WD domain, G-beta repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTC1_LEIIN

TriTrypDb:

LINF_070016000

Length:

879

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	497	501	PF00656	0.474
CLV_MEL_PAP_1	588	594	PF00089	0.492
CLV_NRD_NRD_1	106	108	PF00675	0.640
CLV_NRD_NRD_1	116	118	PF00675	0.512
CLV_NRD_NRD_1	139	141	PF00675	0.420
CLV_NRD_NRD_1	229	231	PF00675	0.601
CLV_NRD_NRD_1	42	44	PF00675	0.716
CLV_NRD_NRD_1	557	559	PF00675	0.410
CLV_NRD_NRD_1	575	577	PF00675	0.507
CLV_NRD_NRD_1	629	631	PF00675	0.608
CLV_NRD_NRD_1	665	667	PF00675	0.482
CLV_NRD_NRD_1	690	692	PF00675	0.654
CLV_NRD_NRD_1	763	765	PF00675	0.756
CLV_PCSK_FUR_1	113	117	PF00082	0.531
CLV_PCSK_FUR_1	752	756	PF00082	0.752
CLV_PCSK_KEX2_1	106	108	PF00082	0.635
CLV_PCSK_KEX2_1	115	117	PF00082	0.533
CLV_PCSK_KEX2_1	139	141	PF00082	0.420
CLV_PCSK_KEX2_1	21	23	PF00082	0.532
CLV_PCSK_KEX2_1	229	231	PF00082	0.618
CLV_PCSK_KEX2_1	575	577	PF00082	0.544
CLV_PCSK_KEX2_1	628	630	PF00082	0.645
CLV_PCSK_KEX2_1	665	667	PF00082	0.482
CLV_PCSK_KEX2_1	690	692	PF00082	0.654
CLV_PCSK_KEX2_1	742	744	PF00082	0.681
CLV_PCSK_KEX2_1	754	756	PF00082	0.672
CLV_PCSK_KEX2_1	762	764	PF00082	0.511
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.520
CLV_PCSK_PC1ET2_1	742	744	PF00082	0.681
CLV_PCSK_PC1ET2_1	754	756	PF00082	0.672
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.511
CLV_PCSK_SKI1_1	101	105	PF00082	0.530
CLV_PCSK_SKI1_1	150	154	PF00082	0.539
CLV_PCSK_SKI1_1	174	178	PF00082	0.600
CLV_PCSK_SKI1_1	323	327	PF00082	0.475
CLV_PCSK_SKI1_1	356	360	PF00082	0.561
CLV_PCSK_SKI1_1	417	421	PF00082	0.384
CLV_PCSK_SKI1_1	558	562	PF00082	0.432
CLV_PCSK_SKI1_1	644	648	PF00082	0.493
CLV_PCSK_SKI1_1	694	698	PF00082	0.702
DEG_APCC_DBOX_1	149	157	PF00400	0.718
DEG_APCC_DBOX_1	845	853	PF00400	0.445
DEG_MDM2_SWIB_1	335	343	PF02201	0.372
DOC_CYCLIN_RxL_1	556	567	PF00134	0.443
DOC_CYCLIN_yClb3_PxF_3	236	244	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	604	610	PF00134	0.523
DOC_MAPK_DCC_7	150	158	PF00069	0.657
DOC_MAPK_gen_1	115	127	PF00069	0.447
DOC_MAPK_gen_1	558	565	PF00069	0.390
DOC_MAPK_MEF2A_6	150	158	PF00069	0.657
DOC_MAPK_MEF2A_6	404	411	PF00069	0.381
DOC_MAPK_MEF2A_6	558	565	PF00069	0.503
DOC_MAPK_MEF2A_6	603	611	PF00069	0.527
DOC_MAPK_NFAT4_5	558	566	PF00069	0.436
DOC_PP1_RVXF_1	334	340	PF00149	0.353
DOC_PP2B_LxvP_1	253	256	PF13499	0.738
DOC_PP2B_LxvP_1	360	363	PF13499	0.447
DOC_PP4_FxxP_1	177	180	PF00568	0.641
DOC_PP4_FxxP_1	415	418	PF00568	0.497
DOC_PP4_MxPP_1	852	855	PF00568	0.510
DOC_USP7_MATH_1	224	228	PF00917	0.514
DOC_USP7_MATH_1	286	290	PF00917	0.728
DOC_USP7_MATH_1	302	306	PF00917	0.685
DOC_USP7_MATH_1	308	312	PF00917	0.621
DOC_USP7_MATH_1	375	379	PF00917	0.756
DOC_USP7_MATH_1	440	444	PF00917	0.445
DOC_USP7_MATH_1	494	498	PF00917	0.571
DOC_USP7_MATH_1	61	65	PF00917	0.568
DOC_USP7_MATH_1	638	642	PF00917	0.430
DOC_USP7_MATH_1	677	681	PF00917	0.748
DOC_USP7_MATH_1	724	728	PF00917	0.588
DOC_USP7_MATH_1	748	752	PF00917	0.762
DOC_USP7_MATH_1	768	772	PF00917	0.524
DOC_USP7_MATH_1	805	809	PF00917	0.581
DOC_WW_Pin1_4	143	148	PF00397	0.406
DOC_WW_Pin1_4	267	272	PF00397	0.632
DOC_WW_Pin1_4	303	308	PF00397	0.694
DOC_WW_Pin1_4	373	378	PF00397	0.700
DOC_WW_Pin1_4	384	389	PF00397	0.557
DOC_WW_Pin1_4	504	509	PF00397	0.354
DOC_WW_Pin1_4	590	595	PF00397	0.486
DOC_WW_Pin1_4	611	616	PF00397	0.391
DOC_WW_Pin1_4	63	68	PF00397	0.656
DOC_WW_Pin1_4	720	725	PF00397	0.741
DOC_WW_Pin1_4	731	736	PF00397	0.633
DOC_WW_Pin1_4	793	798	PF00397	0.761
LIG_14-3-3_CanoR_1	101	110	PF00244	0.534
LIG_14-3-3_CanoR_1	12	17	PF00244	0.538
LIG_14-3-3_CanoR_1	229	239	PF00244	0.683
LIG_14-3-3_CanoR_1	244	248	PF00244	0.584
LIG_14-3-3_CanoR_1	250	256	PF00244	0.590
LIG_14-3-3_CanoR_1	316	322	PF00244	0.591
LIG_14-3-3_CanoR_1	338	347	PF00244	0.482
LIG_14-3-3_CanoR_1	356	361	PF00244	0.534
LIG_14-3-3_CanoR_1	446	451	PF00244	0.400
LIG_14-3-3_CanoR_1	478	486	PF00244	0.524
LIG_14-3-3_CanoR_1	650	657	PF00244	0.436
LIG_Actin_WH2_2	549	566	PF00022	0.500
LIG_AP2alpha_2	130	132	PF02296	0.417
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_BIR_III_1	1	5	PF00653	0.634
LIG_BIR_III_2	794	798	PF00653	0.758
LIG_BIR_III_3	1	5	PF00653	0.634
LIG_BRCT_BRCA1_1	12	16	PF00533	0.562
LIG_BRCT_BRCA1_1	128	132	PF00533	0.411
LIG_BRCT_BRCA1_1	411	415	PF00533	0.473
LIG_CaM_IQ_9	438	453	PF13499	0.517
LIG_deltaCOP1_diTrp_1	33	38	PF00928	0.450
LIG_EVH1_2	854	858	PF00568	0.506
LIG_FHA_1	120	126	PF00498	0.449
LIG_FHA_1	387	393	PF00498	0.738
LIG_FHA_1	436	442	PF00498	0.448
LIG_FHA_1	510	516	PF00498	0.506
LIG_FHA_1	575	581	PF00498	0.518
LIG_FHA_1	658	664	PF00498	0.532
LIG_FHA_1	676	682	PF00498	0.515
LIG_FHA_1	842	848	PF00498	0.426
LIG_FHA_2	535	541	PF00498	0.400
LIG_FHA_2	820	826	PF00498	0.358
LIG_FXI_DFP_1	479	483	PF00024	0.666
LIG_IRF3_LxIS_1	406	412	PF10401	0.405
LIG_LIR_Apic_2	175	180	PF02991	0.522
LIG_LIR_Apic_2	194	200	PF02991	0.549
LIG_LIR_Apic_2	33	39	PF02991	0.462
LIG_LIR_Apic_2	399	403	PF02991	0.593
LIG_LIR_Apic_2	412	418	PF02991	0.249
LIG_LIR_Gen_1	416	425	PF02991	0.363
LIG_LIR_Gen_1	527	535	PF02991	0.444
LIG_LIR_Gen_1	802	811	PF02991	0.615
LIG_LIR_LC3C_4	204	207	PF02991	0.362
LIG_LIR_Nem_3	146	152	PF02991	0.377
LIG_LIR_Nem_3	327	333	PF02991	0.503
LIG_LIR_Nem_3	35	41	PF02991	0.510
LIG_LIR_Nem_3	416	422	PF02991	0.367
LIG_LIR_Nem_3	527	532	PF02991	0.429
LIG_LIR_Nem_3	802	806	PF02991	0.667
LIG_MYND_1	547	551	PF01753	0.408
LIG_Pex14_1	173	177	PF04695	0.518
LIG_Pex14_2	32	36	PF04695	0.433
LIG_Pex14_2	335	339	PF04695	0.370
LIG_Pex14_2	415	419	PF04695	0.379
LIG_PTAP_UEV_1	482	487	PF05743	0.500
LIG_Rb_LxCxE_1	350	368	PF01857	0.447
LIG_SH2_CRK	118	122	PF00017	0.506
LIG_SH2_CRK	149	153	PF00017	0.418
LIG_SH2_CRK	331	335	PF00017	0.446
LIG_SH2_CRK	400	404	PF00017	0.537
LIG_SH2_NCK_1	221	225	PF00017	0.429
LIG_SH2_NCK_1	331	335	PF00017	0.394
LIG_SH2_STAP1	14	18	PF00017	0.456
LIG_SH2_STAP1	509	513	PF00017	0.377
LIG_SH2_STAP1	631	635	PF00017	0.431
LIG_SH2_STAT5	14	17	PF00017	0.484
LIG_SH2_STAT5	201	204	PF00017	0.475
LIG_SH2_STAT5	331	334	PF00017	0.390
LIG_SH2_STAT5	625	628	PF00017	0.538
LIG_SH2_STAT5	631	634	PF00017	0.442
LIG_SH2_STAT5	655	658	PF00017	0.412
LIG_SH3_3	233	239	PF00018	0.543
LIG_SH3_3	268	274	PF00018	0.654
LIG_SH3_3	31	37	PF00018	0.438
LIG_SH3_3	346	352	PF00018	0.363
LIG_SH3_3	369	375	PF00018	0.729
LIG_SH3_3	480	486	PF00018	0.630
LIG_SH3_3	847	853	PF00018	0.580
LIG_SUMO_SIM_anti_2	838	844	PF11976	0.501
LIG_SUMO_SIM_par_1	122	130	PF11976	0.397
LIG_SUMO_SIM_par_1	407	413	PF11976	0.359
LIG_SUMO_SIM_par_1	536	542	PF11976	0.507
LIG_SUMO_SIM_par_1	644	649	PF11976	0.338
LIG_TRAF2_1	352	355	PF00917	0.416
LIG_TRAF2_1	701	704	PF00917	0.675
LIG_TRAF2_1	778	781	PF00917	0.711
LIG_TRAF2_2	161	166	PF00917	0.629
LIG_WRC_WIRS_1	325	330	PF05994	0.495
LIG_WRC_WIRS_1	618	623	PF05994	0.447
LIG_WRC_WIRS_1	800	805	PF05994	0.623
LIG_WW_1	198	201	PF00397	0.457
MOD_CDC14_SPxK_1	270	273	PF00782	0.671
MOD_CDC14_SPxK_1	796	799	PF00782	0.751
MOD_CDK_SPxK_1	267	273	PF00069	0.676
MOD_CDK_SPxK_1	793	799	PF00069	0.760
MOD_CDK_SPxxK_3	143	150	PF00069	0.430
MOD_CDK_SPxxK_3	272	279	PF00069	0.668
MOD_CK1_1	186	192	PF00069	0.724
MOD_CK1_1	240	246	PF00069	0.780
MOD_CK1_1	289	295	PF00069	0.659
MOD_CK1_1	311	317	PF00069	0.712
MOD_CK1_1	51	57	PF00069	0.559
MOD_CK1_1	63	69	PF00069	0.763
MOD_CK1_1	727	733	PF00069	0.756
MOD_CK1_1	841	847	PF00069	0.430
MOD_CK1_1	860	866	PF00069	0.630
MOD_CK2_1	208	214	PF00069	0.337
MOD_CK2_1	289	295	PF00069	0.695
MOD_CK2_1	504	510	PF00069	0.396
MOD_CK2_1	565	571	PF00069	0.577
MOD_CK2_1	617	623	PF00069	0.608
MOD_CK2_1	819	825	PF00069	0.343
MOD_GlcNHglycan	193	196	PF01048	0.654
MOD_GlcNHglycan	209	213	PF01048	0.340
MOD_GlcNHglycan	253	256	PF01048	0.770
MOD_GlcNHglycan	291	294	PF01048	0.674
MOD_GlcNHglycan	317	320	PF01048	0.716
MOD_GlcNHglycan	367	372	PF01048	0.723
MOD_GlcNHglycan	384	387	PF01048	0.545
MOD_GlcNHglycan	483	486	PF01048	0.527
MOD_GlcNHglycan	50	53	PF01048	0.671
MOD_GlcNHglycan	540	544	PF01048	0.505
MOD_GlcNHglycan	567	570	PF01048	0.607
MOD_GlcNHglycan	585	588	PF01048	0.374
MOD_GlcNHglycan	667	670	PF01048	0.718
MOD_GlcNHglycan	684	687	PF01048	0.580
MOD_GlcNHglycan	729	732	PF01048	0.661
MOD_GlcNHglycan	758	761	PF01048	0.643
MOD_GlcNHglycan	807	810	PF01048	0.614
MOD_GlcNHglycan	816	819	PF01048	0.327
MOD_GlcNHglycan	859	862	PF01048	0.767
MOD_GlcNHglycan	868	871	PF01048	0.653
MOD_GSK3_1	10	17	PF00069	0.515
MOD_GSK3_1	183	190	PF00069	0.626
MOD_GSK3_1	20	27	PF00069	0.614
MOD_GSK3_1	311	318	PF00069	0.684
MOD_GSK3_1	382	389	PF00069	0.677
MOD_GSK3_1	392	399	PF00069	0.532
MOD_GSK3_1	477	484	PF00069	0.513
MOD_GSK3_1	590	597	PF00069	0.509
MOD_GSK3_1	720	727	PF00069	0.717
MOD_GSK3_1	856	863	PF00069	0.611
MOD_LATS_1	99	105	PF00433	0.534
MOD_N-GLC_1	230	235	PF02516	0.613
MOD_NEK2_1	172	177	PF00069	0.624
MOD_NEK2_1	187	192	PF00069	0.630
MOD_NEK2_1	32	37	PF00069	0.572
MOD_NEK2_1	329	334	PF00069	0.417
MOD_NEK2_1	434	439	PF00069	0.432
MOD_NEK2_1	503	508	PF00069	0.378
MOD_NEK2_1	539	544	PF00069	0.481
MOD_NEK2_1	552	557	PF00069	0.299
MOD_NEK2_1	648	653	PF00069	0.431
MOD_NEK2_1	857	862	PF00069	0.532
MOD_NEK2_2	14	19	PF00069	0.397
MOD_NEK2_2	453	458	PF00069	0.545
MOD_PIKK_1	248	254	PF00454	0.756
MOD_PIKK_1	311	317	PF00454	0.742
MOD_PIKK_1	338	344	PF00454	0.396
MOD_PIKK_1	392	398	PF00454	0.502
MOD_PIKK_1	650	656	PF00454	0.437
MOD_PKA_1	629	635	PF00069	0.380
MOD_PKA_1	665	671	PF00069	0.571
MOD_PKA_1	754	760	PF00069	0.780
MOD_PKA_2	119	125	PF00069	0.456
MOD_PKA_2	222	228	PF00069	0.499
MOD_PKA_2	237	243	PF00069	0.767
MOD_PKA_2	315	321	PF00069	0.714
MOD_PKA_2	477	483	PF00069	0.567
MOD_PKA_2	574	580	PF00069	0.625
MOD_PKA_2	61	67	PF00069	0.568
MOD_PKA_2	629	635	PF00069	0.493
MOD_PKA_2	665	671	PF00069	0.571
MOD_PKA_2	754	760	PF00069	0.722
MOD_PKB_1	336	344	PF00069	0.376
MOD_PKB_1	46	54	PF00069	0.674
MOD_Plk_1	32	38	PF00069	0.595
MOD_Plk_1	527	533	PF00069	0.441
MOD_Plk_1	648	654	PF00069	0.432
MOD_Plk_4	119	125	PF00069	0.569
MOD_Plk_4	183	189	PF00069	0.535
MOD_Plk_4	237	243	PF00069	0.704
MOD_Plk_4	321	327	PF00069	0.538
MOD_Plk_4	375	381	PF00069	0.690
MOD_Plk_4	453	459	PF00069	0.537
MOD_Plk_4	534	540	PF00069	0.414
MOD_Plk_4	677	683	PF00069	0.599
MOD_ProDKin_1	143	149	PF00069	0.417
MOD_ProDKin_1	267	273	PF00069	0.634
MOD_ProDKin_1	303	309	PF00069	0.694
MOD_ProDKin_1	373	379	PF00069	0.700
MOD_ProDKin_1	384	390	PF00069	0.553
MOD_ProDKin_1	504	510	PF00069	0.354
MOD_ProDKin_1	590	596	PF00069	0.474
MOD_ProDKin_1	611	617	PF00069	0.391
MOD_ProDKin_1	63	69	PF00069	0.658
MOD_ProDKin_1	720	726	PF00069	0.742
MOD_ProDKin_1	731	737	PF00069	0.633
MOD_ProDKin_1	793	799	PF00069	0.760
MOD_SUMO_for_1	72	75	PF00179	0.710
MOD_SUMO_for_1	778	781	PF00179	0.676
TRG_DiLeu_BaEn_1	426	431	PF01217	0.366
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.514
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.436
TRG_ENDOCYTIC_2	149	152	PF00928	0.420
TRG_ER_diArg_1	106	108	PF00400	0.600
TRG_ER_diArg_1	115	117	PF00400	0.515
TRG_ER_diArg_1	217	220	PF00400	0.458
TRG_ER_diArg_1	335	338	PF00400	0.394
TRG_ER_diArg_1	46	49	PF00400	0.758
TRG_ER_diArg_1	561	564	PF00400	0.497
TRG_ER_diArg_1	628	630	PF00400	0.453
TRG_ER_diArg_1	743	746	PF00400	0.789
TRG_NLS_MonoCore_2	741	746	PF00514	0.723
TRG_NLS_MonoExtC_3	42	47	PF00514	0.611
TRG_NLS_MonoExtC_3	741	746	PF00514	0.793
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN7	Leptomonas seymouri	42%	100%
A0A3S5H609	Leishmania donovani	99%	100%
A4H545	Leishmania braziliensis	71%	100%
E9ALB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QIJ0	Leishmania major	88%	100%