Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTG8_LEIIN

TriTrypDb:

LINF_080006700

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A4HTG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTG8

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	5
GO:0006952	defense response	3	5
GO:0050896	response to stimulus	1	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	537	541	PF00656	0.445
CLV_MEL_PAP_1	578	584	PF00089	0.586
CLV_NRD_NRD_1	170	172	PF00675	0.687
CLV_NRD_NRD_1	230	232	PF00675	0.591
CLV_NRD_NRD_1	29	31	PF00675	0.621
CLV_NRD_NRD_1	314	316	PF00675	0.706
CLV_NRD_NRD_1	317	319	PF00675	0.641
CLV_NRD_NRD_1	341	343	PF00675	0.503
CLV_NRD_NRD_1	373	375	PF00675	0.498
CLV_NRD_NRD_1	634	636	PF00675	0.609
CLV_NRD_NRD_1	638	640	PF00675	0.605
CLV_NRD_NRD_1	76	78	PF00675	0.582
CLV_PCSK_FUR_1	312	316	PF00082	0.720
CLV_PCSK_KEX2_1	170	172	PF00082	0.687
CLV_PCSK_KEX2_1	230	232	PF00082	0.591
CLV_PCSK_KEX2_1	29	31	PF00082	0.621
CLV_PCSK_KEX2_1	314	316	PF00082	0.649
CLV_PCSK_KEX2_1	317	319	PF00082	0.598
CLV_PCSK_KEX2_1	341	343	PF00082	0.500
CLV_PCSK_KEX2_1	634	636	PF00082	0.609
CLV_PCSK_KEX2_1	638	640	PF00082	0.605
CLV_PCSK_PC7_1	630	636	PF00082	0.494
CLV_PCSK_SKI1_1	14	18	PF00082	0.681
CLV_PCSK_SKI1_1	147	151	PF00082	0.547
CLV_PCSK_SKI1_1	24	28	PF00082	0.528
CLV_PCSK_SKI1_1	294	298	PF00082	0.633
CLV_PCSK_SKI1_1	355	359	PF00082	0.588
CLV_PCSK_SKI1_1	374	378	PF00082	0.290
CLV_PCSK_SKI1_1	400	404	PF00082	0.503
CLV_PCSK_SKI1_1	477	481	PF00082	0.468
CLV_PCSK_SKI1_1	630	634	PF00082	0.603
DEG_APCC_DBOX_1	419	427	PF00400	0.519
DEG_APCC_DBOX_1	629	637	PF00400	0.531
DEG_Nend_Nbox_1	1	3	PF02207	0.734
DEG_ODPH_VHL_1	58	70	PF01847	0.618
DEG_SCF_FBW7_1	296	301	PF00400	0.692
DEG_SPOP_SBC_1	298	302	PF00917	0.772
DEG_SPOP_SBC_1	33	37	PF00917	0.465
DOC_CDC14_PxL_1	413	421	PF14671	0.493
DOC_CDC14_PxL_1	490	498	PF14671	0.491
DOC_CDC14_PxL_1	585	593	PF14671	0.455
DOC_CYCLIN_RxL_1	312	323	PF00134	0.691
DOC_CYCLIN_RxL_1	471	483	PF00134	0.576
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.558
DOC_MAPK_gen_1	144	154	PF00069	0.528
DOC_MAPK_gen_1	170	178	PF00069	0.646
DOC_MAPK_gen_1	312	321	PF00069	0.778
DOC_MAPK_gen_1	371	381	PF00069	0.554
DOC_MAPK_gen_1	49	58	PF00069	0.551
DOC_MAPK_gen_1	634	643	PF00069	0.621
DOC_MAPK_MEF2A_6	170	178	PF00069	0.549
DOC_PP1_RVXF_1	409	416	PF00149	0.501
DOC_PP2B_LxvP_1	457	460	PF13499	0.468
DOC_PP2B_LxvP_1	618	621	PF13499	0.441
DOC_USP7_MATH_1	135	139	PF00917	0.614
DOC_USP7_MATH_1	206	210	PF00917	0.586
DOC_USP7_MATH_1	340	344	PF00917	0.574
DOC_USP7_MATH_1	438	442	PF00917	0.674
DOC_USP7_MATH_1	464	468	PF00917	0.577
DOC_USP7_MATH_1	470	474	PF00917	0.527
DOC_USP7_MATH_1	621	625	PF00917	0.539
DOC_USP7_UBL2_3	214	218	PF12436	0.628
DOC_WW_Pin1_4	129	134	PF00397	0.710
DOC_WW_Pin1_4	163	168	PF00397	0.531
DOC_WW_Pin1_4	195	200	PF00397	0.556
DOC_WW_Pin1_4	208	213	PF00397	0.544
DOC_WW_Pin1_4	257	262	PF00397	0.725
DOC_WW_Pin1_4	287	292	PF00397	0.712
DOC_WW_Pin1_4	294	299	PF00397	0.748
DOC_WW_Pin1_4	429	434	PF00397	0.519
DOC_WW_Pin1_4	516	521	PF00397	0.496
DOC_WW_Pin1_4	6	11	PF00397	0.607
LIG_14-3-3_CanoR_1	123	127	PF00244	0.614
LIG_14-3-3_CanoR_1	183	193	PF00244	0.659
LIG_14-3-3_CanoR_1	230	236	PF00244	0.683
LIG_14-3-3_CanoR_1	24	33	PF00244	0.617
LIG_14-3-3_CanoR_1	320	329	PF00244	0.585
LIG_14-3-3_CanoR_1	341	345	PF00244	0.610
LIG_14-3-3_CanoR_1	374	381	PF00244	0.575
LIG_14-3-3_CanoR_1	400	405	PF00244	0.553
LIG_14-3-3_CanoR_1	420	426	PF00244	0.276
LIG_14-3-3_CanoR_1	526	534	PF00244	0.595
LIG_14-3-3_CanoR_1	581	585	PF00244	0.575
LIG_14-3-3_CanoR_1	597	603	PF00244	0.330
LIG_Actin_WH2_2	145	163	PF00022	0.522
LIG_Actin_WH2_2	186	203	PF00022	0.643
LIG_Actin_WH2_2	386	402	PF00022	0.532
LIG_Actin_WH2_2	406	422	PF00022	0.587
LIG_BRCT_BRCA1_1	368	372	PF00533	0.439
LIG_FHA_1	105	111	PF00498	0.639
LIG_FHA_1	205	211	PF00498	0.550
LIG_FHA_1	230	236	PF00498	0.557
LIG_FHA_1	314	320	PF00498	0.717
LIG_FHA_1	375	381	PF00498	0.581
LIG_FHA_1	598	604	PF00498	0.425
LIG_FHA_2	232	238	PF00498	0.684
LIG_FHA_2	473	479	PF00498	0.462
LIG_FHA_2	535	541	PF00498	0.441
LIG_FHA_2	567	573	PF00498	0.562
LIG_LIR_Gen_1	422	433	PF02991	0.538
LIG_LIR_Gen_1	480	490	PF02991	0.488
LIG_LIR_Gen_1	567	578	PF02991	0.560
LIG_LIR_Nem_3	386	390	PF02991	0.476
LIG_LIR_Nem_3	422	428	PF02991	0.457
LIG_LIR_Nem_3	488	493	PF02991	0.499
LIG_LIR_Nem_3	567	573	PF02991	0.554
LIG_LIR_Nem_3	605	609	PF02991	0.471
LIG_MYND_1	261	265	PF01753	0.843
LIG_MYND_3	496	500	PF01753	0.473
LIG_PCNA_PIPBox_1	186	195	PF02747	0.577
LIG_PCNA_yPIPBox_3	179	193	PF02747	0.658
LIG_PTB_Apo_2	358	365	PF02174	0.598
LIG_PTB_Phospho_1	358	364	PF10480	0.595
LIG_SH2_NCK_1	364	368	PF00017	0.618
LIG_SH2_SRC	570	573	PF00017	0.555
LIG_SH2_STAT5	227	230	PF00017	0.626
LIG_SH2_STAT5	425	428	PF00017	0.487
LIG_SH2_STAT5	570	573	PF00017	0.453
LIG_SH3_3	232	238	PF00018	0.684
LIG_SH3_3	491	497	PF00018	0.499
LIG_SH3_3	617	623	PF00018	0.487
LIG_SH3_3	7	13	PF00018	0.621
LIG_SUMO_SIM_anti_2	580	586	PF11976	0.463
LIG_SUMO_SIM_anti_2	66	71	PF11976	0.468
LIG_SUMO_SIM_par_1	172	177	PF11976	0.615
LIG_TYR_ITIM	423	428	PF00017	0.492
LIG_TYR_ITIM	568	573	PF00017	0.456
LIG_UBA3_1	110	115	PF00899	0.455
LIG_Vh1_VBS_1	469	487	PF01044	0.509
LIG_WRC_WIRS_1	465	470	PF05994	0.474
LIG_WRC_WIRS_1	5	10	PF05994	0.714
LIG_WW_3	11	15	PF00397	0.525
MOD_CDC14_SPxK_1	198	201	PF00782	0.563
MOD_CDC14_SPxK_1	211	214	PF00782	0.527
MOD_CDK_SPK_2	516	521	PF00069	0.496
MOD_CDK_SPxK_1	195	201	PF00069	0.558
MOD_CDK_SPxK_1	208	214	PF00069	0.548
MOD_CDK_SPxxK_3	163	170	PF00069	0.642
MOD_CDK_SPxxK_3	287	294	PF00069	0.717
MOD_CK1_1	129	135	PF00069	0.641
MOD_CK1_1	195	201	PF00069	0.558
MOD_CK1_1	257	263	PF00069	0.724
MOD_CK1_1	300	306	PF00069	0.769
MOD_CK1_1	313	319	PF00069	0.597
MOD_CK1_1	35	41	PF00069	0.656
MOD_CK1_1	432	438	PF00069	0.573
MOD_CK1_1	458	464	PF00069	0.511
MOD_CK1_1	472	478	PF00069	0.307
MOD_CK1_1	488	494	PF00069	0.405
MOD_CK2_1	447	453	PF00069	0.612
MOD_CK2_1	472	478	PF00069	0.510
MOD_CK2_1	580	586	PF00069	0.587
MOD_CK2_1	621	627	PF00069	0.491
MOD_Cter_Amidation	636	639	PF01082	0.592
MOD_Cter_Amidation	75	78	PF01082	0.650
MOD_GlcNHglycan	137	140	PF01048	0.717
MOD_GlcNHglycan	322	325	PF01048	0.612
MOD_GlcNHglycan	338	341	PF01048	0.391
MOD_GlcNHglycan	440	443	PF01048	0.646
MOD_GlcNHglycan	449	452	PF01048	0.550
MOD_GlcNHglycan	472	475	PF01048	0.536
MOD_GlcNHglycan	487	490	PF01048	0.523
MOD_GSK3_1	122	129	PF00069	0.588
MOD_GSK3_1	204	211	PF00069	0.620
MOD_GSK3_1	257	264	PF00069	0.705
MOD_GSK3_1	294	301	PF00069	0.718
MOD_GSK3_1	302	309	PF00069	0.630
MOD_GSK3_1	33	40	PF00069	0.665
MOD_GSK3_1	336	343	PF00069	0.616
MOD_GSK3_1	434	441	PF00069	0.618
MOD_GSK3_1	528	535	PF00069	0.553
MOD_N-GLC_1	257	262	PF02516	0.782
MOD_N-GLC_1	455	460	PF02516	0.488
MOD_N-GLC_1	597	602	PF02516	0.595
MOD_N-GLC_2	551	553	PF02516	0.569
MOD_NEK2_1	192	197	PF00069	0.587
MOD_NEK2_1	219	224	PF00069	0.531
MOD_NEK2_1	229	234	PF00069	0.581
MOD_NEK2_1	319	324	PF00069	0.658
MOD_NEK2_1	334	339	PF00069	0.365
MOD_NEK2_1	4	9	PF00069	0.718
MOD_NEK2_1	419	424	PF00069	0.558
MOD_NEK2_1	447	452	PF00069	0.546
MOD_NEK2_1	455	460	PF00069	0.419
MOD_NEK2_1	485	490	PF00069	0.518
MOD_NEK2_1	514	519	PF00069	0.557
MOD_NEK2_1	534	539	PF00069	0.383
MOD_NEK2_1	571	576	PF00069	0.555
MOD_NEK2_1	68	73	PF00069	0.493
MOD_PIKK_1	274	280	PF00454	0.723
MOD_PIKK_1	525	531	PF00454	0.486
MOD_PK_1	375	381	PF00069	0.503
MOD_PKA_1	230	236	PF00069	0.609
MOD_PKA_1	374	380	PF00069	0.476
MOD_PKA_2	122	128	PF00069	0.618
MOD_PKA_2	229	235	PF00069	0.587
MOD_PKA_2	313	319	PF00069	0.750
MOD_PKA_2	340	346	PF00069	0.546
MOD_PKA_2	419	425	PF00069	0.494
MOD_PKA_2	525	531	PF00069	0.508
MOD_PKA_2	580	586	PF00069	0.587
MOD_PKB_1	318	326	PF00069	0.594
MOD_Plk_1	411	417	PF00069	0.608
MOD_Plk_1	455	461	PF00069	0.549
MOD_Plk_1	477	483	PF00069	0.460
MOD_Plk_1	597	603	PF00069	0.592
MOD_Plk_4	122	128	PF00069	0.618
MOD_Plk_4	375	381	PF00069	0.581
MOD_Plk_4	383	389	PF00069	0.565
MOD_Plk_4	411	417	PF00069	0.554
MOD_Plk_4	421	427	PF00069	0.412
MOD_Plk_4	477	483	PF00069	0.482
MOD_Plk_4	566	572	PF00069	0.542
MOD_Plk_4	580	586	PF00069	0.383
MOD_Plk_4	598	604	PF00069	0.498
MOD_Plk_4	621	627	PF00069	0.470
MOD_ProDKin_1	129	135	PF00069	0.716
MOD_ProDKin_1	163	169	PF00069	0.530
MOD_ProDKin_1	195	201	PF00069	0.558
MOD_ProDKin_1	208	214	PF00069	0.548
MOD_ProDKin_1	257	263	PF00069	0.727
MOD_ProDKin_1	287	293	PF00069	0.713
MOD_ProDKin_1	294	300	PF00069	0.750
MOD_ProDKin_1	429	435	PF00069	0.529
MOD_ProDKin_1	516	522	PF00069	0.489
MOD_ProDKin_1	6	12	PF00069	0.599
TRG_DiLeu_BaEn_2	187	193	PF01217	0.527
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.548
TRG_ENDOCYTIC_2	364	367	PF00928	0.487
TRG_ENDOCYTIC_2	425	428	PF00928	0.487
TRG_ENDOCYTIC_2	570	573	PF00928	0.453
TRG_ER_diArg_1	142	145	PF00400	0.444
TRG_ER_diArg_1	169	171	PF00400	0.681
TRG_ER_diArg_1	229	231	PF00400	0.663
TRG_ER_diArg_1	312	315	PF00400	0.735
TRG_ER_diArg_1	317	320	PF00400	0.628
TRG_ER_diArg_1	417	420	PF00400	0.503
TRG_ER_diArg_1	633	635	PF00400	0.503
TRG_NES_CRM1_1	164	177	PF08389	0.543
TRG_NES_CRM1_1	540	554	PF08389	0.570
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P939	Leptomonas seymouri	46%	98%
A0A3S5H632	Leishmania donovani	100%	100%
A4H584	Leishmania braziliensis	75%	100%
E9AM96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	97%
Q4QIF2	Leishmania major	92%	100%