LeishMANIAdb
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RNA binding protein-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RNA binding protein-like protein
Gene product:
RNA binding protein-like protein
Species:
Leishmania infantum
UniProt:
A4HTC4_LEIIN
TriTrypDb:
LINF_070016300
Length:
364

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA binding -like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Promastigote: 100, 111, 113

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HTC4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTC4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 116 120 PF00656 0.507
CLV_C14_Caspase3-7 164 168 PF00656 0.687
CLV_C14_Caspase3-7 180 184 PF00656 0.483
CLV_C14_Caspase3-7 205 209 PF00656 0.552
CLV_C14_Caspase3-7 235 239 PF00656 0.621
CLV_C14_Caspase3-7 247 251 PF00656 0.530
CLV_NRD_NRD_1 139 141 PF00675 0.638
CLV_NRD_NRD_1 361 363 PF00675 0.530
CLV_PCSK_KEX2_1 139 141 PF00082 0.638
CLV_PCSK_KEX2_1 361 363 PF00082 0.530
CLV_PCSK_PC1ET2_1 139 141 PF00082 0.638
CLV_PCSK_SKI1_1 118 122 PF00082 0.490
DOC_MAPK_gen_1 118 127 PF00069 0.557
DOC_PP2B_LxvP_1 18 21 PF13499 0.267
DOC_PP2B_LxvP_1 64 67 PF13499 0.267
DOC_USP7_MATH_1 108 112 PF00917 0.589
DOC_USP7_MATH_1 148 152 PF00917 0.647
DOC_USP7_MATH_1 53 57 PF00917 0.380
DOC_USP7_MATH_1 82 86 PF00917 0.371
DOC_USP7_UBL2_3 122 126 PF12436 0.610
DOC_WW_Pin1_4 304 309 PF00397 0.666
DOC_WW_Pin1_4 324 329 PF00397 0.627
DOC_WW_Pin1_4 334 339 PF00397 0.573
DOC_WW_Pin1_4 354 359 PF00397 0.526
DOC_WW_Pin1_4 8 13 PF00397 0.267
LIG_FHA_1 147 153 PF00498 0.608
LIG_FHA_1 40 46 PF00498 0.292
LIG_FHA_1 66 72 PF00498 0.258
LIG_FHA_2 131 137 PF00498 0.613
LIG_LIR_Gen_1 4 12 PF02991 0.267
LIG_LIR_Nem_3 4 8 PF02991 0.267
LIG_PTAP_UEV_1 224 229 PF05743 0.559
LIG_REV1ctd_RIR_1 78 87 PF16727 0.267
LIG_SH2_NCK_1 52 56 PF00017 0.371
LIG_SH2_STAT3 74 77 PF00017 0.338
LIG_SH2_STAT5 44 47 PF00017 0.267
LIG_SH3_3 122 128 PF00018 0.519
LIG_SH3_3 222 228 PF00018 0.561
LIG_SH3_3 28 34 PF00018 0.283
LIG_TRAF2_1 168 171 PF00917 0.534
LIG_TRAF2_1 245 248 PF00917 0.693
LIG_TRAF2_1 256 259 PF00917 0.705
MOD_CDC14_SPxK_1 11 14 PF00782 0.255
MOD_CDK_SPxK_1 8 14 PF00069 0.255
MOD_CDK_SPxxK_3 324 331 PF00069 0.644
MOD_CDK_SPxxK_3 354 361 PF00069 0.555
MOD_CK1_1 29 35 PF00069 0.256
MOD_CK1_1 294 300 PF00069 0.682
MOD_CK1_1 316 322 PF00069 0.574
MOD_CK1_1 346 352 PF00069 0.539
MOD_CK1_1 56 62 PF00069 0.371
MOD_CK2_1 130 136 PF00069 0.716
MOD_CK2_1 148 154 PF00069 0.526
MOD_CK2_1 165 171 PF00069 0.466
MOD_CK2_1 179 185 PF00069 0.611
MOD_CK2_1 227 233 PF00069 0.565
MOD_CK2_1 242 248 PF00069 0.590
MOD_Cter_Amidation 359 362 PF01082 0.542
MOD_GlcNHglycan 110 113 PF01048 0.589
MOD_GlcNHglycan 167 170 PF01048 0.689
MOD_GlcNHglycan 171 175 PF01048 0.629
MOD_GlcNHglycan 293 296 PF01048 0.681
MOD_GlcNHglycan 302 305 PF01048 0.572
MOD_GlcNHglycan 315 318 PF01048 0.548
MOD_GlcNHglycan 332 335 PF01048 0.561
MOD_GlcNHglycan 345 348 PF01048 0.557
MOD_GlcNHglycan 45 48 PF01048 0.338
MOD_GlcNHglycan 84 87 PF01048 0.278
MOD_GSK3_1 110 117 PF00069 0.614
MOD_GSK3_1 130 137 PF00069 0.428
MOD_GSK3_1 146 153 PF00069 0.479
MOD_GSK3_1 175 182 PF00069 0.629
MOD_GSK3_1 223 230 PF00069 0.663
MOD_GSK3_1 300 307 PF00069 0.681
MOD_GSK3_1 330 337 PF00069 0.605
MOD_GSK3_1 34 41 PF00069 0.314
MOD_N-GLC_1 313 318 PF02516 0.593
MOD_N-GLC_1 343 348 PF02516 0.542
MOD_NEK2_1 26 31 PF00069 0.454
MOD_NEK2_2 39 44 PF00069 0.267
MOD_NEK2_2 84 89 PF00069 0.267
MOD_PIKK_1 316 322 PF00454 0.545
MOD_PIKK_1 346 352 PF00454 0.526
MOD_PIKK_1 56 62 PF00454 0.267
MOD_PKA_2 291 297 PF00069 0.681
MOD_PKA_2 300 306 PF00069 0.570
MOD_PKA_2 330 336 PF00069 0.623
MOD_PKA_2 34 40 PF00069 0.338
MOD_Plk_2-3 110 116 PF00069 0.548
MOD_Plk_2-3 130 136 PF00069 0.391
MOD_Plk_2-3 150 156 PF00069 0.492
MOD_Plk_2-3 175 181 PF00069 0.635
MOD_Plk_2-3 242 248 PF00069 0.618
MOD_Plk_4 26 32 PF00069 0.267
MOD_Plk_4 39 45 PF00069 0.304
MOD_ProDKin_1 304 310 PF00069 0.665
MOD_ProDKin_1 324 330 PF00069 0.627
MOD_ProDKin_1 334 340 PF00069 0.572
MOD_ProDKin_1 354 360 PF00069 0.523
MOD_ProDKin_1 8 14 PF00069 0.267
MOD_SUMO_rev_2 113 123 PF00179 0.491
MOD_SUMO_rev_2 46 51 PF00179 0.267
MOD_SUMO_rev_2 9 18 PF00179 0.250
TRG_NLS_Bipartite_1 121 143 PF00514 0.579

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2Y4 Leptomonas seymouri 48% 100%
A0A3S7WQ00 Leishmania donovani 100% 100%
A4H548 Leishmania braziliensis 63% 100%
E9ALB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 96%
Q4QII7 Leishmania major 80% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS