LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTF4_LEIIN

TriTrypDb:

LINF_080005300

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.655
CLV_NRD_NRD_1	105	107	PF00675	0.459
CLV_NRD_NRD_1	38	40	PF00675	0.513
CLV_PCSK_KEX2_1	105	107	PF00082	0.484
CLV_PCSK_KEX2_1	116	118	PF00082	0.467
CLV_PCSK_KEX2_1	38	40	PF00082	0.513
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.516
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.498
CLV_PCSK_SKI1_1	39	43	PF00082	0.619
DEG_APCC_DBOX_1	131	139	PF00400	0.505
DEG_APCC_DBOX_1	209	217	PF00400	0.594
DEG_Nend_UBRbox_2	1	3	PF02207	0.673
DOC_MAPK_gen_1	105	114	PF00069	0.469
DOC_MAPK_gen_1	207	217	PF00069	0.606
DOC_MAPK_MEF2A_6	210	217	PF00069	0.590
DOC_USP7_MATH_1	4	8	PF00917	0.461
DOC_USP7_MATH_1	70	74	PF00917	0.767
DOC_WW_Pin1_4	180	185	PF00397	0.565
DOC_WW_Pin1_4	79	84	PF00397	0.730
LIG_14-3-3_CanoR_1	172	181	PF00244	0.488
LIG_14-3-3_CanoR_1	210	214	PF00244	0.586
LIG_14-3-3_CanoR_1	38	48	PF00244	0.610
LIG_14-3-3_CanoR_1	56	62	PF00244	0.744
LIG_14-3-3_CanoR_1	87	95	PF00244	0.804
LIG_FHA_1	173	179	PF00498	0.535
LIG_FHA_1	191	197	PF00498	0.275
LIG_FHA_1	40	46	PF00498	0.604
LIG_FHA_2	8	14	PF00498	0.676
LIG_LIR_Gen_1	7	17	PF02991	0.608
LIG_LIR_Nem_3	7	12	PF02991	0.600
LIG_PTB_Apo_2	215	222	PF02174	0.571
LIG_PTB_Phospho_1	215	221	PF10480	0.568
LIG_SH2_NCK_1	118	122	PF00017	0.437
LIG_SH2_STAP1	118	122	PF00017	0.437
LIG_SH2_STAP1	174	178	PF00017	0.530
LIG_SH2_STAT5	152	155	PF00017	0.551
LIG_SH2_STAT5	174	177	PF00017	0.529
LIG_SH2_STAT5	35	38	PF00017	0.447
LIG_SH3_3	156	162	PF00018	0.522
LIG_SH3_3	178	184	PF00018	0.500
LIG_SH3_3	64	70	PF00018	0.767
LIG_UBA3_1	111	116	PF00899	0.564
LIG_WW_3	93	97	PF00397	0.587
MOD_CDC14_SPxK_1	183	186	PF00782	0.653
MOD_CDK_SPxK_1	180	186	PF00069	0.619
MOD_CK1_1	7	13	PF00069	0.672
MOD_CK1_1	89	95	PF00069	0.744
MOD_CK2_1	7	13	PF00069	0.630
MOD_CMANNOS	219	222	PF00535	0.495
MOD_GlcNHglycan	88	91	PF01048	0.746
MOD_GlcNHglycan	97	102	PF01048	0.631
MOD_GSK3_1	172	179	PF00069	0.529
MOD_GSK3_1	186	193	PF00069	0.511
MOD_GSK3_1	78	85	PF00069	0.667
MOD_NEK2_1	31	36	PF00069	0.532
MOD_NEK2_1	41	46	PF00069	0.467
MOD_PK_1	186	192	PF00069	0.666
MOD_PKA_2	145	151	PF00069	0.476
MOD_PKA_2	209	215	PF00069	0.593
MOD_PKA_2	55	61	PF00069	0.664
MOD_PKA_2	70	76	PF00069	0.489
MOD_PKA_2	86	92	PF00069	0.819
MOD_Plk_1	186	192	PF00069	0.571
MOD_Plk_1	4	10	PF00069	0.673
MOD_Plk_4	4	10	PF00069	0.637
MOD_ProDKin_1	180	186	PF00069	0.572
MOD_ProDKin_1	79	85	PF00069	0.730
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.459
TRG_ER_diArg_1	132	135	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAM0	Leptomonas seymouri	58%	100%
A0A1X0NQK9	Trypanosomatidae	34%	91%
A0A3S7WQ20	Leishmania donovani	100%	100%
A0A422N813	Trypanosoma rangeli	33%	83%
A4H571	Leishmania braziliensis	80%	100%
C9ZPN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	84%
E9AM82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QIG5	Leishmania major	92%	100%