_1 157 164 PF00069 0.239
MOD_GSK3_1 173 180 PF00069 0.260
MOD_GSK3_1 185 192 PF00069 0.268
MOD_GSK3_1 249 256 PF00069 0.263
MOD_GSK3_1 258 265 PF00069 0.297
MOD_GSK3_1 360 367 PF00069 0.498
MOD_GSK3_1 404 411 PF00069 0.530
MOD_GSK3_1 440 447 PF00069 0.396
MOD_GSK3_1 488 495 PF00069 0.589
MOD_GSK3_1 544 551 PF00069 0.726
MOD_GSK3_1 565 572 PF00069 0.752
MOD_GSK3_1 607 614 PF00069 0.628
MOD_GSK3_1 78 85 PF00069 0.344
MOD_N-GLC_1 201 206 PF02516 0.457
MOD_N-GLC_1 350 355 PF02516 0.757
MOD_N-GLC_1 617 622 PF02516 0.315
MOD_NEK2_1 147 152 PF00069 0.267
MOD_NEK2_1 173 178 PF00069 0.324
MOD_NEK2_1 184 189 PF00069 0.299
MOD_NEK2_1 201 206 PF00069 0.257
MOD_NEK2_1 262 267 PF00069 0.311
MOD_NEK2_1 404 409 PF00069 0.483
MOD_NEK2_1 607 612 PF00069 0.657
MOD_NEK2_1 617 622 PF00069 0.423
MOD_NEK2_1 78 83 PF00069 0.314
MOD_NEK2_1 99 104 PF00069 0.304
MOD_NEK2_2 504 509 PF00069 0.623
MOD_NEK2_2 523 528 PF00069 0.496
MOD_PIKK_1 157 163 PF00454 0.300
MOD_PIKK_1 173 179 PF00454 0.244
MOD_PIKK_1 201 207 PF00454 0.257
MOD_PIKK_1 275 281 PF00454 0.324
MOD_PIKK_1 440 446 PF00454 0.389
MOD_PIKK_1 93 99 PF00454 0.249
MOD_PKA_1 467 473 PF00069 0.580
MOD_PKA_1 579 585 PF00069 0.728
MOD_PKA_2 173 179 PF00069 0.244
MOD_PKA_2 189 195 PF00069 0.337
MOD_PKA_2 360 366 PF00069 0.524
MOD_PKA_2 467 473 PF00069 0.582
MOD_PKA_2 492 498 PF00069 0.663
MOD_PKA_2 579 585 PF00069 0.728
MOD_Plk_1 143 149 PF00069 0.273
MOD_Plk_2-3 51 57 PF00069 0.248
MOD_Plk_4 143 149 PF00069 0.300
MOD_Plk_4 223 229 PF00069 0.284
MOD_Plk_4 262 268 PF00069 0.331
MOD_Plk_4 426 432 PF00069 0.352
MOD_Plk_4 78 84 PF00069 0.346
MOD_ProDKin_1 405 411 PF00069 0.502
MOD_ProDKin_1 417 423 PF00069 0.416
MOD_ProDKin_1 534 540 PF00069 0.666
MOD_ProDKin_1 544 550 PF00069 0.672
MOD_ProDKin_1 581 587 PF00069 0.703
MOD_ProDKin_1 63 69 PF00069 0.267
MOD_SUMO_for_1 270 273 PF00179 0.324
MOD_SUMO_for_1 471 474 PF00179 0.630
TRG_DiLeu_BaEn_1 56 61 PF01217 0.337
TRG_ENDOCYTIC_2 108 111 PF00928 0.319
TRG_ENDOCYTIC_2 156 159 PF00928 0.313
TRG_ENDOCYTIC_2 170 173 PF00928 0.241
TRG_ENDOCYTIC_2 266 269 PF00928 0.317
TRG_ENDOCYTIC_2 378 381 PF00928 0.360
TRG_ENDOCYTIC_2 44 47 PF00928 0.244
TRG_ENDOCYTIC_2 450 453 PF00928 0.355
TRG_ER_diArg_1 466 468 PF00400 0.567
TRG_ER_diArg_1 75 77 PF00400 0.322
TRG_Pf-PMV_PEXEL_1 206 211 PF00026 0.457
TRG_Pf-PMV_PEXEL_1 232 236 PF00026 0.537
TRG_Pf-PMV_PEXEL_1 334 339 PF00026 0.527
TRG_Pf-PMV_PEXEL_1 596 600 PF00026 0.467

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P935 Leptomonas seymouri 57% 100%
A0A1X0NNY2 Trypanosomatidae 40% 100%
A0A3S5H634 Leishmania donovani 100% 100%
A0A422NTR5 Trypanosoma rangeli 44% 100%
A4H587 Leishmania braziliensis 73% 100%
C9ZPP9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9AM99 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 98%
Q4QIE9 Leishmania major 94% 100%
V5BLM5 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS