MPN domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTE9_LEIIN

TriTrypDb:

LINF_070012000

Length:

335

Annotations

Annotations by Jardim et al.

Translation, eukaryotic translation initiation factor 3 subunit h

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005852	eukaryotic translation initiation factor 3 complex	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HTE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTE9

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0016579	protein deubiquitination	6	1
GO:0019538	protein metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0008233	peptidase activity	3	1
GO:0008237	metallopeptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0044877	protein-containing complex binding	2	1
GO:0070628	proteasome binding	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	316	320	PF00656	0.485
CLV_NRD_NRD_1	105	107	PF00675	0.530
CLV_NRD_NRD_1	108	110	PF00675	0.491
CLV_NRD_NRD_1	151	153	PF00675	0.480
CLV_NRD_NRD_1	207	209	PF00675	0.568
CLV_PCSK_KEX2_1	206	208	PF00082	0.513
CLV_PCSK_PC7_1	202	208	PF00082	0.532
CLV_PCSK_SKI1_1	109	113	PF00082	0.490
CLV_PCSK_SKI1_1	116	120	PF00082	0.419
CLV_PCSK_SKI1_1	56	60	PF00082	0.480

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2B4	Leptomonas seymouri	73%	100%
A0A0S4KFQ8	Bodo saltans	28%	99%
A0A1X0NPP9	Trypanosomatidae	35%	100%
A0A3S7WPX1	Leishmania donovani	100%	100%
A0A422MVQ1	Trypanosoma rangeli	33%	100%
A4H515	Leishmania braziliensis	94%	100%
E9AL77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4QIM7	Leishmania major	99%	100%
V5BNS6	Trypanosoma cruzi	32%	100%

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