LeishMANIAdb
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PIG-H domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PIG-H domain-containing protein
Gene product:
GPI-GlcNAc transferase complex - PIG-H component - putative
Species:
Leishmania infantum
UniProt:
A4HTG6_LEIIN
TriTrypDb:
LINF_080006500 *
Length:
499

Annotations

Annotations by Jardim et al.

GPI anchor biosynthesis, GPI-GlcNAc transferase complex, PIG-H component

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex 3 7
GO:0016020 membrane 2 7
GO:0032991 protein-containing complex 1 7
GO:0098796 membrane protein complex 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0140534 endoplasmic reticulum protein-containing complex 2 7
GO:1902494 catalytic complex 2 7
GO:1990234 transferase complex 3 7

Expansion

Sequence features

A4HTG6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTG6

Function

Biological processes
Term Name Level Count
GO:0006497 protein lipidation 5 7
GO:0006505 GPI anchor metabolic process 6 7
GO:0006506 GPI anchor biosynthetic process 6 7
GO:0006629 lipid metabolic process 3 7
GO:0006643 membrane lipid metabolic process 4 7
GO:0006644 phospholipid metabolic process 4 7
GO:0006650 glycerophospholipid metabolic process 5 7
GO:0006661 phosphatidylinositol biosynthetic process 6 7
GO:0006664 glycolipid metabolic process 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0008610 lipid biosynthetic process 4 7
GO:0008654 phospholipid biosynthetic process 5 7
GO:0009058 biosynthetic process 2 7
GO:0009247 glycolipid biosynthetic process 5 7
GO:0009987 cellular process 1 7
GO:0019538 protein metabolic process 3 7
GO:0019637 organophosphate metabolic process 3 7
GO:0036211 protein modification process 4 7
GO:0043170 macromolecule metabolic process 3 7
GO:0043412 macromolecule modification 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0044249 cellular biosynthetic process 3 7
GO:0044255 cellular lipid metabolic process 3 7
GO:0045017 glycerolipid biosynthetic process 4 7
GO:0046467 membrane lipid biosynthetic process 4 7
GO:0046474 glycerophospholipid biosynthetic process 5 7
GO:0046486 glycerolipid metabolic process 4 7
GO:0046488 phosphatidylinositol metabolic process 6 7
GO:0071704 organic substance metabolic process 2 7
GO:0090407 organophosphate biosynthetic process 4 7
GO:1901135 carbohydrate derivative metabolic process 3 7
GO:1901137 carbohydrate derivative biosynthetic process 4 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:1901576 organic substance biosynthetic process 3 7
GO:1903509 liposaccharide metabolic process 4 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016740 transferase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 465 469 PF00656 0.620
CLV_NRD_NRD_1 41 43 PF00675 0.433
CLV_PCSK_KEX2_1 345 347 PF00082 0.345
CLV_PCSK_KEX2_1 41 43 PF00082 0.433
CLV_PCSK_KEX2_1 5 7 PF00082 0.447
CLV_PCSK_PC1ET2_1 345 347 PF00082 0.345
CLV_PCSK_PC1ET2_1 5 7 PF00082 0.439
CLV_PCSK_SKI1_1 203 207 PF00082 0.406
CLV_PCSK_SKI1_1 311 315 PF00082 0.650
CLV_PCSK_SKI1_1 432 436 PF00082 0.330
CLV_PCSK_SKI1_1 439 443 PF00082 0.373
DEG_APCC_DBOX_1 431 439 PF00400 0.504
DEG_SPOP_SBC_1 294 298 PF00917 0.454
DOC_CKS1_1 149 154 PF01111 0.688
DOC_CKS1_1 482 487 PF01111 0.657
DOC_CYCLIN_RxL_1 41 52 PF00134 0.628
DOC_MAPK_gen_1 379 386 PF00069 0.469
DOC_MAPK_MEF2A_6 379 388 PF00069 0.469
DOC_MAPK_RevD_3 331 346 PF00069 0.303
DOC_PP1_RVXF_1 201 207 PF00149 0.641
DOC_PP1_RVXF_1 309 316 PF00149 0.446
DOC_PP1_RVXF_1 415 422 PF00149 0.469
DOC_PP2B_LxvP_1 153 156 PF13499 0.680
DOC_USP7_MATH_1 11 15 PF00917 0.690
DOC_USP7_MATH_1 24 28 PF00917 0.762
DOC_USP7_MATH_1 260 264 PF00917 0.465
DOC_USP7_MATH_1 294 298 PF00917 0.474
DOC_USP7_MATH_1 31 35 PF00917 0.715
DOC_USP7_MATH_1 82 86 PF00917 0.659
DOC_USP7_MATH_2 446 452 PF00917 0.650
DOC_WW_Pin1_4 145 150 PF00397 0.745
DOC_WW_Pin1_4 156 161 PF00397 0.698
DOC_WW_Pin1_4 176 181 PF00397 0.649
DOC_WW_Pin1_4 275 280 PF00397 0.485
DOC_WW_Pin1_4 321 326 PF00397 0.261
DOC_WW_Pin1_4 481 486 PF00397 0.671
DOC_WW_Pin1_4 6 11 PF00397 0.629
DOC_WW_Pin1_4 71 76 PF00397 0.792
LIG_14-3-3_CanoR_1 183 187 PF00244 0.672
LIG_14-3-3_CanoR_1 231 235 PF00244 0.371
LIG_14-3-3_CanoR_1 458 466 PF00244 0.615
LIG_14-3-3_CanoR_1 94 98 PF00244 0.606
LIG_Actin_WH2_2 418 434 PF00022 0.515
LIG_AP_GAE_1 474 480 PF02883 0.682
LIG_APCC_ABBAyCdc20_2 439 445 PF00400 0.536
LIG_EH1_1 381 389 PF00400 0.516
LIG_eIF4E_1 355 361 PF01652 0.541
LIG_EVH1_1 7 11 PF00568 0.611
LIG_FHA_1 104 110 PF00498 0.501
LIG_FHA_1 166 172 PF00498 0.671
LIG_FHA_1 211 217 PF00498 0.318
LIG_FHA_1 308 314 PF00498 0.432
LIG_FHA_1 322 328 PF00498 0.299
LIG_FHA_1 330 336 PF00498 0.313
LIG_FHA_1 338 344 PF00498 0.359
LIG_FHA_1 86 92 PF00498 0.660
LIG_FHA_1 93 99 PF00498 0.538
LIG_FHA_2 481 487 PF00498 0.688
LIG_FHA_2 492 498 PF00498 0.620
LIG_GBD_Chelix_1 343 351 PF00786 0.412
LIG_Integrin_isoDGR_2 181 183 PF01839 0.425
LIG_LIR_Gen_1 247 256 PF02991 0.437
LIG_LIR_Gen_1 339 347 PF02991 0.405
LIG_LIR_Nem_3 247 251 PF02991 0.452
LIG_LIR_Nem_3 339 344 PF02991 0.404
LIG_LIR_Nem_3 370 375 PF02991 0.469
LIG_LIR_Nem_3 377 383 PF02991 0.469
LIG_LIR_Nem_3 396 401 PF02991 0.469
LIG_MYND_1 57 61 PF01753 0.670
LIG_MYND_3 251 255 PF01753 0.341
LIG_NRBOX 332 338 PF00104 0.369
LIG_Pex14_1 202 206 PF04695 0.641
LIG_Pex14_2 206 210 PF04695 0.516
LIG_REV1ctd_RIR_1 396 402 PF16727 0.469
LIG_RPA_C_Fungi 37 49 PF08784 0.533
LIG_SH2_NCK_1 318 322 PF00017 0.502
LIG_SH2_STAP1 117 121 PF00017 0.417
LIG_SH2_STAP1 167 171 PF00017 0.503
LIG_SH2_STAT5 167 170 PF00017 0.546
LIG_SH2_STAT5 318 321 PF00017 0.508
LIG_SH2_STAT5 355 358 PF00017 0.359
LIG_SH2_STAT5 420 423 PF00017 0.477
LIG_SH3_1 5 11 PF00018 0.505
LIG_SH3_3 146 152 PF00018 0.735
LIG_SH3_3 416 422 PF00018 0.304
LIG_SH3_3 427 433 PF00018 0.369
LIG_SH3_3 479 485 PF00018 0.564
LIG_SH3_3 5 11 PF00018 0.533
LIG_SH3_3 54 60 PF00018 0.650
LIG_SH3_3 69 75 PF00018 0.747
LIG_SUMO_SIM_anti_2 328 335 PF11976 0.349
LIG_SUMO_SIM_anti_2 357 363 PF11976 0.369
LIG_SUMO_SIM_par_1 213 219 PF11976 0.303
LIG_SUMO_SIM_par_1 225 230 PF11976 0.313
LIG_SUMO_SIM_par_1 332 340 PF11976 0.406
LIG_SUMO_SIM_par_1 385 391 PF11976 0.369
LIG_SUMO_SIM_par_1 95 101 PF11976 0.424
LIG_WRC_WIRS_1 171 176 PF05994 0.510
LIG_WRC_WIRS_1 338 343 PF05994 0.270
MOD_CDK_SPxxK_3 176 183 PF00069 0.598
MOD_CK1_1 14 20 PF00069 0.559
MOD_CK1_1 145 151 PF00069 0.611
MOD_CK1_1 165 171 PF00069 0.531
MOD_CK1_1 230 236 PF00069 0.483
MOD_CK1_1 244 250 PF00069 0.597
MOD_CK1_1 25 31 PF00069 0.552
MOD_CK1_1 263 269 PF00069 0.465
MOD_CK1_1 275 281 PF00069 0.537
MOD_CK1_1 297 303 PF00069 0.642
MOD_CK1_1 464 470 PF00069 0.450
MOD_CK1_1 491 497 PF00069 0.620
MOD_CK1_1 85 91 PF00069 0.597
MOD_CK2_1 263 269 PF00069 0.551
MOD_CK2_1 406 412 PF00069 0.304
MOD_CK2_1 448 454 PF00069 0.502
MOD_CK2_1 473 479 PF00069 0.567
MOD_GlcNHglycan 13 16 PF01048 0.612
MOD_GlcNHglycan 145 148 PF01048 0.638
MOD_GlcNHglycan 17 20 PF01048 0.615
MOD_GlcNHglycan 174 177 PF01048 0.573
MOD_GlcNHglycan 24 27 PF01048 0.751
MOD_GlcNHglycan 243 246 PF01048 0.532
MOD_GlcNHglycan 262 265 PF01048 0.660
MOD_GlcNHglycan 274 277 PF01048 0.760
MOD_GlcNHglycan 280 283 PF01048 0.580
MOD_GlcNHglycan 347 350 PF01048 0.377
MOD_GlcNHglycan 369 372 PF01048 0.369
MOD_GlcNHglycan 42 45 PF01048 0.469
MOD_GlcNHglycan 461 464 PF01048 0.536
MOD_GlcNHglycan 84 87 PF01048 0.582
MOD_GSK3_1 11 18 PF00069 0.609
MOD_GSK3_1 162 169 PF00069 0.574
MOD_GSK3_1 170 177 PF00069 0.683
MOD_GSK3_1 237 244 PF00069 0.559
MOD_GSK3_1 25 32 PF00069 0.695
MOD_GSK3_1 259 266 PF00069 0.542
MOD_GSK3_1 293 300 PF00069 0.675
MOD_GSK3_1 303 310 PF00069 0.525
MOD_GSK3_1 316 323 PF00069 0.535
MOD_GSK3_1 345 352 PF00069 0.601
MOD_GSK3_1 81 88 PF00069 0.652
MOD_NEK2_1 174 179 PF00069 0.580
MOD_NEK2_1 246 251 PF00069 0.494
MOD_NEK2_1 314 319 PF00069 0.583
MOD_NEK2_1 327 332 PF00069 0.272
MOD_NEK2_1 336 341 PF00069 0.314
MOD_NEK2_1 367 372 PF00069 0.304
MOD_NEK2_1 388 393 PF00069 0.304
MOD_NEK2_1 405 410 PF00069 0.304
MOD_NEK2_1 49 54 PF00069 0.525
MOD_PIKK_1 316 322 PF00454 0.514
MOD_PKA_1 345 351 PF00069 0.471
MOD_PKA_2 182 188 PF00069 0.588
MOD_PKA_2 230 236 PF00069 0.501
MOD_PKA_2 345 351 PF00069 0.471
MOD_PKA_2 40 46 PF00069 0.530
MOD_PKA_2 93 99 PF00069 0.508
MOD_Plk_1 190 196 PF00069 0.572
MOD_Plk_1 327 333 PF00069 0.331
MOD_Plk_1 473 479 PF00069 0.597
MOD_Plk_2-3 448 454 PF00069 0.502
MOD_Plk_2-3 470 476 PF00069 0.477
MOD_Plk_4 230 236 PF00069 0.574
MOD_Plk_4 300 306 PF00069 0.565
MOD_Plk_4 329 335 PF00069 0.404
MOD_Plk_4 337 343 PF00069 0.369
MOD_Plk_4 93 99 PF00069 0.443
MOD_ProDKin_1 145 151 PF00069 0.689
MOD_ProDKin_1 156 162 PF00069 0.623
MOD_ProDKin_1 176 182 PF00069 0.556
MOD_ProDKin_1 275 281 PF00069 0.606
MOD_ProDKin_1 321 327 PF00069 0.292
MOD_ProDKin_1 481 487 PF00069 0.590
MOD_ProDKin_1 6 12 PF00069 0.533
MOD_ProDKin_1 71 77 PF00069 0.753
MOD_SUMO_rev_2 408 415 PF00179 0.369
TRG_DiLeu_BaEn_4 447 453 PF01217 0.495
TRG_ENDOCYTIC_2 372 375 PF00928 0.304
TRG_ENDOCYTIC_2 380 383 PF00928 0.304
TRG_ENDOCYTIC_2 401 404 PF00928 0.304
TRG_NES_CRM1_1 385 396 PF08389 0.304

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I406 Leptomonas seymouri 52% 100%
A0A3S5H631 Leishmania donovani 99% 96%
A4H582 Leishmania braziliensis 68% 100%
E9AM94 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 99%
Q4QIF4 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS