MPN domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTE9_LEIIN

TriTrypDb:

LINF_070012000

Length:

335

Annotations

Annotations by Jardim et al.

Translation, eukaryotic translation initiation factor 3 subunit h

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005852	eukaryotic translation initiation factor 3 complex	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HTE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTE9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0016579	protein deubiquitination	6	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0036211	protein modification process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0008233	peptidase activity	3	1
GO:0008237	metallopeptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0044877	protein-containing complex binding	2	1
GO:0070628	proteasome binding	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	316	320	PF00656	0.485
CLV_NRD_NRD_1	105	107	PF00675	0.530
CLV_NRD_NRD_1	108	110	PF00675	0.491
CLV_NRD_NRD_1	151	153	PF00675	0.480
CLV_NRD_NRD_1	207	209	PF00675	0.568
CLV_PCSK_KEX2_1	206	208	PF00082	0.513
CLV_PCSK_PC7_1	202	208	PF00082	0.532
CLV_PCSK_SKI1_1	109	113	PF00082	0.490
CLV_PCSK_SKI1_1	116	120	PF00082	0.419
CLV_PCSK_SKI1_1	56	60	PF00082	0.480
CLV_PCSK_SKI1_1	62	66	PF00082	0.440
DEG_APCC_DBOX_1	158	166	PF00400	0.452
DEG_Nend_Nbox_1	1	3	PF02207	0.527
DOC_CYCLIN_RxL_1	104	115	PF00134	0.536
DOC_MAPK_DCC_7	159	167	PF00069	0.444
DOC_MAPK_MEF2A_6	159	167	PF00069	0.444
DOC_MAPK_MEF2A_6	83	90	PF00069	0.576
DOC_PP2B_PxIxI_1	85	91	PF00149	0.594
DOC_PP4_FxxP_1	35	38	PF00568	0.487
DOC_USP7_MATH_1	214	218	PF00917	0.524
DOC_USP7_MATH_1	256	260	PF00917	0.421
DOC_USP7_MATH_1	58	62	PF00917	0.531
DOC_USP7_UBL2_3	27	31	PF12436	0.605
DOC_WW_Pin1_4	183	188	PF00397	0.400
LIG_14-3-3_CanoR_1	173	177	PF00244	0.332
LIG_14-3-3_CanoR_1	206	211	PF00244	0.579
LIG_14-3-3_CanoR_1	56	65	PF00244	0.506
LIG_14-3-3_CanoR_1	7	17	PF00244	0.606
LIG_14-3-3_CanoR_1	95	102	PF00244	0.592
LIG_AP2alpha_2	170	172	PF02296	0.356
LIG_BRCT_BRCA1_1	139	143	PF00533	0.466
LIG_EH_1	143	147	PF12763	0.448
LIG_eIF4E_1	192	198	PF01652	0.490
LIG_FHA_1	128	134	PF00498	0.495
LIG_FHA_1	172	178	PF00498	0.498
LIG_FHA_1	275	281	PF00498	0.437
LIG_FHA_1	302	308	PF00498	0.411
LIG_FHA_1	313	319	PF00498	0.335
LIG_FHA_1	74	80	PF00498	0.363
LIG_FHA_2	95	101	PF00498	0.569
LIG_LIR_Apic_2	33	38	PF02991	0.516
LIG_LIR_Gen_1	235	245	PF02991	0.412
LIG_LIR_Nem_3	140	146	PF02991	0.468
LIG_LIR_Nem_3	168	172	PF02991	0.454
LIG_LIR_Nem_3	188	194	PF02991	0.210
LIG_LIR_Nem_3	235	240	PF02991	0.401
LIG_LIR_Nem_3	252	257	PF02991	0.411
LIG_LIR_Nem_3	44	48	PF02991	0.360
LIG_PTB_Apo_2	39	46	PF02174	0.421
LIG_SH2_CRK	194	198	PF00017	0.382
LIG_SH2_CRK	328	332	PF00017	0.480
LIG_SH2_SRC	265	268	PF00017	0.456
LIG_SH2_STAP1	194	198	PF00017	0.453
LIG_SH2_STAP1	328	332	PF00017	0.497
LIG_SH2_STAT5	185	188	PF00017	0.336
LIG_SH2_STAT5	265	268	PF00017	0.341
LIG_SUMO_SIM_par_1	75	81	PF11976	0.429
LIG_TRAF2_1	97	100	PF00917	0.587
LIG_TYR_ITIM	326	331	PF00017	0.480
LIG_UBA3_1	305	309	PF00899	0.444
MOD_CK1_1	147	153	PF00069	0.434
MOD_CK1_1	196	202	PF00069	0.501
MOD_CK1_1	217	223	PF00069	0.534
MOD_CK2_1	94	100	PF00069	0.602
MOD_DYRK1A_RPxSP_1	183	187	PF00069	0.440
MOD_GlcNHglycan	139	142	PF01048	0.355
MOD_GlcNHglycan	216	219	PF01048	0.473
MOD_GlcNHglycan	323	326	PF01048	0.488
MOD_GSK3_1	193	200	PF00069	0.535
MOD_GSK3_1	256	263	PF00069	0.426
MOD_GSK3_1	54	61	PF00069	0.522
MOD_GSK3_1	73	80	PF00069	0.382
MOD_LATS_1	310	316	PF00433	0.479
MOD_N-GLC_1	274	279	PF02516	0.479
MOD_N-GLC_1	41	46	PF02516	0.412
MOD_N-GLC_1	8	13	PF02516	0.609
MOD_NEK2_1	136	141	PF00069	0.444
MOD_NEK2_1	172	177	PF00069	0.342
MOD_NEK2_1	260	265	PF00069	0.450
MOD_NEK2_1	269	274	PF00069	0.332
MOD_NEK2_1	321	326	PF00069	0.397
MOD_NEK2_1	327	332	PF00069	0.353
MOD_PKA_1	206	212	PF00069	0.575
MOD_PKA_2	158	164	PF00069	0.486
MOD_PKA_2	172	178	PF00069	0.310
MOD_PKA_2	206	212	PF00069	0.576
MOD_PKA_2	94	100	PF00069	0.559
MOD_Plk_1	41	47	PF00069	0.409
MOD_Plk_2-3	94	100	PF00069	0.577
MOD_Plk_4	172	178	PF00069	0.376
MOD_Plk_4	193	199	PF00069	0.526
MOD_Plk_4	301	307	PF00069	0.432
MOD_Plk_4	327	333	PF00069	0.400
MOD_Plk_4	64	70	PF00069	0.423
MOD_ProDKin_1	183	189	PF00069	0.411
MOD_SUMO_for_1	230	233	PF00179	0.446
MOD_SUMO_rev_2	103	112	PF00179	0.519
MOD_SUMO_rev_2	75	84	PF00179	0.459
TRG_DiLeu_BaEn_1	303	308	PF01217	0.496
TRG_ENDOCYTIC_2	169	172	PF00928	0.353
TRG_ENDOCYTIC_2	194	197	PF00928	0.390
TRG_ENDOCYTIC_2	2	5	PF00928	0.573
TRG_ENDOCYTIC_2	328	331	PF00928	0.493
TRG_ER_diArg_1	206	208	PF00400	0.603
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2B4	Leptomonas seymouri	73%	100%
A0A0S4KFQ8	Bodo saltans	28%	99%
A0A1X0NPP9	Trypanosomatidae	35%	100%
A0A3S7WPX1	Leishmania donovani	100%	100%
A0A422MVQ1	Trypanosoma rangeli	33%	100%
A4H515	Leishmania braziliensis	94%	100%
E9AL77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4QIM7	Leishmania major	99%	100%
V5BNS6	Trypanosoma cruzi	32%	100%