LeishMANIAdb
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Splicing factor ptsr1-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Splicing factor ptsr1-like protein
Gene product:
splicing factor ptsr1-like protein
Species:
Leishmania infantum
UniProt:
A4HTB3_LEIIN
TriTrypDb:
LINF_070014900
Length:
375

Annotations

Annotations by Jardim et al.

RNA Processing, Splicing factor ptsr1-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 3
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HTB3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTB3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 163 165 PF00675 0.641
CLV_NRD_NRD_1 218 220 PF00675 0.579
CLV_NRD_NRD_1 234 236 PF00675 0.357
CLV_NRD_NRD_1 258 260 PF00675 0.690
CLV_NRD_NRD_1 273 275 PF00675 0.460
CLV_NRD_NRD_1 288 290 PF00675 0.535
CLV_NRD_NRD_1 297 299 PF00675 0.595
CLV_NRD_NRD_1 303 305 PF00675 0.535
CLV_NRD_NRD_1 327 329 PF00675 0.740
CLV_NRD_NRD_1 340 342 PF00675 0.503
CLV_NRD_NRD_1 343 345 PF00675 0.477
CLV_NRD_NRD_1 353 355 PF00675 0.492
CLV_NRD_NRD_1 363 365 PF00675 0.721
CLV_NRD_NRD_1 366 368 PF00675 0.677
CLV_NRD_NRD_1 371 373 PF00675 0.465
CLV_PCSK_FUR_1 301 305 PF00082 0.735
CLV_PCSK_FUR_1 325 329 PF00082 0.741
CLV_PCSK_FUR_1 338 342 PF00082 0.501
CLV_PCSK_FUR_1 364 368 PF00082 0.717
CLV_PCSK_KEX2_1 163 165 PF00082 0.641
CLV_PCSK_KEX2_1 218 220 PF00082 0.579
CLV_PCSK_KEX2_1 234 236 PF00082 0.357
CLV_PCSK_KEX2_1 260 262 PF00082 0.722
CLV_PCSK_KEX2_1 273 275 PF00082 0.527
CLV_PCSK_KEX2_1 287 289 PF00082 0.554
CLV_PCSK_KEX2_1 296 298 PF00082 0.598
CLV_PCSK_KEX2_1 303 305 PF00082 0.521
CLV_PCSK_KEX2_1 327 329 PF00082 0.740
CLV_PCSK_KEX2_1 340 342 PF00082 0.503
CLV_PCSK_KEX2_1 343 345 PF00082 0.477
CLV_PCSK_KEX2_1 352 354 PF00082 0.574
CLV_PCSK_KEX2_1 363 365 PF00082 0.721
CLV_PCSK_KEX2_1 366 368 PF00082 0.677
CLV_PCSK_KEX2_1 371 373 PF00082 0.465
CLV_PCSK_PC1ET2_1 163 165 PF00082 0.635
CLV_PCSK_PC1ET2_1 260 262 PF00082 0.722
CLV_PCSK_PC7_1 269 275 PF00082 0.721
CLV_PCSK_PC7_1 293 299 PF00082 0.697
CLV_PCSK_PC7_1 359 365 PF00082 0.726
CLV_PCSK_PC7_1 367 373 PF00082 0.712
CLV_PCSK_SKI1_1 117 121 PF00082 0.525
CLV_PCSK_SKI1_1 185 189 PF00082 0.527
CLV_PCSK_SKI1_1 88 92 PF00082 0.559
DEG_APCC_KENBOX_2 159 163 PF00400 0.619
DEG_SPOP_SBC_1 121 125 PF00917 0.516
DOC_MAPK_gen_1 142 149 PF00069 0.553
DOC_MAPK_MEF2A_6 142 151 PF00069 0.555
DOC_MAPK_MEF2A_6 74 83 PF00069 0.566
DOC_MAPK_RevD_3 248 261 PF00069 0.501
DOC_USP7_MATH_1 15 19 PF00917 0.726
DOC_USP7_MATH_1 202 206 PF00917 0.463
DOC_USP7_MATH_1 23 27 PF00917 0.648
DOC_WW_Pin1_4 261 266 PF00397 0.751
DOC_WW_Pin1_4 304 309 PF00397 0.736
DOC_WW_Pin1_4 328 333 PF00397 0.788
DOC_WW_Pin1_4 58 63 PF00397 0.713
LIG_14-3-3_CanoR_1 301 307 PF00244 0.718
LIG_14-3-3_CanoR_1 31 39 PF00244 0.726
LIG_14-3-3_CanoR_1 311 317 PF00244 0.648
LIG_14-3-3_CanoR_1 325 331 PF00244 0.761
LIG_14-3-3_CanoR_1 88 93 PF00244 0.563
LIG_BIR_II_1 1 5 PF00653 0.717
LIG_FHA_1 121 127 PF00498 0.529
LIG_FHA_1 231 237 PF00498 0.553
LIG_FHA_1 87 93 PF00498 0.545
LIG_FHA_1 94 100 PF00498 0.459
LIG_FHA_2 122 128 PF00498 0.522
LIG_FHA_2 153 159 PF00498 0.602
LIG_FHA_2 227 233 PF00498 0.494
LIG_FHA_2 46 52 PF00498 0.705
LIG_FHA_2 59 65 PF00498 0.548
LIG_FHA_2 89 95 PF00498 0.551
LIG_GBD_Chelix_1 236 244 PF00786 0.556
LIG_Integrin_RGD_1 367 369 PF01839 0.650
LIG_NRP_CendR_1 372 375 PF00754 0.698
LIG_PTB_Apo_2 135 142 PF02174 0.545
LIG_PTB_Phospho_1 135 141 PF10480 0.525
LIG_SH2_GRB2like 180 183 PF00017 0.603
LIG_SH2_NCK_1 224 228 PF00017 0.375
LIG_SH2_SRC 224 227 PF00017 0.511
LIG_SH2_STAT5 180 183 PF00017 0.608
LIG_SH2_STAT5 221 224 PF00017 0.526
LIG_SH2_STAT5 306 309 PF00017 0.737
LIG_SH2_STAT5 98 101 PF00017 0.592
LIG_SH3_2 69 74 PF14604 0.720
LIG_SH3_3 46 52 PF00018 0.610
LIG_SH3_3 66 72 PF00018 0.735
LIG_SUMO_SIM_par_1 88 94 PF11976 0.530
LIG_TRAF2_1 125 128 PF00917 0.575
MOD_CDC14_SPxK_1 264 267 PF00782 0.718
MOD_CDK_SPxK_1 261 267 PF00069 0.717
MOD_CDK_SPxxK_3 304 311 PF00069 0.738
MOD_CK1_1 152 158 PF00069 0.592
MOD_CK1_1 30 36 PF00069 0.733
MOD_CK1_1 302 308 PF00069 0.753
MOD_CK1_1 309 315 PF00069 0.676
MOD_CK1_1 317 323 PF00069 0.571
MOD_CK1_1 331 337 PF00069 0.492
MOD_CK2_1 121 127 PF00069 0.562
MOD_CK2_1 152 158 PF00069 0.589
MOD_CK2_1 202 208 PF00069 0.536
MOD_CK2_1 45 51 PF00069 0.648
MOD_CK2_1 88 94 PF00069 0.565
MOD_Cter_Amidation 294 297 PF01082 0.631
MOD_Cter_Amidation 325 328 PF01082 0.743
MOD_DYRK1A_RPxSP_1 304 308 PF00069 0.738
MOD_DYRK1A_RPxSP_1 328 332 PF00069 0.736
MOD_GlcNHglycan 17 20 PF01048 0.606
MOD_GlcNHglycan 21 24 PF01048 0.555
MOD_GlcNHglycan 27 30 PF01048 0.534
MOD_GlcNHglycan 45 48 PF01048 0.630
MOD_GlcNHglycan 7 10 PF01048 0.719
MOD_GSK3_1 1 8 PF00069 0.739
MOD_GSK3_1 13 20 PF00069 0.588
MOD_GSK3_1 21 28 PF00069 0.511
MOD_GSK3_1 226 233 PF00069 0.586
MOD_GSK3_1 29 36 PF00069 0.527
MOD_GSK3_1 302 309 PF00069 0.736
MOD_GSK3_1 310 317 PF00069 0.632
MOD_GSK3_1 86 93 PF00069 0.503
MOD_LATS_1 285 291 PF00433 0.733
MOD_NEK2_1 1 6 PF00069 0.749
MOD_NEK2_1 120 125 PF00069 0.518
MOD_PIKK_1 7 13 PF00454 0.656
MOD_PKA_1 287 293 PF00069 0.736
MOD_PKA_2 169 175 PF00069 0.732
MOD_PKA_2 280 286 PF00069 0.740
MOD_PKA_2 287 293 PF00069 0.675
MOD_PKA_2 30 36 PF00069 0.750
MOD_PKA_2 302 308 PF00069 0.544
MOD_PKA_2 310 316 PF00069 0.669
MOD_PKA_2 326 332 PF00069 0.754
MOD_PKA_2 339 345 PF00069 0.509
MOD_PKB_1 287 295 PF00069 0.735
MOD_PKB_1 319 327 PF00069 0.742
MOD_PKB_1 352 360 PF00069 0.556
MOD_Plk_1 121 127 PF00069 0.529
MOD_Plk_2-3 122 128 PF00069 0.530
MOD_Plk_4 253 259 PF00069 0.546
MOD_Plk_4 75 81 PF00069 0.562
MOD_ProDKin_1 261 267 PF00069 0.752
MOD_ProDKin_1 304 310 PF00069 0.735
MOD_ProDKin_1 328 334 PF00069 0.789
MOD_ProDKin_1 58 64 PF00069 0.717
TRG_DiLeu_BaEn_1 128 133 PF01217 0.593
TRG_DiLeu_BaEn_1 247 252 PF01217 0.480
TRG_ENDOCYTIC_2 224 227 PF00928 0.511
TRG_ER_diArg_1 112 115 PF00400 0.553
TRG_ER_diArg_1 234 236 PF00400 0.472
TRG_ER_diArg_1 258 261 PF00400 0.698
TRG_ER_diArg_1 272 274 PF00400 0.475
TRG_ER_diArg_1 287 289 PF00400 0.540
TRG_ER_diArg_1 296 298 PF00400 0.595
TRG_ER_diArg_1 301 304 PF00400 0.547
TRG_ER_diArg_1 325 328 PF00400 0.743
TRG_ER_diArg_1 340 343 PF00400 0.481
TRG_ER_diArg_1 352 354 PF00400 0.574
TRG_ER_diArg_1 371 374 PF00400 0.694
TRG_NLS_MonoCore_2 162 167 PF00514 0.637
TRG_NLS_MonoExtC_3 162 168 PF00514 0.636
TRG_NLS_MonoExtN_4 160 167 PF00514 0.632
TRG_Pf-PMV_PEXEL_1 130 135 PF00026 0.492
TRG_Pf-PMV_PEXEL_1 249 253 PF00026 0.476

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WPZ1 Leishmania donovani 99% 100%
A4H537 Leishmania braziliensis 80% 100%
E9ALA4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QIK0 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS