Putative vesicle-associated membrane protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qc-SNARE protein - putative

Species:

Leishmania infantum

UniProt:

A4HTF3_LEIIN

TriTrypDb:

LINF_080005200

Length:

215

Annotations

LeishMANIAdb annotations

A conserved SNARE protein with a tail anchor. Distantly similar to mammalian VAMP7.. Localization: Endosomal (by homology)

Annotations by Jardim et al.

Vesicle mediated transport, vesicle-associated membrane

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Phosphorylation

Amastigote: 160

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HTF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTF3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0016192	vesicle-mediated transport	4	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.608
CLV_PCSK_KEX2_1	177	179	PF00082	0.223
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.233
CLV_PCSK_SKI1_1	106	110	PF00082	0.324
CLV_PCSK_SKI1_1	183	187	PF00082	0.231
CLV_PCSK_SKI1_1	78	82	PF00082	0.286
DOC_CYCLIN_RxL_1	177	188	PF00134	0.476
DOC_CYCLIN_yClb5_NLxxxL_5	180	189	PF00134	0.512
DOC_MAPK_gen_1	183	192	PF00069	0.440
DOC_MAPK_MEF2A_6	183	191	PF00069	0.433
LIG_14-3-3_CanoR_1	172	180	PF00244	0.476
LIG_14-3-3_CanoR_1	76	81	PF00244	0.498
LIG_Actin_WH2_2	173	188	PF00022	0.492
LIG_Actin_WH2_2	88	105	PF00022	0.619
LIG_FHA_1	10	16	PF00498	0.548
LIG_FHA_1	186	192	PF00498	0.317
LIG_FHA_2	152	158	PF00498	0.448
LIG_FHA_2	159	165	PF00498	0.441
LIG_FHA_2	44	50	PF00498	0.523
LIG_FHA_2	69	75	PF00498	0.515
LIG_GBD_Chelix_1	195	203	PF00786	0.366
LIG_Integrin_RGD_1	148	150	PF01839	0.241
LIG_LIR_Apic_2	114	119	PF02991	0.522
LIG_LIR_Gen_1	79	89	PF02991	0.502
LIG_LIR_Nem_3	79	84	PF02991	0.459
LIG_NRP_CendR_1	213	215	PF00754	0.615
LIG_PCNA_PIPBox_1	77	86	PF02747	0.507
LIG_PCNA_yPIPBox_3	123	135	PF02747	0.462
LIG_SH2_CRK	116	120	PF00017	0.535
LIG_SH2_CRK	5	9	PF00017	0.470
LIG_SH2_CRK	56	60	PF00017	0.497
LIG_SH2_NCK_1	116	120	PF00017	0.535
LIG_SH2_NCK_1	5	9	PF00017	0.476
LIG_SH2_STAT5	58	61	PF00017	0.487
LIG_SUMO_SIM_anti_2	188	193	PF11976	0.313
LIG_TYR_ITIM	3	8	PF00017	0.474
LIG_TYR_ITIM	54	59	PF00017	0.506
LIG_UBA3_1	138	144	PF00899	0.451
LIG_UBA3_1	199	208	PF00899	0.295
MOD_CK1_1	94	100	PF00069	0.650
MOD_CK2_1	151	157	PF00069	0.471
MOD_CK2_1	57	63	PF00069	0.500
MOD_Cter_Amidation	104	107	PF01082	0.350
MOD_LATS_1	156	162	PF00433	0.492
MOD_N-GLC_1	209	214	PF02516	0.590
MOD_N-GLC_2	179	181	PF02516	0.262
MOD_NEK2_1	185	190	PF00069	0.463
MOD_NEK2_1	26	31	PF00069	0.551
MOD_PIKK_1	94	100	PF00454	0.663
MOD_PKA_2	171	177	PF00069	0.476
MOD_PKA_2	91	97	PF00069	0.606
MOD_Plk_4	185	191	PF00069	0.452
MOD_SUMO_rev_2	6	15	PF00179	0.502
TRG_ENDOCYTIC_2	5	8	PF00928	0.468
TRG_ENDOCYTIC_2	56	59	PF00928	0.487
TRG_ER_diArg_1	75	78	PF00400	0.520
TRG_NES_CRM1_1	129	143	PF08389	0.436
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I418	Leptomonas seymouri	92%	99%
A0A0N1IMB1	Leptomonas seymouri	28%	98%
A0A0S4IUW0	Bodo saltans	80%	100%
A0A0S4IXW4	Bodo saltans	44%	96%
A0A0S4JCC4	Bodo saltans	30%	92%
A0A0S4JYF9	Bodo saltans	34%	100%
A0A1X0NF95	Trypanosomatidae	30%	97%
A0A1X0NQE9	Trypanosomatidae	86%	100%
A0A1X0P780	Trypanosomatidae	31%	100%
A0A3S7WQ28	Leishmania donovani	100%	100%
A0A3S7X115	Leishmania donovani	27%	98%
A0A422N3E0	Trypanosoma rangeli	28%	100%
A0A422N7W7	Trypanosoma rangeli	85%	100%
A0A422NDY3	Trypanosoma rangeli	31%	97%
A4H570	Leishmania braziliensis	94%	100%
A4HG15	Leishmania braziliensis	26%	97%
A4I337	Leishmania infantum	27%	98%
C9ZJK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	97%
C9ZPM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
E9ACV5	Leishmania major	28%	96%
E9AM81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AZE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	96%
O23429	Arabidopsis thaliana	25%	97%
O48850	Arabidopsis thaliana	28%	75%
O49377	Arabidopsis thaliana	28%	98%
P47192	Arabidopsis thaliana	28%	97%
P51809	Homo sapiens	27%	98%
P70280	Mus musculus	27%	98%
Q17QI5	Bos taurus	27%	98%
Q4QIG6	Leishmania major	100%	100%
Q54NW7	Dictyostelium discoideum	25%	100%
Q5RF94	Pongo abelii	27%	98%
Q5ZL74	Gallus gallus	26%	98%
Q86AQ7	Dictyostelium discoideum	23%	83%
Q9FMR5	Arabidopsis thaliana	27%	97%
Q9JHW5	Rattus norvegicus	27%	98%
Q9LFP1	Arabidopsis thaliana	25%	97%
Q9MAS5	Arabidopsis thaliana	30%	98%
Q9SIQ9	Arabidopsis thaliana	28%	98%
Q9ZTW3	Arabidopsis thaliana	28%	98%
V5BFM1	Trypanosoma cruzi	28%	97%