Protein phosphatase inhibitor 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTE3_LEIIN

TriTrypDb:

LINF_070014400

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HTE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.848
CLV_NRD_NRD_1	123	125	PF00675	0.674
CLV_NRD_NRD_1	140	142	PF00675	0.589
CLV_NRD_NRD_1	154	156	PF00675	0.757
CLV_NRD_NRD_1	170	172	PF00675	0.583
CLV_NRD_NRD_1	184	186	PF00675	0.672
CLV_NRD_NRD_1	194	196	PF00675	0.769
CLV_NRD_NRD_1	324	326	PF00675	0.706
CLV_NRD_NRD_1	99	101	PF00675	0.811
CLV_PCSK_KEX2_1	140	142	PF00082	0.694
CLV_PCSK_KEX2_1	154	156	PF00082	0.757
CLV_PCSK_KEX2_1	170	172	PF00082	0.583
CLV_PCSK_KEX2_1	183	185	PF00082	0.593
CLV_PCSK_KEX2_1	314	316	PF00082	0.737
CLV_PCSK_KEX2_1	324	326	PF00082	0.531
CLV_PCSK_KEX2_1	99	101	PF00082	0.811
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.737
CLV_PCSK_SKI1_1	218	222	PF00082	0.652
CLV_PCSK_SKI1_1	314	318	PF00082	0.734
DEG_APCC_DBOX_1	98	106	PF00400	0.800
DEG_Nend_UBRbox_3	1	3	PF02207	0.651
DOC_CKS1_1	208	213	PF01111	0.658
DOC_MAPK_MEF2A_6	33	41	PF00069	0.669
DOC_PP2B_LxvP_1	225	228	PF13499	0.850
DOC_PP4_FxxP_1	161	164	PF00568	0.821
DOC_PP4_FxxP_1	59	62	PF00568	0.811
DOC_USP7_MATH_1	104	108	PF00917	0.798
DOC_USP7_MATH_1	164	168	PF00917	0.824
DOC_USP7_MATH_1	187	191	PF00917	0.696
DOC_USP7_MATH_1	349	353	PF00917	0.745
DOC_USP7_MATH_1	361	365	PF00917	0.650
DOC_USP7_MATH_1	73	77	PF00917	0.765
DOC_USP7_UBL2_3	388	392	PF12436	0.679
DOC_WW_Pin1_4	100	105	PF00397	0.798
DOC_WW_Pin1_4	183	188	PF00397	0.877
DOC_WW_Pin1_4	207	212	PF00397	0.833
DOC_WW_Pin1_4	231	236	PF00397	0.685
DOC_WW_Pin1_4	257	262	PF00397	0.845
LIG_14-3-3_CanoR_1	170	176	PF00244	0.684
LIG_14-3-3_CanoR_1	239	246	PF00244	0.877
LIG_14-3-3_CanoR_1	281	288	PF00244	0.846
LIG_14-3-3_CanoR_1	418	423	PF00244	0.759
LIG_ActinCP_TwfCPI_2	161	171	PF01115	0.656
LIG_BRCT_BRCA1_1	253	257	PF00533	0.845
LIG_CtBP_PxDLS_1	235	239	PF00389	0.695
LIG_deltaCOP1_diTrp_1	106	114	PF00928	0.642
LIG_EVH1_1	413	417	PF00568	0.792
LIG_FHA_1	219	225	PF00498	0.737
LIG_FHA_1	265	271	PF00498	0.676
LIG_FHA_2	108	114	PF00498	0.648
LIG_FHA_2	240	246	PF00498	0.701
LIG_LIR_Apic_2	398	404	PF02991	0.642
LIG_LIR_Gen_1	425	431	PF02991	0.648
LIG_LIR_Gen_1	83	94	PF02991	0.582
LIG_LIR_Nem_3	425	430	PF02991	0.702
LIG_LIR_Nem_3	83	89	PF02991	0.559
LIG_MYND_1	411	415	PF01753	0.790
LIG_PCNA_yPIPBox_3	336	348	PF02747	0.533
LIG_PTB_Apo_2	421	428	PF02174	0.651
LIG_PTB_Phospho_1	421	427	PF10480	0.651
LIG_RPA_C_Fungi	172	184	PF08784	0.694
LIG_SH2_CRK	201	205	PF00017	0.628
LIG_SH2_CRK	347	351	PF00017	0.728
LIG_SH2_CRK	401	405	PF00017	0.639
LIG_SH2_CRK	427	431	PF00017	0.703
LIG_SH2_CRK	86	90	PF00017	0.576
LIG_SH2_SRC	11	14	PF00017	0.647
LIG_SH2_STAT5	11	14	PF00017	0.602
LIG_SH2_STAT5	223	226	PF00017	0.843
LIG_SH3_1	401	407	PF00018	0.638
LIG_SH3_3	12	18	PF00018	0.641
LIG_SH3_3	205	211	PF00018	0.650
LIG_SH3_3	401	407	PF00018	0.778
LIG_SH3_3	408	414	PF00018	0.640
LIG_SUMO_SIM_anti_2	202	208	PF11976	0.635
LIG_SUMO_SIM_par_1	223	229	PF11976	0.847
LIG_TRAF2_1	391	394	PF00917	0.673
LIG_WRC_WIRS_1	301	306	PF05994	0.784
MOD_CDK_SPK_2	207	212	PF00069	0.658
MOD_CK1_1	107	113	PF00069	0.572
MOD_CK1_1	135	141	PF00069	0.668
MOD_CK1_1	166	172	PF00069	0.840
MOD_CK1_1	25	31	PF00069	0.688
MOD_CK1_1	260	266	PF00069	0.669
MOD_CK1_1	294	300	PF00069	0.811
MOD_CK1_1	303	309	PF00069	0.609
MOD_CK1_1	351	357	PF00069	0.661
MOD_CK1_1	365	371	PF00069	0.734
MOD_CK1_1	7	13	PF00069	0.659
MOD_CK1_1	93	99	PF00069	0.652
MOD_CK2_1	100	106	PF00069	0.797
MOD_CK2_1	239	245	PF00069	0.704
MOD_Cter_Amidation	181	184	PF01082	0.707
MOD_Cter_Amidation	322	325	PF01082	0.694
MOD_GlcNHglycan	171	174	PF01048	0.803
MOD_GlcNHglycan	177	180	PF01048	0.818
MOD_GlcNHglycan	189	192	PF01048	0.608
MOD_GlcNHglycan	253	256	PF01048	0.678
MOD_GlcNHglycan	351	354	PF01048	0.758
MOD_GlcNHglycan	41	44	PF01048	0.675
MOD_GlcNHglycan	6	9	PF01048	0.638
MOD_GlcNHglycan	95	98	PF01048	0.801
MOD_GSK3_1	100	107	PF00069	0.797
MOD_GSK3_1	162	169	PF00069	0.824
MOD_GSK3_1	171	178	PF00069	0.704
MOD_GSK3_1	183	190	PF00069	0.667
MOD_GSK3_1	214	221	PF00069	0.647
MOD_GSK3_1	251	258	PF00069	0.819
MOD_GSK3_1	260	267	PF00069	0.662
MOD_GSK3_1	300	307	PF00069	0.785
MOD_GSK3_1	357	364	PF00069	0.852
MOD_GSK3_1	405	412	PF00069	0.653
MOD_N-GLC_1	1	6	PF02516	0.821
MOD_N-GLC_1	175	180	PF02516	0.693
MOD_N-GLC_1	231	236	PF02516	0.851
MOD_N-GLC_1	361	366	PF02516	0.859
MOD_N-GLC_1	370	375	PF02516	0.701
MOD_N-GLC_1	73	78	PF02516	0.761
MOD_NEK2_1	1	6	PF00069	0.821
MOD_NEK2_1	175	180	PF00069	0.850
MOD_NEK2_1	302	307	PF00069	0.776
MOD_NEK2_1	348	353	PF00069	0.741
MOD_OFUCOSY	101	108	PF10250	0.795
MOD_PIKK_1	304	310	PF00454	0.761
MOD_PK_1	22	28	PF00069	0.669
MOD_PK_1	90	96	PF00069	0.792
MOD_PKA_2	169	175	PF00069	0.680
MOD_PKA_2	282	288	PF00069	0.828
MOD_PKB_1	183	191	PF00069	0.701
MOD_PKB_1	20	28	PF00069	0.665
MOD_Plk_1	1	7	PF00069	0.644
MOD_Plk_1	135	141	PF00069	0.668
MOD_Plk_1	65	71	PF00069	0.737
MOD_Plk_1	73	79	PF00069	0.682
MOD_Plk_4	22	28	PF00069	0.672
MOD_Plk_4	7	13	PF00069	0.638
MOD_ProDKin_1	100	106	PF00069	0.797
MOD_ProDKin_1	183	189	PF00069	0.876
MOD_ProDKin_1	207	213	PF00069	0.832
MOD_ProDKin_1	231	237	PF00069	0.686
MOD_ProDKin_1	257	263	PF00069	0.844
MOD_SUMO_for_1	391	394	PF00179	0.673
MOD_SUMO_rev_2	118	127	PF00179	0.667
TRG_DiLeu_BaEn_4	334	340	PF01217	0.708
TRG_ENDOCYTIC_2	201	204	PF00928	0.629
TRG_ENDOCYTIC_2	347	350	PF00928	0.724
TRG_ENDOCYTIC_2	426	429	PF00928	0.712
TRG_ENDOCYTIC_2	86	89	PF00928	0.567
TRG_ER_diArg_1	139	141	PF00400	0.682
TRG_ER_diArg_1	153	155	PF00400	0.752
TRG_ER_diArg_1	183	185	PF00400	0.707
TRG_ER_diArg_1	20	23	PF00400	0.660
TRG_ER_diArg_1	324	327	PF00400	0.711
TRG_ER_diArg_1	89	92	PF00400	0.693
TRG_ER_diArg_1	98	100	PF00400	0.736
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.731
TRG_Pf-PMV_PEXEL_1	33	38	PF00026	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AI28	Leishmania braziliensis	67%	100%