Dpy-30 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dpy-30 motif containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HTD1_LEIIN

TriTrypDb:

LINF_070017100

Length:

116

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:0034708	methyltransferase complex	4	2
GO:0035097	histone methyltransferase complex	3	2
GO:0044666	MLL3/4 complex	4	2
GO:0048188	Set1C/COMPASS complex	4	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

A4HTD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTD1

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0051568	histone H3-K4 methylation	7	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	91	93	PF00675	0.317
CLV_PCSK_KEX2_1	91	93	PF00082	0.317
CLV_PCSK_SKI1_1	60	64	PF00082	0.407
DEG_APCC_DBOX_1	59	67	PF00400	0.607
DEG_SCF_FBW7_1	4	11	PF00400	0.555
DOC_CYCLIN_yCln2_LP_2	33	39	PF00134	0.663
DOC_PP2B_LxvP_1	23	26	PF13499	0.722
DOC_WW_Pin1_4	4	9	PF00397	0.627
LIG_14-3-3_CanoR_1	91	99	PF00244	0.676
LIG_Actin_WH2_2	78	93	PF00022	0.517
LIG_BIR_II_1	1	5	PF00653	0.699
LIG_eIF4E_1	84	90	PF01652	0.556
LIG_FHA_1	38	44	PF00498	0.462
LIG_FHA_1	96	102	PF00498	0.713
LIG_SH2_STAP1	103	107	PF00017	0.640
LIG_SH2_STAT5	57	60	PF00017	0.517
LIG_SH2_STAT5	84	87	PF00017	0.551
LIG_SH2_STAT5	88	91	PF00017	0.539
LIG_SH3_1	75	81	PF00018	0.517
LIG_SH3_3	73	79	PF00018	0.496
LIG_SUMO_SIM_par_1	97	102	PF11976	0.626
LIG_TRAF2_1	16	19	PF00917	0.725
MOD_CK1_1	2	8	PF00069	0.616
MOD_CK2_1	110	116	PF00069	0.748
MOD_GSK3_1	4	11	PF00069	0.622
MOD_GSK3_1	47	54	PF00069	0.635
MOD_GSK3_1	91	98	PF00069	0.637
MOD_GSK3_1	99	106	PF00069	0.376
MOD_N-GLC_1	95	100	PF02516	0.623
MOD_NEK2_1	58	63	PF00069	0.505
MOD_NEK2_1	90	95	PF00069	0.594
MOD_PIKK_1	51	57	PF00454	0.629
MOD_PKA_1	91	97	PF00069	0.671
MOD_PKA_2	90	96	PF00069	0.651
MOD_Plk_1	103	109	PF00069	0.388
MOD_Plk_1	47	53	PF00069	0.595
MOD_Plk_1	58	64	PF00069	0.468
MOD_Plk_1	95	101	PF00069	0.624
MOD_Plk_4	84	90	PF00069	0.525
MOD_ProDKin_1	4	10	PF00069	0.633
TRG_DiLeu_BaEn_4	18	24	PF01217	0.721
TRG_ER_diArg_1	75	78	PF00400	0.517
TRG_ER_diArg_1	90	92	PF00400	0.517
TRG_NES_CRM1_1	48	59	PF08389	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9I1	Leptomonas seymouri	66%	100%
A0A3S7WQ32	Leishmania donovani	99%	100%
A4H554	Leishmania braziliensis	77%	100%
E9ALC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QII1	Leishmania major	90%	100%
V5BYE7	Trypanosoma cruzi	45%	100%