Putative RNA-editing complex protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-editing complex protein - putative

Species:

Leishmania infantum

UniProt:

A4HTD3_LEIIN

TriTrypDb:

LINF_070017300

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HTD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTD3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0010035	response to inorganic substance	3	1
GO:0010038	response to metal ion	4	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042221	response to chemical	2	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004527	exonuclease activity	5	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0005488	binding	1	3
GO:0008270	zinc ion binding	6	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003697	single-stranded DNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.728
CLV_NRD_NRD_1	11	13	PF00675	0.560
CLV_NRD_NRD_1	2	4	PF00675	0.596
CLV_PCSK_FUR_1	213	217	PF00082	0.561
CLV_PCSK_KEX2_1	11	13	PF00082	0.546
CLV_PCSK_KEX2_1	2	4	PF00082	0.578
CLV_PCSK_KEX2_1	215	217	PF00082	0.598
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.598
CLV_PCSK_SKI1_1	215	219	PF00082	0.502
DEG_Nend_UBRbox_1	1	4	PF02207	0.568
DEG_SPOP_SBC_1	116	120	PF00917	0.698
DEG_SPOP_SBC_1	122	126	PF00917	0.653
DEG_SPOP_SBC_1	135	139	PF00917	0.726
DEG_SPOP_SBC_1	167	171	PF00917	0.725
DOC_CKS1_1	269	274	PF01111	0.650
DOC_CKS1_1	377	382	PF01111	0.533
DOC_MAPK_gen_1	95	103	PF00069	0.628
DOC_MAPK_MEF2A_6	344	352	PF00069	0.537
DOC_MAPK_MEF2A_6	431	440	PF00069	0.381
DOC_PP2B_PxIxI_1	435	441	PF00149	0.381
DOC_PP4_FxxP_1	153	156	PF00568	0.628
DOC_PP4_FxxP_1	377	380	PF00568	0.462
DOC_PP4_FxxP_1	399	402	PF00568	0.512
DOC_SPAK_OSR1_1	412	416	PF12202	0.412
DOC_USP7_MATH_1	117	121	PF00917	0.639
DOC_USP7_MATH_1	122	126	PF00917	0.607
DOC_USP7_MATH_1	134	138	PF00917	0.544
DOC_USP7_MATH_1	160	164	PF00917	0.664
DOC_USP7_MATH_1	168	172	PF00917	0.652
DOC_USP7_MATH_1	267	271	PF00917	0.698
DOC_USP7_MATH_1	283	287	PF00917	0.661
DOC_USP7_MATH_1	301	305	PF00917	0.583
DOC_USP7_UBL2_3	91	95	PF12436	0.548
DOC_WW_Pin1_4	125	130	PF00397	0.646
DOC_WW_Pin1_4	136	141	PF00397	0.674
DOC_WW_Pin1_4	144	149	PF00397	0.526
DOC_WW_Pin1_4	169	174	PF00397	0.686
DOC_WW_Pin1_4	183	188	PF00397	0.607
DOC_WW_Pin1_4	24	29	PF00397	0.634
DOC_WW_Pin1_4	258	263	PF00397	0.655
DOC_WW_Pin1_4	268	273	PF00397	0.575
DOC_WW_Pin1_4	376	381	PF00397	0.446
LIG_14-3-3_CanoR_1	12	20	PF00244	0.638
LIG_14-3-3_CanoR_1	50	58	PF00244	0.596
LIG_CaM_IQ_9	220	236	PF13499	0.439
LIG_Clathr_ClatBox_1	100	104	PF01394	0.614
LIG_FHA_1	103	109	PF00498	0.615
LIG_FHA_1	224	230	PF00498	0.433
LIG_FHA_1	389	395	PF00498	0.383
LIG_FHA_1	41	47	PF00498	0.585
LIG_FHA_1	414	420	PF00498	0.399
LIG_FHA_1	69	75	PF00498	0.537
LIG_FHA_2	269	275	PF00498	0.768
LIG_LIR_Apic_2	375	380	PF02991	0.452
LIG_LIR_Apic_2	398	402	PF02991	0.514
LIG_LIR_Gen_1	386	395	PF02991	0.401
LIG_LIR_Nem_3	386	392	PF02991	0.419
LIG_LIR_Nem_3	398	403	PF02991	0.400
LIG_LIR_Nem_3	71	75	PF02991	0.517
LIG_LYPXL_yS_3	435	438	PF13949	0.383
LIG_PDZ_Class_2	445	450	PF00595	0.409
LIG_Pex14_2	149	153	PF04695	0.663
LIG_SH2_CRK	433	437	PF00017	0.389
LIG_SH2_STAT3	311	314	PF00017	0.700
LIG_SH2_STAT5	311	314	PF00017	0.580
LIG_SH2_STAT5	362	365	PF00017	0.467
LIG_SH3_3	266	272	PF00018	0.754
LIG_SH3_3	317	323	PF00018	0.516
LIG_SH3_3	328	334	PF00018	0.500
LIG_SH3_3	379	385	PF00018	0.466
LIG_TRAF2_1	209	212	PF00917	0.692
LIG_TRAF2_1	333	336	PF00917	0.481
MOD_CK1_1	118	124	PF00069	0.616
MOD_CK1_1	125	131	PF00069	0.613
MOD_CK1_1	139	145	PF00069	0.691
MOD_CK1_1	169	175	PF00069	0.687
MOD_CK1_1	248	254	PF00069	0.589
MOD_CK1_1	268	274	PF00069	0.520
MOD_CK1_1	30	36	PF00069	0.680
MOD_CK1_1	41	47	PF00069	0.682
MOD_CK2_1	195	201	PF00069	0.689
MOD_CK2_1	268	274	PF00069	0.752
MOD_GlcNHglycan	125	128	PF01048	0.649
MOD_GlcNHglycan	141	144	PF01048	0.613
MOD_GlcNHglycan	15	18	PF01048	0.654
MOD_GlcNHglycan	183	186	PF01048	0.617
MOD_GlcNHglycan	203	206	PF01048	0.617
MOD_GlcNHglycan	247	250	PF01048	0.556
MOD_GlcNHglycan	252	255	PF01048	0.560
MOD_GlcNHglycan	281	284	PF01048	0.743
MOD_GlcNHglycan	285	288	PF01048	0.698
MOD_GlcNHglycan	29	32	PF01048	0.624
MOD_GlcNHglycan	408	411	PF01048	0.518
MOD_GlcNHglycan	443	446	PF01048	0.495
MOD_GSK3_1	116	123	PF00069	0.607
MOD_GSK3_1	135	142	PF00069	0.723
MOD_GSK3_1	169	176	PF00069	0.617
MOD_GSK3_1	244	251	PF00069	0.525
MOD_GSK3_1	279	286	PF00069	0.600
MOD_GSK3_1	372	379	PF00069	0.545
MOD_N-GLC_1	201	206	PF02516	0.646
MOD_N-GLC_1	301	306	PF02516	0.630
MOD_N-GLC_2	347	349	PF02516	0.399
MOD_NEK2_1	181	186	PF00069	0.631
MOD_NEK2_1	218	223	PF00069	0.448
MOD_NEK2_1	369	374	PF00069	0.460
MOD_NEK2_1	413	418	PF00069	0.454
MOD_NEK2_2	223	228	PF00069	0.435
MOD_NEK2_2	68	73	PF00069	0.536
MOD_PIKK_1	424	430	PF00454	0.554
MOD_PKA_2	49	55	PF00069	0.672
MOD_Plk_1	301	307	PF00069	0.627
MOD_Plk_4	30	36	PF00069	0.640
MOD_ProDKin_1	125	131	PF00069	0.645
MOD_ProDKin_1	136	142	PF00069	0.675
MOD_ProDKin_1	144	150	PF00069	0.523
MOD_ProDKin_1	169	175	PF00069	0.687
MOD_ProDKin_1	183	189	PF00069	0.608
MOD_ProDKin_1	24	30	PF00069	0.634
MOD_ProDKin_1	258	264	PF00069	0.658
MOD_ProDKin_1	268	274	PF00069	0.574
MOD_ProDKin_1	376	382	PF00069	0.451
TRG_DiLeu_BaEn_2	213	219	PF01217	0.650
TRG_ENDOCYTIC_2	435	438	PF00928	0.368
TRG_ER_diArg_1	1	3	PF00400	0.612
TRG_ER_diArg_1	11	13	PF00400	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P1	Leptomonas seymouri	57%	97%
A0A0S4IKI2	Bodo saltans	44%	100%
A0A1X0NPK8	Trypanosomatidae	47%	100%
A0A3S5H616	Leishmania donovani	100%	91%
A0A422N9Y4	Trypanosoma rangeli	45%	100%
A4H556	Leishmania braziliensis	72%	96%
C9ZUI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ALC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QIH9	Leishmania major	93%	100%
V5DQ35	Trypanosoma cruzi	48%	100%