LeishMANIAdb
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Radial spoke head protein 9

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Radial spoke head protein 9
Gene product:
Radial spokehead-like protein - putative
Species:
Leishmania infantum
UniProt:
A4HTB7_LEIIN
TriTrypDb:
LINF_070015600
Length:
337

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1
GO:0001534 radial spoke 2 2
GO:0032991 protein-containing complex 1 2

Expansion

Sequence features

A4HTB7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTB7

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0001578 microtubule bundle formation 4 1
GO:0003341 cilium movement 4 3
GO:0006996 organelle organization 4 3
GO:0007010 cytoskeleton organization 5 1
GO:0007017 microtubule-based process 2 3
GO:0007018 microtubule-based movement 3 3
GO:0009987 cellular process 1 3
GO:0016043 cellular component organization 3 3
GO:0022607 cellular component assembly 4 3
GO:0030030 cell projection organization 4 3
GO:0030031 cell projection assembly 5 3
GO:0035082 axoneme assembly 5 1
GO:0044458 motile cilium assembly 7 1
GO:0044782 cilium organization 5 3
GO:0060271 cilium assembly 6 3
GO:0060294 cilium movement involved in cell motility 5 3
GO:0070925 organelle assembly 5 3
GO:0071840 cellular component organization or biogenesis 2 3
GO:0120031 plasma membrane bounded cell projection assembly 6 3
GO:0120036 plasma membrane bounded cell projection organization 5 3
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 182 184 PF00675 0.670
CLV_PCSK_KEX2_1 184 186 PF00082 0.561
CLV_PCSK_PC1ET2_1 184 186 PF00082 0.561
CLV_PCSK_SKI1_1 185 189 PF00082 0.643
CLV_PCSK_SKI1_1 301 305 PF00082 0.464
DOC_CKS1_1 125 130 PF01111 0.633
DOC_MAPK_gen_1 183 194 PF00069 0.488
DOC_MAPK_gen_1 34 42 PF00069 0.483
DOC_PP1_SILK_1 129 134 PF00149 0.426
DOC_USP7_MATH_1 152 156 PF00917 0.713
DOC_USP7_MATH_1 229 233 PF00917 0.604
DOC_USP7_MATH_1 66 70 PF00917 0.475
DOC_USP7_UBL2_3 184 188 PF12436 0.543
DOC_USP7_UBL2_3 41 45 PF12436 0.444
DOC_WW_Pin1_4 124 129 PF00397 0.661
DOC_WW_Pin1_4 35 40 PF00397 0.451
LIG_14-3-3_CanoR_1 190 195 PF00244 0.504
LIG_14-3-3_CanoR_1 212 216 PF00244 0.412
LIG_14-3-3_CanoR_1 230 235 PF00244 0.605
LIG_BIR_II_1 1 5 PF00653 0.392
LIG_FHA_1 270 276 PF00498 0.395
LIG_FHA_1 292 298 PF00498 0.429
LIG_FHA_2 15 21 PF00498 0.514
LIG_LIR_Apic_2 272 277 PF02991 0.485
LIG_LIR_Apic_2 308 314 PF02991 0.344
LIG_LIR_Gen_1 105 114 PF02991 0.524
LIG_LIR_Gen_1 246 254 PF02991 0.398
LIG_LIR_Gen_1 78 85 PF02991 0.548
LIG_LIR_Nem_3 69 73 PF02991 0.393
LIG_LIR_Nem_3 78 82 PF02991 0.405
LIG_PDZ_Class_2 332 337 PF00595 0.436
LIG_Pex14_1 287 291 PF04695 0.373
LIG_Pex14_2 331 335 PF04695 0.449
LIG_PTB_Apo_2 2 9 PF02174 0.527
LIG_PTB_Apo_2 299 306 PF02174 0.359
LIG_PTB_Apo_2 58 65 PF02174 0.503
LIG_PTB_Phospho_1 2 8 PF10480 0.534
LIG_PTB_Phospho_1 299 305 PF10480 0.395
LIG_SH2_CRK 100 104 PF00017 0.520
LIG_SH2_CRK 323 327 PF00017 0.454
LIG_SH2_STAP1 106 110 PF00017 0.526
LIG_SH2_STAT3 219 222 PF00017 0.464
LIG_SH2_STAT5 219 222 PF00017 0.407
LIG_SH2_STAT5 248 251 PF00017 0.375
LIG_SH2_STAT5 274 277 PF00017 0.478
LIG_SH2_STAT5 323 326 PF00017 0.382
LIG_SH2_STAT5 8 11 PF00017 0.421
LIG_SH3_3 120 126 PF00018 0.592
LIG_SH3_3 176 182 PF00018 0.676
LIG_SH3_5 270 274 PF00018 0.506
LIG_SUMO_SIM_par_1 190 196 PF11976 0.429
MOD_CAAXbox 334 337 PF01239 0.452
MOD_CDK_SPxK_1 35 41 PF00069 0.465
MOD_CK1_1 14 20 PF00069 0.475
MOD_CK1_1 69 75 PF00069 0.400
MOD_CK1_1 83 89 PF00069 0.465
MOD_CK2_1 14 20 PF00069 0.390
MOD_CK2_1 190 196 PF00069 0.479
MOD_GSK3_1 143 150 PF00069 0.586
MOD_N-GLC_1 230 235 PF02516 0.527
MOD_N-GLC_1 291 296 PF02516 0.538
MOD_NEK2_1 11 16 PF00069 0.536
MOD_NEK2_1 24 29 PF00069 0.224
MOD_NEK2_2 211 216 PF00069 0.452
MOD_NEK2_2 285 290 PF00069 0.494
MOD_NEK2_2 305 310 PF00069 0.154
MOD_NEK2_2 66 71 PF00069 0.471
MOD_PIKK_1 29 35 PF00454 0.524
MOD_PK_1 190 196 PF00069 0.514
MOD_PKA_1 243 249 PF00069 0.510
MOD_PKA_2 211 217 PF00069 0.413
MOD_PKA_2 229 235 PF00069 0.601
MOD_Plk_1 19 25 PF00069 0.470
MOD_Plk_1 230 236 PF00069 0.557
MOD_Plk_2-3 147 153 PF00069 0.712
MOD_Plk_4 305 311 PF00069 0.358
MOD_Plk_4 66 72 PF00069 0.434
MOD_ProDKin_1 124 130 PF00069 0.653
MOD_ProDKin_1 35 41 PF00069 0.450
TRG_DiLeu_BaEn_3 257 263 PF01217 0.526
TRG_DiLeu_BaEn_4 87 93 PF01217 0.559
TRG_DiLeu_BaLyEn_6 26 31 PF01217 0.405
TRG_DiLeu_BaLyEn_6 7 12 PF01217 0.440
TRG_ENDOCYTIC_2 100 103 PF00928 0.508
TRG_ENDOCYTIC_2 106 109 PF00928 0.546
TRG_ENDOCYTIC_2 248 251 PF00928 0.369
TRG_ENDOCYTIC_2 8 11 PF00928 0.501
TRG_ER_diArg_1 182 185 PF00400 0.691
TRG_ER_diArg_1 259 262 PF00400 0.447
TRG_NLS_MonoExtN_4 180 187 PF00514 0.568
TRG_Pf-PMV_PEXEL_1 301 306 PF00026 0.471

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL99 Leptomonas seymouri 72% 99%
A0A0S4J8G1 Bodo saltans 39% 100%
A0A1X0NQ76 Trypanosomatidae 50% 100%
A0A3Q8IKD9 Leishmania donovani 24% 100%
A0A3R7MSU5 Trypanosoma rangeli 50% 100%
A0A3S7WQ16 Leishmania donovani 97% 100%
A4H541 Leishmania braziliensis 85% 99%
C9ZUK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
D0A660 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AHR8 Leishmania infantum 24% 100%
E9ALB0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 98%
E9B489 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
Q4Q3T7 Leishmania major 24% 100%
Q4QIJ4 Leishmania major 97% 99%
Q5TYW6 Danio rerio 26% 100%
Q9D9V4 Mus musculus 24% 100%
Q9H1X1 Homo sapiens 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS