Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTF2_LEIIN

TriTrypDb:

LINF_080005100

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.635
CLV_PCSK_KEX2_1	240	242	PF00082	0.487
CLV_PCSK_KEX2_1	25	27	PF00082	0.596
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.487
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.612
CLV_PCSK_SKI1_1	143	147	PF00082	0.483
DOC_MAPK_DCC_7	39	47	PF00069	0.645
DOC_MAPK_MEF2A_6	160	167	PF00069	0.498
DOC_MAPK_MEF2A_6	39	47	PF00069	0.658
DOC_PP2B_LxvP_1	181	184	PF13499	0.507
DOC_PP2B_LxvP_1	20	23	PF13499	0.642
DOC_PP2B_PxIxI_1	162	168	PF00149	0.487
DOC_PP4_FxxP_1	124	127	PF00568	0.626
DOC_PP4_FxxP_1	82	85	PF00568	0.469
DOC_WW_Pin1_4	147	152	PF00397	0.570
DOC_WW_Pin1_4	195	200	PF00397	0.589
LIG_14-3-3_CanoR_1	172	177	PF00244	0.532
LIG_14-3-3_CanoR_1	214	222	PF00244	0.546
LIG_14-3-3_CanoR_1	70	79	PF00244	0.564
LIG_APCC_ABBA_1	95	100	PF00400	0.641
LIG_BIR_II_1	1	5	PF00653	0.723
LIG_BIR_III_2	35	39	PF00653	0.564
LIG_BIR_III_4	66	70	PF00653	0.622
LIG_BRCT_BRCA1_1	1	5	PF00533	0.645
LIG_BRCT_BRCA1_1	72	76	PF00533	0.622
LIG_EVH1_1	181	185	PF00568	0.589
LIG_EVH1_2	184	188	PF00568	0.605
LIG_FHA_1	104	110	PF00498	0.616
LIG_FHA_1	171	177	PF00498	0.532
LIG_FHA_1	53	59	PF00498	0.703
LIG_FHA_1	92	98	PF00498	0.590
LIG_FHA_2	257	263	PF00498	0.523
LIG_LIR_Apic_2	266	272	PF02991	0.475
LIG_LIR_Gen_1	55	65	PF02991	0.517
LIG_LIR_Nem_3	187	191	PF02991	0.518
LIG_LIR_Nem_3	2	8	PF02991	0.611
LIG_LIR_Nem_3	55	60	PF02991	0.525
LIG_LIR_Nem_3	73	79	PF02991	0.485
LIG_LYPXL_yS_3	162	165	PF13949	0.551
LIG_MLH1_MIPbox_1	1	5	PF16413	0.645
LIG_PTB_Apo_2	201	208	PF02174	0.516
LIG_SH2_CRK	269	273	PF00017	0.515
LIG_SH2_CRK	83	87	PF00017	0.618
LIG_SH2_STAP1	32	36	PF00017	0.699
LIG_SH2_STAT3	205	208	PF00017	0.490
LIG_SH2_STAT5	209	212	PF00017	0.636
LIG_SH2_STAT5	252	255	PF00017	0.557
LIG_SH3_3	176	182	PF00018	0.555
LIG_SUMO_SIM_anti_2	175	180	PF11976	0.601
LIG_WRC_WIRS_1	54	59	PF05994	0.428
MOD_CK1_1	198	204	PF00069	0.575
MOD_CK1_1	213	219	PF00069	0.524
MOD_CK2_1	101	107	PF00069	0.593
MOD_CK2_1	256	262	PF00069	0.538
MOD_GlcNHglycan	226	229	PF01048	0.548
MOD_GlcNHglycan	72	75	PF01048	0.649
MOD_GlcNHglycan	91	94	PF01048	0.463
MOD_GSK3_1	166	173	PF00069	0.519
MOD_GSK3_1	194	201	PF00069	0.649
MOD_GSK3_1	52	59	PF00069	0.616
MOD_GSK3_1	89	96	PF00069	0.564
MOD_GSK3_1	99	106	PF00069	0.557
MOD_LATS_1	68	74	PF00433	0.524
MOD_N-GLC_1	100	105	PF02516	0.466
MOD_N-GLC_1	262	267	PF02516	0.511
MOD_N-GLC_1	52	57	PF02516	0.701
MOD_NEK2_1	99	104	PF00069	0.619
MOD_NEK2_2	93	98	PF00069	0.642
MOD_PIKK_1	166	172	PF00454	0.586
MOD_PK_1	172	178	PF00069	0.548
MOD_PKA_2	213	219	PF00069	0.538
MOD_Plk_1	100	106	PF00069	0.628
MOD_Plk_1	152	158	PF00069	0.598
MOD_Plk_1	52	58	PF00069	0.658
MOD_Plk_4	174	180	PF00069	0.514
MOD_Plk_4	53	59	PF00069	0.596
MOD_ProDKin_1	147	153	PF00069	0.572
MOD_ProDKin_1	195	201	PF00069	0.583
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.683
TRG_ENDOCYTIC_2	162	165	PF00928	0.551
TRG_ENDOCYTIC_2	83	86	PF00928	0.629
TRG_ER_diArg_1	23	26	PF00400	0.686
TRG_NLS_MonoExtC_3	23	28	PF00514	0.685
TRG_NLS_MonoExtN_4	23	28	PF00514	0.684
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE07	Leptomonas seymouri	59%	98%
A0A1X0NNW9	Trypanosomatidae	28%	100%
A0A3S5H624	Leishmania donovani	99%	100%
A0A422N819	Trypanosoma rangeli	34%	100%
A4H569	Leishmania braziliensis	73%	100%
C9ZPM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AM80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QIG7	Leishmania major	90%	100%
V5BLP6	Trypanosoma cruzi	33%	100%