SANT domain-containing protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTE6_LEIIN

TriTrypDb:

LINF_070015100

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 104, 107, 336

Expansion

Sequence features

A4HTE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.639
CLV_C14_Caspase3-7	405	409	PF00656	0.641
CLV_C14_Caspase3-7	492	496	PF00656	0.663
CLV_NRD_NRD_1	150	152	PF00675	0.741
CLV_NRD_NRD_1	183	185	PF00675	0.674
CLV_NRD_NRD_1	446	448	PF00675	0.761
CLV_NRD_NRD_1	504	506	PF00675	0.674
CLV_NRD_NRD_1	80	82	PF00675	0.745
CLV_PCSK_KEX2_1	149	151	PF00082	0.749
CLV_PCSK_KEX2_1	183	185	PF00082	0.674
CLV_PCSK_KEX2_1	221	223	PF00082	0.734
CLV_PCSK_KEX2_1	504	506	PF00082	0.674
CLV_PCSK_KEX2_1	80	82	PF00082	0.745
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.725
CLV_PCSK_PC7_1	500	506	PF00082	0.636
CLV_PCSK_SKI1_1	151	155	PF00082	0.738
CLV_PCSK_SKI1_1	370	374	PF00082	0.723
CLV_PCSK_SKI1_1	627	631	PF00082	0.664
DOC_CDC14_PxL_1	432	440	PF14671	0.766
DOC_CKS1_1	265	270	PF01111	0.767
DOC_CKS1_1	274	279	PF01111	0.618
DOC_MAPK_gen_1	170	178	PF00069	0.764
DOC_MAPK_MEF2A_6	170	178	PF00069	0.729
DOC_MAPK_RevD_3	67	81	PF00069	0.581
DOC_PP2B_PxIxI_1	173	179	PF00149	0.640
DOC_USP7_MATH_1	133	137	PF00917	0.632
DOC_USP7_MATH_1	159	163	PF00917	0.846
DOC_USP7_MATH_1	346	350	PF00917	0.747
DOC_USP7_MATH_1	479	483	PF00917	0.784
DOC_USP7_MATH_1	485	489	PF00917	0.726
DOC_USP7_MATH_1	540	544	PF00917	0.837
DOC_USP7_MATH_1	595	599	PF00917	0.737
DOC_USP7_MATH_1	621	625	PF00917	0.594
DOC_USP7_UBL2_3	451	455	PF12436	0.742
DOC_USP7_UBL2_3	626	630	PF12436	0.579
DOC_WW_Pin1_4	170	175	PF00397	0.640
DOC_WW_Pin1_4	235	240	PF00397	0.823
DOC_WW_Pin1_4	261	266	PF00397	0.778
DOC_WW_Pin1_4	273	278	PF00397	0.592
DOC_WW_Pin1_4	304	309	PF00397	0.761
DOC_WW_Pin1_4	406	411	PF00397	0.717
DOC_WW_Pin1_4	572	577	PF00397	0.751
LIG_14-3-3_CanoR_1	183	191	PF00244	0.671
LIG_14-3-3_CanoR_1	206	215	PF00244	0.727
LIG_14-3-3_CanoR_1	229	239	PF00244	0.778
LIG_14-3-3_CanoR_1	370	375	PF00244	0.819
LIG_14-3-3_CanoR_1	52	58	PF00244	0.745
LIG_14-3-3_CanoR_1	554	560	PF00244	0.689
LIG_14-3-3_CanoR_1	619	629	PF00244	0.594
LIG_14-3-3_CanoR_1	8	13	PF00244	0.646
LIG_APCC_ABBA_1	559	564	PF00400	0.612
LIG_BIR_II_1	1	5	PF00653	0.720
LIG_BRCT_BRCA1_1	250	254	PF00533	0.678
LIG_FHA_1	22	28	PF00498	0.690
LIG_FHA_1	232	238	PF00498	0.809
LIG_FHA_1	241	247	PF00498	0.739
LIG_FHA_1	274	280	PF00498	0.744
LIG_FHA_1	492	498	PF00498	0.664
LIG_FHA_1	73	79	PF00498	0.757
LIG_FHA_2	243	249	PF00498	0.715
LIG_Integrin_isoDGR_2	87	89	PF01839	0.720
LIG_SH2_STAP1	250	254	PF00017	0.678
LIG_SH2_STAP1	291	295	PF00017	0.684
LIG_SH3_2	165	170	PF14604	0.635
LIG_SH3_3	162	168	PF00018	0.642
LIG_SH3_3	259	265	PF00018	0.729
LIG_SH3_3	397	403	PF00018	0.728
LIG_SH3_3	453	459	PF00018	0.739
LIG_SH3_3	495	501	PF00018	0.642
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.740
LIG_SUMO_SIM_par_1	242	249	PF11976	0.668
LIG_SUMO_SIM_par_1	436	441	PF11976	0.723
LIG_TRAF2_1	614	617	PF00917	0.631
LIG_WRC_WIRS_1	351	356	PF05994	0.627
LIG_WW_3	575	579	PF00397	0.616
MOD_CAAXbox	632	635	PF01239	0.750
MOD_CDC14_SPxK_1	575	578	PF00782	0.701
MOD_CDK_SPxK_1	572	578	PF00069	0.704
MOD_CDK_SPxxK_3	170	177	PF00069	0.642
MOD_CK1_1	104	110	PF00069	0.764
MOD_CK1_1	182	188	PF00069	0.665
MOD_CK1_1	233	239	PF00069	0.772
MOD_CK1_1	240	246	PF00069	0.701
MOD_CK1_1	264	270	PF00069	0.817
MOD_CK1_1	36	42	PF00069	0.826
MOD_CK1_1	362	368	PF00069	0.667
MOD_CK1_1	376	382	PF00069	0.762
MOD_CK1_1	409	415	PF00069	0.668
MOD_CK1_1	470	476	PF00069	0.807
MOD_CK1_1	525	531	PF00069	0.717
MOD_CK1_1	566	572	PF00069	0.728
MOD_CK1_1	615	621	PF00069	0.712
MOD_CK2_1	134	140	PF00069	0.761
MOD_CK2_1	252	258	PF00069	0.620
MOD_CK2_1	304	310	PF00069	0.704
MOD_CK2_1	468	474	PF00069	0.741
MOD_CK2_1	611	617	PF00069	0.786
MOD_GlcNHglycan	140	143	PF01048	0.666
MOD_GlcNHglycan	186	189	PF01048	0.762
MOD_GlcNHglycan	223	226	PF01048	0.753
MOD_GlcNHglycan	248	253	PF01048	0.723
MOD_GlcNHglycan	361	364	PF01048	0.633
MOD_GlcNHglycan	375	378	PF01048	0.759
MOD_GlcNHglycan	397	400	PF01048	0.691
MOD_GlcNHglycan	411	414	PF01048	0.668
MOD_GlcNHglycan	511	514	PF01048	0.669
MOD_GlcNHglycan	529	532	PF01048	0.602
MOD_GlcNHglycan	542	545	PF01048	0.637
MOD_GlcNHglycan	587	590	PF01048	0.716
MOD_GlcNHglycan	597	600	PF01048	0.654
MOD_GSK3_1	134	141	PF00069	0.824
MOD_GSK3_1	182	189	PF00069	0.651
MOD_GSK3_1	231	238	PF00069	0.792
MOD_GSK3_1	240	247	PF00069	0.653
MOD_GSK3_1	248	255	PF00069	0.712
MOD_GSK3_1	257	264	PF00069	0.733
MOD_GSK3_1	269	276	PF00069	0.680
MOD_GSK3_1	33	40	PF00069	0.830
MOD_GSK3_1	346	353	PF00069	0.749
MOD_GSK3_1	388	395	PF00069	0.740
MOD_GSK3_1	402	409	PF00069	0.653
MOD_GSK3_1	446	453	PF00069	0.750
MOD_GSK3_1	469	476	PF00069	0.807
MOD_GSK3_1	53	60	PF00069	0.785
MOD_GSK3_1	611	618	PF00069	0.778
MOD_LATS_1	458	464	PF00433	0.611
MOD_N-GLC_1	36	41	PF02516	0.813
MOD_N-GLC_1	479	484	PF02516	0.748
MOD_N-GLC_1	522	527	PF02516	0.722
MOD_N-GLC_1	566	571	PF02516	0.738
MOD_N-GLC_2	579	581	PF02516	0.610
MOD_NEK2_1	1	6	PF00069	0.713
MOD_NEK2_1	138	143	PF00069	0.784
MOD_NEK2_1	50	55	PF00069	0.805
MOD_NEK2_1	527	532	PF00069	0.768
MOD_NEK2_2	252	257	PF00069	0.672
MOD_NEK2_2	26	31	PF00069	0.583
MOD_NEK2_2	621	626	PF00069	0.592
MOD_PIKK_1	207	213	PF00454	0.734
MOD_PIKK_1	37	43	PF00454	0.752
MOD_PIKK_1	378	384	PF00454	0.768
MOD_PIKK_1	50	56	PF00454	0.556
MOD_PIKK_1	566	572	PF00454	0.754
MOD_PIKK_1	60	66	PF00454	0.788
MOD_PK_1	65	71	PF00069	0.616
MOD_PKA_1	221	227	PF00069	0.726
MOD_PKA_1	509	515	PF00069	0.631
MOD_PKA_2	182	188	PF00069	0.652
MOD_PKA_2	21	27	PF00069	0.664
MOD_PKA_2	221	227	PF00069	0.726
MOD_PKA_2	341	347	PF00069	0.716
MOD_PKA_2	446	452	PF00069	0.729
MOD_Plk_1	252	258	PF00069	0.725
MOD_Plk_1	298	304	PF00069	0.610
MOD_Plk_1	479	485	PF00069	0.766
MOD_Plk_1	514	520	PF00069	0.627
MOD_Plk_4	298	304	PF00069	0.641
MOD_Plk_4	460	466	PF00069	0.609
MOD_Plk_4	522	528	PF00069	0.704
MOD_Plk_4	555	561	PF00069	0.629
MOD_Plk_4	72	78	PF00069	0.727
MOD_Plk_4	8	14	PF00069	0.652
MOD_ProDKin_1	170	176	PF00069	0.640
MOD_ProDKin_1	235	241	PF00069	0.822
MOD_ProDKin_1	261	267	PF00069	0.780
MOD_ProDKin_1	273	279	PF00069	0.590
MOD_ProDKin_1	304	310	PF00069	0.764
MOD_ProDKin_1	406	412	PF00069	0.717
MOD_ProDKin_1	572	578	PF00069	0.752
MOD_SUMO_rev_2	419	426	PF00179	0.630
MOD_SUMO_rev_2	512	518	PF00179	0.660
TRG_DiLeu_BaEn_4	313	319	PF01217	0.625
TRG_ER_diArg_1	110	113	PF00400	0.762
TRG_ER_diArg_1	149	151	PF00400	0.749
TRG_ER_diArg_1	603	606	PF00400	0.754
TRG_ER_diArg_1	79	81	PF00400	0.708
TRG_NLS_MonoExtC_3	625	630	PF00514	0.666
TRG_NLS_MonoExtN_4	626	631	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	605	609	PF00026	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQ13	Leishmania donovani	99%	100%
A4H538	Leishmania braziliensis	26%	100%
E9ALA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	98%
Q4QIJ8	Leishmania major	72%	99%