Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTG1_LEIIN

TriTrypDb:

LINF_080006000

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.594
CLV_MEL_PAP_1	156	162	PF00089	0.669
CLV_NRD_NRD_1	246	248	PF00675	0.584
CLV_NRD_NRD_1	254	256	PF00675	0.628
CLV_NRD_NRD_1	316	318	PF00675	0.559
CLV_NRD_NRD_1	545	547	PF00675	0.545
CLV_NRD_NRD_1	570	572	PF00675	0.465
CLV_NRD_NRD_1	582	584	PF00675	0.579
CLV_NRD_NRD_1	587	589	PF00675	0.621
CLV_NRD_NRD_1	91	93	PF00675	0.718
CLV_PCSK_FUR_1	568	572	PF00082	0.463
CLV_PCSK_FUR_1	89	93	PF00082	0.562
CLV_PCSK_KEX2_1	246	248	PF00082	0.584
CLV_PCSK_KEX2_1	254	256	PF00082	0.628
CLV_PCSK_KEX2_1	316	318	PF00082	0.559
CLV_PCSK_KEX2_1	365	367	PF00082	0.600
CLV_PCSK_KEX2_1	568	570	PF00082	0.466
CLV_PCSK_KEX2_1	582	584	PF00082	0.556
CLV_PCSK_KEX2_1	587	589	PF00082	0.545
CLV_PCSK_KEX2_1	91	93	PF00082	0.718
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.515
CLV_PCSK_PC7_1	312	318	PF00082	0.545
CLV_PCSK_PC7_1	583	589	PF00082	0.571
CLV_PCSK_SKI1_1	402	406	PF00082	0.613
CLV_PCSK_SKI1_1	446	450	PF00082	0.555
CLV_PCSK_SKI1_1	547	551	PF00082	0.465
CLV_PCSK_SKI1_1	553	557	PF00082	0.459
CLV_PCSK_SKI1_1	587	591	PF00082	0.796
CLV_PCSK_SKI1_1	91	95	PF00082	0.570
CLV_Separin_Metazoa	515	519	PF03568	0.561
DEG_APCC_DBOX_1	531	539	PF00400	0.553
DEG_Nend_UBRbox_2	1	3	PF02207	0.579
DEG_SCF_FBW7_1	93	98	PF00400	0.576
DEG_SPOP_SBC_1	170	174	PF00917	0.530
DEG_SPOP_SBC_1	612	616	PF00917	0.586
DOC_MAPK_gen_1	126	135	PF00069	0.635
DOC_MAPK_gen_1	468	476	PF00069	0.501
DOC_MAPK_gen_1	546	552	PF00069	0.451
DOC_MAPK_gen_1	558	565	PF00069	0.443
DOC_MAPK_MEF2A_6	126	135	PF00069	0.709
DOC_MAPK_MEF2A_6	27	34	PF00069	0.527
DOC_PP2B_LxvP_1	266	269	PF13499	0.549
DOC_PP4_FxxP_1	594	597	PF00568	0.515
DOC_PP4_FxxP_1	636	639	PF00568	0.564
DOC_USP7_MATH_1	151	155	PF00917	0.681
DOC_USP7_MATH_1	169	173	PF00917	0.613
DOC_USP7_MATH_1	325	329	PF00917	0.608
DOC_USP7_MATH_1	39	43	PF00917	0.691
DOC_USP7_MATH_1	411	415	PF00917	0.752
DOC_USP7_MATH_1	485	489	PF00917	0.577
DOC_USP7_MATH_1	578	582	PF00917	0.542
DOC_USP7_MATH_1	613	617	PF00917	0.597
DOC_WW_Pin1_4	103	108	PF00397	0.632
DOC_WW_Pin1_4	146	151	PF00397	0.677
DOC_WW_Pin1_4	210	215	PF00397	0.669
DOC_WW_Pin1_4	238	243	PF00397	0.688
DOC_WW_Pin1_4	261	266	PF00397	0.673
DOC_WW_Pin1_4	277	282	PF00397	0.419
DOC_WW_Pin1_4	37	42	PF00397	0.560
DOC_WW_Pin1_4	588	593	PF00397	0.638
DOC_WW_Pin1_4	616	621	PF00397	0.696
DOC_WW_Pin1_4	637	642	PF00397	0.636
DOC_WW_Pin1_4	7	12	PF00397	0.734
DOC_WW_Pin1_4	91	96	PF00397	0.623
LIG_14-3-3_CanoR_1	205	214	PF00244	0.686
LIG_14-3-3_CanoR_1	233	239	PF00244	0.617
LIG_14-3-3_CanoR_1	247	253	PF00244	0.521
LIG_14-3-3_CanoR_1	298	305	PF00244	0.437
LIG_14-3-3_CanoR_1	338	346	PF00244	0.528
LIG_14-3-3_CanoR_1	348	357	PF00244	0.482
LIG_14-3-3_CanoR_1	489	497	PF00244	0.525
LIG_14-3-3_CanoR_1	523	527	PF00244	0.453
LIG_Actin_WH2_2	487	504	PF00022	0.464
LIG_Actin_WH2_2	514	531	PF00022	0.461
LIG_BIR_III_4	631	635	PF00653	0.776
LIG_BRCT_BRCA1_1	590	594	PF00533	0.612
LIG_FHA_1	115	121	PF00498	0.682
LIG_FHA_1	130	136	PF00498	0.566
LIG_FHA_1	233	239	PF00498	0.644
LIG_FHA_1	277	283	PF00498	0.613
LIG_FHA_1	29	35	PF00498	0.697
LIG_FHA_1	338	344	PF00498	0.524
LIG_FHA_1	352	358	PF00498	0.411
LIG_FHA_1	432	438	PF00498	0.454
LIG_FHA_1	445	451	PF00498	0.466
LIG_FHA_1	489	495	PF00498	0.462
LIG_FHA_1	523	529	PF00498	0.457
LIG_FHA_2	359	365	PF00498	0.659
LIG_FHA_2	378	384	PF00498	0.415
LIG_FHA_2	403	409	PF00498	0.692
LIG_FHA_2	434	440	PF00498	0.635
LIG_FHA_2	50	56	PF00498	0.560
LIG_Integrin_RGD_1	219	221	PF01839	0.707
LIG_LIR_Apic_2	221	225	PF02991	0.642
LIG_LIR_Apic_2	591	597	PF02991	0.530
LIG_LIR_Apic_2	635	639	PF02991	0.563
LIG_LIR_Gen_1	172	182	PF02991	0.566
LIG_LIR_Nem_3	172	178	PF02991	0.586
LIG_MYND_1	261	265	PF01753	0.662
LIG_NRBOX	184	190	PF00104	0.520
LIG_NRBOX	342	348	PF00104	0.410
LIG_NRBOX	79	85	PF00104	0.497
LIG_PCNA_yPIPBox_3	468	480	PF02747	0.499
LIG_RPA_C_Fungi	578	590	PF08784	0.548
LIG_SH2_CRK	175	179	PF00017	0.512
LIG_SH2_CRK	222	226	PF00017	0.640
LIG_SH2_GRB2like	19	22	PF00017	0.669
LIG_SH2_NCK_1	20	24	PF00017	0.561
LIG_SH2_STAP1	175	179	PF00017	0.512
LIG_SH2_STAT3	479	482	PF00017	0.496
LIG_SH2_STAT5	293	296	PF00017	0.498
LIG_SH2_STAT5	479	482	PF00017	0.549
LIG_SH3_1	222	228	PF00018	0.634
LIG_SH3_1	27	33	PF00018	0.522
LIG_SH3_3	104	110	PF00018	0.752
LIG_SH3_3	128	134	PF00018	0.689
LIG_SH3_3	147	153	PF00018	0.524
LIG_SH3_3	222	228	PF00018	0.634
LIG_SH3_3	27	33	PF00018	0.450
LIG_SH3_3	272	278	PF00018	0.575
LIG_SH3_3	636	642	PF00018	0.635
LIG_SH3_3	8	14	PF00018	0.650
LIG_SH3_3	90	96	PF00018	0.630
LIG_SUMO_SIM_anti_2	433	439	PF11976	0.454
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.497
LIG_SUMO_SIM_par_1	433	439	PF11976	0.452
LIG_SUMO_SIM_par_1	561	567	PF11976	0.534
LIG_SUMO_SIM_par_1	58	64	PF11976	0.637
LIG_TRAF2_1	145	148	PF00917	0.621
LIG_TRAF2_1	381	384	PF00917	0.465
LIG_TRAF2_1	512	515	PF00917	0.574
LIG_UBA3_1	437	446	PF00899	0.410
MOD_CDC14_SPxK_1	40	43	PF00782	0.581
MOD_CDC14_SPxK_1	640	643	PF00782	0.645
MOD_CDK_SPK_2	588	593	PF00069	0.650
MOD_CDK_SPxK_1	238	244	PF00069	0.602
MOD_CDK_SPxK_1	37	43	PF00069	0.564
MOD_CDK_SPxK_1	637	643	PF00069	0.638
MOD_CDK_SPxxK_3	106	113	PF00069	0.588
MOD_CK1_1	109	115	PF00069	0.601
MOD_CK1_1	141	147	PF00069	0.709
MOD_CK1_1	149	155	PF00069	0.774
MOD_CK1_1	201	207	PF00069	0.706
MOD_CK1_1	328	334	PF00069	0.557
MOD_CK1_1	349	355	PF00069	0.520
MOD_CK1_1	421	427	PF00069	0.611
MOD_CK1_1	488	494	PF00069	0.562
MOD_CK1_1	581	587	PF00069	0.626
MOD_CK1_1	614	620	PF00069	0.577
MOD_CK1_1	637	643	PF00069	0.592
MOD_CK2_1	141	147	PF00069	0.684
MOD_CK2_1	358	364	PF00069	0.507
MOD_CK2_1	377	383	PF00069	0.412
MOD_CK2_1	402	408	PF00069	0.663
MOD_CK2_1	49	55	PF00069	0.619
MOD_CK2_1	492	498	PF00069	0.491
MOD_CK2_1	509	515	PF00069	0.570
MOD_Cter_Amidation	314	317	PF01082	0.588
MOD_DYRK1A_RPxSP_1	588	592	PF00069	0.583
MOD_GlcNHglycan	144	147	PF01048	0.698
MOD_GlcNHglycan	2	5	PF01048	0.707
MOD_GlcNHglycan	200	203	PF01048	0.664
MOD_GlcNHglycan	299	302	PF01048	0.575
MOD_GlcNHglycan	327	330	PF01048	0.604
MOD_GlcNHglycan	334	337	PF01048	0.515
MOD_GlcNHglycan	408	412	PF01048	0.657
MOD_GlcNHglycan	413	416	PF01048	0.619
MOD_GlcNHglycan	420	423	PF01048	0.692
MOD_GlcNHglycan	469	473	PF01048	0.411
MOD_GlcNHglycan	493	497	PF01048	0.428
MOD_GlcNHglycan	583	586	PF01048	0.678
MOD_GlcNHglycan	606	609	PF01048	0.557
MOD_GlcNHglycan	621	624	PF01048	0.684
MOD_GlcNHglycan	635	639	PF01048	0.537
MOD_GlcNHglycan	98	101	PF01048	0.704
MOD_GSK3_1	109	116	PF00069	0.662
MOD_GSK3_1	138	145	PF00069	0.748
MOD_GSK3_1	201	208	PF00069	0.732
MOD_GSK3_1	234	241	PF00069	0.687
MOD_GSK3_1	255	262	PF00069	0.703
MOD_GSK3_1	28	35	PF00069	0.666
MOD_GSK3_1	328	335	PF00069	0.627
MOD_GSK3_1	407	414	PF00069	0.675
MOD_GSK3_1	417	424	PF00069	0.763
MOD_GSK3_1	488	495	PF00069	0.476
MOD_GSK3_1	541	548	PF00069	0.487
MOD_GSK3_1	55	62	PF00069	0.757
MOD_GSK3_1	611	618	PF00069	0.634
MOD_GSK3_1	91	98	PF00069	0.574
MOD_LATS_1	253	259	PF00433	0.604
MOD_N-GLC_1	444	449	PF02516	0.495
MOD_N-GLC_1	84	89	PF02516	0.657
MOD_N-GLC_2	69	71	PF02516	0.520
MOD_NEK2_1	346	351	PF00069	0.457
MOD_NEK2_1	431	436	PF00069	0.449
MOD_NEK2_1	545	550	PF00069	0.451
MOD_NEK2_1	84	89	PF00069	0.657
MOD_PIKK_1	101	107	PF00454	0.659
MOD_PIKK_1	255	261	PF00454	0.665
MOD_PIKK_1	439	445	PF00454	0.537
MOD_PIKK_1	509	515	PF00454	0.535
MOD_PIKK_1	61	67	PF00454	0.608
MOD_PKA_2	232	238	PF00069	0.674
MOD_PKA_2	297	303	PF00069	0.495
MOD_PKA_2	337	343	PF00069	0.469
MOD_PKA_2	488	494	PF00069	0.506
MOD_PKA_2	522	528	PF00069	0.455
MOD_PKA_2	545	551	PF00069	0.452
MOD_PKA_2	581	587	PF00069	0.590
MOD_Plk_1	444	450	PF00069	0.498
MOD_Plk_1	485	491	PF00069	0.570
MOD_Plk_2-3	22	28	PF00069	0.574
MOD_Plk_2-3	358	364	PF00069	0.506
MOD_Plk_2-3	433	439	PF00069	0.492
MOD_Plk_4	151	157	PF00069	0.670
MOD_Plk_4	433	439	PF00069	0.594
MOD_Plk_4	545	551	PF00069	0.465
MOD_Plk_4	76	82	PF00069	0.494
MOD_ProDKin_1	103	109	PF00069	0.631
MOD_ProDKin_1	146	152	PF00069	0.677
MOD_ProDKin_1	210	216	PF00069	0.669
MOD_ProDKin_1	238	244	PF00069	0.690
MOD_ProDKin_1	261	267	PF00069	0.665
MOD_ProDKin_1	277	283	PF00069	0.408
MOD_ProDKin_1	37	43	PF00069	0.564
MOD_ProDKin_1	588	594	PF00069	0.636
MOD_ProDKin_1	616	622	PF00069	0.695
MOD_ProDKin_1	637	643	PF00069	0.638
MOD_ProDKin_1	7	13	PF00069	0.733
MOD_ProDKin_1	91	97	PF00069	0.625
MOD_SUMO_for_1	538	541	PF00179	0.472
MOD_SUMO_rev_2	439	448	PF00179	0.514
MOD_SUMO_rev_2	493	501	PF00179	0.552
TRG_DiLeu_BaEn_1	76	81	PF01217	0.492
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.595
TRG_ENDOCYTIC_2	175	178	PF00928	0.542
TRG_ENDOCYTIC_2	20	23	PF00928	0.566
TRG_ER_diArg_1	557	560	PF00400	0.497
TRG_ER_diArg_1	568	571	PF00400	0.475
TRG_ER_diArg_1	89	92	PF00400	0.699
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P938	Leptomonas seymouri	42%	78%
A0A3S7WQ53	Leishmania donovani	100%	100%
A4H578	Leishmania braziliensis	68%	100%
E9AM89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QIF8	Leishmania major	90%	100%