Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTH0_LEIIN

TriTrypDb:

LINF_080006900

Length:

687

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HTH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTH0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.362
CLV_NRD_NRD_1	322	324	PF00675	0.366
CLV_PCSK_KEX2_1	134	136	PF00082	0.326
CLV_PCSK_KEX2_1	353	355	PF00082	0.415
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.415
CLV_PCSK_SKI1_1	134	138	PF00082	0.344
CLV_PCSK_SKI1_1	277	281	PF00082	0.578
CLV_PCSK_SKI1_1	391	395	PF00082	0.430
CLV_PCSK_SKI1_1	651	655	PF00082	0.432
DEG_APCC_DBOX_1	133	141	PF00400	0.567
DEG_APCC_DBOX_1	551	559	PF00400	0.254
DEG_SPOP_SBC_1	271	275	PF00917	0.333
DOC_CDC14_PxL_1	21	29	PF14671	0.342
DOC_CKS1_1	188	193	PF01111	0.342
DOC_CKS1_1	256	261	PF01111	0.377
DOC_CKS1_1	329	334	PF01111	0.604
DOC_CKS1_1	72	77	PF01111	0.590
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.431
DOC_MAPK_gen_1	131	140	PF00069	0.534
DOC_MAPK_gen_1	321	329	PF00069	0.569
DOC_MAPK_MEF2A_6	131	140	PF00069	0.564
DOC_MAPK_MEF2A_6	321	329	PF00069	0.569
DOC_MAPK_MEF2A_6	542	549	PF00069	0.368
DOC_MAPK_MEF2A_6	552	559	PF00069	0.272
DOC_MAPK_NFAT4_5	542	550	PF00069	0.296
DOC_MAPK_NFAT4_5	552	560	PF00069	0.261
DOC_PP1_RVXF_1	454	461	PF00149	0.617
DOC_PP2B_LxvP_1	108	111	PF13499	0.427
DOC_PP4_FxxP_1	206	209	PF00568	0.405
DOC_PP4_FxxP_1	329	332	PF00568	0.600
DOC_USP7_MATH_1	109	113	PF00917	0.430
DOC_USP7_MATH_1	210	214	PF00917	0.422
DOC_USP7_MATH_1	271	275	PF00917	0.372
DOC_USP7_MATH_1	379	383	PF00917	0.698
DOC_USP7_MATH_1	437	441	PF00917	0.287
DOC_USP7_MATH_1	443	447	PF00917	0.295
DOC_USP7_MATH_1	495	499	PF00917	0.681
DOC_USP7_MATH_1	594	598	PF00917	0.404
DOC_USP7_MATH_1	66	70	PF00917	0.534
DOC_WW_Pin1_4	145	150	PF00397	0.631
DOC_WW_Pin1_4	187	192	PF00397	0.467
DOC_WW_Pin1_4	205	210	PF00397	0.344
DOC_WW_Pin1_4	255	260	PF00397	0.496
DOC_WW_Pin1_4	291	296	PF00397	0.367
DOC_WW_Pin1_4	328	333	PF00397	0.600
DOC_WW_Pin1_4	360	365	PF00397	0.693
DOC_WW_Pin1_4	71	76	PF00397	0.550
LIG_14-3-3_CanoR_1	144	149	PF00244	0.634
LIG_14-3-3_CanoR_1	158	168	PF00244	0.544
LIG_14-3-3_CanoR_1	263	271	PF00244	0.384
LIG_14-3-3_CanoR_1	499	509	PF00244	0.610
LIG_14-3-3_CanoR_1	552	558	PF00244	0.317
LIG_14-3-3_CanoR_1	607	615	PF00244	0.422
LIG_Actin_WH2_2	529	544	PF00022	0.317
LIG_AP2alpha_1	202	206	PF02296	0.406
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_BRCT_BRCA1_1	111	115	PF00533	0.251
LIG_Clathr_ClatBox_1	26	30	PF01394	0.290
LIG_Clathr_ClatBox_1	661	665	PF01394	0.624
LIG_deltaCOP1_diTrp_1	166	174	PF00928	0.566
LIG_deltaCOP1_diTrp_1	266	272	PF00928	0.382
LIG_EH1_1	299	307	PF00400	0.342
LIG_EH1_1	542	550	PF00400	0.296
LIG_eIF4E_1	300	306	PF01652	0.342
LIG_EVH1_2	325	329	PF00568	0.616
LIG_FHA_1	100	106	PF00498	0.339
LIG_FHA_1	115	121	PF00498	0.229
LIG_FHA_1	263	269	PF00498	0.415
LIG_FHA_1	329	335	PF00498	0.640
LIG_FHA_1	500	506	PF00498	0.634
LIG_FHA_1	521	527	PF00498	0.324
LIG_FHA_1	531	537	PF00498	0.258
LIG_FHA_1	567	573	PF00498	0.593
LIG_FHA_1	607	613	PF00498	0.354
LIG_FHA_1	644	650	PF00498	0.484
LIG_FHA_1	71	77	PF00498	0.550
LIG_FHA_2	199	205	PF00498	0.487
LIG_FHA_2	216	222	PF00498	0.374
LIG_GBD_Chelix_1	44	52	PF00786	0.342
LIG_LIR_Apic_2	204	209	PF02991	0.407
LIG_LIR_Apic_2	328	332	PF02991	0.595
LIG_LIR_Gen_1	112	122	PF02991	0.426
LIG_LIR_Gen_1	154	164	PF02991	0.551
LIG_LIR_Gen_1	201	210	PF02991	0.409
LIG_LIR_Gen_1	533	541	PF02991	0.663
LIG_LIR_Nem_3	112	118	PF02991	0.426
LIG_LIR_Nem_3	201	205	PF02991	0.406
LIG_LIR_Nem_3	265	270	PF02991	0.386
LIG_LIR_Nem_3	294	300	PF02991	0.463
LIG_LIR_Nem_3	318	322	PF02991	0.388
LIG_LIR_Nem_3	533	537	PF02991	0.290
LIG_MAD2	135	143	PF02301	0.580
LIG_NRBOX	583	589	PF00104	0.342
LIG_PAM2_1	525	537	PF00658	0.290
LIG_PCNA_yPIPBox_3	398	412	PF02747	0.459
LIG_Pex14_1	129	133	PF04695	0.515
LIG_Pex14_1	46	50	PF04695	0.342
LIG_Pex14_2	202	206	PF04695	0.406
LIG_SH2_CRK	133	137	PF00017	0.521
LIG_SH2_CRK	176	180	PF00017	0.254
LIG_SH2_CRK	629	633	PF00017	0.407
LIG_SH2_GRB2like	251	254	PF00017	0.440
LIG_SH2_GRB2like	289	292	PF00017	0.382
LIG_SH2_NCK_1	252	256	PF00017	0.380
LIG_SH2_PTP2	300	303	PF00017	0.342
LIG_SH2_STAP1	176	180	PF00017	0.254
LIG_SH2_STAP1	335	339	PF00017	0.563
LIG_SH2_STAT3	335	338	PF00017	0.630
LIG_SH2_STAT5	156	159	PF00017	0.616
LIG_SH2_STAT5	289	292	PF00017	0.386
LIG_SH2_STAT5	300	303	PF00017	0.290
LIG_SH2_STAT5	401	404	PF00017	0.538
LIG_SH2_STAT5	519	522	PF00017	0.342
LIG_SH3_3	137	143	PF00018	0.567
LIG_SH3_3	185	191	PF00018	0.342
LIG_SH3_3	206	212	PF00018	0.417
LIG_SH3_3	319	325	PF00018	0.593
LIG_SH3_3	363	369	PF00018	0.690
LIG_SUMO_SIM_anti_2	102	107	PF11976	0.342
LIG_SUMO_SIM_anti_2	117	124	PF11976	0.220
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.342
LIG_SUMO_SIM_anti_2	313	318	PF11976	0.342
LIG_SUMO_SIM_anti_2	438	443	PF11976	0.317
LIG_SUMO_SIM_anti_2	553	559	PF11976	0.342
LIG_SUMO_SIM_par_1	100	107	PF11976	0.336
LIG_SUMO_SIM_par_1	117	124	PF11976	0.205
LIG_SUMO_SIM_par_1	184	190	PF11976	0.342
LIG_SUMO_SIM_par_1	24	30	PF11976	0.290
LIG_SUMO_SIM_par_1	301	307	PF11976	0.420
LIG_SUMO_SIM_par_1	313	318	PF11976	0.282
LIG_SUMO_SIM_par_1	556	562	PF11976	0.332
LIG_TRAF2_1	397	400	PF00917	0.602
LIG_TRAF2_1	663	666	PF00917	0.655
LIG_TYR_ITIM	298	303	PF00017	0.296
LIG_TYR_ITIM	627	632	PF00017	0.407
LIG_WRC_WIRS_1	199	204	PF05994	0.402
LIG_WRC_WIRS_1	316	321	PF05994	0.427
MOD_CDC14_SPxK_1	208	211	PF00782	0.463
MOD_CDK_SPxK_1	205	211	PF00069	0.454
MOD_CK1_1	147	153	PF00069	0.631
MOD_CK1_1	15	21	PF00069	0.317
MOD_CK1_1	215	221	PF00069	0.424
MOD_CK1_1	328	334	PF00069	0.600
MOD_CK1_1	414	420	PF00069	0.290
MOD_CK1_1	525	531	PF00069	0.290
MOD_CK1_1	596	602	PF00069	0.416
MOD_CK2_1	215	221	PF00069	0.424
MOD_CK2_1	394	400	PF00069	0.612
MOD_GlcNHglycan	125	128	PF01048	0.428
MOD_GlcNHglycan	214	217	PF01048	0.700
MOD_GlcNHglycan	376	379	PF01048	0.540
MOD_GlcNHglycan	381	384	PF01048	0.611
MOD_GlcNHglycan	413	416	PF01048	0.444
MOD_GlcNHglycan	418	421	PF01048	0.342
MOD_GlcNHglycan	471	474	PF01048	0.479
MOD_GlcNHglycan	480	484	PF01048	0.452
MOD_GlcNHglycan	596	599	PF01048	0.677
MOD_GSK3_1	143	150	PF00069	0.613
MOD_GSK3_1	211	218	PF00069	0.418
MOD_GSK3_1	277	284	PF00069	0.389
MOD_GSK3_1	414	421	PF00069	0.257
MOD_GSK3_1	443	450	PF00069	0.463
MOD_GSK3_1	495	502	PF00069	0.643
MOD_GSK3_1	522	529	PF00069	0.278
MOD_GSK3_1	62	69	PF00069	0.575
MOD_GSK3_1	97	104	PF00069	0.325
MOD_N-GLC_1	230	235	PF02516	0.642
MOD_N-GLC_1	285	290	PF02516	0.647
MOD_N-GLC_2	171	173	PF02516	0.329
MOD_NEK2_1	114	119	PF00069	0.367
MOD_NEK2_1	12	17	PF00069	0.342
MOD_NEK2_1	159	164	PF00069	0.575
MOD_NEK2_1	186	191	PF00069	0.374
MOD_NEK2_1	232	237	PF00069	0.474
MOD_NEK2_1	315	320	PF00069	0.241
MOD_NEK2_1	39	44	PF00069	0.290
MOD_NEK2_1	413	418	PF00069	0.290
MOD_NEK2_1	520	525	PF00069	0.329
MOD_NEK2_1	532	537	PF00069	0.274
MOD_NEK2_1	559	564	PF00069	0.474
MOD_NEK2_1	70	75	PF00069	0.544
MOD_NEK2_1	99	104	PF00069	0.424
MOD_NEK2_2	175	180	PF00069	0.342
MOD_NEK2_2	631	636	PF00069	0.342
MOD_PKA_1	478	484	PF00069	0.651
MOD_PKA_2	143	149	PF00069	0.596
MOD_PKA_2	164	170	PF00069	0.573
MOD_PKA_2	262	268	PF00069	0.389
MOD_PKA_2	551	557	PF00069	0.317
MOD_PKA_2	606	612	PF00069	0.416
MOD_Plk_1	230	236	PF00069	0.403
MOD_Plk_1	285	291	PF00069	0.430
MOD_Plk_1	66	72	PF00069	0.548
MOD_Plk_4	101	107	PF00069	0.367
MOD_Plk_4	114	120	PF00069	0.290
MOD_Plk_4	12	18	PF00069	0.342
MOD_Plk_4	164	170	PF00069	0.573
MOD_Plk_4	175	181	PF00069	0.303
MOD_Plk_4	198	204	PF00069	0.435
MOD_Plk_4	247	253	PF00069	0.447
MOD_Plk_4	285	291	PF00069	0.490
MOD_Plk_4	310	316	PF00069	0.373
MOD_Plk_4	39	45	PF00069	0.290
MOD_Plk_4	418	424	PF00069	0.259
MOD_Plk_4	437	443	PF00069	0.457
MOD_Plk_4	522	528	PF00069	0.290
MOD_Plk_4	553	559	PF00069	0.444
MOD_ProDKin_1	145	151	PF00069	0.629
MOD_ProDKin_1	187	193	PF00069	0.467
MOD_ProDKin_1	205	211	PF00069	0.349
MOD_ProDKin_1	255	261	PF00069	0.497
MOD_ProDKin_1	291	297	PF00069	0.365
MOD_ProDKin_1	328	334	PF00069	0.600
MOD_ProDKin_1	360	366	PF00069	0.694
MOD_ProDKin_1	71	77	PF00069	0.551
MOD_SUMO_for_1	371	374	PF00179	0.711
MOD_SUMO_for_1	87	90	PF00179	0.587
TRG_DiLeu_BaEn_1	657	662	PF01217	0.630
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.290
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.342
TRG_ENDOCYTIC_2	133	136	PF00928	0.530
TRG_ENDOCYTIC_2	156	159	PF00928	0.578
TRG_ENDOCYTIC_2	176	179	PF00928	0.241
TRG_ENDOCYTIC_2	300	303	PF00928	0.342
TRG_ENDOCYTIC_2	519	522	PF00928	0.342
TRG_ENDOCYTIC_2	629	632	PF00928	0.407
TRG_ER_diArg_1	133	135	PF00400	0.564
TRG_ER_diArg_1	320	323	PF00400	0.545
TRG_ER_diArg_1	387	390	PF00400	0.672
TRG_Pf-PMV_PEXEL_1	625	630	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9F4	Leptomonas seymouri	48%	75%
A0A3S5H633	Leishmania donovani	100%	74%
E9AM98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QIF0	Leishmania major	92%	100%