PIG-H domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI-GlcNAc transferase complex - PIG-H component - putative

Species:

Leishmania infantum

UniProt:

A4HTG6_LEIIN

TriTrypDb:

LINF_080006500

Length:

499

Annotations

Annotations by Jardim et al.

GPI anchor biosynthesis, GPI-GlcNAc transferase complex, PIG-H component

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	3	7
GO:0016020	membrane	2	7
GO:0032991	protein-containing complex	1	7
GO:0098796	membrane protein complex	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0140534	endoplasmic reticulum protein-containing complex	2	7
GO:1902494	catalytic complex	2	7
GO:1990234	transferase complex	3	7

Expansion

Sequence features

A4HTG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTG6

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	7
GO:0006505	GPI anchor metabolic process	6	7
GO:0006506	GPI anchor biosynthetic process	6	7
GO:0006629	lipid metabolic process	3	7
GO:0006643	membrane lipid metabolic process	4	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006661	phosphatidylinositol biosynthetic process	6	7
GO:0006664	glycolipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0009058	biosynthetic process	2	7
GO:0009247	glycolipid biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0019637	organophosphate metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	7
GO:0046467	membrane lipid biosynthetic process	4	7
GO:0046474	glycerophospholipid biosynthetic process	5	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1903509	liposaccharide metabolic process	4	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	465	469	PF00656	0.620
CLV_NRD_NRD_1	41	43	PF00675	0.433
CLV_PCSK_KEX2_1	345	347	PF00082	0.345
CLV_PCSK_KEX2_1	41	43	PF00082	0.433
CLV_PCSK_KEX2_1	5	7	PF00082	0.447
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.345
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.439
CLV_PCSK_SKI1_1	203	207	PF00082	0.406
CLV_PCSK_SKI1_1	311	315	PF00082	0.650
CLV_PCSK_SKI1_1	432	436	PF00082	0.330
CLV_PCSK_SKI1_1	439	443	PF00082	0.373
DEG_APCC_DBOX_1	431	439	PF00400	0.504
DEG_SPOP_SBC_1	294	298	PF00917	0.454
DOC_CKS1_1	149	154	PF01111	0.688
DOC_CKS1_1	482	487	PF01111	0.657
DOC_CYCLIN_RxL_1	41	52	PF00134	0.628
DOC_MAPK_gen_1	379	386	PF00069	0.469
DOC_MAPK_MEF2A_6	379	388	PF00069	0.469
DOC_MAPK_RevD_3	331	346	PF00069	0.303
DOC_PP1_RVXF_1	201	207	PF00149	0.641
DOC_PP1_RVXF_1	309	316	PF00149	0.446
DOC_PP1_RVXF_1	415	422	PF00149	0.469
DOC_PP2B_LxvP_1	153	156	PF13499	0.680
DOC_USP7_MATH_1	11	15	PF00917	0.690
DOC_USP7_MATH_1	24	28	PF00917	0.762
DOC_USP7_MATH_1	260	264	PF00917	0.465
DOC_USP7_MATH_1	294	298	PF00917	0.474
DOC_USP7_MATH_1	31	35	PF00917	0.715
DOC_USP7_MATH_1	82	86	PF00917	0.659
DOC_USP7_MATH_2	446	452	PF00917	0.650
DOC_WW_Pin1_4	145	150	PF00397	0.745
DOC_WW_Pin1_4	156	161	PF00397	0.698
DOC_WW_Pin1_4	176	181	PF00397	0.649
DOC_WW_Pin1_4	275	280	PF00397	0.485
DOC_WW_Pin1_4	321	326	PF00397	0.261
DOC_WW_Pin1_4	481	486	PF00397	0.671
DOC_WW_Pin1_4	6	11	PF00397	0.629
DOC_WW_Pin1_4	71	76	PF00397	0.792
LIG_14-3-3_CanoR_1	183	187	PF00244	0.672
LIG_14-3-3_CanoR_1	231	235	PF00244	0.371
LIG_14-3-3_CanoR_1	458	466	PF00244	0.615
LIG_14-3-3_CanoR_1	94	98	PF00244	0.606
LIG_Actin_WH2_2	418	434	PF00022	0.515
LIG_AP_GAE_1	474	480	PF02883	0.682
LIG_APCC_ABBAyCdc20_2	439	445	PF00400	0.536
LIG_EH1_1	381	389	PF00400	0.516
LIG_eIF4E_1	355	361	PF01652	0.541
LIG_EVH1_1	7	11	PF00568	0.611
LIG_FHA_1	104	110	PF00498	0.501
LIG_FHA_1	166	172	PF00498	0.671
LIG_FHA_1	211	217	PF00498	0.318
LIG_FHA_1	308	314	PF00498	0.432
LIG_FHA_1	322	328	PF00498	0.299
LIG_FHA_1	330	336	PF00498	0.313
LIG_FHA_1	338	344	PF00498	0.359
LIG_FHA_1	86	92	PF00498	0.660
LIG_FHA_1	93	99	PF00498	0.538
LIG_FHA_2	481	487	PF00498	0.688
LIG_FHA_2	492	498	PF00498	0.620
LIG_GBD_Chelix_1	343	351	PF00786	0.412
LIG_Integrin_isoDGR_2	181	183	PF01839	0.425
LIG_LIR_Gen_1	247	256	PF02991	0.437
LIG_LIR_Gen_1	339	347	PF02991	0.405
LIG_LIR_Nem_3	247	251	PF02991	0.452
LIG_LIR_Nem_3	339	344	PF02991	0.404
LIG_LIR_Nem_3	370	375	PF02991	0.469
LIG_LIR_Nem_3	377	383	PF02991	0.469
LIG_LIR_Nem_3	396	401	PF02991	0.469
LIG_MYND_1	57	61	PF01753	0.670
LIG_MYND_3	251	255	PF01753	0.341
LIG_NRBOX	332	338	PF00104	0.369
LIG_Pex14_1	202	206	PF04695	0.641
LIG_Pex14_2	206	210	PF04695	0.516
LIG_REV1ctd_RIR_1	396	402	PF16727	0.469
LIG_RPA_C_Fungi	37	49	PF08784	0.533
LIG_SH2_NCK_1	318	322	PF00017	0.502
LIG_SH2_STAP1	117	121	PF00017	0.417
LIG_SH2_STAP1	167	171	PF00017	0.503
LIG_SH2_STAT5	167	170	PF00017	0.546
LIG_SH2_STAT5	318	321	PF00017	0.508
LIG_SH2_STAT5	355	358	PF00017	0.359
LIG_SH2_STAT5	420	423	PF00017	0.477
LIG_SH3_1	5	11	PF00018	0.505
LIG_SH3_3	146	152	PF00018	0.735
LIG_SH3_3	416	422	PF00018	0.304
LIG_SH3_3	427	433	PF00018	0.369
LIG_SH3_3	479	485	PF00018	0.564
LIG_SH3_3	5	11	PF00018	0.533
LIG_SH3_3	54	60	PF00018	0.650
LIG_SH3_3	69	75	PF00018	0.747
LIG_SUMO_SIM_anti_2	328	335	PF11976	0.349
LIG_SUMO_SIM_anti_2	357	363	PF11976	0.369
LIG_SUMO_SIM_par_1	213	219	PF11976	0.303
LIG_SUMO_SIM_par_1	225	230	PF11976	0.313
LIG_SUMO_SIM_par_1	332	340	PF11976	0.406
LIG_SUMO_SIM_par_1	385	391	PF11976	0.369
LIG_SUMO_SIM_par_1	95	101	PF11976	0.424
LIG_WRC_WIRS_1	171	176	PF05994	0.510
LIG_WRC_WIRS_1	338	343	PF05994	0.270
MOD_CDK_SPxxK_3	176	183	PF00069	0.598
MOD_CK1_1	14	20	PF00069	0.559
MOD_CK1_1	145	151	PF00069	0.611
MOD_CK1_1	165	171	PF00069	0.531
MOD_CK1_1	230	236	PF00069	0.483
MOD_CK1_1	244	250	PF00069	0.597
MOD_CK1_1	25	31	PF00069	0.552
MOD_CK1_1	263	269	PF00069	0.465
MOD_CK1_1	275	281	PF00069	0.537
MOD_CK1_1	297	303	PF00069	0.642
MOD_CK1_1	464	470	PF00069	0.450
MOD_CK1_1	491	497	PF00069	0.620
MOD_CK1_1	85	91	PF00069	0.597
MOD_CK2_1	263	269	PF00069	0.551
MOD_CK2_1	406	412	PF00069	0.304
MOD_CK2_1	448	454	PF00069	0.502
MOD_CK2_1	473	479	PF00069	0.567
MOD_GlcNHglycan	13	16	PF01048	0.612
MOD_GlcNHglycan	145	148	PF01048	0.638
MOD_GlcNHglycan	17	20	PF01048	0.615
MOD_GlcNHglycan	174	177	PF01048	0.573
MOD_GlcNHglycan	24	27	PF01048	0.751
MOD_GlcNHglycan	243	246	PF01048	0.532
MOD_GlcNHglycan	262	265	PF01048	0.660
MOD_GlcNHglycan	274	277	PF01048	0.760
MOD_GlcNHglycan	280	283	PF01048	0.580
MOD_GlcNHglycan	347	350	PF01048	0.377
MOD_GlcNHglycan	369	372	PF01048	0.369
MOD_GlcNHglycan	42	45	PF01048	0.469
MOD_GlcNHglycan	461	464	PF01048	0.536
MOD_GlcNHglycan	84	87	PF01048	0.582
MOD_GSK3_1	11	18	PF00069	0.609
MOD_GSK3_1	162	169	PF00069	0.574
MOD_GSK3_1	170	177	PF00069	0.683
MOD_GSK3_1	237	244	PF00069	0.559
MOD_GSK3_1	25	32	PF00069	0.695
MOD_GSK3_1	259	266	PF00069	0.542
MOD_GSK3_1	293	300	PF00069	0.675
MOD_GSK3_1	303	310	PF00069	0.525
MOD_GSK3_1	316	323	PF00069	0.535
MOD_GSK3_1	345	352	PF00069	0.601
MOD_GSK3_1	81	88	PF00069	0.652
MOD_NEK2_1	174	179	PF00069	0.580
MOD_NEK2_1	246	251	PF00069	0.494
MOD_NEK2_1	314	319	PF00069	0.583
MOD_NEK2_1	327	332	PF00069	0.272
MOD_NEK2_1	336	341	PF00069	0.314
MOD_NEK2_1	367	372	PF00069	0.304
MOD_NEK2_1	388	393	PF00069	0.304
MOD_NEK2_1	405	410	PF00069	0.304
MOD_NEK2_1	49	54	PF00069	0.525
MOD_PIKK_1	316	322	PF00454	0.514
MOD_PKA_1	345	351	PF00069	0.471
MOD_PKA_2	182	188	PF00069	0.588
MOD_PKA_2	230	236	PF00069	0.501
MOD_PKA_2	345	351	PF00069	0.471
MOD_PKA_2	40	46	PF00069	0.530
MOD_PKA_2	93	99	PF00069	0.508
MOD_Plk_1	190	196	PF00069	0.572
MOD_Plk_1	327	333	PF00069	0.331
MOD_Plk_1	473	479	PF00069	0.597
MOD_Plk_2-3	448	454	PF00069	0.502
MOD_Plk_2-3	470	476	PF00069	0.477
MOD_Plk_4	230	236	PF00069	0.574
MOD_Plk_4	300	306	PF00069	0.565
MOD_Plk_4	329	335	PF00069	0.404
MOD_Plk_4	337	343	PF00069	0.369
MOD_Plk_4	93	99	PF00069	0.443
MOD_ProDKin_1	145	151	PF00069	0.689
MOD_ProDKin_1	156	162	PF00069	0.623
MOD_ProDKin_1	176	182	PF00069	0.556
MOD_ProDKin_1	275	281	PF00069	0.606
MOD_ProDKin_1	321	327	PF00069	0.292
MOD_ProDKin_1	481	487	PF00069	0.590
MOD_ProDKin_1	6	12	PF00069	0.533
MOD_ProDKin_1	71	77	PF00069	0.753
MOD_SUMO_rev_2	408	415	PF00179	0.369
TRG_DiLeu_BaEn_4	447	453	PF01217	0.495
TRG_ENDOCYTIC_2	372	375	PF00928	0.304
TRG_ENDOCYTIC_2	380	383	PF00928	0.304
TRG_ENDOCYTIC_2	401	404	PF00928	0.304
TRG_NES_CRM1_1	385	396	PF08389	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I406	Leptomonas seymouri	52%	100%
A0A3S5H631	Leishmania donovani	99%	96%
A4H582	Leishmania braziliensis	68%	100%
E9AM94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QIF4	Leishmania major	90%	100%